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| 1 | Recent insights in the pathogenesis of post-transplantation lymphoproliferative disorders显示文摘Post-transplant lymphoproliferative disorder(PTLD) is an aggressive complication of solid organ and hematopoietic stem cell transplantation that arises in up to 20% of transplant recipients. Infection or reactivation of the Epstein-Barr virus(EBV), a ubiquitous human herpesvirus, in combination with chronic immunosuppression are considered as the main predisposing factors, however insight in PTLD biology is fragmentary. The study of PTLD is complicated by its morphological heterogeneity and the lack of prospective trials, which also impede treatment optimization. Furthermore, the broad spectrum of underlying disorders and the graft type represent important confounding factors. PTLD encompasses different malignant subtypes that resemble histologically similar lymphomas in the general population. Post-transplant diffuse large B-cell lymphoma(PT-DLBCL), Burkitt lymphoma(PTBL) and plasmablastic lymphoma(PT-PBL) occur most frequently. However, in many studies various EBV+ and EBV- PTLD subtypes are pooled, complicating the interpretation of the results. In this review, studies of the gene expression pattern, the microenvironment and the genetic profile of PT-DLBCL, PT-BL and PT-PBL are summarized to better understand the mechanisms underlying post-transplantation lymphomagenesis. Based on the available findings we propose stratification of PTLD according to the histological subtype and the EBV status to facilitate the interpretation of future studies and the establishment of clinical trials. | Julie Morscio Thomas Tousseyn | 2016 | World Journal of Transplantation2016，6，3： | 11 |
| 2 | Gastrointestinal B-cell lymphomas:From understanding B-cell physiology to classification and molecular pathology显示文摘The gut is the most common extranodal site where lymphomas arise. Although all histological lymphoma types may develop in the gut, small and large B-cell lymphomas predominate. The sometimes unexpected finding of a lymphoid lesion in an endoscopic biopsy of the gut may challenge both the clinician (who is not always familiar with lymphoma pathogenesis) and the pathologist (who will often be hampered in his/her diagnostic skill by the limited amount of available tissue). Moreover, the past 2 decades have spawned an avalanche of new data that encompasses both the function of the reactive B-cell as well as the pathogenic pathways that lead to its neoplastic counterpart, the B-cell lymphoma. Therefore, this review aims to offer clinicians an overview of B-cell lymphomas in the gut, and their pertinent molecular features that have led to new insights regarding lymphomagenesis. It addresses the question as how to incorporate all presently available information on normal and neoplastic B-cell differentiation, and how this knowledge can be applied in daily clinical practice (e.g., diagnostic tools, prognostic biomarkers or therapeutic targets) to optimalise the managment of this heterogeneous group of neoplasms. | Xavier Sagaert Thomas Tousseyn Rhonda K Yantiss | 2012 | World Journal of Gastrointestinal Oncology2012，4，12： | 2 |
| 3 | Validation of Prognostic Scores in Post-Transplantation Lymphoproliferative Disorders显示文摘 | Daan Dierickx Thomas Tousseyn Julie Morscio Steffen Fieuws Gregor Verhoef | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
| 4 | Single-center analysis of biopsy-confirmed posttransplant lymphoproliferative disorder: incidence, clinicopathological characteristics and prognostic factors显示文摘 | Daan Dierickx Thomas Tousseyn Xavier Sagaert Steffen Fieuws Iwona Wlodarska Julie Morscio Lieselot Brepoels Dirk Kuypers Johan Vanhaecke Frederik Nevens Geert Verleden Rita Van Damme-Lombaerts Marleen Renard Jacques Pirenne Christiane De Wolf-Peeters Greg | 2013 | Leukemia & Lymphoma2013，，11： | 1 |
| 5 | Pitfall in the diagnosis of en- dometrial cancer:case report of an endometrioid adenocarcinoma arising from uterine adenomyosis显示文摘 | Boes AS Tousseyn T Vandenput I | 2011 | Eur J Gynaecol Oncol2011，32，4： | 1 |
| 6 | Sensitivity and specificity of interictal EEG-fMRI for detecting the ictal onset zone at different statistical thresholds显示文摘 | Tousseyn S Dupont P Goffin K | 2014 | Front Neurol2014，5，： | 1 |
| 7 | BMI1 , The polycomb‐group gene, is recurrently targeted by genomic rearrangements in progressive B‐cell leukemia/lymphoma显示文摘 | Leila Rouhigharabaei Julio Finalet Ferreiro Natalie Put Lucienne Michaux Thomas Tousseyn Christine Lefebvre Anne Gardiner Wim Kelver Hilde Demuynck Johan Verschuere Ivan Théate Carmen Vicente Peter Vandenberghe Jan Cools Iwona Wlodarska | 2013 | Genes Chromosomes Cancer2013，，10： | 1 |
| 8 | How Itreat posttrans-plant lymphoproliferative disorders显示文摘 | Dierickx D Tousseyn T Gheysens O | 2015 | Blood2015，126，20： | 1 |
| 9 | Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell nonHodgkin's lymphoma显示文摘 | Kleppe M Tousseyn T Geissinger E | 2011 | Haematologica2011，96，： | 1 |
| 10 | Single-center analy-sis of biopsy-confirmed posttransplant lymphoproliferative disor-der; Incidence, clinico-pathological characteristics and prognosticfactors显示文摘 | Dierickx D Tousseyn T Sagaert X | 2013 | Leuk Lymphoma2013，54，11： | 1 |
| 11 | Pitfall in the diagnosis of endometrial cancer:case report of an endom- etrioid adenocarcinoma arising from uterine adenomyosis 显示文摘 | BOES A S TOUSSEYN T VANDENPUT I | 2011 | Eur J Gynaecol Oncol2011，32，4： | 1 |
| 12 | Pitfall in thediagnosis of endometrial cancer:case report of an endometrioidadenocarcinoma arising from uterine adenomyosis显示文摘 | BOES AS TOUSSEYN T VANDENPUT I | 2011 | Eur J Gy-naecol Oncol2011，32，4： | 1 |
| 13 | The accuracy of positron e- mission tomography in the detection of post-transpLant Lymphoprolif- erative disorder显示文摘 | Dierickx D Tousseyn T Requile A | 2013 | HaematoLogica2013，98，： | 1 |
| 14 | Pitfall in thediagnosis of endometrial cancer: case report of an endometrioidadenocarcinoma arising from uterine adenomyosis显示文摘 | Boes AS Tousseyn T Vandenput I | 2011 | Eur JGynaecol Oncol2011，32，4： | 1 |
| 15 | ADAMlO,the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins,is processed by ADAMS-9,ADAMS-15,and the gamma- secrctase显示文摘 | Tousseyn T Thathiah A Jorissen E | 2009 | J Biol Chem2009，284，11： | 1 |
| 16 | T(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas are heterogeneous with respect to the V_H gene mutation status显示文摘AIM: To investigate how t(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas relate to other marginal zone lymphomas with respect to the somatic mutation pattern of the VH genes and the expression of the marker CD27. METHODS: The VH gene of 7 t(11;18)(q21;q21)- positive gastrointestinal MALT lymphomas was amplif iedby PCR using family specif ic VH primers and a consensus JH primer. PCR products were sequenced and mutation analysis of the CDR and the FR regions was performed. All cases were immunostained for CD27. RESULTS: One case showed unmutated VH genes while the others showed mutated VH genes with mutation frequencies ranging from 1.3 to 14.7% and with evidence of antigen selection in 2 cases. These data suggest that the translocation t(11;18)(q21;q21) can target either B-cells at different stages of differentiation or naive B-cells that retain the capacity to differentiate upon antigen stimulation. All cases but one displayed weak to strong CD27 expression which did not correlate with the VH gene mutation status. CONCLUSION: t(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas are heterogeneous with respect to the VH mutation status and CD27 is not a marker of somatically mutated B-cells. | Xavier Sagaert Vera Vanhentenrijk Gert De Hertogh Karel Geboes Thomas Tousseyn Brigitte Maes Mathijs Baens Eric Van Cutsem | 2011 | World Journal of Gastrointestinal Oncology2011，3，2： | 0 |
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