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| 1 | Coronary spasm: It's common, but it's still unsolved显示文摘Coronary spasm is caused by a transient coronary nar -rowing due to the constriction of epicardial coronary artery, which leads to myocardial ischemia. More than 50 years have passed since the first recognition of coronary spasm, and many findings on coronary spasm have been reported. Coronary spasm has been considered as having pivotal roles in the cause of not only rest angina but also exertional angina, acute coronary syndrome, and heart failure. In addition, several new findings of the mechanism of coronary spasm have emerged recently. The diagnosis based mainly on coronary angiography and spasm provo-cation test and the mainstream treatment with a focus on a calcium-channel blocker have been established. At a glance, coronary spasm or vasospastic angina(VSA) has become a common disease. On the contrary, there are several uncertain or unsolved problems regarding coronary spasm, including the presence of medically refractory coronary spasm(intractable VSA), or an appropriate use of implantable cardioverter defibrillator in patients with cardiac arrest who have been confirmed as having coronary spasm. This editorial focused on coronary spasm, including recent topics and unsolved problems. | Hiroki Teragawa Chikage Oshita Tomohiro Ueda | 2018 | World Journal of Cardiology2018，10，11： | 7 |
| 2 | TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis显示文摘 | Charles Thomas Antimo Gioiello Lilia Noriega Axelle Strehle Julien Oury Giovanni Rizzo Antonio Macchiarulo Hiroyasu Yamamoto Chikage Mataki Mark Pruzanski Roberto Pellicciari Johan Auwerx Kristina Schoonjans | 2009 | Cell Metabolism2009，，3： | 4 |
| 3 | Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle显示文摘 | Carles Cantó Lake Q. Jiang Atul S. Deshmukh Chikage Mataki Agnes Coste Marie Lagouge Juleen R. Zierath Johan Auwerx | 2010 | Cell Metabolism2010，，3： | 2 |
| 4 | Isolation and characterization of two cDNA clones for mRNAs that are abundantly expressed in immature anthers of rice (Oryza sativa L.)显示文摘 | Yukako Hihara Chikage Hara Hirofumi Uchimiya | 1996 | Plant Molecular Biology1996，，6： | 1 |
| 5 | Does the intracoronary pressure differ according to two types(diffuse or focal)of coronary spasm?显示文摘BACKGROUND Several reports show that two types of coronary vasospasm(diffuse and focal spasm)are associated with the severity or prognosis of coronary spasm in patients with vasospastic angina(VSA).It is unclear whether intracoronary pressure differs between the two spasm types.AIM To investigate such relationships using a pressure wire during the spasm provocation test(SPT)in patients with VSA.METHODS Eighty-seven patients with VSA(average age:67 years;50 men,37 women)underwent SPT.During the SPT,a pressure wire was advanced into the distal portion of the right coronary artery and left anterior descending coronary artery,and the ratio of the intracoronary pressure to the aortic pressure(Pd/Pa)was continuously monitored.An SPT was performed using acetylcholine(ACh),and the presence of coronary spasm was defined as the presence of>90%arterial narrowing in response to an ACh infusion,with the usual chest symptoms and/or ischemic ECG changes.Focal spasm was defined as total or subtotal spasm within one segment of the AHA classification,while diffuse spasm was defined as>90%spasm with two or more segments.RESULTS Among 87 patients,the frequencies of metabolic syndrome and having coronary atherosclerosis were higher in the focal group(n=33)than in the diffuse spasm group(n=54,P<0.05).In the vessel analyses,in these 134 spastic segments,diffuse and focal spasms were detected in 100 and 34 vessels,respectively.The Pd/Pa at baseline was similar in both groups(diffuse:0.96±0.05,focal:0.95±0.05,P=0.35);however,the Pd/Pa during coronary spasm was lower in focal spastic vessels(0.66±0.20)than in diffuse spastic vessels(0.76±0.11,P<0.01),and the reduction in Pd/Pa during an SPT was also lower in focal spastic vessels(-0.29±0.20)than in diffuse spastic vessels(-0.18±0.11,P<0.01).The presence of focal spasm was a significant factor responsible for reduction in Pd/Pa during SPT.CONCLUSION These findings suggest that focal spasm may be more severe than diffuse spasm,judging from the intracoronary pressure during coronary spasm. | Hiroki Teragawa Chikage Oshita Yuko Uchimura | 2023 | World Journal of Cardiology2023，15，1： | 1 |
| 6 | An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway显示文摘 | Gaku Tsuji Masakazu Takahara Hiroshi Uchi Satoshi Takeuchi Chikage Mitoma Yoichi Moroi Masutaka Furue | 2011 | Journal of Dermatological Science2011，，1： | 1 |
| 7 | Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation显示文摘 | Watanabe Mitsuhiro Houten Sander M Mataki Chikage | 2006 | Nature2006，439，7075： | 1 |
| 8 | Partial characterization of rat marrow stromal cells显示文摘 | David J. Simmons Patricia Seitz Louis Kidder Gordon L. Klein Mark Waeltz Caren M. Gundberg Chikage Tabuchi Chyunyu Yang Ren Wen Zhang | 1991 | Calcified Tissue International1991，，5： | 1 |
| 9 | Isolation and characterization of two cDNA clones for mRNAs that are abundantly expressed in immature anthers of rice (Oryza sativa L.)显示文摘 | Yukako Hihara Chikage Hara Hirofumi Uchimiya | 1996 | Plant Molecular Biology1996，，6： | 1 |
| 10 | Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation显示文摘 | Jér?me N. Feige Marie Lagouge Carles Canto Axelle Strehle Sander M. Houten Jill C. Milne Philip D. Lambert Chikage Mataki Peter J. Elliott Johan Auwerx | 2008 | Cell Metabolism2008，，5： | 1 |
| 11 | Concept and symptomatology in diabetic nephropathy显示文摘 | Chikage Sato Hirofumi Makino | | 0，，09： | 1 |
| 12 | Triterpenoid saponins from llex integra显示文摘 | Chikage N Kazuko Y | 1993 | Phytochemistry1993，32，2： | 1 |
| 13 | Relationship between retinal vein occlusion and carotid artery lesions显示文摘 | Matsushima Chikage | 2007 | Retina2007，27，8： | 1 |
| 14 | Isolation and characterization of two cDNA clones for mRNAs that are abundantly expressed in immature anthers of rice (Oryza sativa L.)显示文摘 | Yukako Hihara Chikage Hara Hirofumi Uchimiya | 1996 | Plant Molecular Biology1996，，6： | 1 |
| 15 | Development of interstitial pneumonia in a rheumatoid arthritis patient treated with infliximab, an anti-tumor necrosis factor α-neutralizing antibody显示文摘 | Shunsuke Mori Fumiya Imamura Chikage Kiyofuji Mineharu Sugimoto | 2006 | Modern Rheumatology2006，，4： | 1 |
| 16 | Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation显示文摘 | Jér?me N. Feige Marie Lagouge Carles Canto Axelle Strehle Sander M. Houten Jill C. Milne Philip D. Lambert Chikage Mataki Peter J. Elliott Johan Auwerx | 2008 | Cell Metabolism2008，，5： | 1 |
| 17 | Isolation and characterization of two cDNA clones for mRNAs that are abundantly expressed in immature anthers of rice (Oryza sativa L.)显示文摘 | Yukako Hihara Chikage Hara Hirofumi Uchimiya | 1996 | Plant Molecular Biology1996，，6： | 1 |
| 18 | Assessing the equity impact of the Euro- pean Union Emission Trading Scheme on an African airline显示文摘 | Chikage Miyoshi | 2014 | Transport Policy2014，，33： | 1 |
| 19 | Primary aldosteronism due to bilateral micronodular hyperplasia and concomitant subclinical Cushing’s syndrome:A case report显示文摘BACKGROUND Adrenal incidentaloma(AI)has been frequently encountered in the clinical setting.It has been shown that primary aldosteronism(PA)or subclinical Cushing’s syndrome(SCS)are the representative causative diseases of AI.However,the coexistence of PA and SCS has been reportedly observed.Recently,we encountered a case of AI,in which PA and SCS coexisted,confirmed by histopathological examinations after a laparoscopic adrenalectomy.We believe that there were some clinical implications in the diagnosis of the present case.CASE SUMMARY A 58-year-old man presented with lower right abdominal pain with a blood pressure of 170/100 mmHg.A subsequent computed tomography scan revealed right ureterolithiasis,which was the cause of right abdominal pain,and right AI measuring 22 mm×25 mm.After the disappearance of right abdominal pain,subsequent endocrinological examinations were performed.Aldosterone-related evaluations,including adrenal venous sampling,revealed the presence of bilateral PA.In addition,several cortisol-related evaluations showed the presence of SCS on the right adrenal adenoma.A laparoscopic right adrenalectomy was then performed.The histopathological examination of the resected right adrenal revealed the presence of a cortisol-producing adenoma,while CYP11B2 immunoreactivity was absent in this adenoma.However,in the adjacent nonneoplastic adrenal,multiple CYP11B2-positive adrenocortical micronodules were detected,showing the presence of aldosterone-producing adrenocortical micronodules.CONCLUSION Careful clinical and pathological examination should be performed when a patient harboring AI presents with concomitant SCS and PA. | Hiroki Teragawa Chikage Oshita Yuichi Orita Kunihiro Hashimoto Hirofumi Nakayama Yuto Yamazaki Hironobu Sasano | 2021 | World Journal of Clinical Cases2021，9，5： | 1 |
| 20 | Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina:Two case reports显示文摘It is well known that calcium channel blockers(CCBs) are the first line of therapy for vasospastic angina(VSA). Here, we report two cases of VSA with an increase in the frequency of angina attacks after switching from a brand-name to a generic CCB. In both cases, angina recurred upon switching from a brand-name CCB to a generic CCB during follow-up. The patients' condition improved upon switching back to the original CCB. Both cases involved a high severity of VSA, based on the results of spasm provocation testing. These findings suggest that, in some patients with severe VSA, the frequency of angina attacks increases when switching from a brand-name CCB to a generic CCB. Cardiologists should consider this factor when prescribing drugs for angina. | Remi Goto-Semba Yuichi Fujii Tomohiro Ueda Chikage Oshita Hiroki Teragawa | 2018 | World Journal of Cardiology2018，10，3： | 1 |
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