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| 1 | Current status of laparoscopic and robotic ventral mesh rectopexy for external and internal rectal prolapse显示文摘External and internal rectal prolapse with their affiliated rectocele and enterocele, are associated with debilitating symptoms such as obstructed defecation, pelvic pain and faecal incontinence. Since perineal procedures are associated with a higher recurrence rate, an abdominal approach is commonly preferred. Despite the description of greater than three hundred different procedures, thus far no clear superiority of one surgical technique has been demonstrated. Ventral mesh rectopexy(VMR) is a relatively new and promising technique to correct rectal prolapse. In contrast to the abdominal procedures of past decades, VMR avoids posterolateral rectal mobilisation and thereby minimizes the risk of postoperative constipation. Because of a perceived acceptable recurrence rate, good functional results and low mesh-related morbidity in the short to medium term, VMR has been popularized in the past decade. Laparoscopic or robotic-assisted VMR is now being progressively performed internationally and several articles and guidelines propose the procedure as the treatment of choice for rectal prolapse. In this article, an outline of the current status of laparoscopic and robotic ventral mesh rectopexy for the treatment of internal and external rectal prolapse is presented. | Jan J van Iersel Tim JC Paulides Paul M Verheijen John W Lumley Ivo AMJ Broeders Esther CJ Consten | 2016 | World Journal of Gastroenterology2016，22，21： | 20 |
| 2 | 基于遗传算法的多目标最小二乘支持向量机在近红外多组分定量分析中的应用显示文摘近红外(NIR)定量分析通常涉及多个组分,采用遗传算法和自适应建模策略,建立了能够对多组分同时定量的多目标最小二乘支持向量机(LS-SVM),并将其应用于玉米中四个组分和连翘中两个活性成分的NIR分析。结果表明多目标遗传算法配合自适应建模策略可保证优化收敛于全局最优解。所建玉米多目标LS-SVM模型明显优于PLS1和PLS2模型;连翘多目标LS-SVM模型与PLS模型均可取得较好的校正和预测效果。两组数据中,径向基神经网络(RBFNN)模型均出现过拟合现象。多目标LS-SVM和单目标LS-SVM性能相近,但多目标LS-SVM建模运行一次即可得到结果,在NIR多组分定量分析中具有潜在应用优势。 | 徐冰 王星 Dhaene Tom 史新元 Couckuyt Ivo 白雁 乔延江 | 2014 | 光谱学与光谱分析2014，34，3： | 17 |
| 3 | Value of three-dimensional reconstructions in pancreatic carcinoma using multidetector CT:Initial results显示文摘AIM:To evaluate the use of three-dimensional imaging of pancreatic carcinoma using multidetector computed tomography(CT)in a prospective study.METHODS:Ten patients with suspected pancreatic tumors were examined prospectively using multidetec-tor CT(Somatom Sensation 16,Siemens,Erlangen,Germany).The images were evaluated for the pres-ence of a pancreatic carcinoma and invasion of the peripancreatic vessels and surrounding organs.Using the isotropic CT data sets,a three-dimensional image was created with automatic vascular analysis and semi-automatic segmentation of the organs and pancreatic tumor by a radiologist.The CT examinations and the three-dimensional images were presented to the sur-geon directly before and during the patient's operation using the Medical Imaging Interaction Toolkit-based software 'ReLiver'.Immediately after surgery,the value of the two images was judged by the surgeon.The operation and the histological results served as the gold standard.RESULTS:Nine patients had a pancreatic carcinoma(all pT3),and one patient had a serous cystadenoma.One tumor inf iltrated the superior mesenteric vein.The inf iltration was correctly evaluated.All carcinomas were resectable.In comparison to the CT image with axial and coronal reconstructions,the three-dimensional image was judged by the surgeons as better for operation planning and consistently described as useful.CONCLUSION:A 3D-image of the pancreas repre-sents an invaluable aid to the surgeon.However,the 3D-software must be further developed in order to be integrated into daily clinical routine. | Miriam Klauβ Max Schbinger Ivo Wolf Jens Werner Hans-Peter Meinzer Hans-Ulrich Kauczor Lars Grenacher | 2009 | World Journal of Gastroenterology2009，15，46： | 16 |
| 4 | 计算机辅助设计与制作一体化玻璃纤维桩核修复漏斗状根管的抗疲劳和抗折性能显示文摘目的:评价计算机辅助设计与制作(computer aided design and computer aided manufacturing,CAD/CAM)一体化玻璃纤维桩核修复漏斗状根管的抗疲劳性能和抗折强度。方法:收集32颗离体上颌中切牙,制作漏斗状根管模型后,利用随机数字表分为4组,每组8颗牙齿,分别用4种桩核修复,第1组:CAD/CAM一体化玻璃纤维桩核;第2组:预成石英纤维桩与树脂核;第3组:铸造金合金桩核;第4组:CAD/CAM一体化氧化锆桩核。使用化学固化的树脂粘接剂Superbond C&B将制作完成的桩核粘入到预备后的根管中,为每个牙齿制作氧化锆全冠并使用Superbond C&B粘接。使用加成型硅橡胶模拟牙周膜后把制作完成的试件固定到专用的咀嚼模拟器上,以1.67 Hz的频率在5℃和50℃每2 min交替一次的水浴中沿牙体长轴45°角,用49 N的力在牙冠舌侧加载1.2×106次,再将试件用力学测试机沿牙体长轴45°角加力将桩核折断,记录抗折强度,观察折断模式。结果:咀嚼模拟结束时,预成石英纤维桩组有4个样本的牙冠脱落,剩余样本中未观察到破坏;在抗力测试中,CAD/CAM一体化玻璃纤维桩核组和铸造金合金桩核组的抗折强度分别为(441.5±103.2)N和(462.9±170.0)N,差异无统计学意义(P>0.05),但是都高于CAD/CAM一体化氧化锆桩核组[(284.1±99.0)N]和预成石英纤维桩组[(315.4±112.3)N],其差异有统计学意义(F=4.613,P<0.05)。结论:漏斗状根管使用CAD/CAM一体化玻璃纤维桩核或铸造金合金桩核修复可能能取得更好的临床效果。 | 李智 王新知 高承志 IVO Krejci | 2013 | 北京大学学报(医学版)2013，45，1： | 13 |
| 5 | State coordinated voltage control in an active distribution network with on-load tap changers and photovoltaic systems显示文摘Decreasing costs and favorable policies have resulted in increased penetration of solar photovoltaic(PV)power generation in distribution networks.As the PV systems penetration is likely to increase in the future,utilizing the reactive power capability of PV inverters to mitigate voltage deviations is being promoted.In recent years,droop control of inverter-based distributed energy resources has emerged as an essential tool for use in this study.The participation of PV systems in voltage regulation and its coordination with existing controllers,such as on-load tap changers,is paramount for controlling the voltage within specified limits.In this work,control strategies are presented that can be coordinated with the existing controls in a distributed manner.The effectiveness of the proposed method was demonstrated through simulation results on a distribution system. | Praveen Prakash Singh Ivo Palu | 2021 | Global Energy Interconnection2021，4，2： | 11 |
| 6 | Total Replacement of Fish Oil with Vegetable Oils in the Diet of Juvenile Jade Perch Scortum barcoo Reared in Recirculating Aquaculture Systems显示文摘 | Stijn Van Hoestenberghe Ivo Roelants Daniel Vermeulen Bruno Maria Goddeeris | 2013 | Journal of Agricultural Science and Technology(B)2013，3，5： | 10 |
| 7 | Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities显示文摘Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma(PRP) therapy is a promising treatment for musculoskeletal injuries.Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field.Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms.This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and(pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed. | Yan Huang Michael M Bornstein Ivo Lambrichts Hai-Yang Yu Constantinus Politis Reinhilde Jacobs | 2017 | International Journal of Oral Science2017，9，1： | 10 |
| 8 | Label-free sensing of ultralow-weight molecules with all-dielectric metasurfaces supporting bound states in the continuum显示文摘The realization of an efficient optical sensor based on a photonic crystal metasurface supporting bound states in the continuum is reported. Liquids with different refractive indices, ranging from 1.4000 to 1.4480, are infiltrated in a microfluidic chamber bonded to the sensing dielectric metasurface. A bulk liquid sensitivity of 178 nm/RIU is achieved, while a Q-factor of about 2000 gives a sensor figure of merit up to 445 in air at both visible and infrared excitations. Furthermore, the detection of ultralow-molecular-weight(186 Da) molecules is demonstrated with a record resonance shift of 6 nm per less than a 1 nm thick single molecular layer. The system exploits a normal-to-the-surface optical launching scheme, with excellent interrogation stability and demonstrates alignment-free performances, overcoming the limits of standard photonic crystals and plasmonic resonant configurations. | SILVIA ROMANO GIANLUIGI ZITO STEFANIA TORINO GIUSEPPE CALAFIORE ERIKA PENZO GIUSEPPE COPPOLA STEFANO CABRINI IVO RENDINA VITO MOCELLA | 2018 | Photonics Research2018，6，7： | 9 |
| 9 | Small bowel adenocarcinoma in Crohn's disease:A case report and review of literature显示文摘小肠腺癌为他们的稀有,困难的诊断和差的预后是显著的。这里,我们报导小肠的渗透性的腺癌在 Crohn 的疾病的 10 年的历史以后在被诊断的一个 33 岁的病人的一个不平常的案例。在最以前报导的案例中, Crohn 的疾病的察觉对小肠的癌的随后或包含的病人有疾病的甚至更长的历史。我们的文学评论建议小肠腺癌的风险比在全面人口在有 Crohn 的疾病的病人是更高的。我们传染病学以及这个稀罕疾病实体的临床、诊断的方面上的现在的细节。 | Irmgard E Kronberger Ivo W Graziadei Wolfgang Vogel | 2006 | World Journal of Gastroenterology2006，12，8： | 8 |
| 10 | High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging显示文摘Progress in neuroscience relies on new techniques for investigating the complex dynamics of neuronal networks.An ongoing challenge is to achieve minimally invasive and high-resolution observations of neuronal activity in vivo inside deep brain areas.Recently introduced methods for holographic control of light propagation in complex media enable the use of a hair-thin multimode optical fibre as an ultranarrow imaging tool.Compared to endoscopes based on graded-index lenses or fibre bundles,this new approach offers a footprint reduction exceeding an order of magnitude,combined with a significant enhancement in resolution.We designed a compact and high-speed system for fluorescent imaging at the tip of a fibre,achieving a resolution of 1.18±0.04μm across a 50-μm field of view,yielding 7-kilopixel images at a rate of 3.5 frames/s.Furthermore,we demonstrate in vivo observations of cell bodies and processes of inhibitory neurons within deep layers of the visual cortex and hippocampus of anaesthetised mice.This study paves the way for modern microscopy to be applied deep inside tissues of living animal models while exerting a minimal impact on their structural and functional properties. | Sergey Turtaev Ivo T.Leite Tristan Altwegg-Boussac Janelle M.P.Pakan Nathalie L.Rochefort Tomáš Čižmár | 2018 | Light(Science & Applications)2018，7，1： | 8 |
| 11 | Transjugular intrahepatic portosystemic shunt in liver transplant recipients显示文摘AIM:To evaluate the efficacy of transjugular intrahepatic portosystemic shunts (TIPSs) after liver transplantation (LT). METHODS: Between November 1996 and December 2005, 10 patients with severe recurrent hepatitis C virus infection (n=4), ductopenic rejection (n=5) or portal vein thrombosis (n=1) were included in this analysis. Eleven TIPSs (one patient underwent two TIPS procedures) were placed for management of therapy-refractory ascites (n=7), hydrothorax (n=2) or bleeding from colonic varices (n=1). The median time interval between LT and TIPS placement was 15 (4-158) mo. RESULTS: TIPS placement was successful in all patients. The mean portosystemic pressure gradient was reduced from 12.5 to 8.7 mmHg. Complete and partial remission could be achieved in 43% and 29% of patients with ascites. Both patients with hydrothorax did not respond to TIPS. No recurrent bleeding was seen in the patient with colonic varices. Nine of 10 patients died during the study period. Only one of two patients, who underwent retransplantation after the TIPS procedure, survived. The median survival period after TIPS placement was 3.3 (range 0.4-20) mo. The majority of patients died from sepsis with multiorgan failure.CONCLUSION: Indications for TIPS and technical performance in LT patients correspond to those in non-transplanted patients. At least partial control of therapy-refractory ascites and variceal bleeding could be achieved in most patients. Nevertheless, survival rates were disappointing, most probably because of the advanced stages of liver disease at the time of TIPS placement and the high risk of sepsis as a consequence of immunosuppression. | Armin Finkenstedt Ivo W Graziadei Karin Nachbaur Werner Jaschke Walter Mark Raimund Margreiter Wolfgang Vogel | 2009 | World Journal of Gastroenterology2009，15，16： | 8 |
| 12 | Cerebral processing of auditory stimuli in patients with irritable bowel syndrome显示文摘瞄准:用大脑决定功能的磁性的回声成像(fMRI ) 非内脏的刺激的服的处理是否在急躁的肠症候群(IBS ) 被改变病人与健康题目相比。围绕针的内脏躯体集中机制,并且识别心理因素的可能的影响,我们使用了听觉的刺激刺激在他们的感情的质量不同。方法:在 8 个 IBS 病人和 8 控制, fMRI 大小用不同感情的质量(钟声,讨厌的偷看(2000 Hz ) ,中立的词,和感情的词的愉快的声音) 的 4 听觉的刺激的一个块图案被执行。坡度回响 T2 * 加权的顺序被用于功能的扫描。统计地图用一般线性模型被构造。结果:到感情的听觉的刺激,,相对控制的 IBS 病人在感情的处理区域的一个更大的变化与更强壮的释放反应了反应模式,在控制不同,没在令人烦恼或愉快的声音之间区分。到中立听觉的刺激,由对比,仅仅 IBS 病人与大重要激活反应了。结论:到在感情的处理刺激的区域的听觉的刺激的改变的服的反应模式建议在 IBS 的改变的感觉处理不能为内脏的感觉是特定的,但是可能在感情的敏感和感情方面的反应反映概括变化,可能与经常在 IBS 病人发现的心理 comorbidity 联系了。 | Viola Andresen Alexander Poellinger Chedwa Tsrouya Dominik Bach Albrecht Stroh Annette Foerschler Petra Georgiewa Marco Schmidtmann Ivo R van der Voort Peter Kobelt Claus Zimmer Bertram Wiedenmann Burghard F Klapp Hubert Monnikes | 2006 | World Journal of Gastroenterology2006，12，11： | 8 |
| 13 | Sensory innervation around immediately vs. delayed loaded implants: a pilot study显示文摘Although neurophysiological and psychophysical proof of osseoperception is accumulating, histomorphometric evidence for the neural mechanisms of functional compensation following immediate and delayed implant loading is still lacking. For this randomized split-mouth study, six mongrel dogs randomly received one of four treatment protocols at 36 implant-recipient sites over 16 weeks(third maxillary incisor, third and fourth mandibular premolar): immediate implant placement and immediate loading(IIP1IL);delayed implant placement and delayed loading(DIP1DL); delayed implant placement and immediate loading(DIP1IL); and natural extraction socket healing(control). Histomorphometry was performed in the peri-implant bone and soft tissues within 300 mm around the implants. Immunocytochemistry and transmission electron microscopy were used to confirm the presence of neural structures and to reveal their ultrastructural characteristics, respectively. Myelinated nerve fibres densely populated the peri-implant crestal gingival and apical regions, although they were also identified in the woven bone and in the osteons near the implant threads. Compared with the control group in the mandible, the group that received IIP1 IL showed a higher innervation(in Nmm22, 5.9461.12 vs. 3.1560.63,P,0.001) and smaller fibre diameter(in mm, 1.3760.05 vs. 1.6460.13, P50.016), smaller axon diameter(in mm, 0.8960.05 vs.1.2460.10, P50.009) and g-ratio(0.6460.04 vs. 0.7660.05, P,0.001) in the middle region around the implants. Compared with DIP1 IL in the mandible, IIP1 IL had a higher nerve density(in Nmm22, 13.2362.54 vs. 9.6461.86, P50.027), greater fibre diameter(in mm, 1.3260.02 vs. 1.2060.04, P50.021), greater axon diameter(in mm, 0.9260.01 vs. 0.8960.03, P50.035) and lower g-ratio(0.6960.01 vs. 0.7460.01, P50.033) in the apical region around the implants. It may be assumed that the treatment protocol with IIP1 IL is the preferred method to allow optimized peri-implant re-innervation, but further functional measurements are still required. | Yan Huang Jeroen van Dessel Wendy Martens Ivo Lambrichts Wei-Jian Zhong Guo-Wu Ma Dan Lin Xin Liang Reinhilde Jacobs | 2015 | International Journal of Oral Science2015，7，1： | 7 |
| 14 | Validation of a novel imaging approach using multi-slice CT and cone-beam CT to follow-up on condylar remodeling after bimaxillary surgery显示文摘The main goal of this study was to introduce a novel three-dimensional procedure to objectively quantify both inner and outer condylar remodelling on preoperative multi-slice computed tomography(MSCT) and postoperative cone-beam computed tomography(CBCT) images. Second, the reliability and accuracy of this condylar volume quantification method was assessed. The mandibles of 20 patients(11 female and 9 male) who underwent bimaxillary surgery were semi-automatically extracted from MSCT/CBCT scans and rendered in 3D. The resulting condyles were spatially matched by using an anatomical landmark-based registration procedure.A standardized sphere was created around each condyle, and the condylar bone volume within this selected region of interest was automatically calculated. To investigate the reproducibility of the method, inter-and intra-observer reliability was calculated for assessments made by two experienced radiologists twice five months apart in a set of ten randomly selected patients. To test the accuracy of the bone segmentation, the inner and outer bone structures of one dry mandible, scanned according to the clinical set-up, were compared with the gold standard, micro-CT. Thirty-eight condyles showed a significant(P<0.05) mean bone volume decrease of 26.4% ± 11.4%(502.9 mm^3± 268.1 mm^3). No significant effects of side, sex or age were found. Good to excellent(ICC>0.6) intra-and inter-observer reliability was observed for both MSCT and CBCT. Moreover, the bone segmentation accuracy was less than one voxel(0.4 mm) for MSCT(0.3 mm ± 0.2 mm) and CBCT(0.4 mm ± 0.3 mm), thus indicating the clinical potential of this method for objective follow-up in pathological condylar resorption. | laura ferreira pinheiro nicolielo jeroen van dessel eman shaheen carolina letelier marina codari constantinus politis ivo lambrichts reinhilde jacobs | 2017 | International Journal of Oral Science2017，9，3： | 7 |
| 15 | Advanced Fiber-Optic Acoustic Sensors显示文摘声学的察觉到是现在在现代社会起一个重要作用的一块很费力的地,用从监视到医药成像的结构的健康跨越的应用。Fiber-optics 能把许多优点带到这域,并且光纤的声学的传感器已经显示出能够基于压电的变换器与标准传感器竞争的性能层次。这评论在光纤的动态紧张察觉到的地里介绍最近的进展,特别地为声学的察觉。三种主导的技术是识别纤维布拉格栅栏, interferometric Mach-Zehnder,和 | Joao G. V. TEIXEIRA Ivo T. LEITE Susana SILVA Orlando FRAZAO | 2014 | Photonic Sensors2014，4，3： | 6 |
| 16 | “Isara400”超精密坐标测量机的设计与标定(英文)显示文摘介绍了Isara 400 3维超精坐标测量机标定的关键技术,包括平台标定和系统镜面台非垂直度标定。同时,提出了一种新的超精接触探针系统,给出了这种3维灵敏度探针的标定结果。 | Henny Spaan Ivo Widdershoven Rilpho Donker | 2011 | 光学精密工程2011，19，9： | 6 |
| 17 | Identifying more reliable parameters for the detection of change during the follow-up of mild to moderate keratoconus patients显示文摘Background:Reaching a consensus on which parameters are most reliable at detecting progressive keratoconus patients with serial topography imaging is not evident.The aim of the study was to isolate the parameters best positioned to detect keratoconus progression using the Pentacam HR^(®)measures based on the respective limits of repeatability and range of measurement.Method:Using the Pentacam HR^(®),a tolerance index was calculated on anterior segment parameters in healthy and keratoconic eyes.The tolerance index provides a scale from least to most affected parameters in terms of measurement noise relative to that observed in healthy eyes.Then,based on the“number of increments”from no disease to advanced disease,a relative utility(RU)score was also calculated.RU values close to 1 indicate parameters best positioned to detect a change in keratoconic eyes.Results:The tolerance index values indicated that 36%of ocular parameters for keratoconic eyes had repeatability limits which were wider than normative limits(worse),but 28%of the ocular parameters were narrower than normative limits(better).Considering only those parameters with a RU greater than 0.95,a small number of parameters were within this range,such as corneal curvature and asphericity indices.Conclusions:This study demonstrates that measurement error in keratoconic eyes is significantly greater than healthy eyes.Indices implemented here provide guidance on the levels of expected precision in keratoconic eyes relative to healthy eyes to aid clinicians in distinguishing real change from noise.Importantly maximal keratometry(Kmax),central corneal thickness(CCT)and thinnest corneal thickness(TCT)were highlighted as problematic indices for the follow-up of keratoconus in terms of repeatability. | Ivo Guber Colm McAlinden François Majo Ciara Bergin | 2017 | Eye and Vision2017，4，1： | 6 |
| 18 | Photoluminescent Tb^(3+)-based metal-organic framework as a sensor for detection of methanol in ethanol fuel显示文摘The sensing capability of a Tb^(3+)-metal-organic framework, based on its photoluminescence, was used for detection of methanol in ethanol fuel. It was synthesized using terbium and trimesic acid as a metal ion center and ligand, respectively. Powder X-ray diffraction, infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy were employed to characterize the synthesized MOF-76 structural features. According to the results, MOF-76 was successfully obtained with minor synthetic modification and its activated form(named TbTMA) was tested as a sensor for methanol. Tb^(3+) luminescence intensity increases as the methanol concentration in ethanol fuel also increases and the water content does not affect this response. Our findings indicate TbTMA as an appropriate sensor for evaluating ethanol fuel adulteration by methanol addition above the allowed limit. | Ramon R.F.Fonseca Rafael D.L.Gaspar Ivo M.Raimundo Jr. Priscilla P.Luz | 2019 | Journal of Rare Earths2019，37，3： | 6 |
| 19 | Phosphoinositide and Inositolpolyphosphate Signalling in Defense Responses of Arabidopsis thaliana Challenged by Mechanical Wounding显示文摘各种各样的生物化学的信号在 Arabidopsis 创伤发信号被含有,包括 jasmonic 酸(JA ) ,水杨酸酸,植物生长素,和 Ca2+ 。这里,我们与 phosphoinositide 在植物激素的串音上报导信号不以前在植物创伤回答含有。在 30 以内 ? Arabidopsis 插座叶子的机械伤害的 min,导出类脂化合物的可溶的 inositolpolyphosphate 的层次,肌醇 1,4,5-trisphosphate (InsP3 ) ,增加了四到五倍。附随地,先锋类脂化合物, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 4 磷酸盐和 phosphatidylinositol 短暂地弄空,在 3060 以后由重新合成列在后面 ? 刺激的 min。有伤害的增加的 InsP3 层次在刺激的第一个小时与 JA 与增加一致。在在 JA 生合成缺乏的 dde2-2-mutant 植物,没有 InsP3 增加在伤害之上被观察,显示 JA 为层次在与山梨糖醇质问的野类型的植物增加了的 InsP3 形成,和 InsP3 被要求,增加内长的 JA 层次。在有稀释 phosphoinositide 发信号的 InsP 5-ptase 植物,创伤可诱导的基因的正式就职与野类型的植物相比被减少,建议为在调停表明植物创伤回答的 phosphoinositide 的一个角色。基因表示模式建议 phosphoinositides 贡献发信号弯屈的 JA 依赖、 JA 独立的方面。在 InsP 5-ptase 植物上喂的 Plutella xylostella 毛虫的重量获得与在野类型的植物上喂的毛虫的相比被增加。在对 herbivory 的植物防卫回答的 phosphoinositide 信号的 ecophysiological 关联在植物激素受体功能考虑到 inositolpolyphosphate 参与的最近的调查结果被讨论。 | Alina Mosblech Sabine Konig Irene Stenzel Peter Grzeganek Ivo Feussner Ingo Heilmann | 2008 | Molecular Plant2008，1，2： | 5 |
| 20 | Six-year outcomes in neovascular age-related macular degeneration with ranibizumab显示文摘● AIM: To evaluate the outcomes of ≥6y ranibizumab therapy in neovascular age-related macular degeneration(AMD).● METHODS: HELIX was a retrospective, observational effeciveness study using medical records of patients treated in three clinics in Belgium. Patients had neovascular AMD and were initially treated with intravitreal ranibizumab(0.5 mg) between November 1, 2007 and October 31, 2008, had ≥6y of data available, and were treated on an ongoing, as-needed basis. Outcomes included best-corrected visual acuity(BCVA) and central retinal thickness(CRT).● RESULTS: The sample consisted of 88 eyes from 69 patients. Mean age was 76.4±6.5y, most patients were female(62.3%). Most eyes(62.5%) were treatment-naive, 33 previously treated eyes had received predominantly other anti-vascular endothelial growth factor agents and verteporfin. Mean baseline BCVA was 57.4±12.7 ETDRS letters and CRT was 292±86 μm. On average, patients received 20.6±11.9 ranibizumab injections over the ≥6y. Intervals between injections were on average 12.7±16.1wk. Mean change in BCVA from baseline to last observation for the sample was less than one letter(-0.9±17.3 letters), with an average loss of-3.2±15.6 letters in previously treated eyes versus a gain of 0.6±18.4 letters in treatment-na?ve eyes. When considering a loss of <15 letters over 6y as stabilization of disease, 75.9% of all eyes showed a positive(improvement or stabilization) outcome. Mean change in CRT from baseline to last observation for the sample was-26.9±148.4 μm with the greatest reduction observed in treatment-naive eyes.● CONCLUSION: This retrospective study of 69 neovascular AMD patients treated for ≥6y with ranibizumab demonstrates long-term visual stabilization. In light of the natural evolution of the disease, these data confirm that ranibizumab is effective long-term under real-world conditions of heterogeneity of patients, clinicians, and centers. | Julie Jacob Heidi Brié Anita Leys Laurent Levecq Filip Mevgaerts Kris Denhaerynck Stefaan Vancayzeele Eline Van Craeyveld Ivo Abraham Karen MacDonald | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 5 |
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