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| 1 | Minimal hepatic encephalopathy matters in daily life显示文摘Minimal hepatic encephalopathy is a neuro-cognitive dysfunction which occurs in an epidemic proportion of cirrhotic patients,estimated as high as 80% of the population tested. It is characterized by a specific,complex cognitive dysfunction which is independent of sleep dysfunction or problems with overall intelligence. Although named 'minimal',minimal hepatic encephalopathy(MHE) can have a far-reaching impact on quality of life,ability to function in daily life and progression to overt hepatic encephalopathy. Importantly,MHE has a profound negative impact on the ability to drive a car and may be a significant factor behind motor vehicle accidents. A crucial aspect of the clinical care of MHE patients is their driving history,which is often ignored in routine care and can add a vital dimension to the overall disease assessment. Driving history should be an integral part of care in patients with MHE. The lack of specific signs and symptoms,the preserved communication skills and lack of insight make MHE a difficult condition to diagnose. Diagnostic strategies for MHE abound,but are usually limited by financial,normative or time constraints. Recent studies into the inhibitory control and critical flicker frequency tests are encouraging since these tests can increase the rates of MHE diagnosis without requiring a psychologist. Although testing for MHE and subsequent therapy is not standard of care at this time,it is important to consider this in cirrhotics in order to improve their ability to live their life to the fullest. | Jasmohan S Bajaj | 2008 | World Journal of Gastroenterology2008，14，23： | 30 |
| 2 | The human gut sterolbiome:bile acid-microbiome endocrine aspects and therapeutics显示文摘The human body is now viewed as a complex ecosystem that on a cellular and gene level is mainly prokaryotic. The mammalian liver synthesizes and secretes hydrophilic primary bile acids, some of which enter the colon during the enterohepatic circulation, and are converted into numerous hydrophobic metabolites which are capable of entering the portal circulation, returned to the liver, and in humans,accumulating in the biliary pool. Bile acids are hormones that regulate their own synthesis, transport, in addition to glucose and lipid homeostasis, and energy balance. The gut microbial community through their capacity to produce bile acid metabolites distinct from the liver can be thought of as an 'endocrine organ'with potential to alter host physiology, perhaps to their own favor. We propose the term 'sterolbiome' to describe the genetic potential of the gut microbiome to produce endocrine molecules from endogenous and exogenous steroids in the mammalian gut. The affinity of secondary bile acid metabolites to host nuclear receptors is described, the potential of secondary bile acids to promote tumors, and the potential of bile acids to serve as therapeutic agents are discussed. | Jason M.Ridlon Jasmohan S.Bajaj | 2015 | Acta Pharmaceutica Sinica B2015，5，2： | 14 |
| 3 | Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation显示文摘 | Jasmohan S. Bajaj Phillip B. Hylemon Jason M. Ridlon Douglas M. Heuman Kalyani Daita Melanie B. White Pamela Monteith Nicole A. Noble Masoumeh Sikaroodi Patrick M. Gillevet | 2012 | AJP: Gastrointestinal and Liver Physiology2012，，6： | 3 |
| 4 | Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver显示文摘 | Hendrik Vilstrup Piero Amodio Jasmohan Bajaj Juan Cordoba Peter Ferenci Kevin D. Mullen Karin Weissenborn Philip Wong | 2014 | Hepatology2014，，2： | 2 |
| 5 | Antibiotics for the treatment of hepatic encephalopathy显示文摘 | Kavish R. Patidar Jasmohan S. Bajaj | 2013 | Metabolic Brain Disease2013，，2： | 2 |
| 6 | Effects of N ‐acetylcysteine on cytokines in non‐acetaminophen acute liver failure: potential mechanism of improvement in transplant‐free survival显示文摘 | R. Todd Stravitz Arun J. Sanyal Joan Reisch Jasmohan S. Bajaj Farid Mirshahi Jenfeng Cheng William M. Lee | 2013 | Liver Int2013，，9： | 2 |
| 7 | Cirrhosis, bile acids and gut microbiota显示文摘 | Jason M Ridlon Joao Marcelo Alves Phillip B Hylemon Jasmohan S Bajaj | 2013 | Gut Microbes2013，，5： | 1 |
| 8 | Rifaximin Improves Driving Simulator Performance in a Randomized Trial of Patients With Minimal Hepatic Encephalopathy显示文摘 | Jasmohan S. Bajaj Douglas M. Heuman James B. Wade Douglas P. Gibson Kia Saeian Jacob A. Wegelin Muhammad Hafeezullah Debulon E. Bell Richard K. Sterling R. Todd Stravitz Michael Fuchs Velimir Luketic Arun J. Sanyal | 2011 | Gastroenterology2011，，2： | 1 |
| 9 | Assessment of Minimal Hepatic Encephalopathy (with Emphasis on Computerized Psychometric Tests)显示文摘 | Matthew R. Kappus Jasmohan S. Bajaj | 2012 | Clinics in Liver Disease2012，，1： | 1 |
| 10 | Prospective, Randomized Trial Comparing Effect of Oral Versus Intravenous Pantoprazole on Rebleeding After Nonvariceal Upper Gastrointestinal Bleeding: A Pilot Study显示文摘 | Jasmohan S. Bajaj Kulwinder S. Dua Kristin Hanson Kenneth Presberg | 2007 | Digestive Diseases and Sciences2007，，9： | 1 |
| 11 | Defining Acute-on-Chronic Liver Failure: Will East and West Ever Meet?显示文摘 | Jasmohan S. Bajaj | 2013 | Gastroenterology2013，，7： | 1 |
| 12 | Correction of hyponatraemia improves cognition, quality of life, and brain oedema in cirrhosis显示文摘 | Vishwadeep Ahluwalia Douglas M. Heuman George Feldman James B. Wade Leroy R. Thacker Edith Gavis HoChong Gilles Ariel Unser Melanie B. White Jasmohan S. Bajaj | 2014 | Journal of Hepatology2014，，： | 1 |
| 13 | Impact of Clostridium difficile on Inflammatory Bowel Disease显示文摘 | Mazen Issa Aravind Vijayapal Mary Beth Graham Dawn B. Beaulieu Mary F. Otterson Sarah Lundeen Susan Skaros Lydia R. Weber Richard A. Komorowski Josh F. Knox Jeanne Emmons Jasmohan S. Bajaj David G. Binion | 2007 | Clinical Gastroenterology and Hepatology2007，，3： | 1 |
| 14 | Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis<!-- Doctopic: CIRR -->显示文摘 | Vishwadeep Ahluwalia James B. Wade Leroy Thacker Kenneth A. Kraft Richard K. Sterling R. Todd Stravitz Michael Fuchs Iliana Bouneva Puneet Puri Velimir Luketic Arun J. Sanyal HoChong Gilles Douglas M. Heuman Jasmohan S. Bajaj | 2013 | Journal of Hepatology2013，，： | 1 |
| 15 | Hepatic En-cephalopathy in Chronic Liver Disease:2014 Practice Guideline by the American Association for the Study of Liver Diseases and the Eu- ropean Association for the Study of the Liver显示文摘 | Hendrik Vilstrup Piero Amodio Jasmohan Bajaj | 2014 | Hepatology2014，60，2： | 1 |
| 16 | Persistence of Cognitive Impairment After Resolution of Overt Hepatic Encephalopathy显示文摘 | Jasmohan S. Bajaj Christine M. Schubert Douglas M. Heuman James B. Wade Douglas P. Gibson Allyne Topaz Kia Saeian Muhammad Hafeezullah Debulon E. Bell Richard K. Sterling R. Todd Stravitz Velimir Luketic Melanie B. White Arun J. Sanyal | 2010 | Gastroenterology2010，，7： | 1 |
| 17 | Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis显示文摘 | Vishwadeep Ahluwalia James B. Wade Leroy Thacker Kenneth A. Kraft Richard K. Sterling R. Todd Stravitz Michael Fuchs Iliana Bouneva Puneet Puri Velimir Luketic Arun J. Sanyal HoChong Gilles Douglas M. Heuman Jasmohan S. Bajaj | 2013 | Journal of Hepatology2013，，3： | 1 |
| 18 | Bacterial infec- tions in end-stage liver disease: current challenges and fu- ture directions 显示文摘 | Jasmohan SB Jacqueline G O'Leary | 2012 | GUT2012，21，61： | 1 |
| 19 | Bacterial infections in end-stage liver disease: current challenges and future directions显示文摘 | Jasmohan S Bajaj Jacqueline G O’Leary Florence Wong K Rajender Reddy Patrick S Kamath | 2012 | Gut2012，，8： | 1 |
| 20 | Supplementation of Saturated Long-chain Fatty Acids Maintains Intestinal Eubiosis and Reduces Ethanol-induced Liver Injury in Mice显示文摘 | Peng Chen Manolito Torralba Justin Tan Mallory Embree Karsten Zengler Peter St?rkel Jan-Peter van Pijkeren Jessica DePew Rohit Loomba Samuel B. Ho Jasmohan S. Bajaj Ece A. Mutlu Ali Keshavarzian Hidekazu Tsukamoto Karen E. Nelson Derrick E. Fouts Bernd Sc | 2014 | Gastroenterology2014，，： | 1 |
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