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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Brillouin optical time-domain analysis for geotechnical monitoring显示文摘In this paper, we show some recent experimental applications of Brillouin optical time-domain analysis(BOTDA) based sensors for geotechnical monitoring. In particular, how these sensors can be applied to detecting early movements of soil slopes by the direct embedding of suitable fiber cables in the ground is presented. Furthermore, the same technology can be used to realize innovative inclinometers, as well as smart foundation anchors. | L.Zeni L.Picarelli B.Avolio A.Coscetta R.Papa G.Zeni C.Di Maio R.Vassallo A.Minardo | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，4： | 7 |
| 3 | Role of endoscopic retrograde cholangiopancreatography inthe management of benign biliary strictures:What's new?显示文摘Benign biliary strictures comprise a heterogeneous group of diseases. The most common strictures amenable to endoscopic treatment are post-cholecystectomy, post-liver transplantation, related to primary sclerosing cholangitis and to chronic pancreatitis. Endoscopic treatment of benign biliary strictures is widely used as first line therapy, since it is effective, safe, noninvasive and repeatable. Endoscopic techniques currently used are dilation, multiple plastic stents insertion and fully covered self-expandable metal stents. The main indication for dilation alone is primary sclerosing cholangitis related strictures. In the vast majority of the remaining cases, temporary placement of multiple plastic stents with/without dilation is considered the treatment of choice. Although this approach is effective, it requires multiple endoscopic sessions due to the short duration of stent patency. Fully covered self-expandable metal stents appear as a good alternative to plastic stents, since they have an increased radial diameter, longer stent patency, easier insertion technique and similar efficacy. Recent advances in endoscopic technique and various devices have allowed successful treatment in most cases. The development of novel endoscopic techniques and devices is still ongoing. | Rosa Ferreira Rui Loureiro Nuno Nunes António Alberto Santos Rui Maio Marília Cravo Maria AntóniaDuarte | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，4： | 6 |
| 4 | 城市固体废弃物焚烧底灰理化特性研究显示文摘通过对天津市某垃圾焚烧发电厂的底灰按照粗颗粒(颗粒粒径>4.75mm)、细颗粒(颗粒粒径<4.75mm)分类,系统地研究了其化学成分、粒径分布、物理组成、吸水性、压实性、砂当量、表干密度、表面密度、饱和密度、颗粒矿物形态等物理化学特性以及不同液固比条件下重金属浸出毒性的环境质量评价。结果表明,底灰的物化特性主要受硅和钙等几种主要成分质量分数的影响,属于具有高多孔率、与天然矿物质有相似成分、吸水性较高的轻质材料,同时满足建筑材料的大多数工程特性要求,但应用时仍需注意环境影响。文章旨在为今后的底灰的资源化利用和批量处理以及环境保护提供理论依据。 | 胡艳军 陈冠益 Francesco Di Maio | 2008 | 太阳能学报2008，29，10： | 3 |
| 5 | Recycled concrete made with different natural coarse aggregates exposed to high temperature显示文摘 | Claudio Javier Zega Angel Antonio Di Maio | 2008 | Construction and Building Materials2008，，5： | 3 |
| 6 | Chemotherapy-induced neutropenia and treatment efficacy in advanced non-small-cell lung cancer: a pooled analysis of three randomised trials显示文摘 | Massimo Di Maio Cesare Gridelli Ciro Gallo Frances Shepherd Franco Vito Piantedosi Silvio Cigolari Luigi Manzione Alfonso Illiano Santi Barbera Sergio Federico Robbiati Luciano Frontini Elena Piazza Giovanni Pietro Ianniello Enzo Veltri Federico Castiglio | 2005 | Lancet Oncology2005，，9： | 2 |
| 7 | Health effects of air pollution:a Southern European perspective显示文摘Objective:To summarize the main updated evidence about the health effects of air pollution,with a special focus on Southern Europe.Data sources:Literature was obtained through PubMed Central and the official websites of European Agencies and Scientific Societies.Study selection:Recent shreds of evidence about the health effects of air pollution coming from international reports and original research were collected and described in this review.Results:Air pollution is an avoidable risk factor that causes a huge burden for society,in terms of death,health disorders,and huge socio-economic costs.The southern European countries face a more threatening problem because they experience the effects of both anthropogenic pollutants and natural dusts(particulate matter[PM]).The European Environment Agency reported the number of premature deaths in the 28 countries of the European Union attributable to air pollutant exposure in the year 2016:374,000 for PM2.5,68,000 for nitrogen dioxide,and 14,000 for ozone.In Italy,time series and analytical epidemiological studies showed increased cardiorespiratory hospital admissions and mortality,as well as increased risk of respiratory diseases in people living in urban areas.Conclusions:Based on abundant evidence,the World Health Organization,which hosts the Global Alliance against Chronic Respiratory Diseases(GARD),the scientific respiratory societies,and the patients’associations,as well as others in the health sector,must increase their engagement in advocacy for clean air policies. | Giovanni Viegi Sandra Baldacci Sara Maio Salvatore Fasola Isabella Annesi-Maesano Francesco Pistelli Laura Carrozzi Stefania La Grutta Francesco Forastiere | 2020 | Chinese Medical Journal2020，，13： | 2 |
| 8 | Circulating and stool nucleic acid analysis for colorectal cancer diagnosis显示文摘In recent years,the need to identify molecular markers characterized by high sensitivity and specificity in detecting and monitoring early and colorectal cancer lesions has increased.Up to now,none of the markers or panels of markers analyzed have met the rigorous standards required of a screening program.The important discovery of circulating nucleic acids in biological fluids has aroused intense scientific interest because of their usefulness in malignant and non malignant diseases.Over time,their yield and stability have been identified and compared with other'standard'biomarkers.The analysis of circulating DNA from blood and stool is a relatively simple and non-invasive procedure,representing a very attractive marker to detect genetic and epigenetic mutations and to monitor disease progression.A correlation between blood and stool biomarkers could also help to enhance currently available diagnostic approaches.However,various processing and analytic problems need to be resolved before such an approach can be applied in clinical practice. | Giulia De Maio Claudia Rengucci Wainer Zoli Daniele Calistri | 2014 | World Journal of Gastroenterology2014，20，4： | 2 |
| 9 | FVC2000: fingerprint verification competition 显示文摘 | MAIO D MALTONI D CAPPELLI R | 2002 | IEEE Trans on PAMI2002，24，3： | 2 |
| 10 | Optimization of a dynamic uncertain causality graph for fault diagnosis in nuclear power plant显示文摘Fault diagnostics is important for safe operation of nuclear power plants(NPPs). In recent years, data-driven approaches have been proposed and implemented to tackle the problem, e.g., neural networks, fuzzy and neurofuzzy approaches, support vector machine, K-nearest neighbor classifiers and inference methodologies. Among these methods, dynamic uncertain causality graph(DUCG)has been proved effective in many practical cases. However, the causal graph construction behind the DUCG is complicate and, in many cases, results redundant on the symptoms needed to correctly classify the fault. In this paper, we propose a method to simplify causal graph construction in an automatic way. The method consists in transforming the expert knowledge-based DCUG into a fuzzy decision tree(FDT) by extracting from the DUCG a fuzzy rule base that resumes the used symptoms at the basis of the FDT. Genetic algorithm(GA) is, then, used for the optimization of the FDT, by performing a wrapper search around the FDT: the set of symptoms selected during the iterative search are taken as the best set of symptoms for the diagnosis of the faults that can occur in the system. The effectiveness of the approach is shown with respect to a DUCG model initially built to diagnose 23 faults originally using 262 symptoms of Unit-1 in the Ningde NPP of the China Guangdong Nuclear Power Corporation. The results show that the FDT, with GA-optimized symptoms and diagnosis strategy, can drive the construction of DUCG and lower the computational burden without loss of accuracy in diagnosis. | Yue Zhao Francesco Di Maio Enrico Zio Qin Zhang Chun-Ling Dong Jin-Ying Zhang | 2017 | Nuclear Science and Techniques2017，28，3： | 2 |
| 11 | Is human hepatocellular carcinoma a hormone-responsive tumor?显示文摘Before the positive results recently obtained with multitarget tyrosine kinase inhibitor sorafenib,there was no standard systemic treatment for patients with advanced hepatocellular carcinoma(HCC).Sex hormones receptors are expressed in a significant proportion of HCC samples.Following preclinical and epidemiological studies supporting a relationship between sex hormones and HCC tumorigenesis,several randomized controlled trials (RCTs)tested the efficacy of the anti-estrogen tamoxifen as systemic treatment.Largest among these trials showed no survival advantage from the administration of tamoxifen,and the recent Cochrane systematic review produced a completely negative result.This questions the relevance of estrogen receptor-mediated pathways in HCC.However,a possible explanation for these disappointing results is the lack of proper patients selection according to sex hormones receptors expression,but unfortunately the interaction between this expression and efficacy of tamoxifen has not been studied adequately.It has been also proposed that negative results might be explained if tamoxifen acts in HCC via an estrogen receptor-independent pathway,that requires higher doses than those usually administered, but an Asian RCT conducted to assess dose-response effect was completely negative.Interesting,preliminaryresults have been obtained when hormonal treatment (tamoxifen or megestrol)has been selected according to the presence of wild-type or variant estrogen receptors respectively,but no large RCTs are available to support this strategy.Negative results have been obtained also with anti-androgen therapy.In conclusion,there is no robust evidence to consider HCC a hormone-responsive tumor.Hormonal treatments should not be part of the current management of HCC. | Massimo Di Maio Bruno Daniele Sandro Pignata Ciro Gallo Ermelinda De Maio Alessandro Morabito Maria Carmela Piccirillo Francesco Perrone | 2008 | World Journal of Gastroenterology2008，14，11： | 2 |
| 12 | Clinical assessment of patients with advanced non-small-cell lung cancer eligible for second-line chemotherapy: A prognostic score from individual data of nine randomised trials显示文摘 | Massimo Di Maio Nicola Lama Alessandro Morabito Egbert F. Smit Vassilis Georgoulias Koji Takeda Elisabeth Quoix Dora Hatzidaki Floris M. Wachters Vittorio Gebbia Chun-Ming Tsai Carlos Camps Wolfgang Schuette Paolo Chiodini Maria Carmela Piccirillo Frances | 2009 | European Journal of Cancer2009，，4： | 2 |
| 13 | Gefitinib as first-line treatment for patients with advanced non-small-cell lung cancer with activating epidermal growth factor receptor mutation: Review of the evidence显示文摘 | C. Gridelli F. De Marinis M. Di Maio D. Cortinovis F. Cappuzzo T. Mok | 2010 | Lung Cancer2010，，3： | 2 |
| 14 | Real-time face location on gray-scale static images显示文摘 | MAIO D MALTONI D | 2000 | Pattern recognition2000，33，9： | 2 |
| 15 | Towards curative therapy in gastric cancer:Faraway, so close!显示文摘Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer(GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments. | Marília Cravo Catarina Fidalgo Rita Garrido Tania Rodrigues Gon?alo Luz Carolina Palmela Marta Santos Fábio Lopes Rui Maio | 2015 | World Journal of Gastroenterology2015，21，41： | 2 |
| 16 | Chemotherapy-induced neutropenia: a useful predictor of treatment efficacy显示文摘 | Di Maio M Gridelli C Gallo C | 2006 | Nat Clin Pract Oncol2006，3，3： | 1 |
| 17 | Individual patient data meta-analysis of docetaxel administered once every 3 weeks compared with once every week second line treat- ment of advanced non-small-cell lung cancer 显示文摘 | Di Maio M Pernme F Chiodini P | 2007 | J Clin Oncol2007，25，11： | 1 |
| 18 | A polarimetric adaptive matched filter显示文摘 | Maio A D Ricci G | 2001 | Signal Processing2001，81，3： | 1 |
| 19 | Performance evaluation of fingerprint verification systems显示文摘 | CAPPELLI R MAIO D MALTONI D | 2006 | IEEE Transactions on Pattern Analysis and Machine Intelligence2006，28，1： | 1 |
| 20 | Design of Phase Codes for Radar Performance Optimization With a Similarity Constraint 显示文摘 | De Maio A De Nicola S | 2009 | IEEE Transactions Signal Pressing2009，57，2： | 1 |
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