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| 1 | Treatment of retinopathy of prematurity: a review of conventional and promising new therapeutic options显示文摘Retinopathy of prematurity (ROP), a retinal vascular disease of premature infants, continues to be a major cause of preventable childhood blindness all over the world. The incidence of ROP varies among countries, being influenced by the quality of the level of neonatal intensive care. Here, we discuss the potential treatments that are now available or will soon or probably be available for ROP. Although ablation of the avascular retina with laser photocoagulation remains the current gold standard and well established therapy for ROP, some new therapeutic options including angiostatic therapies are being explored based on our knowledge of the pathophysiology of the ROP and complications and efficacy of laser treatment. However, prevention of the development of severe ROP and screening for ROP seem to be the best strategy in avoiding visual impairment caused by ROP in premature infants. New therapeutic interventions including vascular endothelial growth factor antibody administration, gene therapy and supplemental therapies should be supported with evidence-based data for the treatment of ROP. | Fatih Mehmet Mutlu Umit Serdar Sarici | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 11 |
| 2 | Clinical outcomes of 25-gauge vitrectomy surgery for vitreoretinal diseases: comparison of vitrectomy alone and phaco-vitrectomy显示文摘AIM: To compare the clinical outcomes of combined25-gauge pars plana vitrectomy(PPV) and phacoemulsification/posterior chamber intraocular lens(PC-IOL) implantation with vitrectomy alone surgery in patients with various vitreoretinal diseases.METHODS: A total of 306 eyes(145 with PPV alone and 161 with phaco-vitrectomy) were enrolled in this retrospective analysis. The surgical approach was 25-gauge PPV combined with phacoemulsification and PC-IOL implantation at the same time in eyes in phaco-vitrectomy group and only PPV in eyes in vitrectomy alone surgery group. The main outcome measures were postoperative clinical outcomes included anterior chamber inflammation, changes in intraocular pressure(IOP) and best corrected visual acuity(BCVA).RESULTS: The most common postoperative complication was anterior chamber reaction which has higher incidence in phaco-vitrectomy group(P <0.001).The mean postoperative 1^(st) day IOP of vitrectomy alone group was significantly lower than that of phaco-vitrectomy group(16.3 ±5.8 mm Hg vs 17.8 ±8.1 mm Hg,respectively, P =0.02). Hypotony(IOP(8 mm Hg) was not different between groups in the postoperative 1^(st) day(P >0.05). The mean preoperative visual acuity was not different between groups(1.6±0.9 log MAR vs 1.8±0.9 log MAR,respectively, P >0.05). However, the mean visual acuity was decreased in vitrectomy alone group at the final visit compared to phaco-vitrectomy group(1.2 ±0.8 log MAR,0.9±0.7 log MAR, respectively P <0.05).CONCLUSION: Twenty-five gauge PPV combined with phacoemulsification surgery is a safe and efficient procedure, which can be preferred in phacic patients with a variety of vitreoretinal diseases compared to vitrectomy alone. Despite improved outcomes, this approach is not free of limitations as anterior chamber complications especially with combined surgery. | Mucella Arikan Yorgun Yasin Toklu Melek Mutlu Umut Ozen | 2016 | International Journal of Ophthalmology(English edition)2016，9，8： | 10 |
| 3 | Diffusion-weighted and diffusion-tensor imaging of normal and diseased uterus显示文摘Owing to technical advances and improvement of the software, diffusion weighted imaging and diffusion tensor imaging(DWI and DTI) greatly improved the diagnostic value of magnetic resonance imaging(MRI) of the pelvic region. These imaging sequences can exhibit important tissue contrast on the basis of random diffusion(Brownian motion) of water molecules in tissues. Quantitative measurements can be done with DWI and DTI by apparent diffusion coefficient(ADC) and fractional anisotropy(FA) values respectively. ADC and FA values may be changed by various physiological and pathological conditions providing additional information to conventional MRI. The quantitative DWI assists significantly in the differentiation of benign and malignant lesions. It can demonstrate the microstructural architecture and celluler density of the normal and diseased uterine zones. On the other hand, DWI and DTI are useful for monitoring the treatment outcome of the uterine lesions. In this review, we discussed advantages of DWI and DTI of the normal and diseased uterus. | Duygu Kara Bozkurt Murat Bozkurt Mehmet Ali Nazli Ilhan Nahit Mutlu Ozgur Kilickesmez | 2015 | World Journal of Radiology2015，7，7： | 9 |
| 4 | Inpatient capsule endoscopy leads to frequent incomplete small bowel examinations显示文摘AIM:To examine the predictive factors of capsule endoscopy(CE) completion rate(CECR) including the effect of inpatient and outpatient status.METHODS:We identified 355 consecutive patients who completed CE at Rush University Medical Center between March 2003 and October 2005.Subjects for CE had either nothing by mouth or clear liquids for the afternoon and evening of the day before the procedure.CE exams were reviewed by two physicians who were unaware of the study hypotheses.After retrospective analysis,21 cases were excluded due to capsule malfunction,prior gastric surgery,endoscopic capsule placement or insufficient data.Of the remaining 334 exams [264 out-patient(OP),70 in-patient(IP)],CE indications,findings,location of the patients [IP vs OP and intensive care unit(ICU) vs general medical floor(GMF)] and gastrointestinal transit times were analyzed.Statistical analysis was completed using SPSS version 17(Chicago,IL).Chi-square,t test or fisher exact-tests were used as appropriate.Multivariate logistic regression analysis was used to identify variables associated with incomplete CE exams.RESULTS:The mean age for the entire study population was 54.7 years.Sixty-one percent of the study population was female,and gender was not different between IPs vs OPs(P = 0.07).The overall incomplete CECR was 14% in our study.Overt obscure gastrointestinal bleeding(OGB) was a significantly more common indication for the IP CE(P = 0.0001),while abdominal pain and assessment of IBD were more frequent indications for the OP CE exams(P = 0.002 and P = 0.01,respectively).Occult OGB was the most common indication and arteriovenous malformations were the most common finding both in the IPs and OPs.The capsule did not enter the small bowel(SB) in 6/70 IPs and 8/264 OPs(P = 0.04).The capsule never reached the cecum in 31.4%(22/70) of IP vs 9.5%(25/264) of OP examinations(P < 0.001).The mean gastric transit time(GTT) was delayed in IPs compared to OPs,98.5 ± 139.5 min vs 60.4 ± 92.6 min(P = 0.008).Minimal SB transit time was significantly prolonged in the IP compared to the OP setting [IP = 275.1 ±111.6 min vs OP = 244.0 ± 104.3 min(P = 0.037)].CECR was also significantly higher in the subgroup of patients with OGB who had OP vs IP exams(95% vs 80% respectively,P = 0.001).The proportion of patients with incomplete exams was higher in the ICU(n = 7/13,54%) as compared to the GMF(n = 15/57,26%)(P = 0.05).There was only a single permanent SB retention case which was secondary to a previously unknown SB stricture,and the remaining incomplete SB exams were due to slow transit.Medications which affect gastrointestinal system motility were tested both individually and also in aggregate in univariate analysis in hospitalized patients(ICU and GMF) and were not predictive of incomplete capsule passage(P > 0.05).Patient location(IP vs OP) and GTT were independent predictors of incomplete CE exams(P < 0.001 and P = 0.008,respectively).CONCLUSION:Incomplete CE is a multifactorial problem.Patient location and related factors such as severity of illness and sedentary status may contribute to incomplete exams. | Cemal Yazici John Losurdo Michael D Brown Scott Oosterveen Robert Rahimi Ali Keshavarzian Leila Bozorgnia Ece Mutlu | 2012 | World Journal of Gastroenterology2012，18，36： | 6 |
| 5 | Influence of Fluoride Content of Artificial Saliva on Metal Release from 17-4 PH Stainless Steel Foam for Dental Implant Applications显示文摘Highly porous 17-4 PH stainless steel foam for implant applications was produced by space holder technique. Metal release and weight loss from 17-4 PH stainless steel foams were investigated in fluoride added artificial saliva environment by static immersion test.An inductively coupled plasma-mass spectrometer was employed to measure the concentrations of various metal ions.Effects of fluoride content of artificial saliva on metal release and weight loss from the steel foams were investigated.Effects of immersion time,pH value and process parameters on the weight loss and metal release were determined.Pore morphology,pore size and mechanical properties of the 17-4 PH stainless steel foams were also characterized. | Ilven Mutlu Enver Oktay | 2013 | Journal of Materials Science & Technology2013，29，6： | 6 |
| 6 | 组织工程用Mg-Ca-Zn-Co合金泡沫的制备及氟化处理显示文摘以尿素为造孔剂,利用基于粉末冶金法的'造孔剂-水浸出'法制备可用于骨组织工程的多孔Mg-Ca-Zn-Co合金支架。并研究合金浸泡在氟化氢(HF)溶液中进行表面氟化处理对合金耐腐蚀性能的影响。结果表明,随着Zn含量的增加,合金的弹性模量提高。Ca的添加可以阻止烧结过程中样品的氧化。合金在模拟体液中的电化学腐蚀行为的研究表明,当Zn含量从1.0%增加到3.0%时,合金的腐蚀率和质量损失都先减小,随着Zn含量的进一步增加,合金的腐蚀率和质量损失而后增大。氟化处理后合金表面形成了氟化物涂层,提高了合金的耐腐蚀性。 | Ilven MUTLU | 2018 | Transactions of Nonferrous Metals Society of China2018，28，1： | 3 |
| 7 | Efficient adsorption of Th(Ⅳ)from aqueous solution by modified SBA-15 mesoporous silica显示文摘A very effective adsorbent for thorium has been obtained by modification of Santa Barbara Amorphous(SBA-15) using the chelating agent thenoyltrifluoroacetone(TTA).The prepared adsorbent(SBA-15-TTA) was characterized using scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FT-IR),surface area,porosity,and zeta potential analyses.We investigated the factors affecting Th(IV) adsorption on TTA-SBA-15,such as initial p H,contact time,temperature,and initial metal concentration.The effective initial p H for adsorption was found to be 4.The binding sites on TTA-SBA-15 adsorbent were saturated using an initial Th(IV) concentration of 100 mg L-1.The Dubinin–Radushkevich isotherm suggested a strong chemical interaction between adsorbent and adsorbate.Contact time and temperature had no significant effect on the adsorption.Therefore,the studies show that TTA-SBA-15 is a promising adsorbent to treat Th(IV)-contaminated effluents. | Mutlu Gok Senol Sert Gulcin Ozevci Meral Eral | 2018 | Nuclear Science and Techniques2018，29，7： | 3 |
| 8 | Post-procedure Elevated Amylase and Lipase Levels After Double-Balloon Enteroscopy: Relations with the Double-Balloon Technique显示文摘 | Cengiz Pata Umit Akyüz Yusuf Erzin Nilgun Mutlu Arzu Mercan Ahmet Dirican | 2010 | Digestive Diseases and Sciences2010，，7： | 3 |
| 9 | Intraocular pressure-lowering effects of commonly used fixed combination drugs with timolol in the management of primary open angle glaucoma显示文摘AIM:To evaluate intraocular pressure(IOP)-lowering effect and ocular tolerability of brimonidine/timolol,dorzolamide/timolol and latanoprost/timolol fixed combination therapies in the management of primary open angle glaucoma.· METHODS:Each drug was administered for two months, after which a circadian tonometric curve was recorded using a Goldmann applanation tonometer.Ocular discomfort(conjunctival hyperemia, burning or stinging, foreign body sensation, itching, ocular pain) of each eye was assessed by the subject on a standardized ocular discomfort scale.RESULTS:Among the three study groups, there were no significant differences in the mean baseline IOP measurements, mean 2ndmo IOP measurements, and mean(%) change of IOPs from baseline. Among the three study groups, there were no significant differences in the mean IOP measurements obtained at circadian tonometric curves at baseline and at two months controls. In sum brimonidine/timolol, dorzolamide/timolol and latanoprost/timolol fixed combination therapies showed similar effects on IOP levels.· CONCLUSION:Brimonidine/timolol, dorzolamide/timolol and latanoprost/timolol fixed combination therapies showed similar lowering efficaties on IOP levels whereas there was no any difference between each other. | Murat Atabey Ozer Mutlu Acar Cem Yildirim | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 3 |
| 10 | Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease显示文摘 | Cem Aygun Omer Senturk Saadettin Hulagu Suleyman Uraz Altay Celebi Tolga Konduk Birsen Mutlu Zeynep Canturk | 2006 | European Journal of Gastroenterology & Hepatology2006，，2： | 2 |
| 11 | TNF inhibitors to treat ulcerative colitis in a metastatic breast cancer patient:A case report and literature review显示文摘Adalimumab(ADA)is a tumor necrosis factor(TNF)inhibitor,used for the treatment of inflammatory bowel disease.Previous studies have reported an increased risk of cancer following exposure to TNF inhibitors,but little has been reported for patients with cancer receiving TNF-inhibitor treatment.We present a female patient with metastatic breast cancer and ulcerative colitis(UC)who was treated with ADA.A 54-year-old African American female with a past history of left-sided breast cancer(BC)diagnosed at age 30 was initially treated with left-breast lumpectomy,axillary dissection,followed by chemotherapy and radiation therapy.Years after initial diagnosis,she developed recurrent,bilateral BC and had bilateral mastectomy.Subsequent restaging computed tomography(CT)scan demonstrated distant metastases to the bone and lymph nodes.Three years into her treatment of metastatic breast cancer,she was diagnosed with UC by colonoscopy.Her UC was not controlled for 5 mo with 5-aminosalicylates.Subcutaneous ADA was started and resulted in dramatic improvement of UC.Four months after starting ADA,along with ongoing chemotherapy,restaging CT scan showed resolution of the previously seen metastatic lymph nodes.Bone scan and follow-up positron emission tomography/CT scans performed every 6 mo indicated the stability of healed metastatic bone lesions for the past 3 years on ADA.While TNF-αinhibitors could theoretically promote further metastases in patients with prior cancer,this is the first report of a patient with metastatic breast cancer in whom the cancer has remained stable for 3 years after ADA initiation for UC. | Ruwaida Ben Musa Lydia Usha John Hibbeln Ece A Mutlu | 2014 | World Journal of Gastroenterology2014，20，19： | 2 |
| 12 | Hepatitis B vaccination in patients with inflammatory bowel disease显示文摘AIM:To determine the prevalence for hepatitis B virus(HBV) and HBV screening and vaccination practices for inflammatory bowel disease(IBD).METHODS:This study is a retrospective,cross-sectional observational study.A retrospective chart review was performed in 500 patients who have been consecutively treated for IBD between September 2008 and January 2013 at the Rush University Medical Center Gastroenterology section.The patients were identified through the electronic medical record with the criteria that they attended the gastroenterology clinic,and that they had a diagnosis of IBD at the time of visit discharge.Once identified,each record was analyzed to determine whether the subject had been infected with HBV in the past,already been vaccinated against HBV,or advised to get vaccinated and followed through with the recommended vaccination.RESULTS:About 254 out of 500 patients(51%) had HBV screening ordered.Among those ordered to have screening tests,86% followed through with HBV serology.Gastroenterology physicians had significantly different screening ratios from each other(P < 0.001).There were no significant differences in the ratios of HBV screening when IBD specialists were compared to other gastroenterology physicians(0.505 ± 0.023 vs 0.536 ± 0.066,P = 0.66).Of those 220 patients screened,51% of IBD patients were found not to be immune against HBV.Approximately 50% of gastroenterology physicians recommended HBV vaccinations to their patients in whom serology was negative for antibodies against HBV.IBD specialists recommended vaccinations to a higher percentage of their patients compared to other gastroenterology physicians(0.168 ± 0.019 vs 0.038 ± 0.026,P = 0.015).Present and/or past HBV infection was found in 3.6% of the patients who had serology checked.There was no statistically significant difference in the prevalence of hepatitis B surface antigen(HBsAg) between our study and that reported in previous studies done in Spain(4/220 vs 14/2076 respectively,P = 0.070); and in France(4/220 vs 3/315 respectively,P = 0.159).But,the prevalence of anti-HBcAb in this study was less than that reported in the study in Spain(7/220 vs 155/2076 respectively,P = 0.006); and was not sig-nificantly different from that reported in the study in France(7/220 vs 8/315 respectively,P = 0.313).CONCLUSION:The prevalence of HBsAg in our IBD patients was not higher than previously reported European studies.Most IBD patients are not routinely screened or vaccinated against HBV at a tertiary referral center in the United States. | Ruwaida Ben Musa Anuhya Gampa Sanjib Basu Ali Keshavarzian Garth Swanson Michael Brown Rana Abraham Keith Bruninga John Losurdo Mark DeMeo Sohrab Mobarhan David Shapiro Ece Mutlu | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 13 | Comment on survival analysis following early surgical success in intermittent exotropia surgery显示文摘Dear Editor,W e read the article by Lee et al^([1])with great interest.We would like to congratulate the authors for venturing into this area that assess the consecutive recurrence following early success of intermittent exotropia[X(T)]surgery and to determine the clinical factors that affect the survival.However,we would like to make the following comments.In the present study,it was discussed about the correlation of early postoperative overcorrection with long-term outcomes.It is known that most authors would agree to an early postoperative overcorrection in adult patients with X(T)。 | Onder Ayyildz Gokhan Ozge Cem Ozgonul Gokcen Gokce Fatih Mehmet Mutlu | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 2 |
| 14 | 前房注射头孢呋辛对术后眼内炎的预防作用(英文)显示文摘目的:研究前房注射头孢呋辛对术后眼内炎的预防作用。方法:回顾性研究6 099例行超声乳化白内障手术的年龄相关性白内障患者。对照组,2001-10/2004-05,3 075例3 075眼行白内障手术未用眼内抗生素,实验组,2004-06/2007-04,3 024例3 024眼术中前房用0.1mL含1mg的头孢呋辛。两组的术前预防措施和手术步骤相同。结果:对照组和实验组分别有13(0.42%)和4(0.13%)例患者发生术后眼内炎[P=0.031;OR =3.20(1.04-9.84)]。两组发生术后眼内炎的平均时间分别是术后30(3 ~75)d和25(2 ~35)d(P=0.35)。研究细菌感染,实验组,烟曲菌和铜绿假单胞菌对头孢呋辛耐药,而肺炎链球菌对头孢呋辛敏感。未发现前房运用头孢呋辛的毒性和过敏性症状。结论:预防性前房运用头孢呋辛是安全的,可以预防术后细菌性眼内炎。然而抗生素抗菌谱窄和抗生素耐药性的可能性需要考虑。 | Güngr Sobaci Yusuf Uysal Fatih M Mutlu Atilla Bayer Rιza Gungor Suat Karagul | 2009 | 国际眼科杂志2009，9，8： | 2 |
| 15 | Distal humeral coronal plane fractures: management, complications and outcome显示文摘 | Mehmet Oguz Durakbasa Gurkan Gumussuyu Mutlu Gungor Mehmet Nurullah Ermis | 2012 | Journal of Shoulder and Elbow Surgery2012，，： | 2 |
| 16 | Effect of colouring green stage zirconia on the adhesion of veneering ceramics with different thermal expansion coefficients显示文摘This study evaluated the adhesion of zirconia core ceramics with their corresponding veneering ceramics, having different thermal expansion coefficients(TECs), when zirconia ceramics were coloured at green stage. Zirconia blocks(N5240; 6 mm37 mm37 mm) were manufactured from two materials namely, ICE Zirconia(Group 1) and Prettau Zirconia(Group 2). In their green stage, they were randomly divided into two groups. Half of the specimens were coloured with colouring liquid(shade A2). Three different veneering ceramics with different TEC(ICE Ceramic, GC Initial Zr and IPS e.max Ceram) were fired on both coloured and non-coloured zirconia cores. Specimens of high noble alloys(Esteticor Plus) veneered with ceramic(VM 13)(n516) acted as the control group. Core–veneer interface of the specimens were subjected to shear force in the Universal Testing Machine(0.5 mm?min21). Neither the zirconia core material(P50.318) nor colouring(P50.188) significantly affected the results(three-way analysis of variance, Tukey's test). But the results were significantly affected by the veneering ceramic(P50.000). Control group exhibited significantly higher mean bond strength values(45.768) MPa than all other tested groups((27.164.1)2(39.764.7) and(27.465.6)2(35.964.7) MPa with and without colouring, respectively)(P,0.001). While in zirconia–veneer test groups, predominantly mixed type of failures were observed with the veneering ceramic covering,1/3 of the substrate surface, in the metal–ceramic group, veneering ceramic was left adhered.1/3 of the metal surface. Colouring zirconia did not impair adhesion of veneering ceramic, but veneering ceramic had a significant influence on the core–veneer adhesion. Metal–ceramic adhesion was more reliable than all zirconia–veneer ceramics tested. | Guliz Aktas Erdal Sahin Pekka Vallittu Mutlu zcan Lippo Lassila | 2013 | International Journal of Oral Science2013，5，4： | 2 |
| 17 | Evaluation of penile hemodynamic status and adjustment of treatment alternatives in Peyronie's disease显示文摘Aim:Erectile dysfunction may be observed in up to 80%of patients with Peyronis's disease.An objective evaluation of the erectile function is attempted to work out in patients with Peyronie's disease.Methods:Penile deformity,sexual function and penile vascular status were analyzed in 123patients with Peyronis's disease,who had not received any pertinent treatment.Results:Penile edformity,palpable plaque and pain on erection were seen in112(91%),97(78.8%)and27(21.9%)of the123patients,respectively.Of the 76patients evaluated by color Doppler ultrasounography,veno-occlusive dysfunction as the vascular component for erectile dysfunction was found in 17(22.3%),arterial insufficiency in10(13.1%)and a mixed picture in 23(30.2%).Conclusion:The documentation of penile erectile function and the determination of the vascular status using color Doppler ultrasonography can guide the appropriate therapeutic choice. | Tibet Erdogru Murat Savas Namik Yilmaz Mustafa Faruk Usta Turker Koksal Mutlu Ates Mehmet Baykara | 2002 | Asian Journal of Andrology2002，4，3： | 2 |
| 18 | Mechanisms of pulmonary edema clearance显示文摘 | Mutlu G M Sznajder J I | 2005 | Am J Physiol Lung Cell Mol Physiol2005，289，5： | 1 |
| 19 | Severe status asthmaticus:management with permissive hypercapnia and inhalation anesthesia显示文摘 | Mutlu GM Factor P Schwartz DE | 2002 | Crit Care Med2002，30，2： | 1 |
| 20 | Hierarchiesl modeling of availability in distributed systems显示文摘 | Salim Hariri Hasan Mutlu | 1995 | IEEE Trans on Software Engineering1995，21，1： | 1 |
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