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| 1 | indocyanine green-based fluorescence imaging in visceral and hepatobiliary and pancreatic surgery:State of the art and future directions显示文摘In recent years, the use of fluorescence-guided surgery(FGS) to treat benign and malignant visceral, hepatobiliary and pancreatic neoplasms has significantly increased. FGS relies on the fluorescence signal emitted by injected substances(fluorophores) after being illuminated by ad hoc laser sources to help guide the surgical procedure and provide the surgeon with real-time visualization of the fluorescent structures of interest that would be otherwise invisible. This review surveys and discusses the most common and emerging clinical applications of indocyanine green(ICG)-based fluorescence in visceral, hepatobiliary and pancreatic surgery. The analysis, findings, and discussion presented here rely on the authors' significant experience with this technique in their medical institutions, an up-to-date review of the most relevant articles published on this topic between 2014 and 2018, and lengthy discussions with key opinion leaders in the field during recent conferences and congresses. For each application, the benefits and limitations of this technique, as well as applicable future directions, are described. The imaging of fluorescence emitted by ICG is a simple, fast,relatively inexpensive, and harmless tool with numerous different applications in surgery for both neoplasms and benign pathologies of the visceral and hepatobiliary systems. The ever-increasing availability of visual systems that can utilize this tool will transform some of these applications into the standard of care in the near future. Further studies are needed to evaluate the strengths and weaknesses of each application of ICG-based fluorescence imaging in abdominal surgery. | Gian Luca Baiocchi Michele Diana Luigi Boni | 2018 | World Journal of Gastroenterology2018，24，27： | 19 |
| 2 | Bisacodyl plus split 2-L polyethylene glycol-citrate-simethicone improves quality of bowel preparation before screening colonoscopy显示文摘AIM:To compare the bowel cleansing efficacy,tolerability and acceptability of split 2-L polyethylene glycol(PEG)-citrate-simethicone(PEG-CS)plus bisacodyl(BIS)vs 4-L PEG for fecal occult blood test-positive screening colonoscopy.METHODS:This was a randomised,observer-blind comparative study.Two hundred and sixty-four subjects underwent screening colonoscopy(mean age 62.5±7.4years,male 61.7%).The primary objective of the study was to compare the bowel cleansing efficacy of the two preparations.Interventions:BIS plus PEG-CS:3 tablets of 5-mg BIS at 16:00,PEG-CS 1-L at 19:00 and 1-L at7:00,4-L PEG:3-L at 17:00,and 1-L at 7:00.Colonoscopy was carried out after 11:00,at least 3 h after the completion of bowel preparation.Bowel cleansing was evaluated using the Harefield Cleansing Scale.RESULTS:Bowel preparation was successful for 92.8%of subjects in the PEG-CS group and for 92.1%of subjects in the 4-L PEG(RR=1.01;95%CI:0.94-1.08).BIS+PEG-CS was better tolerated than 4-L PEG.A greater rate of patients in the BIS+PEG-CS group had no difficulty and/or were willing to repeat the same preparation compared to split-dose 4-L PEG group.Subjects in the BIS+PEG-CS group rated the prep as good or satisfactory in 90.6%as compared to 77%in the 4-L PEG(P=0.003).Subjects receiving BIS+PEGCS stated they fully adhered to instructions drinking all the 2-L solution in 97.1%compared with 87.3%in the4-L PEG(P=0.003).CONCLUSION:BIS plus split 2-L PEG-CS was as effective as but better tolerated and accepted than split4-L PEG for screening colonoscopy.This new procedure may increase the positive attitude and participation to colorectal cancer screening colonoscopy. | Flavio Valiante Angelo Bellumat Manuela De Bona Michele De Boni | 2013 | World Journal of Gastroenterology2013，19，33： | 10 |
| 3 | Effect of perioperative blood transfusion on clinical outcomes in hepatic surgery for cancer显示文摘Allogeneic blood transfusion during liver resection for malignancies has been associated with an increased incidence of different types of complications: infectious complications, tumor recurrence, decreased survival. Even if there is clear evidence of transfusion-induced immunosuppression, it is difficult to demonstrate that transfusion is the only determinant factor that decisively affects the outcome. In any case there are several motivations to reduce the practice of blood transfusion. The advantages and drawbacks of different transfusion alternatives are reviewed here, emphasizing that surgeons and anesthetists who practice in centers with a high volume of liver resections, should be familiar with all the possible alternatives. | Gianlorenzo Dionigi Luigi Boni Francesca Rovera Stefano Rausei Salvatore Cuffari Giovanni Cantone Alessandro Bacuzzi Renzo Dionigi | 2009 | World Journal of Gastroenterology2009，15，32： | 10 |
| 4 | 胃的癌症的多模式的治疗显示文摘 Gastric cancer is the second leading cause of death from malignant disease worldwide.Although complete surgical resection remains the only curative modality for early stage gastric cancer,surgery alone only provides long-term survival in 20%of patients with advancedstage disease.To improve current results,it is necessary to consider multimodality treatment,including chemotherapy,radiotherapy and surgery.Recent clinical trials have shown survival benefit of combining different neoadjuvant or adjuvant protocols compared with surgery with curative intent.Furthermore,the implementation of chemotherapy with novel targeted agents could play an important role in the multimodal management of advanced gastric cancer.In this paper,we focus on a multidisciplinary approach in the treatment of gastric cancer and discuss future strategies to improve the outcome for these patients. | Ilaria Proserpio Stefano Rausei Sabrina Barzaghi Francesco Frattini Federica Galli Domenico Iovino Francesca Rovera Luigi Boni Gianlorenzo Dionigi Graziella Pinotti | 2014 | World Journal of Gastrointestinal Surgery2014，6，4： | 8 |
| 5 | Identification of colorectal cancer metastasis markers by an angiogenesis-related cytokine-antibody array显示文摘AIM:To investigate the angiogenesis-related protein expression profile characterizing metastatic colorectal cancer (mCRC) with the aim of identifying prognostic markers.METHODS:The expression of 44 angiogenesissecreted factors was measured by a novel cytokine antibody array methodology.The study evaluated vascular endothelial growth factor (VEGF) and its soluble vascular endothelial growth factor receptor (sVEGFR)-1 protein levels by enzyme immunoassay (EIA) in a panel of 16 CRC cell lines.mRNA VEGF and VEGF-A isoforms were quantified by quantitative reverse-transcription polymerase chain reaction (Q-RT-PCR) and vascular endothelial growth factor receptor (VEGFR)-2 expression was analyzed by flow cytometry.RESULTS:Metastasis-derived CRC cell lines expressed a distinctive molecular profile as compared with those isolated from a primary tumor site.Metastatic CRC cell lines were characterized by higher expression of angiogenin-2 (Ang-2),macrophage chemoattractant proteins-3/4 (MCP-3/4),matrix metalloproteinase-1 (MMP-1),and the chemokines interferon γ inducible T cell α chemoattractant protein (I-TAC),monocyte chemoattractant protein I-309,and interleukins interleukin (IL)-2 and IL-1α,as compared to primary tumor cell lines.In contrast,primary CRC cell lines expressed higher levels of interferon γ (IFN-γ),insulin-like growth factor-1 (IGF-1),IL-6,leptin,epidermal growth factor (EGF),placental growth factor (PlGF),thrombopoietin,transforming growth factor β1 (TGF-β1) and VEGF-D,as compared with the metastatic cell lines.VEGF expression does not significantly differ according to the CRC cellular origin in normoxia.Severe hypoxia induced VEGF expression up-regulation but contrary to expectations,metastatic CRC cell lines did not respond as much as primary cell lines to the hypoxic stimulus.In CRC primary-derived cell lines,we observed a twofold increase in VEGF expression between normoxia and hypoxia as compared to metastatic cell lines.CRC cell lines express a similar pattern of VEGF isoforms (VEGF 121,VEGF 165 and VEGF 189) despite variability in VEGF expression,where the major transcript was VEGF 121.No relevant expression of VEGFR-2 was found in CRC cell lines,as compared to that of human umbilical vein endothelial cells and sVEGFR-1 expression did not depend on the CRC cellular origin.CONCLUSION:A distinct angiogenesis-related expression pattern characterizes metastatic CRC cell lines.Factors other than VEGF appear as prognostic markers and intervention targets in the metastatic CRC setting. | Ana Abajo Nerea Bitarte Ruth Zarate Valentina Boni Ines Lopez Marisol Gonzalez-Huarriz Javier Rodriguez Eva Bandres Jesus Garcia-Foncillas | 2012 | World Journal of Gastroenterology2012，18，7： | 8 |
| 6 | Terfenol-D磁致伸缩微小驱动器磁路设计显示文摘提高磁致伸缩驱动器驱动效率的关键环节是建立优化的驱动器磁路。本文基于准静态条件下线性磁致伸缩理论,得出磁致应变S与磁致伸缩材料内部磁场强度B的关系;并根据对无永磁磁偏磁路的分析进一步得出磁致应变S与磁路磁阻R和漏磁磁阻R1的对应关系。应用有限元方法对3种典型磁路结构的磁化效果进行对比分析,验证磁路结构的变化——即磁阻R和漏磁磁阻R1的相应改变对磁致伸缩材料磁化程度的不同影响,进而得出微小驱动器磁路壳体适宜壁厚为2mm,导磁材料的磁导率为2000μ0。根据此结果和磁路设计的2个遵循原则,对一7mm×20mmTerfenolD棒驱动的驱动器进行了磁路设计,应用ANSYS验证了该结构设计的合理性,并试制了驱动器样机。 | 杨斌堂 陶华 Bonis M Prelle C Lamarque F | 2005 | 机械科学与技术2005，24，3： | 7 |
| 7 | Inflammatory bowel diseases and human reproduction:A comprehensive evidence-based review显示文摘To evaluate the effects of inflammatory bowel diseases(IBDs)on human reproduction,we reviewed the current literature using a systematic search for published studies(articles and/or abstracts)without limits for English language.We searched on Medline(through PubMed),the Institute for Scientific Information,the Web of Science and the websites for the registration of controlled trials(http://gffzz872f90091fd340c7h5cxpb65xooo06fcv.ffgz.tsg.suse.edu.cn/).Bibliographies of retrieved articles,books,expert opinion review articles and reviewed bibliographies from subject experts were manually searched.Titles and abstracts were screened initially,and potential relevant articles were identified and reviewed.Whenever possible,data were analyzed by comparing IBD patients vs healthy controls,and patients with active IBDs vs those with disease in remission.The effects of IBDs on female fertility,fertility in infertile couples,pregnancy and male infertility were examined separately.Patients with IBDs in remission have normal fertility.At the moment,there is no established guideline for the preservation of fertility in women with IBD undergoing surgery.Further data are needed regarding guidelines for the management of these patients.Data regarding IBDs and infertility are currently completely lacking.Considering the prevalence of intestinal pathology in young adults of childbearing age,this field is of great scientific and clinical interest,opening up important future perspectives.Another important and as yet unexplored point is the response to treatments for infertility in patients with IBDs.In particular,the question is whether the reproductive outcomes(clinical and biological)can be influenced by the IBD of one of the partners.The goals for successful reproductive outcomes in IBD population are correct counseling and disease remission.IBDs significantly affect several reproductive aspects of human(female,male,couple)reproduction.Further data are needed to develop guidelines for the clinical management of subjects of reproductive age with IBDs. | Stefano Palomba Giuliana Sereni Angela Falbo Marina Beltrami Silvia Lombardini Maria Chiara Boni Giovanni Fornaciari Romano Sassatelli Giovanni Battista La Sala | 2014 | World Journal of Gastroenterology2014，20，23： | 6 |
| 8 | 意德拉半固态流变压铸技术显示文摘意德拉半固态流变压铸工艺与其他半固态压铸工艺的区别,在于它可以利用常规合金,使用现有的压铸设备和工艺,就能减少气孔、缩短压射循环周期时问并延长模具寿命。压铸件成本的降低不仅来自这些优势,还来自于减少的后序铸件的处理,例如取消浸渗和减少机加工。 | Roberto Boni 王杰 | 2009 | 特种铸造及有色合金2009，29，2： | 4 |
| 9 | Eosinophilic esophagitis: Updated consensus recommendations for children and adults显示文摘 | Chris A. Liacouras Glenn T. Furuta Ikuo Hirano Dan Atkins Stephen E. Attwood Peter A. Bonis A. Wesley Burks Mirna Chehade Margaret H. Collins Evan S. Dellon Ranjan Dohil Gary W. Falk Nirmala Gonsalves Sandeep K. Gupta David A. Katzka Alfredo J. Lucendo Jo | 2011 | The Journal of Allergy and Clinical Immunology2011，，1： | 3 |
| 10 | Restored Function of HBV-Specific T Cells After Long-term Effective Therapy With Nucleos(t)ide Analogues显示文摘 | Carolina Boni Diletta Laccabue Pietro Lampertico Tiziana Giuberti Mauro Viganò Simona Schivazappa Arianna Alfieri Marco Pesci Giovanni B. Gaeta Giuseppina Brancaccio Massimo Colombo Gabriele Missale Carlo Ferrari | 2012 | Gastroenterology2012，，4： | 3 |
| 11 | seventh tumor-node-metastasis staging of gastric cancer: Five-year follow-up显示文摘Seventh tumor-node-metastasis(TNM) classification for gastric cancer,published in 2010,introduced changes in all of its three parameters with the aim to increase its accuracy in prognostication. The aim of this review is to analyze the efficacy of these changes and their implication in clinical practice. We reviewed relevant Literature concerning staging systems in gastric cancer from 2010 up to March 2016. Adenocarcinoma of the esophago-gastric junction still remains a debated entity,due to its peculiar anatomical and histological situation: further improvement in its staging are required. Concerning distant metastases,positive peritoneal cytology has been adopted as a criterion to define metastatic disease: however,its search in clinical practice is still far from being routinely performed,as staging laparoscopy has not yet reached wide diffusion. Regarding definition of T and N: in the era of multimodal treatment these parameters should more influence both staging and surgery. The changes about T-staging suggested some modifications in clinical practice. Differently,many controversies on lymph node staging are still ongoing,with the proposal of alternative classification systems in order to minimize the extent of lymphadenectomy. The next TNM classification should take into account all of these aspects to improve its accuracy and the comparability of prognosis in patients from both Eastern and Western world. | Stefano Rausei Laura Ruspi Federica Galli Vincenzo Pappalardo Giuseppe Di Rocco Francesco Martignoni Francesco Frattini Francesca Rovera Luigi Boni Gianlorenzo Dionigi | 2016 | World Journal of Gastroenterology2016，22，34： | 2 |
| 12 | In advanced gastric cancer:Prognosis and treatment of patients with positive peritoneal cytology显示文摘Positive peritoneal cytology in gastric cancer is classified as M1 disease by the 7thEdition of American Joint Committee on Cancer staging system.With the introduction of laparoscopy and peritoneal washing cytology in the staging of gastric cancer a new category of patients has been identified.These are patients with no macroscopic peritoneal metastases but with peritoneal cytology positive(P0C1).Prognosis and treatment of such patientsrepresent a controversial issue.We evaluate the state of the art of staging system in gastric cancer and discusss tandardisation in staging and treatment procedures.There is still a lack of uniformity in the use of laparoscopy with peritoneal cytology in clinical decision making and in the surgical treatment for gastric cancer.Survival of this patient subset remains poor.Multimodal therapies and new therapeutic strategies are required to improve the survival of these patients. | Francesco Frattini Stefano Rausei Corrado Chiappa Francesca Rovera Luigi Boni Gianlorenzo Dionigi | 2013 | World Journal of Gastrointestinal Surgery2013，5，5： | 2 |
| 13 | Similar long-term results of mitral valve repair for anterior compared with posterior leaflet prolapse显示文摘 | Michele De Bonis Roberto Lorusso Elisabetta Lapenna Samer Kassem Giuseppe De Cicco Lucia Torracca Francesco Maisano Giovanni La Canna Ottavio Alfieri | 2006 | The Journal of Thoracic and Cardiovascular Surgery2006，，2： | 2 |
| 14 | Robot-assisted or conventional laparoscoic rectopexy for rectal prolapse? Systematic review and meta-analysis显示文摘 | F. Rondelli W. Bugiantella F. Villa A. Sanguinetti M. Boni E. Mariani N. Avenia | 2014 | International Journal of Surgery2014，，： | 2 |
| 15 | The safety of energy-based devices in open thyroidectomy: a prospective, randomised study comparing the LigaSure? (LF1212) and the Harmonic? FOCUS显示文摘 | Gianlorenzo Dionigi Luigi Boni Stefano Rausei Francesco Frattini Cesare Ferrari Alberto Mangano Andrea Leotta Marco Franchin | 2012 | Langenbeck’s Archives of Surgery2012，，5： | 2 |
| 16 | A randomized controlled trial evaluating a new 2-L PEG solution plus ascorbic acid vs 4-L PEG for bowel cleansing prior to colonoscopy显示文摘 | Flavio Valiante Stefano Pontone Cesare Hassan Angelo Bellumat Manuela De Bona Angelo Zullo Vincenzo de Francesco Michele De Boni | 2011 | Digestive and Liver Disease2011，，3： | 2 |
| 17 | Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections显示文摘 | Bertoletti A D'Elios MM Boni C | | 0，，： | 2 |
| 18 | Eosinophilic Esophagitis in Children and Adults: A Systematic Review and Consensus Recommendations for Diagnosis and Treatment显示文摘 | Glenn T. Furuta Chris A. Liacouras Margaret H. Collins Sandeep K. Gupta Chris Justinich Phil E. Putnam Peter Bonis Eric Hassall Alex Straumann Marc E. Rothenberg | 2007 | Gastroenterology2007，，4： | 2 |
| 19 | MR-Guided High-Intensity Focused Ultrasound: Current Status of an Emerging Technology显示文摘 | Alessandro Napoli Michele Anzidei Federica Ciolina Eugenio Marotta Beatrice Cavallo Marincola Giulia Brachetti Luisa Mare Gaia Cartocci Fabrizio Boni Vincenzo Noce Luca Bertaccini Carlo Catalano | 2013 | CardioVascular and Interventional Radiology2013，，5： | 2 |
| 20 | Injection of colorectal cancer cells in mesenteric and antimesenteric sides of the colon results in different patterns of metastatic diffusion: an experimental study in rats 显示文摘 | Boni L Benevento A Dionigi G | 2005 | World J Surg Oncol2005，3，： | 1 |
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