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| 1 | Current guidelines for the management of non-alcoholic fatty liver disease:A systematic review with comparative analysis显示文摘The current epidemic of non-alcoholic fatty liver disease(NAFLD) is reshaping the field of hepatology all around the world.The widespread diffusion of metabolic risk factors such as obesity,type2-diabetes mellitus,and dyslipidemia has led to a worldwide diffusion of NAFLD.In parallel to the increased availability of effective anti-viral agents,NAFLD is rapidly becoming the most common cause of chronic liver disease in Western Countries,and a similar trend is expected in Eastern Countries in the next years.This epidemic and its consequences have prompted experts from all over the word in identifying effective strategies for the diagnosis,management,and treatment of NAFLD.Different scientific societies from Europe,America,and Asia-Pacific regions have proposed guidelines based on the most recent evidence about NAFLD.These guidelines are consistent with the key elements in the management of NAFLD,but still,show significant difference about some critical points.We reviewed the current literature in English language to identify the most recent scientific guidelines about NAFLD with the aim to find and critically analyse the main differences.We distinguished guidelines from 5 different scientific societies whose reputation is worldwide recognised and who are representative of the clinical practice in different geographical regions.Differences were noted in: the definition of NAFLD,the opportunity of NAFLD screening in high-risk patients,the noninvasive test proposed for the diagnosis of NAFLD and the identification of NAFLD patients with advanced fibrosis,in the follow-up protocols and,finally,in the treatment strategy(especially in the proposed pharmacological management).These difference have been discussed in the light of the possible evolution of the scenario ofNAFLD in the next years. | Simona Leoni Francesco Tovoli Lucia Napoli Ilaria Serio Silvia Ferri Luigi Bolondi | 2018 | World Journal of Gastroenterology2018，24，30： | 42 |
| 2 | Human bocavirus: Current knowledge and future challenges显示文摘Human bocavirus(HBoV) is a parvovirus isolated about a decade ago and found worldwide in both respiratory samples, mainly from early life and children of 6-24 mo of age with acute respiratory infection, and in stool samples, from patients with gastroenteritis. Since then, other viruses related to the first HBoV isolate(HBoV 1), namely HBoV 2, HBoV 3 and HBoV 4, have been detected principally in human faeces. HBo Vs are small nonenveloped single-stranded DNA viruses of about 5300 nucleotides, consisting of three open reading frames encoding the first two the non-structural protein 1(NS1) and nuclear phosphoprotein(NP1) and the third the viral capsid proteins 1 and 2(VP1 and VP2). HBoV pathogenicity remains to be fully clarified mainly due to the lack of animal models for the difficulties in replicating the virus in in vitro cell cultures, and the fact that HBo V infection is frequently accompanied by at least another viral and/or bacterial respiratory and/or gastroenteric pathogen infection. Current diagnostic methods to support HBoV detection include polymerase chain reaction, real-time PCR, enzymelinked immunosorbent assay and enzyme immunoassay using recombinant VP2 or virus-like particle capsid proteins, although sequence-independent amplification techniques combined with next-generation sequencing platforms promise rapid and simultaneous detection of the pathogens in the future. This review presents the current knowledge on HBoV genotypes with emphasis on taxonomy, phylogenetic relationship and genomic analysis, biology, epidemiology, pathogenesis and diagnostic methods. The emerging discussion on HBoV s as true pathogen or innocent bystander is also emphasized. | Marcello Guido Maria Rosaria Tumolo Tiziano Verri Alessandro Romano Francesca Serio Mattia De Giorgi Antonella De Donno Francesco Bagordo Antonella Zizza | 2016 | World Journal of Gastroenterology2016，22，39： | 11 |
| 3 | 蓖麻油酸甲酯乙氧基化物的合成与耐酸耐碱性研究显示文摘在一定的温度和压力条件下,以及特制的均相催化剂作用下,直接由蓖麻油酸甲酯得到了产物蓖麻油酸甲酯乙氧基化物(ECAME-10)。通过皂化值、气相色谱(GC)和1HNMR测定了ECAME-10的平均环氧乙烷(EO)加合数,在不同p H条件下测定了ECAME-10的耐酸耐碱性,并跟踪拍摄了不同p H溶液不同阶段的外观照片,同时测定了不同阶段溶液的表面张力。结果显示:ECAME-10有较强的抗水解能力,当p H=4~9时,ECAME-10的水解较慢,8周后其水解率在40%以下;水解后的表面张力数据表明,水解后溶液的表面张力可保持稳定。 | 张谦 孙永强 王万绪 智丽飞 Martino Di Serio 刘伟 | 2015 | 日用化学工业2015，45，12： | 5 |
| 4 | Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study显示文摘 | William C Huang Andrew S Levey Angel M Serio Mark Snyder Andrew J Vickers Ganesh V Raj Peter T Scardino Paul Russo | 2006 | Lancet Oncology2006，，9： | 4 |
| 5 | Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development显示文摘cytosine 的 Methylation 是与基因压抑联系的 DNA 修正。最近,新奇 cytosine 修正, 5-hydroxymethylcytosine (5-hmC ) 被发现了。这里,我们在哺乳动物的开发期间并且在细胞的系统检验 5-hmC 分发,并且证明 5-hmC 的发展动力学与 5-methylcytosine (5-mC ) 的那些不同;特别地 5-hmC 与成年纸巾相比在胚胎的上下文被充实。一个可检测的 5-hmC 信号在在父亲的染色体受到 5-mC 的染色体宽的 hydroxylation 的地方,在接合子阶段开始的培植前开发出现,它精确在父亲的前核与 5-mC 信号的损失与一致。5-hmC 的层次与在老鼠的表示 nestin 房间人口在在胚囊,和修正 colocalises 的内部房间团的房间高培植以后的胚胎。比作另外的成年哺乳动物的机关, 5-hmC 强烈在骨头髓和大脑被充实, 5-hmC 内容在那里高是 neuronal 祖先和 mitotic 以后神经原的一个特征。我们证明 5-hmC 的那高水平是在老鼠和人的胚胎的干细胞(转换字符) 的不仅现在并且,在区别期间输以前被报导了,而且在导致的 pluripotent 干细胞的产生期间重现;因此, 5-hmC 丰富与一个 pluripotent 房间状态相关。我们的调查结果建议除了 neuronal 系的房间, genomic 5-hmC 的高水平是胚胎的房间人口和细胞的 pluri 系和多系力量的一个 epigenetic 特征。到我们的知识, 5-hmC 那么代表其丰富是的发现的 DNA 的第一 epigenetic 修正房间类型特定。 | Alexey Ruzov Yanina Tsenkina Andrea Serio Tatiana Dudnakova Judy Fletcher Yu Bai Tatiana Chebotareva Steve Pells Zara Hannoun Gareth Sullivan Siddharthan Chandran David C Hay Mark Bradley Ian Wilmut Paul De Sousa | 2011 | Cell Research2011，21，9： | 4 |
| 6 | Viral hepatitis:Innovations and expectations显示文摘Viral hepatitis is a significant health problem worldwide,associated with morbidity and mortality.Hepatitis B,C,D,and occasionally E viruses(HBV,HCV,HDV,and HEV)can evolve in chronic infections,whereas hepatitis A virus(HAV)frequently produces acute self-limiting hepatitis.In the last years,different studies have been performed to introduce new antiviral therapies.The most important goal in the treatment of viral hepatitis is to avoid chronic liver disease and complications.This review analyzes currently available therapies,in particular for viruses associated with chronic liver disease.The focus is especially on HBV and HCV therapies,investigating new drugs already introduced in clinical practice and clinical trials.We also describe new entry inhibitors,developed for the treatment of chronic HDV and HBV and currently available treatments for HEV.The last drugs introduced have shown important efficacy in HCV,with achievable target HCV elimination by 2030.Concurrently,renewed interest in curative HBV therapies has been registered;current nucleotide/nucleoside analogs positively impact liver-related complications,ensuring high safety and tolerability.Novel approaches to HBV cure are based on new antivirals,targeting different steps of the HBV life cycle and immune modulators.The improved knowledge of the HDV life cycle has facilitated the development of some direct-acting agents,as bulevirtide,the first drug conditionally approved in Europe for HDV associated compensated liver disease.Further studies are required to identify a new therapeutic approach in hepatitis E,especially in immunosuppressed patients. | Simona Leoni Alberto Casabianca Benedetta Biagioni Ilaria Serio | 2022 | World Journal of Gastroenterology2022，28，5： | 3 |
| 7 | Adherence to AASLD guidelines for the treatment of hepatocellular carcinoma in clinical practice: Experience of the Bologna Liver Oncology Group显示文摘 | Simona Leoni Fabio Piscaglia Ilaria Serio Eleonora Terzi Irene Pettinari Luca Croci Sara Marinelli Francesca Benevento Rita Golfieri Luigi Bolondi | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 8 | Is there a place for central pancreatectomy in pancreatic surgery?显示文摘 | Calogero Iacono M.D. Luca Bortolasi M.D. Giovanni Serio M.D | 1998 | Journal of Gastrointestinal Surgery1998，，6： | 2 |
| 9 | 聚甘油脂肪酸酯与AEO_9复配性能研究显示文摘聚甘油脂肪酸酯与AEO9复配,对复配体系的性能进行测定,结果表明:m(AEO9)∶m(PGFE)为8∶1时复配体系的cmc和γcmc最低,泡沫体积最大,泡沫稳定性最好;m(AEO9)∶m(PGFE)为1∶2时对体系石蜡的乳化力最强,m(AEO9)∶m(PGFE)为2∶1对大豆油的乳化力最强;复配体系的润湿性能有所提高。 | 耿二欢 孙永强 张勇 孙晋源 Martino Di Serio | 2014 | 当代化工2014，43，12： | 2 |
| 10 | Globular adiponectin induces differentiation and fusion of skeletal muscle cells显示文摘对骨胳的肌肉新生的成长兴趣在损伤,以及几个肌肉发达的退化病理以后为肌肉损害与新治疗学的策略的开始被联系,包括营养障碍,肌肉发达的萎缩,和极度瘦弱。集中于细胞外的因素的能力支持 myogenesis 的研究因此是高度有希望的。我们现在报导那一个导出 adipocyte 的因素,球状的 adiponectin (荡者) ,能导致肌肉基因表示和房间区别。除它在肌肉调整几新陈代谢的功能的著名能力以外,包括葡萄糖举起和消费和丰满的酸分解代谢,荡者能堵住 myoblasts 的房间周期入口,到导致象肌浆球蛋白那样的特定的骨胳的肌肉标记的表示重链或 caveolin-3 ,象一样挑起房间熔化进 multinucleated syncytia 并且,最后肌肉纤维形成。荡者通过 p38, Akt 和 5 鈥 ? 的氧化还原作用依赖者激活施加它的 pro-differentiative 活动激活安培的蛋白质 kinase 小径。有趣地,区分 myoblasts 是为 adiponectin 的 autocrine,并且到氧化应力的支持 inflammatory 背景或暴露的 mimicking 强烈从区分房间增加荷尔蒙的生产。这些数据建议 adiponectin 的一个新奇函数,直接协调 myogenic 区别程序并且在骨胳的 myogenesis 期间服务一个 autocrine 函数。 | Tania Fiaschi Domenico Cirelli Giuseppina Comito Stefania Gelmini Giampietro Ramponi Mario Serio Paola Chiarugi | 2009 | Cell Research2009，19，5： | 2 |
| 11 | 蓖麻油酸甲酯乙氧基化物水溶液的动态表面张力显示文摘用最大气泡压力法分别测定了不同环氧乙烷(EO)加合数(10、12、14、16、20)的蓖麻油酸甲酯乙氧基化物(ECAME)水溶液的动态表面张力(DST)。考察了浓度、温度和无机电解质对DST的影响,探讨了不同浓度时DST参数(动态表面张力特性参数n,平衡时间t*,曲线最大斜率R1/2)的变化规律。结果表明,随着EO数由10增加到20,DST不断增大;随着浓度由0.5×10-5mol/L增加到10×10-5mol/L,n由3.02减小到1.05,t*值由14.45减小到2.29,R1/2由0.43增大到6.44,则动态表面活性增大,DST降低;随着温度由25℃升高至45℃,DST降低;吸附初期DST曲线随无机电解质浓度的增大而升高,吸附后期DST曲线随无机电解质浓度的增大而降低。和常规的脂肪酸甲酯乙氧基化物(FMEE)相比,ECAME的动态表面活性更加优异,这为开拓ECAME的应用指明了新的方向。 | 张谦 孙永强 智丽飞 张勇 孙晋源 武华萍 DI SERIO Martinob | 2015 | 应用化学2015，32，6： | 2 |
| 12 | Polyethoxylation and polypropoxylation reactions:Kinetics,mass transfer and industrial reactor design显示文摘Ethoxylation and propoxylation reactions are performed in the industry to produce mainly non-ionic surfactants and ethylene oxide(EO)–propylene oxide(PO) copolymers.Both the reactions occur in gas–liquid reactors by feeding gaseous EO,PO or both into the reactor containing a solution of an alkaline catalyst(KOH or Na OH).Non-ionic surfactants are produced by using liquid starters like fatty alcohols,fatty acids or alkyl-phenols,while when the scope is to prepare EO–PO copolymers the starter can be a mono-or multi-functional alcohol of low molecular weight.Both reactions are strongly exothermic,and EO and PO,in some conditions,can give place to runaway and also to explosive side reactions.Therefore,the choice of a suitable reactor is a key factor for operating in safe conditions.A correct reactor design requires:(i) the knowledge of the kinetic laws governing the rates of the occurring reactions;(ii) the role of mass and heat transfer in affecting the reaction rate;(iii) the solubility of EO and PO in the reacting mixture with the non-ideality of the reacting solutions considered;(iv) the density of the reacting mixture.All these aspects have been studied by our research group for different starters of industrial interest,and the data collected by using semibatch well stirred laboratory reactors have been employed for the simulation of industrial reactors,in particular Gas–Liquid Spray Tower Loop Reactors. | E.Santacesaria R.Tesser M.Di Serio | 2018 | Chinese Journal of Chemical Engineering2018，26，6： | 2 |
| 13 | A generalization of the Krmack-Mckendrick determinisitic epidemic model显示文摘 | CAPASSO V SERIO G | 1978 | Math Bio Sci1978，，42： | 1 |
| 14 | Interleukin-11and IL-17and the pathogenesis of periodontal disease显示文摘 | Johnson RB Wood N Serio FG | 2004 | J Periodontol2004，75，1： | 1 |
| 15 | Fertilization strategies for lowering nitrate contents in leafy vegetables ehieory rocket salad eases 显示文摘 | Stantamaria P Ella A Serio F | 1998 | Journal of Plant Nutrition1998，21，9： | 1 |
| 16 | Adiponectin, diabetes and ischemic heart failure: a challenging relationship显示文摘 | Baldasseroni S Antenore A Di Serio C | 2012 | Cardiovasc Diabetol2012，11，： | 1 |
| 17 | Ethoxylation of fatty alcohols promoted by an aluminum alkoxide sulphate catalyst显示文摘 | Serio M D Iengo P Gobetto R | 1996 | Journal of Molecular Catalysis1996，112，2： | 1 |
| 18 | Surgical strategy in primary retriperitoneal tumours 显示文摘 | Serio G Tenchini P | 1998 | Br J Surg1998，76，4： | 1 |
| 19 | A generalization of Kermack-Mckendrick deterministic epidemic model显示文摘 | Capasso V Serio G | 1978 | Mathema-tical Biosciences1978，42，12： | 1 |
| 20 | Glucagon like peptide 2 relaxes mouse stomach through vaosactive intestinal peptide realease 显示文摘 | Amato A Baldassno S Serio R | 2009 | Am J Physiol Gastrointest Liver Physio12009，296，3： | 1 |
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