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| 1 | In Vivo Therapeutic Silencing of Hypoxia-Inducible Factor 1 Alpha(HIF-1)Using Single-Walled Carbon Nanotubes Noncovalently Coated with siRNA显示文摘A new approach is described for delivering small interfering RNA(siRNA)into cancer cells by noncovalently complexing unmodifi ed siRNA with pristine single-walled carbon nanotubes(SWCNTs).The complexes were prepared by simple sonication of pristine SWCNTs in a solution of siRNA,which then served both as the cargo and as the suspending agent for the SWCNTs.When complexes containing siRNA targeted to hypoxia-inducible factor 1 alpha(HIF-1)were added to cells growing in serum containing culture media,there was strong specific inhibition of cellular HIF-1 activity.The ability to obtain a biological response to SWCNT/siRNA complexes was seen in a wide variety of cancer cell types.Moreover,intratumoral administration of SWCNT-HIF-1 siRNA complexes in mice bearing MiaPaCa-2/HRE tumors signifi cantly inhibited the activity of tumor HIF-1.As elevated levels of HIF-1 are found in many human cancers and are associated with resistance to therapy and decreased patient survival,these results imply that SWCNT/siRNA complexes may have value as therapeutic agents. | Geoffrey Bartholomeusz Paul Cherukuri John Kingston Laurent Cognet Robert Lemos Jr Tonya KLeeuw Laura Gumbiner-Russo RBruce Weisman Garth Powis | 2009 | Nano Research2009，2，4： | 7 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation显示文摘 | Luana S. Nunes José T.P. Barbosa Andréa P. Fernandes Valfredo A. Lemos Walter N.L. dos Santos Maria Gra?as A. Korn Leonardo S.G. Teixeira | 2011 | Food Chemistry2011，，2： | 4 |
| 4 | Analysis of foundation sliding of an arch dam considering the hydromechanical behavior显示文摘This paper presents the application of a methodology which can be used to assess arch dam foundation stability,using the discrete element method(DEM)and the code 3DEC.A global three-dimensional model of a dam foundation was developed,in which some discontinuities were simulated and both the grout and drainage curtains were represented.The model,calibrated taking into account recorded data,was used to carry out nonlinear mechanical analysis.The same model was employed to perform a hydraulic analysis,based on equivalent continuum concepts,which allowed the water pressure pattern within the foundation to be obtained.These water pressures were applied on discontinuities involved in the possible sliding mechanism along the dam/foundation interface,and the safety of the dam/foundation system was evaluated using a process of reduction of strength characteristics,with the aim of calculating the minimum safety factors that ensure stability.Results were compared with those obtained with the usual bi-linear uplift pressure distribution at the base of the dam,commonly used in concrete dam design.The relevance of carrying out hydraulic analysis in arch dam foundation failure studies is highlighted. | Maria Luísa Braga FARINHA JoséVieira de LEMOS Emanuel MARANHA DAS NEVES | 2012 | Frontiers of Structural and Civil Engineering2012，6，1： | 4 |
| 5 | Physiological and Biochemical Responses of Wheat Subjected to Water Deficit Stress at Different Phenological Stages of Development显示文摘 | J. M. Lemos E. C. G. Vendruscolo I. Schuster M. F. dos Santos | 2011 | Journal of Agricultural Science and Technology(B)2011，1，8： | 3 |
| 6 | Advances in enhanced biological phosphorus removal: From micro to macro scale显示文摘 | Adrian Oehmen Paulo C. Lemos Gilda Carvalho Zhiguo Yuan Jürg Keller Linda L. Blackall Maria A.M. Reis | 2007 | Water Research2007，，11： | 3 |
| 7 | Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis显示文摘BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice. | Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，14： | 2 |
| 8 | 超重和肥胖的不同指标与动脉粥样硬化患病之间的关系:Dallas心脏研究显示文摘目的:本研究拟在大规模人群队列中评估超重和肥胖的不同指标与动脉粥样硬化患病之间的关系。背景:虽然肥胖与心血管性死亡有关,但是尚不清楚这种关系是否由增加的动脉粥样硬化负荷所介导。方法:使用来自Dallas心脏研究的资料,作者评估了性别特异性的肥胖指标犤即体重指数(BMI)、腰围(WC)、腰臀比(WHR)犦与动脉粥样硬化患病之间的关系, | See R. Abdullah S.M. McGuire D.K. J.A. de Lemos 黄欣 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，，12： | 2 |
| 9 | Architecting Fault Tolerance with Exception Handling: Verification and Validation显示文摘When building dependable systems by integrating untrusted software components that were not originally designed to interact with each other, it is likely the occurrence of architectural mismatches related to assumptions in their failure behaviour. These mismatches, if not prevented during system design, have to be tolerated during runtime. This paper presents an architectural abstraction based on exception handling for structuring fault-tolerant software systems. This abstraction comprises several components and connectors that promote an existing untrusted software element into an idealised fault-tolerant architectural element. Moreover, it is considered in the context of a rigorous software development approach based on formal methods for representing the structure and behaviour of the software architecture. The proposed approach relies on a formal specification and verification for analysing exception propagation, and verifying important dependability properties, such as deadlock freedom, and scenarios of architectural reconfiguration. The formal models are automatically generated using model transformation from UML diagrams: component diagram representing the system structure, and sequence diagrams representing the system behaviour. Finally, the formal models are also used for generating unit and integration test cases that are used for assessing the correctness of the source code. The feasibility of the proposed architectural approach was evaluated on an embedded critical case study. | Patrick H. S. Brito Rogério de Lemos Cecília M. F. Rubira Eliane Martins | 2009 | Journal of Computer Science & Technology2009，24，2： | 2 |
| 10 | Role of nickel-regulated small RNA in modulation of Helicobacter pylori virulence factors显示文摘Helicobacter pylori(H.pylori)is a Gram-negative bacterium that infects about half of the world's population.H.pylori infection prevails by several mechanisms of adaptation of the bacteria and by its virulence factors including the cytotoxin associated antigen A(CagA).CagA is an oncoprotein that is the protagonist of gastric carcinogenesis associated with prolonged H.pylori infection.In this sense,small regulatory RNAs(sRNAs)are important macromolecules capable of inhibiting and activating gene expression.This function allows sRNAs to act in adjusting to unstable environmental conditions and in responding to cellular stresses in bacterial infections.Recent discoveries have shown that nickelregulated small RNA(NikS)is a post-transcriptional regulator of virulence properties of H.pylori,including the oncoprotein CagA.Notably,high concentrations of nickel cause the reduction of NikS expression and consequently this increases the levels of CagA.In addition,NikS expression appears to be lower in clinical isolates from patients with gastric cancer when compared to patients without.With that in mind,this minireview approaches,in an accessible way,the most important and current aspects about the role of NikS in the control of virulence factors of H.pylori and the potential clinical repercussions of this modulation. | Fabrício Freire de Melo Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Lorena Sousa de Carvalho Cláudio Lima Souza Márcio Vasconcelos Oliveira | 2022 | World Journal of Clinical Cases2022，10，31： | 2 |
| 11 | TIMI Risk Score for ST-Elevation Myocardial Infarction: A Convenient, Bedside, Clinical Score for Risk Assessment at Presentation: An Intravenous nPA for Treatment of Infarcting Myocardium Early II Trial Substudy显示文摘 | David A. Morrow Elliott M. Antman Andrew Charlesworth Richard Cairns Sabina A. Murphy James A. de Lemos Robert P. Giugliano Carolyn H. McCabe Eugene Braunwald | 2000 | Circulation: Journal of the American Heart Association2000，，17： | 2 |
| 12 | Formulation of three-dimensional distinct element model, Part Ⅱ, Mechanical calculation of a system composed of many polyhedral blocks 显示文摘 | Hart R Cundall P A Lemos J | 1988 | Int J Rock Mech Min Sci & Geomech Abstr1988，25，3： | 2 |
| 13 | USB data acquisition solution显示文摘 | Serges Lemo Zhu June | 2007 | 国外电子测量技术2007，26，2： | 2 |
| 14 | Short and long term clinical benefit of sirolimus-eluting stents compared to conventional bare stents for patients with acute myocardial infarction显示文摘 | Lemos PA Saia F Hofma SH | 2004 | J Am Coll Cardiol2004，43，4： | 1 |
| 15 | Formulation of a three-dimensional distinct element model--part II: mechanical calculations显示文摘 | HART R D CUNDALL P A LEMOS J V | 1988 | International Journal of Rock Mechanics and Mining Sciences and Geomechanics Abstracts1988，25，3： | 1 |
| 16 | Sirolimus-eluting stent implantation in ST elevatioancute myocardial infarction:a clinical and anglographic study显示文摘 | Saia F Lemos PA Lee CH | 2003 | Circulation2003，108，16： | 1 |
| 17 | Combination therapy with Abciximab reduces angiographically evident thrombus in acute myocardial infarction: A TIMI 14 substudy显示文摘 | Gibson C M de Lemos J A Murphy S A | 2001 | Circulation2001，103，21： | 1 |
| 18 | B-type brain natriuretic peptide and prognosis in patients with ST-segment elevation myocardial infarction:an ENTIRE-TIMI-23 substudy显示文摘 | Morrow DA Lemos JA | 2004 | J Am Coll cardiol2004，44，： | 1 |
| 19 | Restenosis rates following bifurcation stenting with sirolimus-eluting stents for de novonarrowings显示文摘 | Tanabe K Hoye A Lemos PA | 2004 | Am J Cardiol2004，94，： | 1 |
| 20 | Soluble CD40L:Risk prediction after acute coronary syndromes 显示文摘 | Varo N de Lemos JA Libby P | 2003 | Circulation2003，108，9： | 1 |
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