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| 1 | Hypoxia-regulated microRNAs in human cancer显示文摘 | Guomin SHEN Xiaobo LI Yong-feng JIA Gary A PIAZZA Yaguang XI | 2013 | Acta Pharmacologica Sinica2013，34，3： | 18 |
| 2 | Unsupervised Electric Motor Fault Detection by Using Deep Autoencoders显示文摘Fault diagnosis of electric motors is a fundamental task for production line testing, and it is usually performed by experienced human operators. In the recent years, several methods have been proposed in the literature for detecting faults automatically. Deep neural networks have been successfully employed for this task, but, up to the authors' knowledge, they have never been used in an unsupervised scenario. This paper proposes an unsupervised method for diagnosing faults of electric motors by using a novelty detection approach based on deep autoencoders. In the proposed method, vibration signals are acquired by using accelerometers and processed to extract LogMel coefficients as features. Autoencoders are trained by using normal data only, i.e., data that do not contain faults. Three different autoencoders architectures have been evaluated: the multilayer perceptron(MLP) autoencoder, the convolutional neural network autoencoder, and the recurrent autoencoder composed of long short-term memory(LSTM) units. The experiments have been conducted by using a dataset created by the authors, and the proposed approaches have been compared to the one-class support vector machine(OC-SVM) algorithm. The performance has been evaluated in terms area under curve(AUC) of the receiver operating characteristic curve, and the results showed that all the autoencoder-based approaches outperform the OCSVM algorithm. Moreover, the MLP autoencoder is the most performing architecture, achieving an AUC equal to 99.11 %. | Emanuele Principi Damiano Rossetti Stefano Squartini Francesco Piazza | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，2： | 10 |
| 3 | The interaction between the Wnt/β-catenin signaling cascade and PKG activation in cancer显示文摘The activation of the Wnt/β-catenin signaling cascade has been well studied and documented in colorectal cancer(CRC).The long-term use of non-steroidal anti-inflammatory drugs(NSAIDs) has been shown to reduce the incidence and risk of death from CRC in numerous epidemiological studies.The NSA1 D sulindac has also been reported to cause regression of precancerous adenomas in individuals with familial adenomatous polyposis who are at high risk of developing CRC.The mechanism responsible for cancer chemopreventive activity of NSAIDs is not well understood but may be unrelated to their cyclooxygenase inhibitory activity.Emerging evidence suggests that sulindac inhibits the growth of colon tumor cells by suppressing the activity of certain phosphodiesterase isozymes to activate cGMβ-dependent protein kinase,PKG,through the elevation of the second messenger cyclic guanosine monophosphote,cGMP.PKG activation has been shown to inhibit the nuclear translocation of β-catenin,reduce β-catenin mRNA and protein levels,and suppress the transcriptional activity of β-catenin.This review describes the relationship between the Wnt/β-catenin signaling cascade and the activation of PKG through PDE inhibition and elevation of intracellular cGMP levels. | Kevin Lee Gary A Piazza | 2017 | The Journal of Biomedical Research2017，31，3： | 7 |
| 4 | Acousto-optical modulation of thin film lithium niobate waveguide devices显示文摘Due to its strong piezoelectric effect and photo-elastic property, lithium niobate is widely used for acousto-optical applications. However, conventional bulk lithium niobate waveguide devices exhibit a large footprint and limited light–sound interaction resulting from the weak guiding of light. Here, we report the first acousto-optical modulators with surface acoustic wave generation, phononic cavity, and low-loss photonic waveguide devices monolithically integrated on a 500 nm thick film of lithium niobate on an insulator. Modulation efficiency was optimized by properly arranging the propagation directions of surface acoustic waves and optical guided modes.The effective photo-elastic coefficient extracted by comparing the first and third harmonic modulation signals from an on-chip Mach–Zehnder interferometer indicates the excellent acousto-optical properties of lithium niobate are preserved in the thin film implementation. Such material property finding is of crucial importance in designing various types of acousto-optical devices. Much stronger amplitude modulation was achieved in a high Q(>300,000) optical resonator due to the higher optical sensitivity. Our results pave the path for developing novel acousto-optical devices using thin film lithium niobate. | LUTONG CAI ASHRAF MAHMOUD MSI KHAN MOHAMED MAHMOUD TAMAL MUKHERJEE JAMES BAIN GIANLUCA PIAZZA | 2019 | Photonics Research2019，7，9： | 5 |
| 5 | Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation显示文摘AIM:To evaluate the role of sequential therapy and Lactobacillus reuteri (L. reuteri ) supplementation, in the eradication treatment of Helicobacter pylori (H. pylori ). METHODS:H. pylori infection was diagnosed in 90 adult dyspeptic patients. Patients were excluded if previously treated for H. pylori infection or if they were taking a proton pump inhibitor (PPI), H2-receptor antagonist or antibiotics. Patients were assigned to receive one of the following therapies:(1) 7-d triple therapy (PPI plus clarithromycin and amoxicillin or metronidazole) plus L. reuteri supplementation dur- ing antibiotic treatment; (2) 7-d triple therapy plus L. reuteri supplementation after antibiotic treatment; (3) sequential regimen (5-d PPI plus amoxicillin therapy followed by a 5-d PPI, clarithromycin and tinidazole) plus L. reuteri supplementation during antibiotic treatment; and (4) sequential regimen plus L. reuteri supplementation after antibiotic treatment. Successful eradication therapy was defined as a negative urea breath test at least 4 wk following treatment. RESULTS:Ninety adult dyspeptic patients were en- rolled, and 83 (30 male, 53 female; mean age 57 ± 13 years) completed the study. Nineteen patients were administered a 7-d triple treatment:11 with L. reuteri supplementation during and 8 after therapy. Sixty-four patients were administered a sequential regimen:32 with L. reuteri supplementation during and 32 after therapy. The eradication rate was significantly higher in the sequential group compared with the 7-d triple regimen (88% vs 63%, P = 0.01). No difference was found between two types of PPI. No difference in erad- ication rates was observed between patients submitted to L. reuteri supplementation during or after antibiotic treatment. Compliance with therapy was excellent in all patients. No difference in adverse effects was observed between the different antibiotic treatments and between patients submitted to L. reuteri supplementation during and after antibiotic treatment. There was a low incidence of adverse effects in all groups of patients with sequential therapy, probably due to the presence of the L. reuteri supplementation. CONCLUSION:The sequential treatment regimen achieved a significantly higher eradication rate of H. pylori compared with standard 7-d regimen. L. reuteri supplementation could reduce the frequency and the intensity of antibiotic-associated side-effects. | Cesare Efrati Giorgia Nicolini Claudio Cannaviello Nicole Piazza O'Sed Stefano Valabrega | 2012 | World Journal of Gastroenterology2012，18，43： | 4 |
| 6 | Mars Ion and Neutral Particle Analyzer (MINPA) for Chinese Mars Exploration Mission (Tianwen-1): Design and ground calibration显示文摘The main objective of the Mars Ion and Neutral Particle Analyzer(MINPA)aboard the Chinese Mars Exploration Mission(Tianwen-1)is to study the solar wind-Mars interaction by measuring the ions and energetic neutral atoms(ENAs)near Mars.The MINPA integrates ion and ENA measurements into one sensor head,sharing the same electronics box.The MINPA utilizes a standard toroidal top-hat electrostatic analyzer(ESA)followed by a time of flight(TOF)unit to provide measurement of ions with energies from 2.8 eV to 25.9 keV and ENAs from 50 eV to 3 keV with a base time resolution of 4 seconds.Highly polished silicon single crystal substrates with an Al2O3 film coating are used to ionize the ENAs into positive ions.These ions can then be analyzed by the ESA and TOF,to determine the energy and masses of the ENAs.The MINPA provides a 360°×90°field of view(FOV)with 22.5°×5.4°angular resolution for ion measurement,and a 360°×9.7°FOV with 22.5°×9.7°angular resolution for ENA measurement.The TOF unit combines a-15 kV acceleration high voltage with ultra-thin carbon foils to resolve H+,He2+,He+,O+,O2+and CO2+for ion measurement and to resolve H and O(≥16 amu group)for ENA measurement.Here we present the design principle and describe our ground calibration of the MINPA. | LingGao Kong AiBing Zhang Zhen Tian XiangZhi Zheng WenJing Wang Bin Liu Peter Wurz Daniele Piazza Adrian Etter Bin Su YaYa An JianJing Ding WenYa Li Yong Liu Lei Li YiRen Li Xu Tan YueQiang Sun | 2020 | Earth and Planetary Physics2020，4，4： | 4 |
| 7 | Paternal physical exercise modulates global DNA methylation status in the hippocampus of male rat offspring显示文摘It is widely known that maternal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of paternal exercise have not been explored in detail. The present study was designed to evaluate the impact of paternal physical exercise on memory and learning, neuroplasticity and DNA methylation levels in the hippocampus of male offspring. Adult male Wistar rats were divided into two groups: sedentary or exercised fathers. The paternal preconception exercise protocol consisted of treadmill running, 20 minutes daily, 5 consecutive days per week for 22 days, while the mothers were not trained. After mating, paternal sperm was collected for global DNA methylation analysis. At postnatal day 53, the offspring were euthanized, and the hippocampus was dissected to measure cell survival by 5-bromo-2′-deoxiuridine and to determine the expression of synaptophysin, reelin, brain-derived neurotrophic factor and global DNA methylation levels. To measure spatial memory and learning changes in offspring, the Morris water maze paradigm was used. There was an improvement in spatial learning, as well as a significant decrease in hippocampal global DNA methylation levels in the offspring from exercised fathers compared with those from sedentary ones; however, no changes were observed in neuroplasticity biomarkers brain-derived neurotrophic factor, reelin and 5-bromo-2′-deoxiuridine. Finally, the global DNA methylation of paternal sperm was not significantly changed by physical exercise. These results suggest a link between paternal preconception physical activity and cognitive benefit, which may be associated with hippocampal epigenetic programming in male offspring. However, the biological mechanisms of this modulation remain unclear. | Christiano Spindler Ethiane Segabinazi Andre Luis Ferreira de Meireles Francele Valente Piazza Filipe Mega Gabriela dos Santos Salvalaggio Matilde Achaval Viviane Rostirola Elsner Simone Marcuzzo | 2019 | Neural Regeneration Research2019，14，3： | 3 |
| 8 | MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells显示文摘MicroRNAs (miRNAs ) 是小非编码的 RNA 分子,其主要功能是在 post-transcriptional/translational 调整基因表示,铺平。MiRNAs 玩在正常生物过程的关键角色并且在人的疾病是通常调整 dys 的。干细胞被认为是 “ mother”包括身体的纸巾和机关的区分的房间的所有类型的房间。一个新奇假设建议肿瘤由从癌症干细胞导出的异构的房间组成,它有正常干细胞的类似于那些的自强和区别能力。癌症干细胞从各种各样的肿瘤被孤立并且描绘。在癌症干细胞的自强和区别支持 miRNAs 的关键规章的角色的给定的最近的研究,更好理解 miRNAs 的功能将提供无价的卓见进 tumorigenesis 和肿瘤前进的预防。在这评论,我们将在涉及癌症干细胞的自强和区别的 miRNAs 的学习总结研究进步。 | Zheng-ming WANG Wen-jun DU Gary A PIAZZA Yaguang XI | 2013 | Acta Pharmacologica Sinica2013，34，11： | 3 |
| 9 | Chemotherapy-induced neutropenia and treatment efficacy in advanced non-small-cell lung cancer: a pooled analysis of three randomised trials显示文摘 | Massimo Di Maio Cesare Gridelli Ciro Gallo Frances Shepherd Franco Vito Piantedosi Silvio Cigolari Luigi Manzione Alfonso Illiano Santi Barbera Sergio Federico Robbiati Luciano Frontini Elena Piazza Giovanni Pietro Ianniello Enzo Veltri Federico Castiglio | 2005 | Lancet Oncology2005，，9： | 2 |
| 10 | A case of biliary stones and anastomotic biliary stricture after liver transplant treated with the rendez-vous technique and electrokinetic lithotritor显示文摘The paper studies the combined radiologic and endoscopic approach (rendez vous technique) to the treatment of the biliary complications following liver transplant. The 'rendez-vous' technique was used with an electrokinetic lithotripter, in the treatment of a biliary anastomotic stricture with multiple biliary stones in a patient who underwent orthotopic liver transplant. In this patient, endoscopic or percutaneous transhepatic management of the biliary complication failed. The combined approach, percutaneous transhepatic and endoscopic treatment (rendez-vous technique) with the use of an electrokinetic lithotritor, was used to solve the biliary stenosis and to remove the stones. Technical success, defined as disappearance of the biliary stenosis and stone removal, was obtained in just one session, which definitively solved the complications. The combined approach of percutaneous transhepatic and endoscopic (rendez-vous technique) treatment, in association with an electrokinetic lithotritor, is a safe and feasible alternative treatment, especially after the failure of endoscopic and/or percutaneous trans-hepatic isolated procedures. | Marta Di Pisa Mario Traina Roberto Miraglia Luigi Maruzzelli Riccardo Volpes Salvatore Piazza Angelo Luca Bruno Gridelli | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 11 | Comparative analysis of different techniques for spatial interpolation of rainfall data to create a serially complete monthly time series of precipitation for Sicily, Italy显示文摘 | A. Di Piazza F. Lo Conti L.V. Noto F. Viola G. La Loggia | 2011 | International Journal of Applied Earth Observations and Geoinformation2011，，3： | 2 |
| 12 | Facial nerve paralysis in temporal bone fractures: outcomes after late decompression surgery 显示文摘 | Quaranta A Campobasso G Piazza F | 2001 | Acta Otolaryngol2001，121，5： | 1 |
| 13 | Transcatheter aortic valve implantation for failing surgical aortic bioprosthetic valve 显示文摘 | Piazza N | 2011 | JACC : Cardiovascular Interventions2011，4，7： | 1 |
| 14 | Narrow band imaging and high definition television in the assessment of laryngeal cancer:a propective study on 279 patients显示文摘 | Piazza C Cocco D Benedetto L | 2010 | Eur Arch Otorhinolaryngol2010，267，3： | 1 |
| 15 | A 3-center comparison of l-year mortality outcomes between transcatheter aortic valve implantation and surgical aortic valve replacement on the basis of propensity score matching among inter- mediate-risk surgical patients 显示文摘 | Piazza N Kalesan B van Mieghem N | 2013 | JACC Cardiovasc Interv2013，6，5： | 1 |
| 16 | Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis显示文摘 | PIAZZA G A RAHM A L KRUTZSCH M | 1995 | Cancer Res1995，55，14： | 1 |
| 17 | ELM based time variant neural networks with incremental number of output basis functions 显示文摘 | YE Yibin SQUARTIN S PIAZZA F | 2011 | Lecture Notes in Computer Science2011，6675，： | 1 |
| 18 | Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways显示文摘 | Alimam N Z Piazza F M Selby D M | 2000 | Am J Respir Cell Mol Biol2000，22，： | 1 |
| 19 | Picketing emulsions:interfacial tension, colloidal layer morphology, and trapped-particle motion 显示文摘 | Emanuele Vignati Roberto Piazza | 2003 | Langmuir2003，19，19： | 1 |
| 20 | Haloperidol-loaded in- tranasally administered lectin functionalized poly (ethylene glycol )-block-poly ( d, 1 )-lactic-co-glycolic acid ( PEG-PL- GA) nanoparticles for the treatment of schizophrenia显示文摘 | Piazza J Hoare T Molinaro L | 2014 | Eur J Pharm Biopharm2014，87，1： | 1 |
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