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| 1 | Changes in cellular mechanical properties during onset or progression of colorectal cancer显示文摘Colorectal cancer(CRC) development represents a multistep process starting with specific mutations that affect proto-oncogenes and tumour suppressor genes.These mutations confer a selective growth advantage to colonic epithelial cells that form first dysplastic crypts, and then malignant tumours and metastases. All these steps are accompanied by deep mechanical changes at the cellular and the tissue level. A growing consensus is emerging that such modifications are not merely a byproduct of the malignant progression, but they could play a relevant role in the cancer onset and accelerate its progression. In this review, we focus on recent studies investigating the role of the biomechanical signals in the initiation and the development of CRC. We show that mechanical cues might contribute to early phases of the tumour initiation by controlling the Wnt pathway, one of most important regulators of cell proliferation in various systems. We highlight how physical stimuli may be involved in the differentiation of non-invasive cells into metastatic variants and how metastatic cells modify their mechanical properties, both stiffness and adhesion, to survive the mechanical stress associated with intravasation, circulation and extravasation. A deep comprehension of these mechanical modifications may help scientist to define novel molecular targets for the cure of CRC. | Gabriele Ciasca Massimiliano Papi Eleonora Minelli Valentina Palmieri Marco De Spirito | 2016 | World Journal of Gastroenterology2016，22，32： | 3 |
| 2 | Colon capsule endoscopy:What we know and what we would like to know显示文摘Colonoscopy is usually perceived as an invasive and potentially painful procedure,being also affected by a small,but definite,risk of major complications(cardiopulmonary complications,perforation,hemorrhage)and even mortality.To improve both acceptability and safety,Pill Cam Colon Capsule Endoscopy(CCE)(Given Imaging Ltd,Yoqneam,Israel)has been developed.CCE represents a non-invasive technique that is able to explore the colon without sedation and air insufflation.The Second Generation of Colon Capsule Endoscopy(Pill Cam Colon 2)(CCE-2)was proven to be an accurate tool to detect colonic neoplastic lesions when used in average risk individuals.To date,the evidence supports the use of CCE-2 in case of colonoscopy failure,in patients unwilling to perform colonoscopy and when colonoscopy is contraindicated.Other potential applications,such as colorectal cancer screening or diagnostic surveillance ofinflammatory bowel disease need to be clarified.In this paper,the current'state of the art',potential application of CCE and future needs are evaluated. | Cristiano Spada Federico Barbaro Gianluca Andrisani Leonardo Minelli Grazioli Cesare Hassan Isabella Costamagna Mariachiara Campanale Guido Costamagna | 2014 | World Journal of Gastroenterology2014，20，45： | 2 |
| 3 | Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点显示文摘在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 | Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda | 2017 | 现代生物医学进展2017，17，14： | 2 |
| 4 | Evaluation of connected vehicle impact on mobility and mode choice显示文摘Connected vehicle is emerging as a solution to exacerbating congestion problems in urban areas.It is important to understand the impacts of connected vehicle on network and travel behavior of road users.The main objective of this paper is to evaluate the impact of connected vehicle on the mode choice and mobility of transportation networks.An iterative methodology was used in this paper where demands for various modes were modified based on the changes in travel time between each origin-destination(OD) pair caused by introduction of connected vehicle.Then a traffic assignment was performed in a microsimulation model,which was able to accurately simulate vehicle-to-vehicle communication.It is assumed that vehicles are equipped with a dynamic route guidance technology to choose their own route using real-time traffic information obtained through communication.The travel times obtained from the micro-simulation model were compared with a base scenario with no connected vehicle.The methodology was tested for a portion of Downtown Toronto,Ontario,Canada.In order to quantify changes in mode share with changes in travel time associated with each OD pair,mode choice models were developed for auto,transit,cycling and pedestrians using data mainly from the Transportation Tomorrow Survey.The impact of connected vehicle on mode choice was evaluated for different market penetrations of connected vehicle.The results of this study show that average travel times for the whole auto mode will generally increase,with the largest increase from connected vehicles.This causes an overall move away from the auto mode for high market penetrations if a dynamic route guidance algorithm is implemented. | Simon Minelli Pedram Izadpanah Saiedeh Razaui | 2015 | Journal of Traffic and Transportation Engineering(English Edition)2015，2，5： | 2 |
| 5 | DNA points the way ahead in taxonomy显示文摘 | Tautz D Arctander P Minelli A Thomas RH Vogler AP | | 0，，6897： | 1 |
| 6 | Laparoseopic colorectal re- section for bowel endometriosis: feasibility, complications, and clinical outeome显示文摘 | Minelli L Fanfani F Fagotti A | 2009 | Arch Surg2009，144，3： | 1 |
| 7 | DNA points the way ahead in taxonomy显示文摘 | Tautz D Arctander P Minelli A | 2002 | Nature2002，418，： | 1 |
| 8 | Release of antibiotics from polymethylmethacrylate cement显示文摘 | Bertazzoni Minelli E Caveiari C Benini A | 2002 | Chemotherapy2002，14，5： | 1 |
| 9 | A plea for DNA taxonomy显示文摘 | Tautz D Arctander P Minelli A Thomas RH Vogler AP | | 0，，02： | 1 |
| 10 | The use of an epiphyte (Tillandsia caput-medusae morren ) as bloindicator of air pollution in Costa Rica 显示文摘 | Brighigna L Ravanellib M Minelli A | 1997 | The Science of the Total Environment1997，198，： | 1 |
| 11 | Nanosponge-encapsulated camptothecin exerts anti-tumor activity in human prostate cancer cells显示文摘 | Minelli R Cavalli R Ellis L | 2012 | European Journal of Pharmaceutical Sciences2012，47，： | 1 |
| 12 | Systematic review and meta - analysis of the association between {beta} 2 - adrenoceptor polymorphisms and asthma:a HuGE review显示文摘 | Thakkinstian A McEvoy M Minelli C | 2005 | Am J Epidemiol2005，162，3： | 1 |
| 13 | Vascular Endothelial Growth Factor(VEGF)serum concentration during electroconvulsive therapy(ECT)in treatment resistant depressed patients显示文摘 | Minelli A Zanardini R Abate M | 2011 | Prog Neuropsychopharmacol Biol Psychiatry2011，35，5： | 1 |
| 14 | Nrf2 and NF-κB and their concerted modulation in cancer pathogenesis and progression显示文摘 | Bellezza I Mierla A L Minelli A | 2010 | Cancers (basel)2010，2，2： | 1 |
| 15 | A plea for DNA taxonomy显示文摘 | Tautz D Arctander P Minelli A | 2003 | Trends in Ecology and Evolution2003，18，2： | 1 |
| 16 | Isolation and purifi cation of the IGF-I protein complex from rubbit seminal plasma:Effects on sperm motility and viability 显示文摘 | Minelli A Moroni M Castellinic | 2001 | J Exp Zool2001，290，3： | 1 |
| 17 | Results from the ALIVE study intensive 显示文摘 | Brun- Buisson C Minelli C Bertotini G et aI Epidemiology and outcome of acute lung injury in European in- tensive care units | 2004 | Care Med2004，30，1： | 1 |
| 18 | Vanadium in Italian Waters: Monitoring and Speciation of V (IV) andV(V) 显示文摘 | Minelli L Veschetti E Giammanco S | 2000 | MicroehemJ2000，67，123： | 1 |
| 19 | Cause-specific mortality in classic Kaposi's sarcoma:a population-based study in Italy(1995-2002)显示文摘 | Ascoli V Minelli G Kanieff M | 2009 | Br J Cancer2009，101，7： | 1 |
| 20 | Epidemiolo- gy and outcome of acute lung injm3 in European intensive care u- nits - results from the ALIVE study (vo130, pg 51,2003) 显示文摘 | Brun - Buisson C Minelli C Bertolini G | 2004 | Intens Care Med2004，30，3： | 1 |
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