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| 1 | Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study显示文摘AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care system.METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. | Cristina Stasi Caterina Silvestri Roberto Berni Maurizia Rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani | 2018 | World Journal of Hepatology2018，10，5： | 3 |
| 2 | Revision of the Conodont Mockina slovakensis and Its Paleogeographic Implications for the Upper Triassic Intraplatform Basins of the Alps显示文摘Mockina slovakensis,thought to have evolved from Epigondolella praeslovakensis,is an important species of the Norian(Upper Triassic),generally considered as the representative of the uppermost Alaunian to upper Sevatian in the Tethys.The previous description of M.slovakensis was incomplete,thus has led to some misidentifications.We thus update the description of M.slovakensis and discuss its comparisons and occurrence based on the new conodont investigations in Dolomia di Forni and the data from previous literatures.The conodont assemblage in the succession of Dolomia di Forni is dominated by M.slovakensis,along with rare M.postera and E.praeslovakensis.We described two morphotypes of M.slovakensis(morphotypes A and B),on the basis of shape of the lateral profile.These two morphotypes can also be observed in the E.praeslovakensis.Moreover,M.slovakensis is usually documented as almost monospecific conodont association in intraplatform basins,thus its paleogeographic implications are also discussed. | Yixing Du Viktor Karadi Guido Roghi Maurizio Ponton Andrea Cozzi Manuel Rigo | 2021 | Journal of Earth Science2021，32，3： | 1 |
| 3 | Percutaneous Transhepatic Biliary Drainage in the Management of Postsurgical Biliary Leaks in Patients with Nondilated Intrahepatic Bile Ducts显示文摘 | Guido Cozzi Aldo Severini Enrico Civelli Marco Milella Andrea Pulvirenti Monica Salvetti Raffaele Romito Laura Suman Francesca Chiaraviglio Vincenzo Mazzaferro | 2006 | CardioVascular and Interventional Radiology2006，，3： | 1 |
| 4 | Near Field Flow Structure of Isothermal Swirling Flows and Reacting Non-premixed Swirling Flames 显示文摘 | ANDREA OLIVANI GIULIO SOLERO FABIO COZZI | 2007 | Experimental Thermal and Fluid Science2007，31，5： | 1 |
| 5 | Neuroprotective Effects of Propofol in Models of Cerebral Ischemia: Inhibition of Mitochondrial Swelling as a Possible Mechanism显示文摘 | Chiara Adembri Luna Venturi Alessia Tani Alberto Chiarugi Elena Gramigni Andrea Cozzi Tristano Pancani Raffaele A. De Gaudio Domenico E. Pellegrini-Giampietro | 2006 | Anesthesiology2006，，1： | 1 |
| 6 | Comet Assay as a Novel Approach for Studying DNA Damage in Focal Cerebral Ischemia:Differential Effects of NMDA Receptor Antagonists and Poly(ADP-Ribose) Polymerase Inhibitors显示文摘 | Lisa Giovannelli Andrea Cozzi Ilaria Guarnieri Flavio | 2002 | J Cerebral Blood Flow & Metabolism2002，22，： | 1 |
| 7 | Amniotic Fluid and Bone Marrow Derived Mesenchymal Stem Cells Can be Converted to Smooth Muscle Cells in the Cryo-Injured Rat Bladder and Prevent Compensatory Hypertrophy of Surviving Smooth Muscle Cells显示文摘 | Paolo De Coppi Andrea Callegari Angela Chiavegato Lisa Gasparotto Martina Piccoli Jenny Taiani Michela Pozzobon Luisa Boldrin Masaru Okabe Emanuele Cozzi Anthony Atala Piergiorgio Gamba Saverio Sartore | 2007 | The Journal of Urology2007，，1： | 1 |
| 8 | The Applications of Genome Editing in Xenotransplantation显示文摘Higher living standards and better medical care are increasing the lifespan of people around the world.Aging populations,however,have an increased incidence of loss of function or failure of cell,tissue or organ.This has led to the development of new medical disciplines,such as organ transplantation and more recently regenerative medicine.Organ transplantation using human donors(allotransplantation)has made enormous progress thanks to | Andrea Perota Irina Lagutina Corinne Quadalti Giovanna Lazzari Emanuele Cozzi Cesare Galli | 2016 | Journal of Genetics and Genomics2016，43，5： | 0 |
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