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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Functional Dyspepsia: Not All Roads Seem to Lead to Rome显示文摘 | Lieke A. S. van Kerkhoven Robert J. F. Laheij Villy Meineche-Schmidt Sander J. Veldhuyzen-van Zanten Niek J. de Wit Jan B. M. J. Jansen | 2009 | Journal of Clinical Gastroenterology2009，，2： | 1 |
| 3 | Atrophodermia vermiculata: ease report and review of the literature 显示文摘 | Jansen T Sander C Altmeyer P | 2003 | Journal of the European Academy of Dermatology& Venereology2003，17，1： | 1 |
| 4 | Injectable biphasic calcium phosphate cements as a potential bone substitute显示文摘 | Kemal Sariibrahimoglu Joop G. C. Wolke Sander C. G. Leeuwenburgh Li Yubao John A. Jansen | 2014 | J Biomed Mater Res2014，，3： | 1 |
| 5 | Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease显示文摘 | Babelova A Jansen F Sander K | 2013 | PLoS One2013，8，80： | 1 |
| 6 | Activation of Rac-1and RhoA contributes to podocyte injury in chronic kidneydisease显示文摘 | Babelova A Jansen F Sander K | 2013 | PLoS One2013，8，80： | 1 |
| 7 | Activation of Rac-1 and RhoA Contributes to Podocyte Injury in chronic kidney disease显示文摘 | Babelova A Jansen F Sander K | 2013 | PLoS One2013，8，80： | 1 |
| 8 | Invasive pneumococcal and meningococcal disease: association with in- fluenza virus and respiratory syncytial virus activity? 显示文摘 | Jansen AG Sanders EA VAN DER Ende A | 2008 | Epi- demiol Infect2008，136，11： | 1 |
| 9 | Treatment of Crohn’s disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)显示文摘 | Hendrik M. van Dullemen Sander J.H. van Deventer Daan W. Hommes Hannie A. Bijl Jaap Jansen Guido N.J. Tytgat James Woody | 1995 | Gastroenterology1995，，1： | 1 |
| 10 | Ossification in the patellar tendon and patella alta following sports injuries in children显示文摘 | J. D. Bruijn R. J. Sanders B. R. H. Jansen | 1993 | Archives of Orthopaedic and Trauma Surgery1993，，3： | 1 |
| 11 | Organic–Inorganic Surface Modifications for Titanium Implant Surfaces显示文摘 | Lise T. Jonge Sander C. G. Leeuwenburgh Joop G. C. Wolke John A. Jansen | 2008 | Pharmaceutical Research2008，，10： | 1 |
| 12 | 2-Gb/s PDM-8QAM-OFDM Transmissionat 4-b/s/Hz Spectral Efficiency 显示文摘 | Jansen Sander L Amin Abdullah Al Takahashi Hide-nori 132 | 2009 | IEEE PhotonicsTechnology Letters2009，21，12： | 1 |
| 13 | Organic–Inorganic Surface Modifications for Titanium Implant Surfaces显示文摘 | Lise T. Jonge Sander C. G. Leeuwenburgh Joop G. C. Wolke John A. Jansen | 2008 | Pharmaceutical Research2008，，10： | 1 |
| 14 | Invasive pneumococcal and meningococcal disease: association with influenza virus and respiratory syncytial virus activity? 显示文摘 | Jansen AG Sanders EA Van Der Ende A | 2008 | Epidemiol Infect2008，136，11： | 1 |
| 15 | The osteogenic effect of electrosprayed nanoscale collagen/calcium phosphate coatings on titanium显示文摘 | Lise T. de Jonge Sander C.G. Leeuwenburgh Jeroen J.J.P. van den Beucken Joost te Riet Willeke F. Daamen Joop G.C. Wolke Dieter Scharnweber John A. Jansen | 2009 | Biomaterials2009，，9： | 1 |
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