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| 1 | Plant Phosphatidylcholine-Hydrolyzing Phospholipases C NPC3 and NPC4 with Roles in Root Development and Brassinolide Signaling in Arabidopsis thaliana显示文摘水解 Phosphatidylcholine phospholipase C (PC-PLC ) 催化 phosphatidylcholine (PC ) 的水解作用产生 phosphocholine 和 diacylglycerol (DAG ) 。PC-PLC 有在动物信号 transduction 的长传统除切开 phospholipase C (PI-PLC ) 的古典 phosphatidylinositol 以外作为第二个送信人产生 DAG。基于氨基酸顺序类似到细菌的 PC-PLC,六通常认为的 PC-PLC 基因(到 NPC6 的 NPC1 ) 在 Arabidopsis 染色体被识别。RTPCR 分析在根,茎,叶,花,和 silique 揭示了 NPC 基因的重叠表示模式。在对待植物生长素的 PNPC3 : GUS 和 PNPC4 : GUS 幼苗, GUS 活动的猛烈增加在根,叶子,和射击并且,是可见的到更弱的程度,在里面对待 brassinolide (BL ) 幼苗。PNPC4 : GUS 幼苗也在年轻叶子与增加的 GUS 活动对细胞激动素作出回应。比作野类型, T-DNA insertional 大美人 npc3 和 npc4 在低 BL 集中显示出更短的主要的根和更低的侧面的根密度,但是增加了侧面的根密度响应外长 0.051.0 ? M BL。TCH4 和 LRX2 的导致 BL 的表示,涉及房间扩大,在 CPD 的压抑被损害然而并非损害, BL 生合成基因,在对待 BL 的 npc3 和 npc4。这些观察建议 NPC3 和 NPC4 在在根生长的调停 BL 的发信号是重要的。当与 0.1 对待时 ? M BL, DAG 累积在用标记的烟草 BY-2 房间文化被观察荧光灯象 15 一样早的 PC ? 在申请以后的 min。我们假设那至少一 PC-PLC 是在 BL 信号 transduction 表明酶的植物并且更早出现在 elicitor 信号 transduction。 | Rinukshi Wimalasekera Premysl Pejchar Andre Holka Jan Martinec Gunther RE. Scherer | 2010 | Molecular Plant2010,3,3: | 13 |
| 2 | COPPER AMINE OXIDASE1 (CuAO1) of Arabidopsis thaliana Contributes to Abscisic Acid- and Polyamine-lnduced Nitric Oxide Biosynthesis and Abscisic Acid Signal Transduction显示文摘Polyamines (PA ) , polyamine oxidases,铜胺 oxidases,和氮的氧化物(没有) 在植物在生理学和压力回答起重要作用。由于由 polyamine oxidases 和铜胺 oxidases 的 PA 的分解代谢的生合成都可以不解释部分地调停 PA 的回答。铜胺 oxidase 基因的参与,铜胺 OXIDASE1 (CuAO1 ) ,用大美人 cuao1-1 和 cuao1-2 在压力回答为它的角色 Arabidopsis 被测试。导致 PA 、导致骆驼毛的织物萤光计和荧光显微镜学调查的生产都没证明 cuao1-1 和 cuao1-2 在没有生产被损害,在 PA 建议 CuAO1 的功能并且调停骆驼毛的织物没有生产。而且,我们在蛋白质 S-nitrosylation 发现了 PA 依赖的增加。PA 和骆驼毛的织物的增加也导致了 H2O2 增加。cuao1-1 和 cuao1-2 作为与相比在萌芽,幼苗建立,和根生长抑制期间显示出更少的敏感到外长的骆驼毛的织物补充野类型。响应骆驼毛的织物处理,压力应答的基因 RD29A 和 ADH1 的表示层次在大美人是显著地更低的。这些观察作为骆驼毛的织物感觉迟钝的异种描绘 cuao1-1 和 cuao1-2。一起拿,我们的调查结果扩大 ABA 信号 transduction 网络作为一个潜在的贡献者包括 CuAO1 到没由骆驼毛的织物提高生产。 | Rinukshi Wimalasekera Corina Villar Tahmina Begum Giinther F. E. Scherer | 2011 | Molecular Plant2011,4,4: | 12 |
| 3 | The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis显示文摘 | Kai Sun Philipp E Scherer | 2012 | Cell Research2012,22,10: | 7 |
| 4 | Roles of Arabidopsis Patatin-Related Phospholipases A in Root Development Are Related to Auxin Responses and Phosphate Deficiency显示文摘Phospholipase A 酶劈开 phospho- 和 galactolipids 产生在发信号的动物和植物荷尔蒙工作的免费的丰满的酸和 lysolipids。这里,我们描述三 Arabidopsis patatin 相关的 phospholipase A (pPLA ) 基因 AtPLAIVA, AtPLAIVB,和 AtPLAIVC 和他们的相应蛋白质。Loss-of-function 异种在正常开发期间并且在磷酸盐剥夺下面在根为这些 pPLAs 揭示角色。AtPLAIVA 强烈并且专门在根被表示, AtplaIVA 空的异种减少了侧面的根开发,损害植物生长素回答特征。由对比, AtPLAIVB 在根,子叶,和叶子微弱地被表示,但是被植物生长素 transcriptionally 导致,尽管 AtplaIVB 异种通常发展。AtPLAIVC 在花的 gynaecium 被表示并且被 abscisic 酸(骆驼毛的织物) 或磷酸盐缺乏在根导致。当 AtplaIVC-1 loss-of-function 异种显示骆驼毛的织物应答时,它在根开发期间展出损害回答到磷酸盐缺乏。Recombinant AtPLA 蛋白质水解优先地 galactolipids 并且,不太高效地, phospholipids,尽管这些酶不在叶绿体是局部性的。我们发现 AtPLAIVA 和 AtPLAIVB 是由在 vitro 的钙依赖者蛋白质 kinases 的 phosphorylated,这在 phosphatidylcholine 上然而并非在 phosphatidylglycerol 上提高他们的活动。一起拿,数据在在磷酸盐缺乏并且植物生长素发信号之间的接口与单个角色在根开发揭示 pPLAs 的新奇函数。 | Steffen Rietz Georgi Dermendjiev Esther Oppermann Fikadu Getah Tafesse Yunus Effendi Andre Holk Jane E. Parker Markus Teige Gunther F.E. Scherer | 2010 | Molecular Plant2010,3,3: | 7 |
| 5 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009,7,4: | 3 |
| 6 | Bevacizumab in Combination With Chemotherapy As First-Line Therapy in Advanced Gastric Cancer: A Biomarker Evaluation From the AVAGAST Randomized Phase III Trial显示文摘 | Eric Van Cutsem Sanne de Haas Yoon-Koo Kang Atsushi Ohtsu Niall C. Tebbutt Jian Ming Xu Wei Peng Yong Bernd Langer Paul Delmar Stefan J. Scherer Manish A. Shah | 2012 | Journal of Clinical Oncology2012,,17: | 3 |
| 7 | 各种添加剂对卷烟烟气组成的影响综述(Ⅰ)显示文摘以表格的形式简要地介绍了各种烟草添加剂的添加量、添加位置、添加方法、是否转移到主流烟气中。 | Thilo Paschke Gerhard Scherer Wolf-Dieter Heller | 2003 | 烟草科技2003,36,6: | 3 |
| 8 | 前蛋白转化酶枯草杆菌蛋白酶kexin-9在肾病综合征相关性高胆固醇血症中的作用显示文摘肾病综合征中,肾脏足细胞损害可导致严重的高胆固醇血症,迫切需要新的治疗方法。前蛋白转化酶枯草杆菌蛋白酶kexin-9(proprotein convertase subtilisin/kexin type 9,PCSK9)逐渐成为血浆总胆固醇水平和治疗目标的重要调节因子。 | 刘莉 叶鹏 Haas ME Levenson AE Sun X Liao WH Rutkowski JM de Ferranti SD Schumacher VA Scherer PE Salant DJ Biddinger SB | 2016 | 中华高血压杂志2016,24,7: | 3 |
| 9 | Compound and Digenic Heterozygosity Contributes to Arrhythmogenic Right Ventricular Cardiomyopathy显示文摘 | Tianhong Xu Zhao Yang Matteo Vatta Alessandra Rampazzo Giorgia Beffagna Kalliopi Pillichou Steven E. Scherer Jeffrey Saffitz Joshua Kravitz Wojciech Zareba Gian Antonio Danieli Alessandra Lorenzon Andrea Nava Barbara Bauce Gaetano Thiene Cristina Basso Hu | 2010 | Journal of the American College of Cardiology2010,,6: | 2 |
| 10 | NITROGEN FIXATION OF Azorhizobium IN ARTIFICIALLY INDUCED ROOT PARA-NODULES IN WHEAT显示文摘Nodule-like structures (para-nodules) can be induced in wheat roots by low concentrationsof 2,4-dichlorophenoxyacetic acid (2,4-D), a synthetic analogue of the plant growth hor-mone indole-acetic acid. Growth of nodulated wheat plants was not affected by 2,4-D treat-ment. Infection of these?para-nodules by adding oxygen-tolerant Azorhizobium caulinodans isolat-ed from stem nodules of the tropical legume Sesbania rostrata resulted in massive prolifera-tion of bacterial cells in the intercellular spaces as well as inside the para-nodular cells.Para-nodules colonized by Azorhizobium coulinodans not only reduced acetylene, but alsotransferred fixed nitrogen to the plant, contributing up to 16--23% of the nitrogen budgetof infected wheat. | 陈廷伟 SIEGFRIED SCHERER PETER BGER | 1992 | Science China Chemistry1992,35,12: | 2 |
| 11 | Percutaneous Left Atrial Appendage Transcatheter Occlusion to Prevent Stroke in High-Risk Patients With Atrial Fibrillation: Early Clinical Experience显示文摘 | Horst Sievert Michael D. Lesh Thomas Trepels Heyder Omran Antonio Bartorelli Paola Della Bella Toshiko Nakai Mark Reisman Carlo DiMario Peter Block Paul Kramer Dirk Fleschenberg Ulrike Krumsdorf Detlef Scherer | 2002 | Circulation: Journal of the American Heart Association2002,,16: | 2 |
| 12 | Adipokines Linking Obesity with Colorectal Cancer Risk in Postmenopausal Women显示文摘 | Gloria Y.F. Ho Tao Wang Marc J. Gunter Howard D. Strickler Mary Cushman Robert C. Kaplan Sylvia Wassertheil-Smoller Xiaonan Xue Swapnil N. Rajpathak Rowan T. Chlebowski Mara Z. Vitolins Philipp E. Scherer Thomas E. Rohan | 2012 | Cancer Research2012,,12: | 2 |
| 13 | Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling显示文摘 | Ingrid Wernstedt Asterholm Caroline Tao Thomas S. Morley Qiong A. Wang Fernando Delgado-Lopez Zhao V. Wang Philipp E. Scherer | 2014 | Cell Metabolism2014,,1: | 2 |
| 14 | Right Portal Vein Ligation Combined With In Situ Splitting Induces Rapid Left Lateral Liver Lobe Hypertrophy Enabling 2-Staged Extended Right Hepatic Resection in Small-for-Size Settings显示文摘 | Andreas A. Schnitzbauer Sven A. Lang Holger Goessmann Silvio Nadalin Janine Baumgart Stefan A. Farkas Stefan Fichtner-Feigl Thomas Lorf Armin Goralcyk Rüdiger H?rbelt Alexander Kroemer Martin Loss Petra Rümmele Marcus N. Scherer Winfried Padberg Alfred K? | 2012 | Annals of Surgery2012,,3: | 2 |
| 15 | Adipose tissue remodeling and obesity显示文摘 | Sun Kai Kusminski Christine M Scherer Philipp E | 2011 | Journal of Clinical Investigation2011,,6: | 2 |
| 16 | Minireview:The adipocyte at the crossroads of energy homeostasis, inflammation, and atherosclerosis 显示文摘 | Rajala NW Scherer PE | 2003 | Endocrinology2003,144,: | 1 |
| 17 | Multiobjective output-feedback control via LMI optimization显示文摘 | Pascal Gahinet Mahmoud Chilaii | 1997 | IEEE Transactions on Automatic Control1997,42,7: | 1 |
| 18 | A comparison of soil properties after contemporary wildfire and fire suppression 显示文摘 | Jeff Hatten Darlene Zabowski George Scherer | 2005 | Forest Ecology and Management2005,220,: | 1 |
| 19 | Frequency of epithelial debridement during diabetic vitrectomy 显示文摘 | Friberg TR Ohji M Scherer J J Tano Y | 2003 | Am J Ophthalmol2003,135,4: | 1 |
| 20 | ARCP 30/adiponectin : an adipokine regulating glucose and lipid metabolism显示文摘 | Berg AH Combs TP Scherer PE | 2002 | Trends Endocrinol Metab2002,13,: | 1 |