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| 1 | Effects of Helicobacterpyloriinfection on gastric emptying rate in patients with non-ulcer dyspepsia显示文摘AIM: The pathogenesis of delayed gastric emptying in patients with non-ulcer dyspepsia (NUD) remains unclear. We aimed to examine whether gastric emptying rate in NUD patients was associated with Helicobacterpylori(Hpylori) infection and whether it was affected by eradication of the infection. METHODS: Gastric emptying rate of a mixed solid-liquid meal was assessed by the paracetamol absorption method in NUD patients and asymptomatic controls (n=-17). Hpylori status was assessed by serology and biopsy urease test. Hpylori-positive NUD patients (n=-23) received 10-day triple eradication therapy. H pylori status was re-assessed by biopsy urease test four weeks later, and if eradication was confirmed, gastric emptying rate was re-evaluated. RESULTS: Thirty-three NUD patients and 17 controls were evaluated. NUD patients had significantly delayed gastric emptying compared with controls. The mean maximum plasma paracetamol concentration divided by body mass (Cmax/BM) was 0.173 and 0.224 mg/L.kg respectively (P=0.02), the mean area under plasma paracetamol concentration-time curve divided by body mass (AUC/BM) was 18.42 and 24.39 mg.min/L.kg respectively (P=-0.01). Gastric emptying rate did not differ significantly between H pylori-positive and H pylori-negative NUD patients. The mean Cmax/BM was 0.172 and 0.177 mg/Ukg respectively (P=-0.58), the mean AUC/BM was 18.43 and 18.38 rag.min/L.kg respectively (P=0.91). Among 14 NUD patients who were initially H pylori-positive, confirmed eradication of the infection did not significantly alter gastric emptying rate. The mean Cmax/BM was 0.171 and 0.160 mg/Ukg before and after Hp eradication, respectively (P=0.64), the mean AUC/BM was 17.41 and 18.02 mg.min/Ukg before and after eradication, respectively (P=-0.93). CONCLUSION: Although gastric emptying is delayed in NUD patients compared with controls, gastric emptying rate is not associated with H pylori status nor it is affected by eradication of the infection. | Grigoris I Leontiadis George I Minopoulos Efstratios Maltezos Stamatia Kotsiou Konstantinos I Manolas Konstantinos Simopoulos Dimitrios Hatseras | 2004 | World Journal of Gastroenterology2004，10，12： | 9 |
| 2 | Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss显示文摘 | Dimitrios Papazoglou Georgios Galazios Konstantinos Papatheodorou Vasilios Liberis Nikolaos Papanas Efstratios Maltezos Georgios B. Maroulis | 2005 | Fertility and Sterility2005，，： | 2 |
| 3 | Mean platelet volume in patients with type 2 diabetes mellitus显示文摘 | N. Papanas G. Symeonidis E. Maltezos G. Mavridis E. Karavageli Th. Vosnakidis G. Lakasas | 2004 | Platelets2004，，8： | 2 |
| 4 | The diabetic foot: established and emerging treatments显示文摘 | PAPANAS N MALTEZOS E | 2007 | Acta Clin Belg2007，62，： | 1 |
| 5 | The diabetic foot in end stage renal disease显示文摘 | Papanas N Liakopoulos V Maltezos E | | 0，，： | 1 |
| 6 | The female breast and diabetes显示文摘 | Gouveri E Papanas N Maltezos E | 2011 | The Breast2011，20，3： | 1 |
| 7 | Upregulated hypoxia inducible factor-lalpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis显示文摘 | Giatromanolaki A Sivridis E Maltezos E | 2003 | Arthritis Res Ther2003，5，4： | 1 |
| 8 | Benefit risk assessment of beca- plermin in the treatment of diabetic foot ulcers显示文摘 | Papanas N Maltezos E | 2010 | Drug Saf2010，33，6： | 1 |
| 9 | Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an Adult Autism Spectrum Disorder Diagnostic Clinic显示文摘 | C. Ellie Wilson Nicola Gillan Deborah Spain Dene Robertson Gedeon Roberts Clodagh M. Murphy Stefanos Maltezos Janneke Zinkstok Katie Johnston Christina Dardani Chris Ohlsen P. Quinton Deeley Michael Craig Maria A. Mendez Francesca Happé Declan G. M. Murph | 2013 | Journal of Autism and Developmental Disorders2013，，11： | 1 |
| 10 | High-sensitivity CRP is correlated with neurologic symptoms and plaque instability in patients with severe stenosis of the carotid bifurcation 显示文摘 | Papas TT Maltezos CK Papanas N | 2008 | Vasc Endovascudar Surg2008，42，3： | 1 |
| 11 | Mean platelet volume in patients with type 2 diabetes mellitus 显示文摘 | Papanas N Symeonidis G Maltezos E | 2004 | Platelets2004，15，： | 1 |
| 12 | Hypoxia inducible factor 1 alpha and 2 alpha overexpression in inflammatory bowel disease显示文摘 | Giatromanolaki A Sivridis E Maltezos E | 2003 | J Clin Pathol2003，56，3： | 1 |
| 13 | High sensi-tivity CRP is correlated with neurologic symptoms and plaqueinstability in patients with severe stenosis of the carotid bifurca-tion显示文摘 | PAPAS TT MALTEZOS CK PAPANAS N | 2008 | Vasc Endovascular Surg2008，42，3： | 1 |
| 14 | Mean platelet volume in patients with type 2 diabetes mellitus显示文摘 | Papanas N Symeonidis G Maltezos E | 2004 | Platelets2004，15，8： | 1 |
| 15 | Diabetic gastrointestinal autonomic neuropathy: Current status and new achievements for everyday clinical practice显示文摘 | A. Gatopoulou N. Papanas E. Maltezos | 2012 | European Journal of Internal Medicine2012，，6： | 1 |
| 16 | High-sensitivi- ty CRP is correlated with neurologic symptoms and plaque instability in patients with severe stenosis of the carotid bi- furcation显示文摘 | Papas T T Maltezos C K Papanas N | 2008 | Vasc Endovaseular Surg2008，42，3： | 1 |
| 17 | Upregulated hypoxia inducible factor-1 alpha and-2alpha pathway in rheumatoid arthritis and osteoarthritis显示文摘 | Giatromanolaki A Sivridis E Maltezos E | 2003 | Arthritis Res Ther2003，5，4： | 1 |
| 18 | Natural History of Chronic Hepatitis B Virus Infection in Children of Different Ethnic Origins: A Cohort Study with Up to 12 Years? Follow-up in Northern Greece显示文摘 | George Zacharakis John Koskinas Stamatia Kotsiou Evaggelia Pouliou Menelaos Papoutselis Fevronia Tzara Nikolaos Vafeiadis Eustratios Maltezos Athanasios Archimandritis Kostantinos Papoutselis | 2007 | Journal of Pediatric Gastroenterology and Nutrition2007，，1： | 1 |
| 19 | Hemiatrophy of the tongue caused by an extensive vagus nerve schwannoma masquerading as a carotid chemodectoma显示文摘 | RALLIS G MOUROUZIS K MALTEZOS C | 2015 | J Maxillofac Oral Surg2015，14，1： | 1 |
| 20 | a-Lipoic acid, diabetic neurop- athy , and Nathan's prophecy显示文摘 | PAPANAS N MALTEZOS E | 2012 | Angiology2012，63，2： | 1 |
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