|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 2 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 3 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 4 | An experimental study of elastic properties of dragonfly-like flapping wings for use in biomimetic micro air vehicles(BMAVs)显示文摘This article studies the elastic properties of several biomimetic micro air vehicle(BMAV)wings that are based on a dragonfly wing.BMAVs are a new class of unmanned micro-sized air vehicles that mimic the flapping wing motion of flying biological organisms(e.g.,insects,birds,and bats).Three structurally identical wings were fabricated using different materials:acrylonitrile butadiene styrene(ABS),polylactic acid(PLA),and acrylic.Simplified wing frame structures were fabricated from these materials and then a nanocomposite film was adhered to them which mimics the membrane of an actual dragonfly.These wings were then attached to an electromagnetic actuator and passively flapped at frequencies of 10-250 Hz.A three-dimensional high frame rate imaging system was used to capture the flapping motions of these wings at a resolution of 320 pixels x 240 pixels and 35000 frames per second.The maximum bending angle,maximum wing tip deflection,maximum wing tip twist angle,and wing tip twist speed of each wing were measured and compared to each other and the actual dragonfly wing.The results show that the ABS wing has considerable flexibility in the chordwise direction,whereas the PLA and acrylic wings show better conformity to an actual dragonfly wing in the spanwise direction.Past studies have shown that the aerodynamic performance of a BMAV flapping wing is enhanced if its chordwise flexibility is increased and its spanwise flexibility is reduced.Therefore,the ABS wing(fabricated using a 3D printer) shows the most promising results for future applications. | Praveena Nair Sivasankaran Thomas Arthur Ward Erfan Salami Rubentheren Viyapuri Christopher J.Fearday Mohd Rafie Johan | 2017 | Chinese Journal of Aeronautics2017，30，2： | 5 |
| 5 | Treating Clostridium difficile Infection With Fecal Microbiota Transplantation显示文摘 | Johan S. Bakken Thomas Borody Lawrence J. Brandt Joel V. Brill Daniel C. Demarco Marc Alaric Franzos Colleen Kelly Alexander Khoruts Thomas Louie Lawrence P. Martinelli Thomas A. Moore George Russell Christina Surawicz | 2011 | Clinical Gastroenterology and Hepatology2011，，12： | 5 |
| 6 | Interspecific comparison of the flight performance between sparrowhawks and common buzzards migrating at the Falsterbo peninsula: A radar study显示文摘 | Gintaras MALMIGA Cecilia NILSSON Johan BACKMAN Thomas ALERSTAM | 2014 | Current Zoology2014，60，5： | 4 |
| 7 | TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis显示文摘 | Charles Thomas Antimo Gioiello Lilia Noriega Axelle Strehle Julien Oury Giovanni Rizzo Antonio Macchiarulo Hiroyasu Yamamoto Chikage Mataki Mark Pruzanski Roberto Pellicciari Johan Auwerx Kristina Schoonjans | 2009 | Cell Metabolism2009，，3： | 4 |
| 8 | Endoscopic and Percutaneous Preoperative Biliary Drainage in Patients with Suspected Hilar Cholangiocarcinoma显示文摘 | Jaap J. Kloek Niels A. Gaag Yalda Aziz Erik A. J. Rauws Otto M. Delden Johan S. Lameris Olivier R. C. Busch Dirk J. Gouma Thomas M. Gulik | 2010 | Journal of Gastrointestinal Surgery2010，，1： | 3 |
| 9 | Static strength analysis of dragonfly inspired wings for biomimetic micro aerial vehicles显示文摘This article examines the suitability of fabricating artificial, dragonfly-like, wing frames from materials that are commonly used in unmanned aircraft(balsa wood, black graphite carbon fiber and red prepreg fiberglass). Wing frames made with Type 321 stainless steel are also examined for comparison. The purpose of these wings is for future use in biomimetic micro aerial vehicles(BMAV). BMAV are a new class of unmanned micro-sized aerial vehicles that mimic flying biological organisms(like flying insects). Insects, such as dragonflies, possess corrugated and complex vein structures that are difficult to mimic. Simplified dragonfly-like wing frames were fabricated from these materials and then a nano-composite film was adhered to them, which mimics the membrane of an actual dragonfly. Finite element analysis simulations were also performed and compared to experimental results. The results showed good agreement(less than 10% difference for all cases).Analysis of these results shows that stainless steel is a poor choice for this wing configuration, primarily because of the aggressive oxidation observed. Steel, as well as balsa wood, also lacks flexibility. In comparison, black graphite carbon fiber and red prepreg fiberglass offer some structural advantages, making them more suitable for consideration in future BMAV applications. | Praveena Nair Sivasankaran Thomas Arthur Ward Rubentheren Viyapuri Mohd Rafie Johan | 2016 | Chinese Journal of Aeronautics2016，29，2： | 3 |
| 10 | TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading显示文摘 | Thijs W.H. Pols Mitsunori Nomura Taoufiq Harach Giuseppe Lo Sasso Maaike H. Oosterveer Charles Thomas Giovanni Rizzo Antimo Gioiello Luciano Adorini Roberto Pellicciari Johan Auwerx Kristina Schoonjans | 2011 | Cell Metabolism2011，，6： | 3 |
| 11 | Towards a unified paradigm for sequence‐based identification of fungi显示文摘 | Urmas K?ljalg R. Henrik Nilsson Kessy Abarenkov Leho Tedersoo Andy F. S. Taylor Mohammad Bahram Scott T. Bates Thomas D. Bruns Johan Bengtsson‐Palme Tony M. Callaghan Brian Douglas Tiia Drenkhan Ursula Eberhardt Margarita Due?as Tine Grebenc Gareth W. Gri | 2013 | Mol Ecol2013，，21： | 2 |
| 12 | Treatment-by-Histology Interaction Analyses in Three Phase III Trials Show Superiority of Pemetrexed in Nonsquamous Non-small Cell Lung Cancer显示文摘 | Giorgio Scagliotti Thomas Brodowicz Frances A. Shepherd Christoph Zielinski Johan Vansteenkiste Christian Manegold Lorinda Simms Frank Fossella Katherine Sugarman Chandra P. Belani | 2011 | Journal of Thoracic Oncology2011，，1： | 2 |
| 13 | Thrombolytic Therapy for Acute Superior Mesenteric Artery Occlusion显示文摘 | Ivo G. Schoots Marcel M. Levi Jim A. Reekers Johan S. Lameris Thomas M. van Gulik | 2005 | Journal of Vascular and Interventional Radiology2005，，： | 2 |
| 14 | Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome显示文摘 | Christian Widera Shashi K. Gupta Johan M. Lorenzen Claudia Bang Johann Bauersachs Kerstin Bethmann Tibor Kempf Kai C. Wollert Thomas Thum | 2011 | Journal of Molecular and Cellular Cardiology2011，，： | 2 |
| 15 | High Prognostic Impact of Flow Cytometric Minimal Residual Disease Detection in Acute Myeloid Leukemia: Data From the HOVON/SAKK AML 42A Study显示文摘 | Monique Terwijn Wim L.J. van Putten Angèle Kelder Vincent H.J. van der Velden Rik A. Brooimans Thomas Pabst Johan Maertens Nancy Boeckx Georgine E. de Greef Peter J.M. Valk Frank W.M.B. Preijers Peter C. Huijgens Angelika M. Dr?ger Urs Schanz Mojca Jongen | 2013 | Journal of Clinical Oncology2013，，31： | 1 |
| 16 | Form pressures generated by self-consolidating concrete显示文摘 | Billberg Peter Silfwerbrand Johan Osterberg Thomas | 2005 | Concrete International2005，27，10： | 1 |
| 17 | Treating Clostridium difficile Infection With Fecal Microbiota Transplantation显示文摘 | Johan S. Bakken Thomas Borody Lawrence J. Brandt Joel V. Brill Daniel C. Demarco Marc Alaric Franzos Colleen Kelly Alexander Khoruts Thomas Louie Lawrence P. Martinelli Thomas A. Moore George Russell Christina Surawicz | 2011 | Clinical Gastroenterology and Hepatology2011，，12： | 1 |
| 18 | Single-center analysis of biopsy-confirmed posttransplant lymphoproliferative disorder: incidence, clinicopathological characteristics and prognostic factors显示文摘 | Daan Dierickx Thomas Tousseyn Xavier Sagaert Steffen Fieuws Iwona Wlodarska Julie Morscio Lieselot Brepoels Dirk Kuypers Johan Vanhaecke Frederik Nevens Geert Verleden Rita Van Damme-Lombaerts Marleen Renard Jacques Pirenne Christiane De Wolf-Peeters Greg | 2013 | Leukemia & Lymphoma2013，，11： | 1 |
| 19 | The effects of ester chain length and temperature on the catalytic chain transfer polymerization of methacrylates显示文摘 | Johan P A Heuts Darren J Forster Thomas P Davis | 1999 | Macromolecules1999，32，： | 1 |
| 20 | Form Pressures Generated by Self-Consolidating Concrete 显示文摘 | Peter Billberg Johan Silfwerbrand Thomas Osterberg | 2005 | Concrete International2005，，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员