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| 1 | Gastric cancer, Helicobacter pylori infection and other risk factors显示文摘Gastric cancer incidence is declining. However, it is too early to consider this neoplastic disease as rare and the worldwide mortality rate still remains high. Several risk factors have been identif ied for non-cardia gastric cancer and primary prevention is feasible since most of the risk factors can be removed. Helicobacter pylori eradication treatment reduces but does not abolish gastric cancer risk. Indeed, gastric cancer is a multifactorial disease and removing one factor does not therefore prevent all cases. Endoscopic surveillance is still needed, especially in subjects at higher risk. The def inition of high-risk patients will be the future challenge as well as identifying the best surveillance strategy for such patients. | Lorenzo Fuccio Leonardo Henry Eusebi Franco Bazzoli | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 17 |
| 2 | Diagnosis and management of gastric antral vascular ectasia显示文摘Gastric antral vascular ectasia (GAVE) is an uncommon but often severe cause of upper gastrointestinal (GI) bleeding, responsible of about 4% of non-variceal upper GI haemorrhage. The diagnosis is mainly based on endoscopic pattern and, for uncertain cases, on histology. GAVE is characterized by a pathognomonic endoscopic pattern, mainly represented by red spots either organized in stripes radially departing from pylorus, defined as watermelon stomach, or arranged in a diffused-way, the so called honeycomb stomach. The histological pattern, although not pathognomonic, is characterized by four alterations:vascular ectasia of mucosal capillaries, focal thrombosis, spindle cell proliferation and fibrohyalinosis, which consist of homogeneous substance around the ectatic capillaries of the lamina propria. The main differential diagnosis is with Portal Hypertensive Gastropathy, that can frequently co-exists, since about 30% of patients with GAVE co-present a liver cirrhosis. Autoimmune disorders, mainly represented by Reynaud's phenomenon and sclerodactyly, are co-present in about 60% of patients with GAVE; other autoimmune and connective tissue disorders are occasionally reported such as Sjogren's syndrome, systemic lupus erythematosus, primary biliary cirrhosis and systemic sclerosis. In the remaining cases, GAVE syndrome has been described in patients with chronic renal failure, bone marrow transplantation and cardiac diseases. The pathogenesis of GAVE is still obscure and many hypotheses have been proposed such as mechanical stress, humoural and autoimmune factors and hemodynamic alterations. In the last two decades, many therapeutic options have been proposed including surgical, endoscopic and medical choices. Medical therapy has not clearly shown satisfactory results and surgery should only be considered for refractory severe cases, since this approach has significant mortality and morbidity risks, especially in the setting of portal hypertension and liver cirrhosis. Endoscopic therapy, particularly treatment with Argon Plasma Coagulation, has shown to be as effective and also safer than surgery, and should be considered the first-line treatment for patients with GAVE-related bleeding. | Lorenzo Fuccio Alessandro Mussetto Liboria Laterza Leonardo Henry Eusebi Franco Bazzoli | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，1： | 8 |
| 3 | Prevention of pelvic radiation disease显示文摘Pelvic cancers are among the most frequently diagnosed cancers worldwide. Treatment of patients requires a multidisciplinary approach that frequently includes radiotherapy. Gastrointestinal(GI) radiation-induced toxicity is a major complication and the transient or long-term problems, ranging from mild to very severe, arising in non-cancerous tissues resulting from radiation treatment to a tumor of pelvic origin, are actually called as pelvic radiation disease. The incidence of pelvic radiation disease changes according to the radiation technique, the length of follow up, the assessmentmethod, the type and stage of cancer and several other variables. Notably, even with the most recent radiation techniques, i.e., intensity-modulated radiotherapy, the incidence of radiation-induced GI side effects is overall reduced but still not negligible. In addition, radiation-induced GI side effects can develop even after several decades; therefore, the improvement of patient life expectancy will unavoidably increase the risk of developing radiation-induced complications. Once developed, the management of pelvic radiation disease may be challenging. Therefore, the prevention of radiation-induced toxicity represents a reasonable way to avoid a dramatic drop of the quality of life of these patients. In the current manuscript we provide an updated and practical review on the best available evidences in the field of the prevention of pelvic radiation disease. | Lorenzo Fuccio Leonardo Frazzoni Alessandra Guido | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，1： | 6 |
| 4 | The role of K- ras gene mutation analysis in EUS-guided FNA cytology specimens for the differential diagnosis of pancreatic solid masses: a meta-analysis of prospective studies显示文摘 | Lorenzo Fuccio Cesare Hassan Liboria Laterza Loredana Correale Nico Pagano Paolo Bocus Carlo Fabbri Antonella Maimone Vincenzo Cennamo Alessandro Repici Guido Costamagna Franco Bazzoli Alberto Larghi | 2013 | Gastrointestinal Endoscopy2013，，： | 4 |
| 5 | Can early precut implementation reduce endoscopic retrograde cholangiopancreatography-related complication risk? Meta-analysis of randomized controlled trials显示文摘 | V. Cennamo L. Fuccio R. Zagari L. Eusebi L. Ceroni L. Laterza C. Fabbri F. Bazzoli | 2010 | Endoscopy2010，，05： | 3 |
| 6 | Pelvic radiation disease:Updates on treatment options显示文摘Pelvic cancers are among the most frequently diagnosed neoplasms and radiotherapy represents one of the main treatment options. The irradiation field usually encompasses healthy intestinal tissue,especially of distal large bowel,thus inducing gastrointestinal(GI) radiation-induced toxicity. Indeed,up to half of radiationtreated patients say that their quality of life is affected by GI symptoms(e.g.,rectal bleeding,diarrhoea). The constellation of GI symptoms- from transient to longterm,from mild to very severe- experienced by patients who underwent radiation treatment for a pelvic tumor have been comprised in the definition of pelvic radiation disease(PRD). A correct and evidence-based therapeutic approach of patients experiencing GI radiation-induced toxicity is mandatory. Therapeutic non-surgical strategies for PRD can be summarized in two broad categories,i.e.,medical and endoscopic. Of note,most of the studies have investigated the management of radiation-induced rectal bleeding. Patients with clinically significant bleeding(i.e.,causing chronic anemia) should firstly be considered for medical management(i.e.,sucralfate enemas,metronidazole and hyperbaric oxygen); in case of failure,endoscopic treatment should be implemented. This latter should be considered the first choice in case of acute,transfusion requiring,bleeding. More well-performed,high quality studies should be performed,especially the role of medical treatments should be better investigated as well as the comparative studies between endoscopic and hyperbaric oxygen treatments. | Leonardo Frazzoni Marina La Marca Alessandra Guido Alessio Giuseppe Morganti Franco Bazzoli Lorenzo Fuccio | 2015 | World Journal of Clinical Oncology2015，6，6： | 3 |
| 7 | Current status of peroral cholangioscopy in biliary tract diseases显示文摘Peroral cholangioscopy(POC) is an important tool for the management of a selected group of biliary diseases. Because of its direct visualization, POC allows targeted diagnostic and therapeutic procedures. POC can be performed using a dedicated cholangioscope that is advanced through the accessory channel of a duodenoscope or via the insertion of a small-diameter endoscope directly into the bile duct. POC was first described in the 1970 s, but the use of earlier generation devices was substantially limited by the cumbersome equipment setup and high repair costs. For nearly ten years, several technical improvements, including the single-operator system, high-quality images, the development of dedicated accessories and the increased size of the working channel, have led to increased diagnostic accuracy, thus assisting in the differentiation of benign and malignant intraductal lesions, targeting biopsies and the precise delineation of intraductal tumor spread before surgery. Furthermore, lithotripsy of difficult bile duct stones, ablative therapies for biliary malignancies and direct biliary drainage can be performed under POC control. Recent developments of new types of conventional POCs allow feasible, safe and effective procedures at reasonable costs. In the current review, we provide an updated overview of POC, focusing our attention on the main current clinical applications and on areas for future research. | Stefania Ghersi Lorenzo Fuccio Marco Bassi Carlo Fabbri Vincenzo Cennamo | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，5： | 3 |
| 8 | Gastric metastasis from ovarian adenocarcinoma presenting as a subepithelial tumor and diagnosed by endoscopic ultrasound-guided tissue acquisition显示文摘We describe an uncommon case of a patient with a metastatic adenocarcinoma of ovarian origin presented as a gastric subepithelial tumor(SET) and that was diagnosed by endoscopic ultrasound fine-needle biopsy(EUS-FNB). Malignant gastric lesions are rarely metastatic and the primary tumor is mainly breast, lung, esophageal cancer or cutaneous melanoma. Gastric metastasis from ovarian cancer is unusual, presenting synchronously with the primary tumor but also several years later than the initial diagnosis. From an endoscopic point of view, gastric metastasis does not present specific features. They may mimic both a primary gastric tumor or, less frequently, an SET.This case demonstrates the importance of EUS-FNB in distinguishing SETs and how this may alter treatment and prognosis. | Filippo Antonini Liboria Laterza Lorenzo Fuccio Massimo Marcellini Lucia Angelelli Sonia Calcina Corrado Rubini Giampiero Macarri | 2017 | World Journal of Gastrointestinal Oncology2017，9，11： | 3 |
| 9 | Colonoscopy-related colonic ischemia显示文摘Colonoscopy is a risk factor for colon ischemia.The colon is susceptible to ischemia due to its minor blood flow compared to other abdominal organs;the etiology of colon ischemia after colonoscopy is multifactorial.The causative mechanisms include splanchnic circulation impairment,bowel preparation,drugs used for sedation,bowel wall ischemia due to insufflation/barotrauma,and introduction of the endoscope.Gastroenterologists must be aware of this condition and its risk factors for risk minimization,early diagnosis,and proper treatment. | Sinan Sadalla Andrea Lisotti Lorenzo Fuccio Pietro Fusaroli | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 10 | Colorectal stenting as a bridge to surgery reduces morbidity and mortality in left-sided malignant obstruction: a predictive risk score-based comparative study显示文摘 | Vincenzo Cennamo Carmelo Luigiano Gianpiero Manes Rocco Maurizio Zagari Luca Ansaloni Carlo Fabbri Liza Ceroni Fausto Catena Antonio Daniele Pinna Lorenzo Fuccio Alessandro Mussetto Tino Casetti Federico Coccolini Nicola D’Imperio Franco Bazzoli | 2012 | Digestive and Liver Disease2012，，6： | 2 |
| 11 | EUS-guided gold fiducial placement and migration rate显示文摘 | Lorenzo Fuccio Gabriele Lami Alessandra Guido Carlo Fabbri | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 12 | Noninvasive and invasive staging of ovarian cancer review of the literature显示文摘 | Fuccio C Castellucci P Marzola Me | 2011 | Clin Nuce Med2011，36，10： | 1 |
| 13 | Side-viewing endoscope for colonic self-ex pandable metal stenting in patients with malignant colonic obstruction 显示文摘 | Cennamo V Fuccio L Laterza L | 2009 | Eur J Gastroenterol Hepatol2009，21，5： | 1 |
| 14 | A predictive model identifies patients most likely to have inadequate bowel preparation for colonoscopy 显示文摘 | Hassan C Fuccio L Bruno M | 2012 | Clin Gastroenterol Hepatol2012，10，： | 1 |
| 15 | Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain显示文摘 | Siniscalco D Fuccio C Giordano C | 2007 | Pharmacol Res2007，55，2： | 1 |
| 16 | Araxa Niobium Mine显示文摘 | Paraiso O S de Fuccio R | 1982 | Mineral Mag1982，146，2： | 1 |
| 17 | Management of Radiation-Induced Rectal Bleeding显示文摘 | Liboria Laterza Paolo Cecinato Alessandra Guido Alessandro Mussetto Lorenzo Fuccio | 2013 | Current Gastroenterology Reports2013，，11： | 1 |
| 18 | Study of silicon–germanium interdiffusion from pure germanium deposited layers显示文摘 | Mathieu Gavelle El Mehdi Bazizi Emmanuel Scheid Claude Armand Pier Francesco Fazzini Olivier Marcelot Yves Campidelli Aomar Halimaoui Fuccio Cristiano | 2008 | Materials Science & Engineering B2008，，： | 1 |
| 19 | Can early precut implementation reduce endoscopic retrograde cholangiopancreatography-related complication risk? Meta-analysis of randomized controlled trials显示文摘 | V. Cennamo L. Fuccio R. Zagari L. Eusebi L. Ceroni L. Laterza C. Fabbri F. Bazzoli | 2010 | Endoscopy2010，，05： | 1 |
| 20 | Timing of precut procedure does not influence success rate and complications of ERCP procedure: a prospective randomized comparative study显示文摘 | Vincenzo Cennamo Lorenzo Fuccio Alessandro Repici Carlo Fabbri Diego Grilli Massimo Conio Nicola D’Imperio Franco Bazzoli | 2009 | Gastrointestinal Endoscopy2009，，3： | 1 |
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