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| 1 | EFFECTS OF ACUPUNCTURE ON IMMUNE RESPONSE RELATED TO OPIOID-LIKE PEPTIDES显示文摘Experimental research has recently shown that acupuncture induces the formation of opioid-like peptides (OLPs) in animals. In order to provide further evidence, we tested the β-endorphin levels and other parameters (VIP, lymphocyte subsets, NK cells and monocyte phagocytosis) in a group of 90 patients suffering from various painful disorders treated with acupuncture. Zusanli (St 36) and Hegu (LI 4) acupoints were selected. A homogeneous group of 30 subjects was used as control. Evaluation of the above parameters was made with 3 series of blood tests before treatment, 30 minutes and 24 hours after acupuncture treatment. In the acupuncture group, the following results were achieved: 1) A considerable increase in β-endorphin levels remained high even 24 hours after acupuncture treatment. In addition, we demonstrated an inverted correlation between β-endorphins and VIP; 2) 30 minutes after acupuncture session, 80% of the treated patients showed a significant increase of CD3 and CD4 values and an increase of CD8 24 hours after stimulation; 3) Monocyte phagocytosis was increased in 45% of the treated subjects 30 minutes from starting treatment, and in 100% of them after 24 hours. The percentage of NK cells was also increased in 40% of cases after 30 minutes, and in 50% after 24 hours. However, in the control group, no such significant changes in immune parameters were found. | FILOMENA PETTI ALFIO BANGRAZI ALDO LIGUORI GABRIELLA REALE FLORA IPPOLITI | 1998 | Journal of Traditional Chinese Medicine1998，18，1： | 20 |
| 2 | 丝纤维及其织物的起皱机理显示文摘丝纤维及其织物的起皱程度与溶剂极性和生成氢键能力密切相关,且受溶剂分子的体积和粘度的影响,其中丝纤维在50%乙醇溶液中的起皱现象最为严重。 | Real Silk Creasing Mechanism Research Team | 1993 | 丝绸1993，30，6： | 15 |
| 3 | Novel agents and new therapeutic approaches for treatment of multiple myeloma显示文摘This review summarizes the therapeutic strategies and the drugs actually in development for the management of myeloma patients. Multiple myeloma is caused by the expansion of monoclonal plasma cells and secretion of M-protein(immunoglobulins, Bence Jones protein and free light chains). Multiple myeloma still remains an incurable disease with a high incidence rate in the elderly, despite the introduction of several new therapeutic agents(bortezomib, lenalidomide and thalidomide) which have changed its natural history. The high heterogeneity of this disease leads to large differences in clinical responses to treatments. Thus, the choice of the best treatment is a difficult issue. However, the introduction of new drugs has made it possible to achieve high response rates and good quality respons-es with long-term disease control. Interactions between tumor cells and their bone marrow microenvironment play a pivotal role in the development, maintenance, and progression of myeloma, inducing also drug resistance. These knowledges have improved treatment options, leading to the approval of new drugs which not only target the malignant cell itself, but also its microenvironment. These agents are in preclinical/early clinical evaluation and they appear to further improve disease control, but their use is still not approved outside of clinical trials. | Roberto Ria Antonia Reale Angelo Vacca | 2014 | World Journal of Methodology2014，4，2： | 10 |
| 4 | Discussion on the Index System of Intensive Land Use Evaluation in Development Area显示文摘The establishment of evaluation index system is the key to the evaluation of intensive land use.On the basis of expounding connotation,characteristics and the principle of establishing evaluation index system,and as for the problems existing in Evaluation Regulation(Trial)of Intensive Land Use in Development Area,regarding the evaluation index system of intensive land use in the development area,in the light of the connotation of intensive land use in development area,coupled with the practical situation of the land use in China's development area,after referring to the research achievements of domestic and abroad scholars,some suggestions are put forward in order to improve and perfect the evaluation index system of intensive land us in development area. | LIU Xiang-dong1,GAO Jie2 1.School of Land Science and Technology,China University of Geosciences,Beijing 100083,China 2.Weida Real Estate Evaluation Corporation of Henan Province,Luoyang 471000,China | 2011 | Asian Agricultural Research2011，3，2： | 7 |
| 5 | Colorectal cancer risk in hamartomatous polyposis syndromes显示文摘Colorectal cancer(CRC) is a major cause of morbidity and mortality around the world, and approximately 5% of them develop in a context of inherited mutations leading to some form of familial colon cancer syndromes. Recognition and characterization of these patients have contributed to elucidate the genetic basis of CRC. Polyposis Syndromes may be categorized by the predominant histological structure found within the polyps. The aim of the present paper is to review the most important clinical features of the Hamartomatous Polyposis Syndromes, a rare group of genetic disorders formed by the peutz-Jeghers syndrome, juvenil polyposis syndrome and PTEN Hamartoma Tumor Syndrome(Bannayan-Riley-Ruvalacaba and Cowden Syndromes). A literature search was performed in order to retrieve the most recent and important papers(articles, reviews, clinical cases and clinical guidelines) regarding the studied subject. We searched for terms such as 'hamartomatous polyposis syndromes', 'Peutz-Jeghers syndrome', 'juvenile polyposis syndrome', 'juvenile polyp', and 'PTEN hamartoma tumour syndrome'(Cowden syndrome, Bananyan-Riley-Ruvalcaba). The present article reports the wide spectrum of disease severity and extraintestinal manifestations, with a special focus on their potential to develop colorectal and other neoplasia. In the literature, the reported colorectal cancer risk for Juvenile Polyposis, Peutz-Jeghers and PTEN Hamartoma Tumor Syndromes are 39%-68%, 39%-57% and 18%, respectively. A review regarding cancer surveillance recommendations is also presented. | Fábio Guilherme Campos Marleny Novaes Figueiredo Carlos Augusto Real Martinez | 2015 | World Journal of Gastrointestinal Surgery2015，7，3： | 7 |
| 6 | Watt-level and spectrally flat mid-infrared supercontinuum in fluoroindate fibers显示文摘We report on infrared supercontinuum(SC) generation in step-index fluoroindate-based fiber by using an all-fiber laser source. In comparison to widely used ZBLAN fibers for high-power mid-infrared(MIR) SC generation, fluoroindate fibers have multiphoton absorption edges at significantly longer wavelengths and can sustain similar intensities. Recent developments highlighted in the present study allowed the production of fluoroindate fibers with MIR background loss of 2 dB/km, which is similar to or even better than ZBLAN fibers.By using an all-fiber picosecond laser source based on an erbium amplifier followed by a thulium power amplifier,we demonstrate the generation of 1.0 W infrared SC spanning over 2.25 octaves from 1 μm to 5 μm. The generated MIR SC also exhibits high spectral flatness with a 6 dB spectral bandwidth from 1.91 μm to 4.77 μm and an average power two orders of magnitude greater than in previous demonstrations with a similar spectral distribution. | FRANCIS THEBERGE NANCY BERUBE SAMUEL POULAIN SOLENN COXIC LOUIS-RAFAEL ROBICHAUD MARTIN BERNIER REAL VALLEE | 2018 | Photonics Research2018，6，6： | 5 |
| 7 | 肉制品中群勃龙、勃地酮和甲氧酪胺的检测方法显示文摘介绍肉制品中群勃龙、勃地酮的液相色谱-质谱联用检测方法和甲氧酪胺的气相色谱-质谱联用检测方法。样品经β-葡萄糖醛酸甙酶水解后,群勃龙、勃地酮用甲醇-乙酸铵缓冲液提取, C18和Silica固相萃取柱净化,用LC—MS—MS法分析。甲氧酪胺样品经高氯酸溶液提取,SCX固相萃取柱净化,MBTFA衍生化处理,GC—MS法分析。两种方法均采用选择离子模式进行测定,群勃龙、勃地酮、甲氧酪胺选择的子离子(m/z)分别为:253、228、197、159;269、173、135、121;205、233、246、359,外标法定量。,群勃龙、勃地酮、甲氧酪胺的检出限分别为0.3、0.3、2μg/kg,方法回收率为72%~99%,线性范围为5—800μg/kg。 | 刘清 王欣欣 Reale Erwann 高洪波 夏敏 刘清珺 | 2007 | 化学分析计量2007，16，6： | 4 |
| 8 | Identify multiple myeloma stem cells: Utopia?显示文摘Multiple myeloma(MM) is a hematologic malignancy of monoclonal plasma cells which remains incurable despite recent advances in therapies. The presence of cancer stem cells(CSCs) has been demonstrated in many solid and hematologic tumors, so the idea of CSCs has been proposed for MM, even if MM CSCs have not been define yet. The existence of myeloma CSCs with clonotypic B and clonotypic non B cells was postulated by many groups. This review aims to focus on these distinct clonotypic subpopulations and on their ability to develop and sustain MM. The bone marrow microenvironment provides to MM CSCs self-renewal, survival and drug resistance thanks to the presence of normal and cancer stem cell niches. The niches and CSCs interact each other through adhesion molecules and the interplay between ligands and receptors activate stemness signaling(Hedgehog, Wnt and Notch pathways). MM CSCs are also supposed to be responsible for drug resistance that happens in three steps from the initial cancer cell homing microenvironment-mediated to development of microenvironment-independent drug resistance. In this review, we will underline all these aspects of MM CSCs. | Ilaria Saltarella Aurelia Lamanuzzi Antonia Reale Angelo Vacca Roberto Ria | 2015 | World Journal of Stem Cells2015，7，1： | 4 |
| 9 | 利用卫星测高、GRACE 和 GOCE 资料估计全球海洋表面地转流显示文摘重力恢复和气候试验 GRACE(gravity recovery and climate experiment)卫星极大地提高了地球重力场的精度和分辨率,特别是中长波分量,联合卫星测高数据可获得全球海洋表面大尺度洋流循环。另外,新一代地球重力和海洋环流探测卫星 GOCE(gravity field and steady-state ocean circulation explorer)于2009年3月成功发射,采用卫星重力梯度测量原理,对重力场的高频部分非常敏感,使其高分辨率监测全球海洋循环成为可能。本文利用1~7年 GRACE 观测数据确定的重力场模型和18个月 GOCE 观测数据确定的地球重力场模型 GO CONS GCF 2 TIM R3,联合卫星测高确定的平均海面高模型 MSS CNES CLS 11,分别估计全球海洋表面地转流,并且与实测浮标数据结果进行比较。分析表明 GOCE 重力卫星确定的重力场模型具有更高的空间分辨率,能够确定高精度和高空间分辨率的全球海洋地转流,如墨西哥湾暖流的细节和特征,并且与实测浮标结果基本一致。而基于1~4年 GRACE 观测资料的模型不能很好估计全球地转流特征,基于7年 GRACE 观测资料的重力场模型 ITG-Grace2010s 确定的全球地转流的精度仍低于18个月 GOCE 观测数据确定的地球重力场模型 GO CONS GCF 2 TIM R3的结果,估计的全球地转流仍含有较大的噪声,不能很好地反应中小尺度地转流细节特征。并计算 ITG Grace2010s 和 GOCE TIM3的稳态海面地形和全球平均地转流的内符合精度,结果显示,在全球范围内,GOCE TIM3的稳态海面地形和全球平均地转流的精度都比 ITG Grace2010s 结果的精度有着很大的改善,其中 ITG Grace2010s 的稳态海面地形的精度为21.6 cm,而 GOCE TIM3的结果则为7.45 cm,ITG Grace2010s 的全球平均地转流的精度为40.7 cm/s,而 GOCE TIM3的结果则为19.6 cm/s。 | 冯贵平 金双根 Jose M.Sanchez Reales | 2014 | 海洋学报2014，36，9： | 4 |
| 10 | Derailment risk and dynamics of railway vehicles in curved tracks: Analysis of the effect of failed fasteners显示文摘The effect of the fastener's failure in a railway track on the dynamic forces produced in the wheel-rail contact is studied using the simulation software VAMPIRE to assess the derailment risk of two different vehicles in two curves with distinct characteristics. First, a 3D-FEM model of a real track is constructed, paying special attention to fasteners, and calibrated with displacement data obtained experimentally during a train passage. This numerical model is subsequently used to determine the track vertical and lateral stiffness. This study evidences that although the track can practically lose its lateral stiffness as a consequence of the failure of 7 consecutive fasteners, the vehicle stability would not be necessarily compromised in the flawed zone. Moreover, the results reveal that the uncompensated acceleration and the distance along which the fasteners are failed play an important role in the dynamic behavior of the vehicle-track system,influencing strongly the risk of derailment. | Silvia Morales-Ivorra Julia Irene Real Cesar Hernandez Laura Montalbain | 2016 | Journal of Modern Transportation2016，24，1： | 4 |
| 11 | 丝纤维经有机试剂处理后理化性能的研究显示文摘丝纤维经10种不同试剂处理后,其膨化性、初始模量和断裂模量均发生了相应的变化,反映在溶解参数变化曲线上,都呈一定的规律性。 | Real Silk Creasing Mechanism Research Group | 1993 | 丝绸1993，30，7： | 3 |
| 12 | Survival of patients with hepatocellular carcinoma treated by transarterial chemoembolisation (TACE) using Drug Eluting Beads. Implications for clinical practice and trial design显示文摘 | Marta Burrel María Reig Alejandro Forner Marta Barrufet Carlos Rodríguez de Lope Silvia Tremosini Carmen Ayuso Josep M Llovet María Isabel Real Jordi Bruix | 2012 | Journal of Hepatology2012，，6： | 3 |
| 13 | Laparoscopic splenectomy for a littoral cell angioma of the spleen: Case report显示文摘A littoral cell angioma(LCA) is a primary vascular tumor of the spleen, that can have malignant potential and may present association with other malignancies. This is a case of LCA that was discovered incidentally in a 79-year-old woman who presented with a polycythemia at the time of consultation. The neoplasm was evaluated by ultrasound and computed tomography. The patient underwent a splenectomy that revealed LCA by pathological evaluation. The post-operative outcome was favorable with no complications or recurrent disease. This case presentation, clinical, radiographic, and pathological features of an uncommon splenic tumor can be studied in order to advance our knowledge in our understanding of LCA. | Alice Marzetti Federico Messina Daniela Prando Luca A Verza Ugo Vacca Alireza Azabdaftari Leonardo Rubinato Domenico Reale Massimo Favat Mario Barbujani Ferdinando Agresta | 2015 | World Journal of Clinical Cases2015，3，11： | 3 |
| 14 | Duodenal adenoma surveillance in patients with familial adenomatous polyposis显示文摘Familial adenomatous polyposis(FAP) is a hereditary disorder caused by Adenomatous Polyposis Gene mutations that lead to the development of colorectal polyps with great malignant risk throughout life. Moreover, numerous extracolonic manifestations incorporate different clinical features to produce varied individual phenotypes. Among them, the occurrence of duodenal adenomatous polyps is considered an almost inevitable event, and their incidence rates increase as a patient's age advances. Although the majority of patients exhibit different grades of duodenal adenomatosis as they age, only a small proportion(1%-5%) of patients will ultimately develop duodenal carcinoma. Within this context, the aim of the present study was to review the data regarding the epidemiology, classification, genetic features, endoscopic features, carcinogenesis, surveillance and management of duodenal polyps in patients with FAP. | Fábio Guilherme Campos Marianny Sulbaran Adriana Vaz Safatle-Ribeiro Carlos Augusto Real Martinez | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，10： | 3 |
| 15 | Development of a vehicle-track interaction model to predict the vibratory benefits of rail grinding in the time domain显示文摘Imperfections in the wheel-rail contact are one of the main sources of generation of railway vibrations.Consequently,it is essential to take expensive corrective maintenance measures,the results of which may be unknown.In order to assess the effectiveness of these measures,this paper develops a vehicle-track interaction model in the time domain of a curved track with presence of rail corrugation on the inner rail.To characterize the behavior of the track,a numerical finite element model is developed using ANSYS software,while the behavior of the vehicle is characterized by a unidirectional model of two masses developed with VAMPIRE PRO software.The overloads obtained with the dynamic model are applied to the numerical model and then,the vibrational response of the track is obtained.Results are validated with real data and used to assess the effectiveness of rail grinding in the reduction of wheel-rail forces and the vibration generation phenomenon. | Julia Irene Real Clara Zamorano José Luis Velarte Antonio Enrique Blanco | 2015 | Journal of Modern Transportation2015，23，3： | 2 |
| 16 | 中国绿色低碳住区减碳技术评估框架体系 讨论稿节选显示文摘低碳建筑已成为建筑界,产业界普遍关注的问题。但国内外学术界至今对'低碳建筑'并未作出明确科学的界定。要科学地界定低碳建筑需要确定各类建筑低碳排放的标准,同时要建立起建筑碳排放的计算方法和评估办法。这是一个需要多学科多专业共同认真研究的课题。全国工商联房地产商会邀请建筑界部分专家对住宅区减碳排放问题进行了多次讨论,在此基础上提出了'中国绿色低碳住区减碳技术评估框架体系'讨论稿。讨论稿提出了'低碳住区'的技术要点,构建原则及减碳评估指标。对住区建筑节能,节水,住区绿化,住区交通以及住区建造期、运行期的许多技术措施提出了量化的计算方法。对住区各个系统的减碳减排放状况提出了评价办法。讨论稿提出的评估框架体系试图为住宅区的减碳计算和评估提出一个可以实际应用的技术方法。这是我们看到的国内第一个提出的系统的减碳技术评估框架体系。这个讨论稿尽管是邀请各方面建筑专家经数次讨论而成,但这毕竟是'一家'之言。讨论稿中所确定的计算方法是否科学,对碳排放状况的评价方法是否合理等等,都有待于进一步研究和论证。既是讨论稿,稿中的论点、公式、方法就可能有不全面、不准确、不科学的部分。这个讨论稿共有5章,核心内容是2~4章。限于篇幅本刊将讨论稿最核心的2~4章全文发表。希望引起业内人士的关注和讨论。 | China Real Estate Chamber of Commerce, Elite (China) Real Estate Academy | 2010 | 动感(生态城市与绿色建筑)2010，0，1： | 2 |
| 17 | Therapeutic targeting of the mTOR ‐signalling pathway in cancer: benefits and limitations显示文摘 | M Moschetta A Reale C Marasco A Vacca M R Carratù | 2014 | Br J Pharmacol2014，，： | 2 |
| 18 | Peripheral cytokines profile in Parkinson’s disease显示文摘 | M. Reale C. Iarlori A. Thomas D. Gambi B. Perfetti M. Di Nicola M. Onofrj | 2008 | Brain Behavior and Immunity2008，，1： | 2 |
| 19 | 梨花女子大学 校园谷显示文摘"校园谷"项目场地紧邻一个更大的校园和南边的新村,复杂的场地环境要求建筑"大于基地"。建筑师以一种全球化的地景式设计策略将梨花大学校园的组织结构融入到城市中。"校园谷"与"运动带相结合,创造出新型地貌,以一系列方式影响着周围环境。运动带和校园谷一样是多重事物的结合体。它是进入梨花大学校园的新大门,是日常运动消闲的新去处,是年度节庆或盛典的举办地,还是名副其实的将大学带入城市的纽带。 | André Morin Luca Reale Gaёlle Lauriot-Prévost Frederico de Matteis | 2013 | 城市环境设计2013，，9： | 2 |
| 20 | Nonlinear increase,invisibility,and sign inversion of a localized fs-laser-induced refractive index change in crystals and glasses显示文摘Multiphoton absorption via ultrafast laser focusing is the only technology that allows a three-dimensional structural modification of transparent materials.However,the magnitude of the refractive index change is rather limited,preventing the technology from being a tool of choice for the manufacture of compact photonic integrated circuits.We propose to address this issue by employing a femtosecond-laser-induced electronic band-gap shift(FLIBGS),which has an exponential impact on the refractive index change for propagating wavelengths approaching the material electronic resonance,as predicted by the Kramers–Kronig relations.Supported by theoretical calculations,based on a modified Sellmeier equation,the Tauc law,and waveguide bend loss calculations,we experimentally show that several applications could take advantage of this phenomenon.First,we demonstrate waveguide bends down to a submillimeter radius,which is of great interest for higher-density integration of fs-laser-written quantum and photonic circuits.We also demonstrate that the refractive index contrast can be switched from negative to positive,allowing direct waveguide inscription in crystals.Finally,the effect of the FLIBGS can compensate for the fs-laser-induced negative refractive index change,resulting in a zero refractive index change at specific wavelengths,paving the way for new invisibility applications. | Jerome Lapointe Jean-Philippe Berube Yannick Ledemi Albert Dupont Vincent Fortin Younes Messaddeq Real Vallee | 2020 | Light(Science & Applications)2020，9，1： | 2 |
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