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| 1 | Chikungunya virus,epidemiology,clinics and phylogenesis:A review显示文摘Chikungunva virus is a mosquito-transmitted alphavirus that causes chikungunva fever,a febrile illness associated with severe arthralgia and rash.Chikungunva virus is transmitted by culicine mosquitoes:Chikungunya virus replicates in the skin,disseminates to liver,muscle,joints.lymphoid tissue and brain,presumably through the blood.Phylogenetic studies showed that the Indian Ocean and the Indian subcontinent epidemics were caused by two different introductions of distinct strains of East/Central/South African genotype of CHIKV.The paraphyletic grouping of African CHIK viruses supports the historical evidence that the virus was introduced into Asia from Africa.Phylogenetic analysis divided Chikungunva virus isolates into three distinct genotypes based on geographical origins:the first,the West Africa genotype,consisted of isolates from Senegal and Nigeria;the second contained strains from East/Central/South African genotype,while the third contained solely Asian.The most recent common ancestor for the recent epidemic,which ravaged Indian Ocean islands and Indian subcontinent in 2004- 2007.was found to date in 2002.Asian lineage dated about 1952 and exhibits similar spread patterns of the recent Indian Ocean outbreak lineage,with successive epidemics detected along an eastward path.Asian group splitted into two clades:an Indian lineage and a south east lineage.Outbreaks of Chikungunya virus fever in Asia have not been associated necessarily with outbreaks in Africa.Phylogenetic tools can reconstruct geographic spread of Chikungunva virus during the epidemics wave.The good management of patients with acute Chikungunva virus infection is essential for public health in susceptible areas with current Aedes spp activity. | Alessandra Lo Presti Alessia Lai Eleonora Cella Gianguglielmo Zehender Massimo Ciccozzi | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，12： | 8 |
| 2 | Wrist circumference: A new marker for insulin resistance in African women with polycystic ovary syndrome显示文摘BACKGROUND Insulin resistance(IR)is the main complication found in 35%-80%of women with polycystic ovary syndrome(PCOS).However,there is no definite consensus regarding which marker to use for its assessment in PCOS women.Research has shown that hyperinsulinemia is correlated with increased bone mass.Given that most women with PCOS are insulin resistant,which is independent from body fat and characterized by hyperinsulinemia,it could be hypothesized that there would be an increased bone mass in the patient as a result.Subsequently,increased bone mass could be measured using the wrist circumference method.AIM To assess the wrist circumference as an easy-to-detect marker of IR in Congolese women with PCOS.METHODS Seventy-two Congolese women with PCOS and seventy-one controls from the same ethnic group,were enrolled in the study(mean age 24.33±5.36 years).Fasting biochemical parameters,and the Homeostasis Model Assessment of insulin resistance(HOMA-IR)and body composition were evaluated.The nondominant wrist circumference was measured manually,as was the waist circumference(WC),hip circumference,height and weight.Calculated measures included evaluation of body mass index(BMI),Waist-to-Height(WHtR)and Waist-to-hip ratio(WHR).In addition,body composition was assessed by Bioelectrical Impedance Analysis using a body fat analyzer.RESULTS The non-dominant wrist circumference was more closely correlated with HOMAIR(r=0.346;P=0.003)and was the best anthropometrical marker correlated with IR(P=0.011)compared with other anthropometrical markers in women with PCOS:Dominant Wrist Circumference(r=0.315;P=0.007),Waist Circumference(WC)(r=0.259;P=0.028),BMI(r=0.285;P=0.016),WHR(r=0.216;P=0,068)and WHtR(r=0.263;P=0.027).The diagnostic accuracy of the non-dominant wrist circumference for the presence or absence of IR using Receiver-operating characteristic(ROC)curve analysis showed that the area under the ROC curve was 0.72.A cutoff value for the non-dominant wrist circumference of 16.3 cm was found to be the best predictor of IR in Congolese women with PCOS.CONCLUSION Non-dominant wrist circumference is,to date,the best anthropometrical marker of IR in Sub-Saharan African women with PCOS.It could be suggested as an easy-to-detect marker for assessing IR. | Chantal Anifa Amisi Massimo Ciccozzi Paolo Pozzilli | 2020 | World Journal of Diabetes2020，11，2： | 8 |
| 3 | Molecular epidemiology and phylogeny of Nipah virus infection:A mini review显示文摘Nipah virus(Ni V) is a member of the genus Henipavirus of the family Paramyxoviridae,characterized by high pathogenicity and endemic in South Asia.It is classified as a Biosafety Level-4(BSL-4) agent.The case-fatality varies from 40%-70% depending on the severity of the disease and on the availability of adequate healthcare facilities.At present no antiviral drugs are available for Ni V disease and the treatment is just supportive.Phylogenetic and evolutionary analyses can be used to help in understanding the epidemiology and the temporal origin of this virus.This review provides an overview of evolutionary studies performed on Nipah viruses circulating in different countries.Thirty phylogenetic studies have been published from 2000 to 2015 years,searching on pub-med using the key words ‘Nipah virus AND phylogeny' and twenty-eight molecular epidemiological studies from 2006 to 2015 have been performed,typing the key words ‘Nipah virus AND molecular epidemiology'.Overall data from the published study demonstrated as phylogenetic and evolutionary analysis represent promising tools to evidence NiV epidemics,to study their origin and evolution and finally to act with effective preventive measure. | Silvia Angeletti Alessandra Lo Presti Eleonora Cella Massimo Ciccozzi | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，7： | 4 |
| 4 | Enigmatic origin of hepatitis B virus:An ancient travelling companion or a recent encounter?显示文摘Hepatitis B virus(HBV)is the leading cause of liver disease and infects an estimated 240 million people worldwide.It is characterised by a high degree of genetic heterogeneity because of the use of a reverse transcriptase during viral replication.The ten genotypes(A-J)that have been described so far further segregate into a number of subgenotypes which have distinct ethno-geographic distribution.Genotypes A and D are ubiquitous and the most prevalent genotypes in Europe(mainly represented by subgenotypes D1-3 and A2);genotypes B and C are restricted to eastern Asia and Oceania;genotype E to central and western Africa;and genotypes H and F(classified into 4 subgenotypes)to Latin America and Alaska.This review summarises the data obtained by studying the global phylodynamics and phylogeography of HBV genotypes,particularly those concerning the origin and dispersion histories of genotypes A,D,E and F and their subgenotypes.The lack of any consensus concerning the HBV substitution rate and the conflicting data obtained using different calibration approaches make the time of origin and divergence of the various genotypes and subgenotypes largely uncertain.It is hypothesised that HBV evolutionary rates are time dependent,and that the changes depend on the main transmission routes of the genotypes and the dynamics of the infected populations. | Gianguglielmo Zehender Erika Ebranati Elena Gabanelli Chiara Sorrentino Alessra Lo Presti Elisabetta Tanzi Massimo Ciccozzi Massimo Galli | 2014 | World Journal of Gastroenterology2014，20，24： | 3 |
| 5 | Epidemiological network analysis in HIV-1 B infected patients diagnosed in Italy between 2000 and 2008显示文摘 | Annapaola Callegaro Valentina Svicher Claudia Alteri Alessandra Lo Presti Daniela Valenti Antonio Goglio Marco Salemi Eleonora Cella Carlo Federico Perno Massimo Ciccozzi Franco Maggiolo | 2011 | Infection, Genetics and Evolution2011，，3： | 2 |
| 6 | Zika virus spreading in South America: evolutionary analysis of emerging neutralizing resistant Phe279Ser strains显示文摘Objective: To investigate the genetic diversity of Zika virus(ZIKV) and the relationships existing among these circulating viruses worldwide. To evaluate the genetic polymorphisms harboured from ZIKV that can have an influence on the virus circulation. Methods: Three different ZIKV dataset were built. The first dataset included 63 E gene sequences, the second one 22 NS3 sequences and the third dataset was composed of 108 NS5 gene sequences. Phylogenetic and selective pressure analysis was performed. The edited nucleic acid alignment from the Envelope dataset was used to generate a conceptual translation to the corresponding peptide sequences through UGene software. Results: The phylogeographic reconstruction was able to discriminate unambiguously that the Brazilian strains are belonged to the Asian lineage. The structural analysis reveals instead the presence of the Ser residue in the Brazilian sequences(however already observed in other previously reported ZIKV infections) that could suggest the presence of a neutralization-resistant population of viruses. Conclusions: Phylogenetic, evolutionary and selective pressure analysis contributed to improve the knowledge on the circulation of ZIKV. | Marta Giovanetti Teresa Milano Luiz Carlos Alcantara Laura Carcangiu Eleonora Cella Alessia Lai Alessandra Lo Presti Stefano Pascarella Gianguglielmo Zehender Silvia Angeletti Massimo Ciccozzi | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，5： | 2 |
| 7 | Reconstruction of the evolutionary dynamics of the hepatitis C virus 1b epidemic in Turkey显示文摘 | Massimo Ciccozzi Anna-Rita Ciccaglione Alessandra Lo Presti Tulay Yalcinkaya Zeynep Pinar Taskan Michele Equestre Angela Costantino Roberto Bruni Erica Ebranati Marco Salemi Rebecca Gray Giovanni Rezza Massimo Galli Gianguglielmo Zehender | 2011 | Infection, Genetics and Evolution2011，，： | 2 |
| 8 | Haemodgnamic effects of intravenous clonidine on propofol or thiopental induction 显示文摘 | Marinangeli F Colco C Ciccozzi A | 2000 | Acta Anaesthesiol Stand2000，44，2： | 1 |
| 9 | Origin, evolution, and phylogeography of recent epidemic CHIKV strains显示文摘 | Alessandra Lo Presti Massimo Ciccozzi Eleonora Cella Alessia Lai Francesco Roberto Simonetti Massimo Galli Gianguglielmo Zehender Giovanni Rezza | 2012 | Infection Genetics and Evolution2012，，2： | 1 |
| 10 | Rational use of immunodiagnostic tools for tuberculosis infection:guidelines and cost effectiveness studies显示文摘 | Massimo Amicosante L Massimo Ciccozzi | | 0，，： | 1 |
| 11 | Phenotypic and Genotypic Biotyping of Environmental Strains of Vibrio Cholerae Non-O1 Isolated in Italy显示文摘 | Filetici E Bonadonna L Ciccozzi M | 1997 | Appl Environ Microbiol1997，63，10： | 1 |
| 12 | Origin, evolution, and phylogeography of recent epidemic CHIKV strains显示文摘 | Alessandra Lo Presti Massimo Ciccozzi Eleonora Cella Alessia Lai Francesco Roberto Simonetti Massimo Galli Gianguglielmo Zehender Giovanni Rezza | 2012 | Infection, Genetics and Evolution2012，，： | 1 |
| 13 | Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea显示文摘Objective:To study the genetic diversity of Murray Valley encephalitis virus(MVEV) in Australia and Papua New Guinea.Methods:MVEV envelope gene sequences were aligned using Clustal X and manual editing was performed with Bioedit.ModelTest v.3.7 was used to select the simplest evolutionary model that adequately fitted the sequence data.Maximum likelihood analysis was performed using PhyML.The phylogenetic signal of the dataset wa.s investigated by the likelihood mapping analysis.The Bayesian phylogenetic tree was built using BEAST.Results:The phylogenetic trees showed two main clades.The clade Ⅰincluding eight strains isolated from West Australia.The clade Ⅱ was characterized by at least four epidemic entries,three of which localized in Northern West Australia and one in Papua New Guinea.The estimated mean evolutionary rate value of the MVEV envelope gene wa.s0.407 × 10^(-3) substitution/site/year(95%HPD:0.623 × 10~4-0.780× 10^(-3)).Population dynamics defines a relative constant population until the year 2000.when a reduction occurred,probably due to a bottleneck.Conclusions:This study has been useful in supporting the probable connection between climate changes and viral evolution also by the vector point of view:multidisciplinary monitoring studies are important to prevent new viral epidemics inside and outside new endemic areas. | Eleonora Cella Ivan Gabrielli Gianguglielmo Zehender Marta Giovanetti Alessandra Lo Presti Alessia Lai Giordano Dicuonzo Silvia Angeletti Marco Salemi Massimo Ciccozzi | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 1 |
| 14 | Reconstruction of the epidemic history of hepatitis B virus genotype D in Albania显示文摘 | Gianguglielmo Zehender Renata Shkjezi Erika Ebranati Elena Gabanelli Zhani Abazaj Elisabetta Tanzi Dhimiter Kraja Silva Bino Massimo Ciccozzi Massimo Galli | 2011 | Infection, Genetics and Evolution2011，，： | 1 |
| 15 | Molecular epidemiology and genetic diversity of human rhinovirus affecting hospitalized children in Rome显示文摘 | Pierangeli A Ciccozzi M Chiavelli S | 2013 | Med Microbiol Immunol2013，202，4： | 1 |
| 16 | Population Dynamics of HIV-1 Subtype B in a Cohort of Men-Having-Sex-With-Men in Rome, Italy显示文摘 | Gianguglielmo Zehender Erika Ebranati Alessia Lai Maria Mercedes Santoro Claudia Alteri Massimo Giuliani Guido Palamara Carlo Federico Perno Massimo Galli Alessandra Lo Presti Massimo Ciccozzi | 2010 | JAIDS Journal of Acquired Immune Deficiency Syndromes2010，，： | 1 |
| 17 | HIV-1 subtype C transmission network: The phylogenetic reconstruction strongly supports the epidemiological data显示文摘 | Isabella Bon Massimo Ciccozzi Gianni Zehender Carlo Biagetti Gabriella Verrucchi Alessia Lai Alessandra Lo Presti Davide Gibellini Maria Carla Re | 2010 | Journal of Clinical Virology2010，，： | 1 |
| 18 | Origin and evolution of Nipah virus显示文摘 | Alessandra Lo Presti Eleonora Cella Marta Giovanetti Alessia Lai Silvia Angeletti Gianguglielmo Zehender Massimo Ciccozzi | 2016 | J. Med. Virol2016，，： | 1 |
| 19 | Phylogenetic analysis of HCV‐4d in Turkey: the curious case of Kayseri Province显示文摘 | Massimo Ciccozzi Gianguglielmo Zehender Ceylan Polat Alessia Lai Tuba Kayman Chiara Sorrentino Erika Ebranati Eleonora Cella Alessandra Lo Presti Hakan Abacioglu | 2014 | J Med Virol2014，，3： | 1 |
| 20 | Local and global spatio‐temporal dynamics of HIV‐1 subtype F1显示文摘 | Alessia Lai Massimo Ciccozzi Marco Franzetti Francesco R. Simonetti Giorgio Bozzi Francesca Binda Andrea Rosi Stefano Bonora Andrea De Luca Claudia Balotta Gianguglielmo Zehender | 2014 | J Med Virol2014，，2： | 1 |
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