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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | Role of frailty and sarcopenia in predicting outcomes among patients undergoing gastrointestinal surgery显示文摘According to the United States census bureau 20% of Americans will be older than 65 years in 2030 and half of them will need an operation- equating to about 36 million older surgical patients. Older adults are prone to complications during gastrointestinal cancer treatment and therefore may need to undergo special pretreatment assessments that incorporate frailty and sarcopenia assessments. A focused, structured literature review on Pub Med and Google Scholar was performed to identify primary research articles, review articles, as well as practice guidelines on frailty and sarcopenia among patients undergoing gastrointestinal surgery. The initial search identified 450 articles; after eliminating duplicates, reports that did not include surgical patients, case series, as well as case reports, 42 publications on the impact of frailty and/or sarcopenia on outcome of patients undergoing gastrointestinal surgery were included. Frailty is defined as a clinically recognizable state of increased vulnerability to physiologic stressors resulting from aging. Frailty is associated with a decline in physiologic reserve and function across multiple physiologic systems. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. Unlike cachexia, which is typically associated with weight loss due to chemotherapy or a general malignancy-related cachexia syndrome, sarcopenia relates to muscle mass rather than simply weight. As such, while weight reflects nutritional status, sarcopenia- the loss of muscle mass- is a more accurate and quantitative global marker of frailty. While chronologic age is an important element in assessing a patient's peri-operative risk, physiologic age is a more important determinant of outcomes. Geriatric assessment tools are important components of the preoperative work-up and can help identify patients who suffer from frailty. Such data are important, as frailty and sarcopenia have repeatedly been demonstrated among the strongest predictors of both short- and longterm outcome following complicated surgical procedures such as esophageal, gastric, colorectal, and hepatopancreatico-biliary resections. | doris wagner mara mcadams demarco neda amini stefan buttner dorry segev faiz gani timothy m pawlik | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 8 |
| 3 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 4 | Treating Clostridium difficile Infection With Fecal Microbiota Transplantation显示文摘 | Johan S. Bakken Thomas Borody Lawrence J. Brandt Joel V. Brill Daniel C. Demarco Marc Alaric Franzos Colleen Kelly Alexander Khoruts Thomas Louie Lawrence P. Martinelli Thomas A. Moore George Russell Christina Surawicz | 2011 | Clinical Gastroenterology and Hepatology2011，，12： | 5 |
| 5 | Effect of a retrograde-viewing device on adenoma detection rate during colonoscopy: the TERRACE study显示文摘 | Anke M. Leufkens Daniel C. DeMarco Amit Rastogi Paul A. Akerman Kassem Azzouzi Richard I. Rothstein Frank P. Vleggaar Alessandro Repici Giacomo Rando Patrick I. Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H. Deprez Brian P. Sau | 2011 | Gastrointestinal Endoscopy2011，，3： | 5 |
| 6 | Over-nutrition and metabolic cardiomyopathy显示文摘 | Chirag H. Mandavia Lakshmi Pulakat Vincent DeMarco James R. Sowers | 2012 | Metabolism2012，，9： | 2 |
| 7 | Impact of experience with a retrograde-viewing device on adenoma detection rates and withdrawal times during colonoscopy: the Third Eye Retroscope study group显示文摘 | Daniel C. DeMarco Elizabeth Odstrcil Luis F. Lara David Bass Chase Herdman Timothy Kinney Kapil Gupta Leon Wolf Thomas Dewar Thomas M. Deas Manoj K. Mehta M. Badar Anwer Randall Pellish J. Kent Hamilton Daniel Polter K. Gautham Reddy Ira Hanan | 2010 | Gastrointestinal Endoscopy2010，，3： | 2 |
| 8 | Fracture resistance of reattachment coronal fragments influence of different adhesive materials and bevel preparation 显示文摘 | Demarco FF Fay RM Pinzon LM | 2004 | Dent Traumatol2004，20，： | 1 |
| 9 | World Health Organization Pulmonary Hypertension Group2:pulmonary hypertension due to left heart disease in the adult-a summary statement from the Pulmonary Hypertension Council of the International Society for Heart and Lung Transplantation显示文摘 | Fang JC DeMarco T Givertz MM | | 0，，09： | 1 |
| 10 | Dependence of Achievable Plan Quality on Treatment Technique and the Planning Goal Refinement: A Head-and-Neck IMRT Application显示文摘 | X. Sharon Qi Dan Ruan Steve P. Lee Andrew Pham Patrick Kupelian Daniel A. Low Michael Steinberg John Demarco | 2014 | International Journal of Radiation Oncology, Biology, Physics2014，，： | 1 |
| 11 | Bradykinin and ATP accelerate Ca^2+ efflux from rat sensory, neurons via protein kinase C and the plasma membrane Ca^2+ pump isoform 4 显示文摘 | Usachev YM Demarco S J Campbell C | 2002 | Neuron2002，33，1： | 1 |
| 12 | Bradykinin and ATP accelerate Ca^2+ efflux from rat sensory neurons via protein kinase C and the plasma membrane Ca^2+ pump isoform 显示文摘 | Usachev YM Demarco SJ Campbell C | 2002 | Neuron2002，33，1： | 1 |
| 13 | Effects of long term biventric- ular stimulation for resynchronization on echocardiographic measures of remodeling显示文摘 | Saxon L DeMarco T Schafer J | 2002 | Circulation2002，105，11： | 1 |
| 14 | Arsenic removal using apolymeric/inorganie hybrid sorbent显示文摘 | DeMarco M J SenGupta A K GreenleafJ E | | 0，，： | 1 |
| 15 | MRF Polishes Calcium Fluoride to High Quality 显示文摘 | Golini D DeMarco M Kordonski W | 2001 | Optoelectronics World2001，，37： | 1 |
| 16 | Nursing Students'Experiences With and Strategic Approaches to Case-based Instruction:a Replication and Comparison Study Between Two Disciplines显示文摘 | Demarco R Hayward L Lynch M | 2002 | The Journal of Nursing Education2002，41，4： | 1 |
| 17 | Resin bond strength to a zirconia-reinforced ceramic after different surface treatments显示文摘 | Donassollo T A Demarco F F Della Bona A | 2009 | Gen Dent2009，57，4： | 1 |
| 18 | Glutamine supports recovery from loss of transepithelial resistance and increase of permeability induced by media change in Caco-2 cells显示文摘 | Li N DeMarco VG West CM | 2003 | J Nutr Biochem2003，14，7： | 1 |
| 19 | Software risk management显示文摘 | Boehm B W DeMarco T | 1997 | Software IEEE1997，14，3： | 1 |
| 20 | Over-the-counter whitening agents: a concise review显示文摘 | Demarco FF Meireles SS Masotti AS | 2009 | Braz Oral Res2009，231，： | 1 |
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