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| 1 | Risk of cardiovascular,cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)has emerged as a public health problem of epidemic proportions worldwide.Accumulating clinical and epidemiological evidence indicates that NAFLD is not only associated with liver-related morbidity and mortality but also with an increased risk of coronary heart disease(CHD),abnormalities of cardiac function and structure(e.g.,left ventricular dysfunction and hypertrophy,and heart failure),valvular heart disease(e.g.,aortic valve sclerosis)and arrhythmias(e.g.,atrial fibrillation).Experimental evidence suggests that NAFLD itself,especially in its more severe forms,exacerbates systemic/hepatic insulin resistance,causes atherogenic dyslipidemia,and releases a variety of pro-inflammatory,pro-coagulant and pro-fibrogenic mediators that may play important roles in the pathophysiology of cardiac and arrhythmic complications.Collectively,these findings suggest that patients with NAFLD may benefit from more intensive surveillance and early treatment interventions to decrease the risk for CHD and other cardiac/arrhythmic complications.The purpose of this clinical review is to summarize the rapidly expanding body of evidence that supports a strong association between NAFLD and cardiovascular,cardiac and arrhythmic complications,to briefly examine the putative biological mechanisms underlying this association,and to discuss some of the current treatment options that may influence both NAFLD and its related cardiac and arrhythmic complications. | Stefano Ballestri Amedeo Lonardo Stefano Bonapace Christopher D Byrne Paola Loria Giovanni Targher | 2014 | World Journal of Gastroenterology2014，20，7： | 55 |
| 2 | Nonalcoholic Fatty Liver Disease: A Novel Cardiometabolic Risk Factor for Type 2 Diabetes and Its Complications显示文摘 | Giovanni Targher Christopher D. Byrne | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，2： | 5 |
| 3 | Non-invasive fibrosis assessment in non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is estimated to affect approximately 25%of the adult population worldwide.[1]NAFLD encompasses a histopathological spectrum of progressive pathologic conditions ranging from non-alcoholic fatty liver(NAFL)to steatohepatitis(NASH)and cirrhosis. | Rafael S.Rios Kenneth I Zheng Giovanni Targher Christopher D.Byrne Ming-Hua Zheng | 2020 | Chinese Medical Journal2020，，22： | 4 |
| 4 | Relation Between Red Blood Cell Distribution Width and Inflammatory Biomarkers in a Large Cohort of Unselected Outpatients显示文摘 | Lippi Giuseppe Targher Giovanni Montagnana Martina Salvagno Gian Luca Zoppini Giacomo Guidi Gian Cesare | 2009 | Archives of Pathology & Laboratory Medicine2009，，4： | 4 |
| 5 | Fatty liver is associated with an increased risk of diabetes and cardiovascular disease- Evidence from three different disease models: NAFLD, HCV and HIV显示文摘Fatty liver, which frequently coexists with necroinflammatory and fibrotic changes, may occur in the setting of nonalcoholic fatty liver disease(NAFLD) and chronic infections due to either hepatitis C virus(HCV) or human immunodeficiency virus(HIV). These three pathologic conditions are associated with an increased prevalence and incidence of cardiovascular disease(CVD) and type 2 diabetes(T2D). In this multidisciplinary clinical review, we aim to discuss the ever-expanding wealth of clinical and epidemiological evidence supporting a key role of fatty liver in the development of T2 D and CVD in patients with NAFLD and in those with HCV or HIV infections. For each of these three common diseases, the epidemiological features, pathophysiologic mechanisms and clinical implications of the presence of fatty liver in predicting the risk of incident T2 D and CVD are examined in depth. Collectively, the data discussed in this updated review, which follows an innovative comparative approach, further reinforce the conclusion that the presence of fatty/inflamed/fibrotic liver might be a shared important determinant for the development of T2 D and CVD in patients with NAFLD, HCV or HIV. This review may also open new avenues in the clinical and research arenas and paves the way for the planning of future, well-designed prospective and intervention studies. | Amedeo Lonardo Stefano Ballestri Giovanni Guaraldi Fabio Nascimbeni Dante Romagnoli Stefano Zona Giovanni Targher | 2016 | World Journal of Gastroenterology2016，22，44： | 4 |
| 6 | Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey显示文摘 | Jeffrey C. Sirota Kim McFann Giovanni Targher Richard J. Johnson Michel Chonchol Diana I. Jalal | 2012 | Metabolism2012，，： | 3 |
| 7 | NAFLD: A multisystem disease显示文摘 | Christopher D. Byrne Giovanni Targher | 2015 | Journal of Hepatology2015，，1： | 2 |
| 8 | Diagnosis and Management of Nonalcoholic Fatty Liver Disease and Its Hemostatic/Thrombotic and Vascular Complications显示文摘 | Giovanni Targher Christopher Byrne | 2013 | Semin Thromb Hemost2013，，02： | 2 |
| 9 | Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes显示文摘 | Giuseppe Lippi Luca Filippozzi Martina Montagnana Gian Luca Salvagno Massimo Franchini Gian Cesare Guidi Giovanni Targher | 2009 | Clinical Chemistry and Laboratory Medicine2009，，3： | 2 |
| 10 | Associations between serum 25-hydroxyvitamin D 3 concentrations and liver histology in patients with non-alcoholic fatty liver disease显示文摘 | Giovanni Targher Lorenzo Bertolini Luca Scala Massimo Cigolini Luciano Zenari Giancarlo Falezza Guido Arcaro | 2006 | Nutrition Metabolism and Cardiovascular Diseases2006，，7： | 2 |
| 11 | Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?显示文摘 | G. Targher F. Marra G. Marchesini | 2008 | Diabetologia2008，，11： | 2 |
| 12 | Black esophagus syndrome associated with diabetic ketoacidosis显示文摘Acute esophageal necrosis,also known as 'black esophagus syndrome',is a rare acute esophageal disease that is often associated with vomiting and upper gastrointestinal haemorrhage.At present,little is known regarding the pathogenesis of this disease.We present the case of a 50-year-old white male patient with diabetic ketoacidosis suffering from acute esophageal necrosis with nausea and vomiting but without any clinical signs of upper gastrointestinal bleeding. | Riccardo Rigolon Irene Fossà Luca Rodella Giovanni Targher | 2016 | World Journal of Clinical Cases2016，4，2： | 2 |
| 13 | Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD显示文摘 | Amedeo Lonardo Silvia Sookoian Michel Chonchol Paola Loria Giovanni Targher | 2013 | Current Pharmaceutical Design2013，，29： | 2 |
| 14 | Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients显示文摘 | Lippi G Targher G Montagnana M | 2009 | Arch Pathol Lab Med2009，133，4： | 1 |
| 15 | et al Serum u-ric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function 显示文摘 | ZOPPINI G TARGHER G CHONCHOL M | 2012 | Diabetes Care2012，，： | 1 |
| 16 | Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients显示文摘 | Lippi G Targher G Montagnana M | 2009 | Arch Pathol Lab Med2009，133，4： | 1 |
| 17 | Effect of lovastatin on primary prevention of cardiovascular events in mild CKD and kidney function loss: a post hoc analysis of the Air Force/Texas Coronary Atherosclerosis Prevention Study 显示文摘 | Kendrick J Shlipak MG Targher G | 2010 | Am] Kidney Dis2010，，： | 1 |
| 18 | Relation between redblood cell distribution width and inflammatory biomarkers in alarge cohort of unselected outpatients 显示文摘 | Lippi G Targher G Montagnana M | 2009 | Arch Pathol Lab Med2009，133，4： | 1 |
| 19 | Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease显示文摘 | Targher G Day CP Bonora E | 2010 | N Engl J Med2010，363，： | 1 |
| 20 | Disorders of hemostasis associated with chronic kidney disease显示文摘 | Jalal D I Chonchol M Targher G | 2010 | Semin Thromb Hemost2010，36，1： | 1 |
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