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| 1 | Human NK cells: surface receptors, inhibitory checkpoints, and translational applications显示文摘NK cells play important roles in innate defenses against viruses and in the control of tumor growth and metastasis.The regulation/induction of NK cell function is mediated by an array of activating or inhibitory surface receptors.In humans,major activating receptors involved in target cell killing are the natural cytotoxicity receptors(NCRs)and NKG2D.Activating receptors recognize ligands that are overexpressed or expressed de novo upon cell stress,viral infection,or tumor transformation.The HLA-class I-specific inhibitory receptors,including KIRs recognizing HLA-class I allotypic determinants and CD94/NKG2A recognizing the class-Ib HLA-E,constitute a fail-safe mechanism to avoid unwanted NK-mediated damage to healthy cells.Other receptors such as PD-1,primarily expressed by activated T lymphocytes,are important inhibitory checkpoints of immune responses that ensure T-cell tolerance.PD-1 also may be expressed by NK cells in cancer patients.Since PD-1 ligand(PD-L1)may be expressed by different tumors,PD-1/PD-L1 interactions inactivate both T and NK cells.Thus,the reliable evaluation of PD-L1 expression in tumors has become a major issue to select patients who may benefit from therapy with mAbs disrupting PD-1/PD-L1 interactions.Recently,NKG2A was revealed to be an important checkpoint controlling both NK and T-cell activation.Since most tumors express HLA-E,mAbs targeting NKG2A has been used alone or in combination with other therapeutic mAbs targeting PD-1 or tumor antigens(e.g.,EGFR),with encouraging results.The translational value of NK cells and their receptors is evidenced by the extraordinary therapeutic success of haploidentical HSCT to cure otherwise fatal high-risk leukemias. | Simona Sivori Paola Vacca Genny Del Zotto Enrico Munari Maria Cristina Mingari Lorenzo Moretta | 2019 | Cellular & Molecular Immunology2019，16，5： | 33 |
| 2 | Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention显示文摘Colorectal cancer(CRC)is one of the leading causes of cancer and cancer-related mortality worldwide.The disease has been traditionally a major health problem in industrial countries,however the CRC rates are increasing in the developing countries that are undergoing economic growth.Several environmental risk factors,mainly changes in diet and life style,have been suggested to underlie the rise of CRC in these populations.Diet and lifestyle impinge on nuclear receptors,on the intestinal microbiota and on crucial molecular pathways that are implicated in intestinal carcinogenesis.In this respect,the epidemiological transition in several regions of the world offers a unique opportunity to better understand CRC carcinogenesis by studying the disease phenotypes and their environmental and molecular associations in different populations.The data from these studies may have important implications for the global prevention and treatment of CRC. | Faraz Bishehsari Mahboobeh Mahdavinia Michele Vacca Reza Malekzadeh Renato Mariani-Costantini | 2014 | World Journal of Gastroenterology2014，20，20： | 18 |
| 3 | Vascular endothelial growth factor and tryptase changes after chemoembolization in hepatocarcinoma patients显示文摘AIM: To evaluate vascular endothelial growth factor(VEGF) and tryptase in hepatocellular cancer(HCC)before and after trans-arterial chemoembolization(TACE).METHODS: VEGF and tryptase serum concentrations were assessed from 71 unresectable HCC patients before and after hepatic TACE performed by binding DC-Beads?to doxorubicin. VEGF levels were examined for each serum sample using the Quantikine Human VEGF-enzyme-linked immuno-absorbent assay(ELISA),whereas tryptase serum concentrations were assessed for each serum sample by means of fluoro-enzyme immunoassay(FEIA) using the Uni-CAP100 tool.Differences between serum VEGF and tryptase values before and after TACE were evaluated using Student t test. Person's correlation was used to assess the degree of association between the two variables.RESULTS: VEGF levels and serum tryptase in HCCpatients before TACE had a mean value and standard deviation(SD) of 114.31 ± 79.58 pg/mL and 8.13± 3.61 μg/L, respectively. The mean levels and SD of VEGF levels and serum tryptase in HCC patients after TACE were 238.14 ± 109.41 pg/mL and 4.02 ±3.03 μg/L. The changes between the mean values of concentration of VEGF and tryptase before treatment and after treatment was statistically significant(P <0.000231 and P < 0.00124, by Wilcoxon-Mann-Whitney respectively). A significant correlation between VEGF levels before and after TACE and between tryptase levels before and after TACE was demonstrated(r =0.68, P = 0.003; r = 0.84, P = 0.000 respectively).CONCLUSION: Our pilot results suggest that the higher serum VEGF levels and the lower tryptase levels following TACE may be potential biomarkers changing in response to therapy. | Girolamo Ranieri Michele Ammendola Ilaria Marech Annamaria Laterza Ines Abbate Caroline Oakley Angelo Vacca Rosario Sacco Cosmo Damiano Gadaleta | 2015 | World Journal of Gastroenterology2015，21，19： | 13 |
| 4 | Novel agents and new therapeutic approaches for treatment of multiple myeloma显示文摘This review summarizes the therapeutic strategies and the drugs actually in development for the management of myeloma patients. Multiple myeloma is caused by the expansion of monoclonal plasma cells and secretion of M-protein(immunoglobulins, Bence Jones protein and free light chains). Multiple myeloma still remains an incurable disease with a high incidence rate in the elderly, despite the introduction of several new therapeutic agents(bortezomib, lenalidomide and thalidomide) which have changed its natural history. The high heterogeneity of this disease leads to large differences in clinical responses to treatments. Thus, the choice of the best treatment is a difficult issue. However, the introduction of new drugs has made it possible to achieve high response rates and good quality respons-es with long-term disease control. Interactions between tumor cells and their bone marrow microenvironment play a pivotal role in the development, maintenance, and progression of myeloma, inducing also drug resistance. These knowledges have improved treatment options, leading to the approval of new drugs which not only target the malignant cell itself, but also its microenvironment. These agents are in preclinical/early clinical evaluation and they appear to further improve disease control, but their use is still not approved outside of clinical trials. | Roberto Ria Antonia Reale Angelo Vacca | 2014 | World Journal of Methodology2014，4，2： | 10 |
| 5 | Primary sclerosing cholangitis: Updates in diagnosis and therapy显示文摘Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown origin mostly found in males, and characterized by diffuse inflammation and fibrosis of both intra- and extra-hepatic bile ducts. So far, PSC is considered as an autoimmune hepatobiliary disease. In most cases the progression of PSC towards liver cirrhosis and liver failure is slow but irreversible, and liver transplantation is currently the only definitive treatment. In recent years,PSC has been an area of active research worldwide with great interest in etiology, pathogenesis, diagnosis, and therapeutic options such as hydrophilic ursodeoxycholic acid and immunosuppressive agent tacrolimus. Recent updates on clinical and therapeutic aspects of PSC are discussed in the present review. | Piero Portincasa Michele Vacca Antonio Moschetta Michele Petruzzelli Giuseppe Palasciano Karel J.van Erpecum Gerard P.van Berge-Henegouwen | 2005 | World Journal of Gastroenterology2005，11，1： | 7 |
| 6 | Identify multiple myeloma stem cells: Utopia?显示文摘Multiple myeloma(MM) is a hematologic malignancy of monoclonal plasma cells which remains incurable despite recent advances in therapies. The presence of cancer stem cells(CSCs) has been demonstrated in many solid and hematologic tumors, so the idea of CSCs has been proposed for MM, even if MM CSCs have not been define yet. The existence of myeloma CSCs with clonotypic B and clonotypic non B cells was postulated by many groups. This review aims to focus on these distinct clonotypic subpopulations and on their ability to develop and sustain MM. The bone marrow microenvironment provides to MM CSCs self-renewal, survival and drug resistance thanks to the presence of normal and cancer stem cell niches. The niches and CSCs interact each other through adhesion molecules and the interplay between ligands and receptors activate stemness signaling(Hedgehog, Wnt and Notch pathways). MM CSCs are also supposed to be responsible for drug resistance that happens in three steps from the initial cancer cell homing microenvironment-mediated to development of microenvironment-independent drug resistance. In this review, we will underline all these aspects of MM CSCs. | Ilaria Saltarella Aurelia Lamanuzzi Antonia Reale Angelo Vacca Roberto Ria | 2015 | World Journal of Stem Cells2015，7，1： | 4 |
| 7 | A new algorithm for bank-failure mechanisms in 2D morphodynamic models with unstructured grids显示文摘河岸失败是在似地球形状的过程的重要现象。面对河岸或陡峭的 bedforms,水级的上升深深地导致的倒塌机制与沉积运输过程一起影响床进化。在这份报纸,能够在一个二维的二阶段的 morphodynamic 模型模仿如此的机制的一个算法被介绍。混合的 A 以房间为中心、以节点为中心的有限卷的 discretization,使用一个未组织的三角形的网孔并且在只有一个意义地要定义的每个房间允许斜坡,被建议。geo 失败操作员保证当在房间床斜坡超过一个批评角度时,相应的床材料和毛孔水将成为床运输的部分并且然后将跟随二阶段的流动的动态方程。算法有效性被一些试验性的测试的数字繁殖从文学显示出。 | Stefania Evangelista Massimo Greco Michele Iervolino Angelo Leopardi Andrea Vacca | 2015 | International Journal of Sediment Research2015，30，4： | 4 |
| 8 | Laparoscopic splenectomy for a littoral cell angioma of the spleen: Case report显示文摘A littoral cell angioma(LCA) is a primary vascular tumor of the spleen, that can have malignant potential and may present association with other malignancies. This is a case of LCA that was discovered incidentally in a 79-year-old woman who presented with a polycythemia at the time of consultation. The neoplasm was evaluated by ultrasound and computed tomography. The patient underwent a splenectomy that revealed LCA by pathological evaluation. The post-operative outcome was favorable with no complications or recurrent disease. This case presentation, clinical, radiographic, and pathological features of an uncommon splenic tumor can be studied in order to advance our knowledge in our understanding of LCA. | Alice Marzetti Federico Messina Daniela Prando Luca A Verza Ugo Vacca Alireza Azabdaftari Leonardo Rubinato Domenico Reale Massimo Favat Mario Barbujani Ferdinando Agresta | 2015 | World Journal of Clinical Cases2015，3，11： | 3 |
| 9 | Therapeutic targeting of the mTOR ‐signalling pathway in cancer: benefits and limitations显示文摘 | M Moschetta A Reale C Marasco A Vacca M R Carratù | 2014 | Br J Pharmacol2014，，： | 2 |
| 10 | Angiogensis extant and expression of matrix metalloproteinase-2 and-9 correlate with upgranding and myometrial invasion in endometrial carcinoma显示文摘 | Iurlaro G Loverro A Vacca G | 1999 | Eur J Clin Invest1999，29，9： | 2 |
| 11 | Numerical simulation of mud-flows impacting structures显示文摘The study of the interaction of mud-flows with obstacles is important to define inundation zones in urban areas and to design the possible structural countermeasures. The paper numerically investigates the impact of a mud-flow on rigid obstacles to evaluate the force acting on them using two different depth-integrated theoretical models, Single-Phase Model(SPM) and Two-Phase Model(TPM), to compare their performance and limits. In the first one the water-sediment mixture is represented as a homogeneous continuum described by a shearthinning power-law rheology. Alternatively, the twophase model proposed by Di Cristo et al in 2016 is used, which separately accounts for the liquid and solid phases. The considered test cases are represented by a 1D landslide flowing on a steep slope impacting on a rigid wall and a 2D mud dam-break flowing on a horizontal bottom in presence of single and multiple rigid obstacles. In the 1D test case, characterized by a very steep slope, the Two-Phase Model predicts the separation between the two phases with a significant longitudinal variation of the solid concentration. In this case the results indicate appreciable differences between the two models in the estimation of both the wave celerity and the magnitude of the impact, with an overestimation of the peak force when using the Single-Phase Model. In the 2D test-cases, where the liquid and solid phases remain mixed, even if the flow fields predicted by the two models present some differences, the essential features of the interaction with the obstacles, along with the maximum impact force, are comparable. | GRECO Massimo DI CRISTO Cristiana IERVOLINO Michele VACCA Andrea | 2019 | Journal of Mountain Science2019，16，2： | 2 |
| 12 | Bone marrow angiogenesis and progression in multiple myeloma 显示文摘 | VACCA A RIBATTI D RONCALI L | 1994 | Br J Haematal1994，87，： | 1 |
| 13 | Human erythropoietin induces a por-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo显示文摘 | Ribatti D Presta M Vacca A Ria A Giuliani R Dell'Era P | 1999 | Blood1999，93，： | 1 |
| 14 | Measurement of runoff and soil erosion in three areas under different land use in Sardinia( Italy) 显示文摘 | Vacca A Loddo S Ollesch G | 2000 | Catena2000，40，： | 1 |
| 15 | Effect of plants and filter materials on bacteria removal in pilot-scale constructed wetlands显示文摘 | VACCA G WAND H NIKOLAUSZ M | 2005 | Water Research2005，39，7： | 1 |
| 16 | A top-down perspective on dopamine,motivation and memory显示文摘 | Phillipe AG Vacca G Ahn S | 2008 | Pharmacol Biochem Behav2008，90，： | 1 |
| 17 | A paracrine loop in the vascular endothelial growth factor pathway triggers tumor angiogenesis and growth in multiple myeloma显示文摘 | Vacca A Ria R Ribatti D | 2003 | Haematologica2003，88，2： | 1 |
| 18 | Biodegradable starch/day nanocomposite films for food packaging applications显示文摘 | Avella M De Vlieger J J Erfico M E Fischer S Vacca P & Volpe M G | 2005 | Food Chemistry2005，93，： | 1 |
| 19 | The thvmus at the crossroad of neuro innnune inleraclions 显示文摘 | Maroder M BeUavia D Vacca A | 2000 | Annals of the New York Acodemy of sciences2000，917，： | 1 |
| 20 | Bone marrow neo-vascularization, plasma cell angiogenic potential,andmatrix metalloproteinase-2 secretion parallel progres-sion of human multiple myeloma 显示文摘 | Vacca A Ribatti D Presta M | 1999 | Blood1999，93，9： | 1 |
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