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| 1 | Third-line rescue therapy for Helicobacter pylori infection显示文摘H pylori 胃的感染是世界范围的最流行的传染病之一。很上面的胃肠的疾病与 H pylori 感染有关能因此与抗菌素被对待的发现是重要医药进展。当前,首要的三倍的治疗被所有一致会议和指南基于质子泵禁止者(PPI ) 或加二抗菌素(clarithromycin 和 amoxicillin 或 nitroimidazole ) 的 ranitidine 枸橼酸铋(RBC ) 推荐。甚至与这药联合的正确使用,感染不能在多达 23% 病人被根除。因此,几第二线治疗被推荐了。7 d 四倍的治疗基于 PPI,铋,四圜素和灭滴灵,更多经常被接受。与第二线的治疗,然而,细菌的根除可以在多达 40% 盒子失败。当 H pylori 根除严格地被显示时,进一步的治疗的选择是争论的。当前,标准第三线的治疗正在缺乏,各种各样的协议被建议了。甚至在二连续失败以后,最近的文学数据证明了 H pylori 根除能在几乎所有病人被完成,甚至当抗菌素危险性没被测试时。实验治疗的不同可能性存在,可得到的第三线的策略此处被考察。 | Rossella Cianci Massimo Montalto Franco Pandolfi Giovan Battista Gasbarrini Giovanni Cammarota | 2006 | World Journal of Gastroenterology2006，12，15： | 31 |
| 2 | Hypothermic oxygenated perfusion for a steatotic liver graft显示文摘To the Editor:Donor steatosis represents a well-known risk factor for primary non-function,early allograft dysfunction,and biliary complications after liver transplantation(LT)[1,2].Recently,machine perfusion(MP)technology has been implemented in the clinical practice,with the primary intent to assess the graft quality and to optimize the organ selection process[3].A limited number of articles has been published specifically investigated the role of MP in steatotic livers[4–10],with few of them looking at the role of hypothermic MP. | Quirino Lai Franco Ruberto Fabio Melandro Zoe Larghi Laureiro Massimo Rossi Gianluca Mennini | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 7 |
| 3 | Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study显示文摘AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care system.METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. | Cristina Stasi Caterina Silvestri Roberto Berni Maurizia Rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani | 2018 | World Journal of Hepatology2018，10，5： | 3 |
| 4 | 肥厚型心肌病心房颤动:决定因素、临床进程与处理显示文摘心房颤动(房颤)是一个全球性健康问题,东西方患病率相同,反映人群老化,心血管病负担加重。在肥厚型心肌病(HCM)患者中,房颤是最常见的持续性心律不齐,最常见的并发症之一,对临床病程与预后影响很大。房颤成为HCM治疗的棘手问题,特别年轻患者,需要一致的循证治疗策略。尽管HCM房颤的循证依据不多,近期证据提示,新的治疗方法给某些患者带来了希望。 | Iacopo Olivotto Paolo DiDonna Aurelio Sgalambro Massimo Baldi Barry J Maron Franco Cecchi | 2009 | 中华心血管病杂志2009，37，4： | 3 |
| 5 | Hepatic metastases from gastric cancer:A surgical perspective显示文摘Management of patients with hepatic metastases as the sole metastatic site at diagnosis of gastric cancer(synchronous setting) or detected during follow-up(metachronous) is controversial. The prevailing attitude in these cases is passive, leading to surgical palliation and, possibly, to chemotherapy. Authors focused this editorial in order to promote a more pragmatic attitude. They stress the importance of recognizing the good candidates to curative surgery of both gastric cancer and hepatic metastases(synchronous setting) or hepatic disease alone(metachronous disease) from those who will not benefit from surgical therapy. In fact, in adequately selected subgroup of patients surgery, especially if integrated in multimodal therapeutic strategies, may achieve unexpected 5-year survival rates, ranging from 10% to 40%. The critical revision of the literature suggests that some simple clinical criteria exist that may be effectively employed in patients selection. These are mainly related to the gastric cancer(factors T, N, G) and to the extent of hepatic involvement(factor H). Upon these criteria it is possible to adequately select about 50% of cases. In the remaining 50% of cases a critical discussion on a case-by-case basis is recommended, considering that among these patients some potential long-survivors exist, that survival is strictly influenced by the ablation of the tumor bulk and by multimodality treatments including chemotherapy and that in expert institutions this kind of surgery is performed with very low mortality and morbidity rates. | Guido Alberto Massimo Tiberio Franco Roviello Annibale Donini Giovanni de Manzoni | 2015 | World Journal of Gastroenterology2015，21，41： | 2 |
| 6 | Chemotherapy-induced neutropenia and treatment efficacy in advanced non-small-cell lung cancer: a pooled analysis of three randomised trials显示文摘 | Massimo Di Maio Cesare Gridelli Ciro Gallo Frances Shepherd Franco Vito Piantedosi Silvio Cigolari Luigi Manzione Alfonso Illiano Santi Barbera Sergio Federico Robbiati Luciano Frontini Elena Piazza Giovanni Pietro Ianniello Enzo Veltri Federico Castiglio | 2005 | Lancet Oncology2005，，9： | 2 |
| 7 | Epidemiological network analysis in HIV-1 B infected patients diagnosed in Italy between 2000 and 2008显示文摘 | Annapaola Callegaro Valentina Svicher Claudia Alteri Alessandra Lo Presti Daniela Valenti Antonio Goglio Marco Salemi Eleonora Cella Carlo Federico Perno Massimo Ciccozzi Franco Maggiolo | 2011 | Infection, Genetics and Evolution2011，，3： | 2 |
| 8 | Major early complications from diagnostic and therapeutic ERCP: a prospective multicenter study显示文摘 | Silvano Loperfido Giampaolo Angelini Giorgio Benedetti Fausto Chilovi Franco Costan Franco De Berardinis Massimo De Bernardin Andrea Ederle Paolo Fina Agostino Fratton | 1998 | Gastrointestinal Endoscopy1998，，1： | 2 |
| 9 | Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma显示文摘AIM: To investigate the behaviour of total plasma homocysteine (tHcy) and its most common genetic determinant defect, the methylenetetrahydrofolate reductase C677T (C677TMTHFR) polymorphism in patients with early stage colorectal carcinoma. METHODS: tHcy was quantified by Abbott IMx immunoassay; screening for C677TMTHFR substitution was performed by PCR and restriction analysis. RESULTS: The frequency of the C/T and T/T genotypes of the C677TMTHFR gene polymorphism did not differ between the groups. The mean tHcy was statistically higher in cancer patients than in control subjects carrying the same C/C or C/T genotype, whereas there was no difference in the T/T homozygous carriers of the two groups. tHcy was significantly higher in the T/T homozygous carriers than in C/C and C/T genotype carriers. CONCLUSION: The statistically significant increase of tHcy observed in C/C and C/T genotype carriers among our cancer patients is related to substrate consumption dependent on the tumor cell proliferation rate, whereas the tHcy increase observed in T/T genotype carriers of both groups probably depends on the enzymatic deficit of the homocysteine conversion to methionine and/or on the folate deficiency. | Sandra Battistelli Aurelio Vittoria Massimo Stefanoni Camilla Bing Franco Roviello | 2006 | World Journal of Gastroenterology2006，12，38： | 2 |
| 10 | Prevalence and clinical significance of acquired left coronary artery fistulas after surgical myectomy in patients with hypertrophic cardiomyopathy显示文摘 | Aurelio Sgalambro Iacopo Olivotto Alessandra Rossi Stefano Nistri Katia Baldini Massimo Baldi Pierluigi Stefano David Antoniucci Francesca Garbini Franco Cecchi Magdi H. Yacoub | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，5： | 2 |
| 11 | Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: New perspectives for immune therapy显示文摘 | Carolina Boni Amalia Penna Graham S. Ogg Antonio Bertoletti Massimo Pilli Cristina Cavallo Albertina Cavalli Simona Urbani Richard Boehme Ruggero Panebianco Franco Fiaccadori Carlo Ferrari | 2001 | Hepatology2001，，4： | 1 |
| 12 | Occult impaired glucose regulation in patients with atherosclerosis is associated to the number of affected vascular districts and inflammation显示文摘 | Stefano Rizza Marina Cardellini Eugenio Martelli Ottavia Porzio Chiara Pecchioli Antonio Nicolucci Nikolaus Marx Davide Lauro Arnaldo Ippoliti Franco Romeo Renato Lauro Massimo Federici | 2010 | Atherosclerosis2010，，1： | 1 |
| 13 | The effect of iron depletion on chronic hepatitis C virus infection显示文摘 | Massimo Franchini Giovanni Targher Franco Capra Martina Montagnana Giuseppe Lippi | 2008 | Hepatology International2008，，3： | 1 |
| 14 | High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk non-Hodgkin lymphoma显示文摘 | Franca Falzetti Mauro Ianni Stelvio Ballanti Giuseppe Iodice Antonia Reale Olivia Minelli Gabriella Serio Massimo Martelli Franco Dammacco Angelo Vacca Roberto Ria | 2012 | Clinical and Experimental Medicine2012，，3： | 1 |
| 15 | An Integrated Active - Quenching Circuit for Single - Photon Avalanche Diodes 显示文摘 | Franco Zappa Massimo Ghioni Sergio Cova | 2000 | IEEE Trans on Instrumentation and Measurement2000，49，6： | 1 |
| 16 | Timing of precut procedure does not influence success rate and complications of ERCP procedure: a prospective randomized comparative study显示文摘 | Vincenzo Cennamo Lorenzo Fuccio Alessandro Repici Carlo Fabbri Diego Grilli Massimo Conio Nicola D’Imperio Franco Bazzoli | 2009 | Gastrointestinal Endoscopy2009，，3： | 1 |
| 17 | A survey on adrenal incidentaloma in Italy显示文摘 | Massimo T Giorgio A | 2000 | J Clin Endocrinol Metab2000，85，2： | 1 |
| 18 | Wide transcriptional investigation unravel novel insights of the on-tree maturation and postharvest ripening of‘Abate Fetel’pear fruit显示文摘To decipher the transcriptomic regulation of the on-tree fruit maturation in pear cv.‘Abate Fetel’,a RNA-seq transcription analysis identified 8939 genes differentially expressed across four harvesting stages.These genes were grouped into 11 SOTA clusters based on their transcriptional pattern,of which three included genes upregulated while the other four were represented by downregulated genes.Fruit ripening was furthermore investigated after 1 month of postharvest cold storage.The most important variation in fruit firmness,production of ethylene and volatile organic compounds were observed after 5 days of shelf-life at room temperature following cold storage.The role of ethylene in controlling the ripening of‘Abate Fetel’pears was furthermore investigated through the application of 1-methylcyclopropene,which efficiently delayed the progression of ripening by reducing fruit softening and repressing both ethylene and volatile production.The physiological response of the interference at the ethylene receptor level was moreover unraveled investigating the expression pattern of 12 candidate genes,initially selected to validate the RNA-seq profile.This analysis confirmed the effective role of the ethylene competitor in downregulating the expression of cell wall(PG)and ethylene-related genes(ACS,ACO,ERS1,and ERS2),as well as inducing one element involved in the auxin signaling pathway(Aux/IAA),highlighting a possible cross-talk between these two hormones.The expression patterns of these six elements suggest their use as molecular toolkit to monitor at molecular level the progression of the fruit on-tree maturation and postharvest ripening. | Nicola Busatto Brian Farneti Alice Tadiello Vicky Oberkofler Antonio Cellini Franco Biasioli Massimo Delledonne Alessandro Cestaro Christos Noutsos Fabrizio Costa | 2019 | Horticulture Research2019，6，1： | 1 |
| 19 | Photodynamic purging of alloreactive T cells for adoptive immunotherapy after haploidentical stem cell transplantation显示文摘 | Katia Perruccio Fabiana Topini Antonella Tosti Alessandra Carotti Teresa Aloisi Franco Aversa Massimo F. Martelli Andrea Velardi | 2007 | Blood Cells Molecules and Diseases2007，，1： | 1 |
| 20 | The Role of Lymphadenectomy for Liver Tumors: Further Considerations on the Appropriateness of Treatment Strategy显示文摘 | Giorgio Ercolani Gian Luca Grazi Matteo Ravaioli Walter Franco Grigioni Matteo Cescon Andrea Gardini Massimo Del Gaudio Antonino Cavallari | 2004 | Annals of Surgery2004，，2： | 1 |
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