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| 1 | Low-volume plus ascorbic acid vs high-volume plus simethicone bowel preparation before colonoscopy显示文摘AIM:To investigate the effectiveness of low-volumeplus ascorbic acid [polyethylene glycol plus ascorbicacid(PEG + Asc) ] and high-volume plus simethicone[polyethylene glycol plus simethicone(PEG + Sim) ]bowel preparations.METHODS:A total of one hundred and forty-fourout patients(76 males) ,aged from 20 to 84 years(me-dian age 59.5 years) ,who attended our Department,were divided into two groups,age and sex matched,and underwent colonoscopy. Two questionnaires,onefor patients reporting acceptability and the other forendoscopists evaluating bowel cleansing effectivenes saccording to validated scales,were completed. Indications,timing of examination and endoscopical findings were recorded. Biopsy forceps were used as a measuring tool in order to determine polyp endoscopic sizeestimation. Difficulty in completing the preparation wasrated in a 5-point Likert scale(1 = easy to 5 = un-able) . Adverse experiences(fullness,cramps,nausea,vomiting,ab dominal pain,headache and insomnia) ,number of evacuations and types of activities performed during preparation(walking or resting in bed) were also investigated.RESULTS:Seventy-two patients were selected for eachgroup. The two groups were age and sex matched aswell as being comparable in terms of medical historyand drug therapies taken. Fourteen patients droppedout from the trial because they did not complete the preparation procedure. Ratings of global bowel cleansing examinations were considered to be adequate in91% of PEG + Asc and 88% of PEG + Sim patients.Residual Stool Score indicated similar levels of amountand consistency of residual stool;there was a significant difference in the percentage of bowel wall visuali-zation in favour of PEG + Sim patients. In the PEG +Sim group,12 adenomas ≤ 10 mm diameter(5/left co-lon + 7/right colon) vs 9(8/left colon + 1/right colon) in the PEG + Asc group were diagnosed. Visualization of small lesions seems to be one of the primary advantages of the PEG + Sim preparation.CONCLUSION:PEG + Asc is a good alternative solution as a bowel preparation but more improvements arenecessary in order to achieve the target of a perfect preparation. | Stefano Pontone Rita Angelini Monica Standoli Gregorio Patrizi Franco Culasso Paolo Pontone Adriano Redler | 2011 | World Journal of Gastroenterology2011，17，42： | 22 |
| 2 | Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. To date, most patients with HCC are diagnosed at an advanced tumor stage, excluding them from potentially curative therapies (i.e., resection, liver transplantation, percutaneous ablation). Treatments with palliative intent include chemoembolization and systemic therapy. Among systemic treatments, the small-molecule multikinase inhibitor sorafenib has been the only systemic treatment available for advanced HCC over 10 years. More recently, other smallmolecule multikinase inhibitors (e.g., regorafenib, lenvatinib, cabozantinib) have been approved for HCC treatment. The promising immune checkpoint inhibitors (e.g., nivolumab, pembrolizumab) are still under investigation in Europe while in the US nivolumab has already been approved by FDA in sorafenib refractory or resistant patients. Other molecules, such as the selective CDK4/6inhibitors (e.g., palbociclib, ribociclib), are in earlier stages of clinical development, and the c- MET inhibitor tivantinib did not show positive results in a phase III study. However, even if the introduction of targeted agents has led to great advances in patient response and survival with an acceptable toxicity profile, a remarkable inter-individual heterogeneity in therapy outcome persists and constitutes a significant problem in disease management. Thus, the identification of biomarkers that predict which patients will benefit from a specific intervention could significantly affect decision-making and therapy planning. Germ-line variants have been suggested to play an important role in determining outcomes of HCC systemic therapy in terms of both toxicity and treatment efficacy. Particularly, a number of studies have focused on the role of genetic polymorphisms impacting the drug metabolic pathway and membrane translocation as well as the drug mechanism of action as predictive/prognostic markers of HCC treatment. The aim of this review is to summarize and critically discuss the pharmacogenetic literature evidences, with particular attention to sorafenib and regorafenib, which have been used longer than the others in HCC treatment. | Elena De Mattia Erika Cecchin Michela Guardascione Luisa Foltran Tania Di Raimo Francesco Angelini Mario D’Andrea Giuseppe Toffoli | 2019 | World Journal of Gastroenterology2019，25，29： | 8 |
| 3 | Homocysteine and copper interact to promote type 5 phosphodiesterase expression in rabbit cavernosal smooth muscle cells显示文摘瞄准:在类型 5 phosphodiesterase (PDE5 ) 上学习人半胱氨酸和铜的效果在 cavernosal 的表示脉管的光滑的肌肉房间(CVSMC ) 并且调查超级氧化物(当人半胱氨酸和铜产生 O 2 · −, 和 O 2 · − 在上面, O 2 · −) 源于菸碱腺嘌 dinucleotide 磷酸盐 oxidase 调整 PDE5 表示。方法:从兔子阴茎导出的 CVSMC 与人半胱氨酸或铜氯化物被孵化与或没有超级氧化物为 16 h 的 dismutase (草皮)( 菸碱腺嘌 dinucleotide 磷酸盐禁止者) ,过氧化氢酶, sildenafil 柠檬酸盐,或 apocynin。PDE5 并且 glyceraldehyde-3-phosphate 脱氢酶(内部标准) 的表示用西方的污点分析被估计。在平行, O 2 · − spectrophotometrically 被测量。结果:CuCl 2 独自一个(多达 10 μmol/L ) 并且(多达 100 μmol/L ) 人半胱氨酸独自没与控制相比在 CVSMC 在 O 2 · − 形成上有效果。然而,当在一样的时间功课上共同孵化时,在联合,人半胱氨酸和 CuCl 2 显著地增加了 O 2 · − 形成,草皮堵住的效果,过氧化氢酶, apocynin,和 sildenafil (1 μmol/L ) 。PDE5 表示显著地也在与控制相比与人半胱氨酸和 CuCl 2, 孵化的 CVSMC 被增加。这效果被 16-h 合作孵化也与草皮,过氧化氢酶, apocynin 和 sildenafil 否定。结论:这代表位于编辑下面的新奇病原的机制,并且显示延长 sildenafil 使用的治疗学的行动通过这条小径的抑制部分地被调停。 | Matthew Hotston Jamie Y. Jeremy Jonathon Bloor Nick S. Greaves Raj Persad Gianni Angelini Nilima Shukla | 2008 | Asian Journal of Andrology2008，10，6： | 7 |
| 4 | Hepatorenal syndrome: Update on diagnosis and treatment显示文摘Acute kidney injury(AKI) is a common complication in patients with end-stage liver disease and advanced cirrhosis regardless of the underlying cause. Hepatorenal syndrome(HRS), a functional form of kidney failure, is one of the many possible causes of AKI. HRS is potentially reversible but involves highly complex pathogenetic mechanisms and equally complex clinical and therapeutic management. Once HRS has developed, it has a very poor prognosis. This review focuses on the diagnostic approach to HRS and discusses the therapeutic protocols currently adopted in clinical practice. | Olga Baraldi Chiara Valentini Gabriele Donati Giorgia Comai Vania Cuna Irene Capelli Maria Laura Angelini Maria Ilaria Moretti Andrea Angeletti Fabio Piscaglia Gaetano La Manna | 2015 | World Journal of Nephrology2015，4，5： | 5 |
| 5 | Renal function and physical fitness after 12-mo supervised training in kidney transplant recipients显示文摘AIM To evaluate the effect of a 12-mo supervised aerobic and resistance training, on renal function and exercise capacity compared to usual care recommendations.METHODS Ninety-nine kidney transplant recipients(KTRs) were assigned to interventional exercise(Group A; n = 52) and a usual care cohort(Group B; n = 47). Blood and urine chemistry, exercise capacity, muscular strength, anthropometric measures and health-related quality of life(HRQo L) were assessed at baseline, and after 6 and 12 mo. Group A underwent a supervised training three times per week for 12 mo. Group B received only general recommendations about home-based physical activities.RESULTS Eighty-five KTRs completed the study(Group A, n = 44; Group B, n = 41). After 12 mo, renal function remained stable in both groups. Group A significantly increased maximum workload(+13 W, P = 0.0003), V'O2 peak(+3.1 mL/kg per minute, P = 0.0099), muscular strength in plantar flexor(+12 kg, P = 0.0368), height in the countermovement jump(+1.9 cm, P = 0.0293) and decreased in Body Mass Index(-0.5 kg/m^2, P = 0.0013). HRQo L significantly improved in physical function(P = 0.0019), physical-role limitations(P = 0.0321) and social functioning scales(P = 0.0346). Noimprovements were found in Group B.CONCLUSION Twelve-month of supervised aerobic and resistance training improves the physiological variables related to physical fitness and cardiovascular risks without consequences on renal function. Recommendations alone are not sufficient to induce changes in exercise capacity of KTRs. Our study is an example of collaborative working between transplant centres, sports medicine and exercise facilities. | Giulio Sergio Roi Giovanni Mosconi Valentina Totti Maria Laura Angelini Erica Brugin Patrizio Sarto Laura Merlo Sergio Sgarzi Michele Stancari Paola Todeschini Gaetano La Manna Andrea Ermolao Ferdinando Tripi Lucia Andreoli Gianluigi Sella Alberto Anedda Laura Stefani Giorgio Galanti Rocco Di Michele Franco Merni Manuela Trerotola Daniela Storani Alessandro Nanni Costa | 2018 | World Journal of Transplantation2018，8，1： | 4 |
| 6 | Coronary Anomalies: Incidence, Pathophysiology, and Clinical Relevance显示文摘 | Paolo Angelini José Antonio Velasco Scott Flamm | 2002 | Circulation: Journal of the American Heart Association2002，，20： | 4 |
| 7 | Uncovering the Complexity of Transcriptomes with RNA-Seq显示文摘 | Valerio Costa Claudia Angelini Italia De Feis Alfredo Ciccodicola Momiao Xiong | 2010 | Journal of Biomedicine and Biotechnology2010，，： | 3 |
| 8 | Coronary microvasculopathy in heart transplantation: Consequences and therapeutic implications显示文摘Despite the progress made in the prevention and treatment of rejection of the transplanted heart, cardiac allograft vasculopathy(CAV) remains the main cause of death in late survival transplanted patients. CAV consists of a progressive diffuse intimal hyperplasia and the proliferation of vascular smooth muscle cells, ending in wall thickening of epicardial vessels, intramyocardial arteries(50-20 μm), arterioles(20-10 μm), and capillaries(< 10 μm). The etiology of CAV remains unclear; both immunologic and non-immunologic mechanisms contribute to endothelial damage with a sustained inflammatory response. The immunological factors involved are Human Leukocyte Antigen compatibility between donor and recipient, alloreactive T cells and the humoral immune system. The non-immunological factors are older donor age, ischemia-reperfusion time, hyperlipidemia and CMV infections. Diagnostic techniques that are able to assess microvascular function are lacking. Intravascular ultrasound and fractional flow reserve, when performed during coronary angiography, are able to detect epicardial coronary artery disease but are not sensitive enough to assess microvascular changes. Some authors have proposed an index of microcircula-tory resistance during maximal hyperemia, which is calculated by dividing pressure by flow(distal pressure multiplied by the hyperemic mean transit time). Non-invasive methods to assess coronary physiology are stress echocardiography, coronary flow reserve by transthoracic Doppler echocardiography, single photon emission computed tomography, and perfusion cardiac magnetic resonance. In this review, we intend to analyze the mechanisms, consequences and therapeutic implications of microvascular dysfunction, including an extended citation of relevant literature data. | Alessandra Vecchiati Sara Tellatin Annalisa Angelini Sabino Iliceto Francesco Tona | 2014 | World Journal of Transplantation2014，4，2： | 3 |
| 9 | Prevention of spinal cord ischaemia during descending thoracic and thoracoabdominal aortic surgery显示文摘 | Wan IY Angelini GD Bryan AJ Ryder I Underwood MJ | 2001 | Eur J Cardiothorac Surg2001，19，2： | 2 |
| 10 | Major early complications from diagnostic and therapeutic ERCP: a prospective multicenter study显示文摘 | Silvano Loperfido Giampaolo Angelini Giorgio Benedetti Fausto Chilovi Franco Costan Franco De Berardinis Massimo De Bernardin Andrea Ederle Paolo Fina Agostino Fratton | 1998 | Gastrointestinal Endoscopy1998，，1： | 2 |
| 11 | Colorectal cancer metastatic to the breast:A case report显示文摘BACKGROUND Breast metastases from colorectal cancer(CRC)are very uncommon.There is no unanimous consensus regarding the best treatment for this rare condition,and management is,especially in elderly patients,limited to diagnosis and palliative care.Capecitabine,an oral fluoropyrimidine derivative,might be helpful in controlling the disease and may be a treatment option for patients unable to receive more aggressive chemotherapy.CASE SUMMARY We report a case of synchronous massive breast metastasis from CRC in an 85 year old patient who came to the hospital presenting a huge mass originating from the axillary extension of the right breast.A whole body computed tomography also showed a mass in the right colon.The patient underwent a simple right mastectomy along with right hemicolectomy.The resected breast showed massive metastasis from CRC with intense and homogeneous nuclear CDX2 staining,while the colon specimen revealed poorly differentiated adenocarcinoma stage pT4a pN0 pM1(breast)(Tumor Node Metastasis 2017).Three months later she developed a subcutaneous mass at the site of the previous mastectomy.An ultrasound guided biopsy was carried out again and revealed a metastasis from CRC.The patient then started treatment with capecitabine plus bevacizumab,obtaining stable disease(RECIST criteria)and a clinical benefit after 3 mo of therapy.CONCLUSION In our experience,capecitabine and bevacizumab may be a useful treatment option for breast metastases from primary CRC in elderly patients. | Silvia Taccogna Elisa Gozzi Luigi Rossi Davide Caruso Davide Conte Patrizia Trenta Valentina Leoni Silverio Tomao Lucrezia Raimondi Francesco Angelini | 2020 | World Journal of Gastrointestinal Oncology2020，12，9： | 2 |
| 12 | Surgical Treatment of Metastatic Tumors to the Pancreas: A Single Center Experience and Review of the Literature显示文摘 | Stefano Crippa MD Carlo Angelini MD Chiara Mussi Claudia Bonardi MD Fabrizio Romano MD Paola Sartori MD Franco Uggeri MD Giorgio Bovo MD | 2006 | World Journal of Surgery2006，，8： | 2 |
| 13 | Role of ultrasonography in detecting mammographically occult breast carcinoma in women with dense breasts显示文摘 | V. Corsetti A. Ferrari M. Ghirardi R. Bergonzini S. Bellarosa O. Angelini C. Bani S. Ciatto | 2006 | La radiologia medica2006，，3： | 2 |
| 14 | Anomalous origin of coronary arteries and risk of sudden death: A study based on an autopsy population of congenital heart disease显示文摘 | Carla Frescura Cristina Basso Gaetano Thiene Domenico Corrado Tommaso Pennelli Annalisa Angelini Luciano Daliento | 1998 | Human Pathology1998，，： | 2 |
| 15 | Inhaled prostacyclin is safe,effective,and affordable in patients with pulmonary hypertension,right-heart dysfunction,and refractory hypoxemia after cardiothoracic surgery显示文摘 | Muzaffar S Shukla N Angelini GD | 2004 | J Thorac Cardiovasc Surg2004，128，6： | 1 |
| 16 | Sensory, motor, and autonomic neuropathy in patients with multiple symmetric lipomatosis显示文摘 | Enzi G Angelini C Negrin P | 1985 | Medicine (Baltimore)1985，64，6： | 1 |
| 17 | Resistin - like molecule- b in scleroderma- associated pulmonary hypertension 显示文摘 | ANGELINI D J SU Q YAMAJI KEGAN K | 2009 | Am J Respir Cell Mol Biol2009，41，5： | 1 |
| 18 | Major early complications from diagnostic and therapeutic ERCP: a prospective multicenter study显示文摘 | Loperfide S Angelini G Benedelli G | 1998 | Gastrointest Endosc1998，48，1： | 1 |
| 19 | An external, oversized,porous polyester stent reduces vein graft neointimal formation,cholesterol concentration, and vascular cell adhesion molecule 1 expression in cholesterol fed pigs显示文摘 | Angelini GD Lloyd C Bush R | 2002 | J Thorac Cardiovasc Surg2002，124，： | 1 |
| 20 | Kinematic coordination in human gait: relation to mechanical energy cost显示文摘 | Bianchi L Angelini D Orani GP | 1998 | J Neurophysiol1998，79，4： | 1 |
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