|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Spatial patterns of plant diversity and communities in Alpine ecosystems of the Hengduan Mountains, northwest Yunnan, China显示文摘Aims Conduct a quantitative,but rapid,regional-level assessment of the alpine flora across northwest Yunnan(NWY)to provide a broadbased understanding of local and regional patterns of the composition,diversity and health of alpine ecosystems across NWY.Methods A stratified random sampling design was employed to select sites across the different mountain ranges of NWY.Vegetation was sampled by stratifying each site by the three major alpine vegetation community types:meadow,dwarf shrub and scree.Two 50-m transects were randomly located within each community type at each sampling site with 101-m^(2) subplots systematically placed along each transect.Environmental variables were recorded at each transect.Multivariate analyses were used to classify the major plant community assemblages and link community patterns to environmental and habitat variables.Important Findings Forb species richness varied from 19 to 105 species per site(21 sites total)with an average of 59 species per site(60 m^(2) sampled per site).Most species were patchily distributed with narrow distributions and/or small population sizes;over half the species occurred at only one or two sites.Distinct species assemblages were identified in the meadow vegetation that was strongly aggregated by geographic location suggesting the presence of distinct phytogeographic zones of the meadow alpine flora.Elevation and geographic location were the dominant environmental gradients underlying the variations in species composition.Jaccard’s coefficient of similarity averaged only 10%among sites indicating there was little similarity in the alpine flora across the region.The alpine vegetation is highly heterogeneous across the complex landscape of the Hengduan Mountains of NWY.Conservation strategies need to take into account the large geographic differences in the flora to maximize protection of biodiversity. | Ruth Sherman Renee Mullen Li Haomin Fang Zhendong Wang Yi | 2008 | Journal of Plant Ecology2008，1，2： | 20 |
| 2 | Hepatic encephalopathy—Definition, nomenclature, diagnosis, and quantification: Final report of the Working Party at the 11th World Congresses of Gastroenterology, Vienna, 1998显示文摘 | Peter Ferenci Alan Lockwood Kevin Mullen Ralph Tarter Karin Weissenborn Andres T. Blei | 2002 | Hepatology2002，，3： | 10 |
| 3 | Polycyclic aromatic hydrocarbons in the graphene era显示文摘Polycyclic aromatic hydrocarbons(PAHs) have been the subject of interdisciplinary research in the fields of chemistry, physics,materials science, and biology. Notably, PAHs have drawn increasing attention since the discovery of graphene, which has been regarded as the 'wonder' material in the 21 st century. Different from semimetallic graphene, nanoscale graphenes, such as graphene nanoribbons and graphene quantum dots, exhibit finite band gaps owing to the quantum confinement, making them attractive semiconductors for next-generation electronic applications. Researches based on PAHs and graphenes have expanded rapidly over the past decade, thereby posing a challenge in conducting a comprehensive review. This study aims to interconnect the fields of PAHs and graphenes, which have mainly been discussed separately. In particular, by selecting representative examples, we explain how these two domains can stimulate each other. We hope that this integrated approach can offer new opportunities and further promote synergistic developments in these fields. | Xiao-Ye Wang Xuelin Yao Klaus Mullen | 2019 | Science China Chemistry2019，62，9： | 9 |
| 4 | LRIF1 interacts with HPla to coordinate accurate chromosome segregation during mitosis显示文摘Heterochromatin protein 1α (HP1α)regulates chromatin specification and plasticity during cell fate decision.Different structural determinants account for HP1α Localization and function during cell division cycle.Our earlier study showed that centromeric Localization of HP1α depends on the epigenetic mark H3K9me3 in interphase,while its centromeric location in mitosis relies on uncharacterized PXVXL-containing factors.Here,we identified a PXVXL-containing protein,Ligand-dependent nuclear receptorinteracting factor 1 (LRIF1),which recruits HPla to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during mitosis.LRIF1 interacts directly with HPla chromoshadow domain via an evolutionariLy conserved PXVXL motif within its C-terminus.Importantly,the LRIF1-HPla interaction is critical for Aurora B activity in the inner centromere.Mutation of PXVXL motif of LRIF1 Leads to defects in HPla centromere targeting and aberrant chromosome segregation.These findings reveal a previously unrecognized direct Link between LRIF1 and HP1α in centromere plasticity control and illustrate the critical role of LRIF1-HP1α interaction in orchestrating accurate cell division. | Saima Akram Fengrui Yang Junying Li Gregory Adams Yingying Liu Xiaoxuan Zhuang Lingluo Chu Xu Liu Nerimah Emmett Winston Thompson McKay Mullen Saravana Muthusamy Wenwen Wang Fei Mo Xing Liu | 2018 | Journal of Molecular Cell Biology2018，10，6： | 5 |
| 5 | Hepatic Insufficiency and Mortality in 1,059 Noncirrhotic Patients Undergoing Major Hepatectomy显示文摘 | John T. Mullen Dario Ribero Srinevas K. Reddy Matteo Donadon Daria Zorzi Shiva Gautam Eddie K. Abdalla Steven A. Curley Lorenzo Capussotti Bryan M. Clary Jean-Nicolas Vauthey | 2007 | Journal of the American College of Surgeons2007，，5： | 4 |
| 6 | Early pancreatic cancer in Ig G4-related pancreatic mass:A case report显示文摘BACKGROUND IgG4-related disease can manifest diversely,including autoimmune pancreatitis and IgG4-related cholangiopathy.We are reporting a very unusual cause of pancreatic cancer triggered in a previously unknown IgG4-related disease.CASE SUMMARY A 75-year-old man was diagnosed with a 43 mm×33 mm pancreatic head tumor after consulting for abdominal pain and jaundice.A pancreaticoduodenectomy was carried out uneventfully,and the histopathology report showed an early stage of acinar-cell pancreatic cancer.The patient reconsulted on the 30th postoperative day with fever,jaundice and asthenia.Magnetic resonance cholangiopancreatography evidenced an extense bile duct stricture.A percutaneous biliary drainage proved to be ineffective,even after exchanging it with larger bore drainage.Reviewing the surgical specimen,features compatible with IgG4-related disease were observed.Consequently,empiric treatment with steroids was initiated achieving excellent results.CONCLUSION IgG4-related disease may cause chronic inflammation of the pancreas and can condition pancreatic malignancies. | Juan Glinka Francisco Calderón Martín de Santibanes Sung Ho Hyon Adrián Gadano Eduardo Mullen Melina Pol Juan Spina Eduardo de Santibanes | 2019 | World Journal of Gastrointestinal Surgery2019，11，12： | 3 |
| 7 | Acetytation of ACAP4 regutates CCL18-elicited breast cancer cell migration and invasion显示文摘Tumor metastasis represents the main causes of cancer-related death.Our recent study showed that chemokine CCL18 secreted from tumor-associated macrophages regulates breast tumor metastasis,but the underlying mechanisms remain less clear.Here, we show that ARF6 GTPase-activating protein ACAP4 regulates CCL18-elicited breast cancer cell migration via the acetyltransferase PCAF-mediated acetylation.CCL18 stimulation elicited breast cancer cell migration and invasion via PCAF-dependent acetylation.ACAP4 physically interacts with PCAF and is a cognate substrate of PCAF during CCL18 stimulation.The acetylation site of ACAP4 by PCAF was mapped to Lys311 by mass spectrometric analyses.Importantly,dynamic acetylation of ACAP4 is essential for CCL18-induced breast cancer cell migration and invasion,as overexpression of the persistent acetylation-mimicking or nonacetylatable ACAP4 mutant blocked CCL18-elicited cell migration and invasion.Mechanistically,the acetylation of ACAP4 at Lys311 reduced the lipid-binding activity of ACAP4 to ensure a robust and dynamic cycling of ARF6-ACAP4 complex with plasma membrane in response to CCL18 stimulation.Thus,these results present a previously undefined mechanism by which CCL18-elicited acetylation of the PH domain controls dynamic interaction between ACAP4 and plasma membrane during breast cancer cell migration and invasion. | Xiaoyu Song Wei Liu Xiao Yuan Jiying Jiang Wanjuan Wang McKay Mullen Xuannv Zhao Yin Zhang Fusheng Liu Shihao Du Adeel Rehman Ruijun Tian Jian Li Andra Frost Zhenwei Song Hadiyah-Nicole Green Calmour Henry Xing Liu Xia Ding Dongmei Wang Xuebiao Yao | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 8 | Alpine Ecosystems of Northwest Yunnan,China:an Initial Assessment for Conservation显示文摘Implementing conservation actions on-the-ground is not a straightforward process,especially when faced with high scientific uncertainty due to limited available information. This is especially acute in regions of the world that harbor many unique species that have not been well studied,such as the alpine zone of the Hengduan Mountains of Northwest Yunnan (NWY),a global biodiversity hotspot and site of The Nature Conservancy’s Yunnan Great Rivers Project. We conducted a quantitative,but rapid regional-level assessment of the alpine flora across NWY to provide a broad-based understanding of local and regional patterns of the alpine flora,the first large-scale analysis of alpine biodiversity patterns in this region. Multivariate analyses were used to classify the major plant community types and link community patterns to habitat variables. Our analysis indicated that most species had small distributions and/or small population sizes. Strong patterns emerged with higher diversity in the more northern mountains,but beta diversity was high,averaging only 10% among sites. The ordinations indicated that elevation and geographic location were the dominant environ-mental gradients underlying the differences in the species composition among communities. The high beta diversity across the alpine of these mountains implies that conservation strategies ultimately will require the protection of large numbers of species over a large geographical area. However,prioritiza-tion should be given to areas where potential payoffs are greatest. Sites with high species richness also have a greater number of endemic species,and,by focusing efforts on these sites,conservation investments would be maximized by protecting the greatest number of unique species. | Ruth Sherman Renee Mullen LI Haomin FANG Zhendong WANG Yi | 2007 | Journal of Mountain Science2007，4，3： | 3 |
| 9 | Mesenchymal Stem Cell and Islet Co-Transplantation Promotes Graft Revascularization and Function显示文摘 | Taihei Ito Shin Itakura Ivan Todorov Jeffrey Rawson Sadaki Asari Jonathan Shintaku Indu Nair Kevin Ferreri Fouad Kandeel Yoko Mullen | 2010 | Transplantation2010，，12： | 3 |
| 10 | Comparison between hepatic wedge resection and anatomic resection for colorectal liver metastases显示文摘 | Daria Zorzi M.D. John T. Mullen M.D. Eddie K. Abdalla M.D. Timothy M. Pawlik M.D. M.P.H. Axel Andres M.D. Andrea Muratore M.D. Steven A. Curley M.D. Gilles Mentha M.D. Lorenzo Capussotti M.D. Jean-Nicolas Vauthey M.D | 2006 | Journal of Gastrointestinal Surgery2006，，1： | 2 |
| 11 | Cascade弧北部平行海沟的地幔流:来自玄武岩的地球化学证据显示文摘俯冲带是研究地幔对流的重要窗口。二维模型显示,大洋板块俯冲时会因粘滞作用带动上覆地幔,诱发地幔楔流动。而三维空间中,地震波的各向异性、3D数值模拟及实验研究都显示,俯冲带地幔流动情况非常复杂。由于原始弧岩浆能代表地幔楔的组成,因此可以从弧岩浆地球化学性质的空间变化上直接反应地幔楔的流动模式。 | Mullen E K Weis D 夏群科 | 2015 | 矿物岩石地球化学通报2015，34，3： | 2 |
| 12 | Obesity, Visceral Fat, and NAFLD: Queryingthe Role of Adipokines in the Progression ofNonalcoholic Fatty Liver Disease显示文摘 | M. S. Mirza K. D. Mullen C. T. Shun W. Vogel | 2011 | ISRN Gastroenterology2011，，： | 2 |
| 13 | Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver显示文摘 | Hendrik Vilstrup Piero Amodio Jasmohan Bajaj Juan Cordoba Peter Ferenci Kevin D. Mullen Karin Weissenborn Philip Wong | 2014 | Hepatology2014，，2： | 2 |
| 14 | Space radiation effects program:an overview显示文摘 | Gussenhoven M S Mullen E G | | 0，，： | 2 |
| 15 | Rifaximin is Safe and Well Tolerated for Long-Term Maintenance of Remission From Overt Hepatic Encephalopathy显示文摘 | Kevin D. Mullen Arun J. Sanyal Nathan M. Bass Fred F. Poordad Muhammad Y. Sheikh R. Todd Frederick Enoch Bortey William P. Forbes | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 16 | Hepatic encephalopathy—Definition, nomenclature, diagnosis, and quantification: Final report of the Working Party at the 11th World Congresses of Gastroenterology, Vienna, 1998显示文摘 | Peter Ferenci Alan Lockwood Kevin Mullen Ralph Tarter Karin Weissenborn Andres T. Blei | 2002 | Hepatology2002，，3： | 2 |
| 17 | Warman Liquid crystalline coronene derivatives显示文摘 | Rohr U Kohl C Mullen K | 2001 | Materials Chemistry2001，11，7： | 1 |
| 18 | 显示文摘 | Mullen N Kyrou I | 2002 | J Clin Endocrinol Metab2002，87，10： | 1 |
| 19 | Viral oncolysis显示文摘 | Mullen JT Tanabe KK | 2002 | Oncolo- gist2002，7，2： | 1 |
| 20 | Hepatic encephalopathy 显示文摘 | Dasarathy S Mullen KD | 2001 | Curt Treat Options Gastroenterol2001，4，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员