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| 1 | Colorectal cancer screening: An updated review of the available options显示文摘Colorectal cancer(CRC) is a significant cause of morbidity and mortality worldwide. However,colon cancer incidence and mortality is declining over the past decade owing to adoption of effective screening programs. Nevertheless,in some parts of the world,CRC incidence and mortality remain on the rise,likely due to factors including 'westernized' diet,lifestyle,and lack of health-care infrastructure and resources. Participation and adherence to different national screening programs remain obstacles limiting the achievement of screening goals. Different modalities are available ranging from stool based tests to radiology and endoscopy with varying sensitivity and specificity. However,the availability of these tests is limited to areas with high economic resources. Recently,FDA approved a blood-based test(Epi procolon?) for CRC screening. This blood based test may serve to increase the participation and adherence rates. Hence,leading to increase in colon cancer detection and prevention. This article will discuss various CRC screening tests with a particular focus on the data regarding the new approved blood test. Finally,we will propose an algorithm for a simple cost-effective CRC screening program. | Iyad A Issa Malak Noureddine | 2017 | World Journal of Gastroenterology2017，23，28： | 49 |
| 2 | 多级分离缓冲马铃薯收获机设计与试验显示文摘针对云南山地黏土条件下马铃薯机械化收获分离效果差、明薯率低、伤薯率和破皮率较高等问题,采用多级分离振动、多重缓冲和低位侧铺的方式,设计了一种多级分离缓冲马铃薯收获机。在阐述机具整体结构及工作原理的基础上,通过理论计算确定了挖掘装置、多级分离缓冲装置、主动振动装置等主要关键部件的结构参数;建立抛送分离阶段薯土运动模型,获取微波浪形薯土分离相关技术特征;建立马铃薯筛面滑动模型,对薯块的运动特性进行理论分析,得出薯块顺流、回流的运动规律;分析土块在输送分离过程中的碰撞特性,确定了影响分离破碎效果的因素。以含杂率和土壤覆盖度为试验指标,采用二次旋转正交组合试验设计方法进行了空载试验,并利用高速摄影和三轴姿态传感器实时获取分离筛上土壤的分布状态和运动规律,结果表明,分离筛最佳工作参数组合为:一级分离筛线速度1.42 m/s、二级分离筛线速度2.2 m/s、侧输出线速度1 m/s,此时土壤覆盖度69.11%,含杂率2.56%。在分离筛最佳工作参数组合下,以明薯率、破皮率和伤薯率为试验指标进行了田间收获试验,结果表明:当工作速度1.05 m/s、挖掘深度180 mm、振动强度Ⅱ级、筛面倾角22°时,明薯率为99.1%、破皮率为1.41%、伤薯率为1.32%,各项性能指标均符合国家行业标准要求。 | 张兆国 王海翼 李彦彬 杨曦 IBRAHIM Issa 张振东 | 2021 | 农业机械学报2021，52，2： | 27 |
| 3 | Chylous ascites secondary to hyperlipidemic pancreatitis with normal serum amylase and lipase显示文摘A 54-year old man with a family history of hyperlipidemia was admitted with a 12 h history of severe generalized abdominal pain associated with nausea, vomiting and abdominal distension. Examination of the abdomen revealed tenderness in the periumblical area with shifting dullness. Serum pancreatic amylase was 29 IU/L and lipase 44 IU/L, triglyceride 36.28 mmol/L. Ultrasound showed ascites. CT of the abdomen with contrast showed inflammatory changes surrounding the pancreas consistent with acute pancreatitis. Ultrasound (US) guided abdomen paracentesis yielded a milky fluid with high triglyceride content consistent with chylous ascites. The patient was kept fasting and intravenous fluid hydration was provided. Meperidine was administered for pain relief. On the following days the patient’s condition improved and he was gradually restarted on a low-fat diet, and fat lowering agent (gemfibrozil) was begun, 600 mg twice a day. On d 14, abdomen US was repeated and showed fluid free peritoneal cavity. The patient was discharged after 18 d of hospitalization with 600 mg gemfibrozil twice a day. At the time of discharge, the fasting triglyceride was 4.2 mmol/L. After four weeks the patient was seen in the clinic, he was well. | Fahmi Yousef Khan Issa Matar | 2007 | World Journal of Gastroenterology2007，13，3： | 24 |
| 4 | 血液恶性肿瘤化疗后血流感染的病原菌分布及耐药情况分析显示文摘目的分析福建医科大学附属协和医院血液科血培养的病原菌分布及药敏情况,以了解临床真实世界血流感染状况,为临床合理使用抗菌药物提供依据。方法收集2013年1月至2016年12月福建医科大学附属协和医院血液科临床送检血培养阳性标本分离出的657株病原菌资料并对患者临床资料进行分析。结果657株血培养阳性菌株中,革兰阴性菌(G-菌)410株(62.4%),革兰阳性菌(G+菌)163株(24.8%),真菌50株(7.6%)。前五位的致病细菌分别为肺炎克雷伯菌(17.5%)、大肠埃希菌(17.2%)、凝固酶阴性葡萄球菌(cys)(14.9%),铜绿假单胞菌(14.2%)及金黄色葡萄球菌(3.5%)。G菌中肺炎克雷伯菌和大肠埃希菌产超广谱D内酰胺酶(ESBL)菌株的检出率分别为25.2%和55.8%,产ESBL菌株对抗菌药物的耐药率大多高于非产ESBL菌株。肠杆菌科细菌对碳青霉烯类抗生素、哌拉西林/他唑巴坦、替加环素的耐药率均在14%以下。非发酵菌中,铜绿假单胞菌对各种抗菌药物的耐药率均在12.0%以下;鲍曼不动杆菌对头孢克肟和头孢噻肟耐药率均为7.1%,未发现对替加环素耐药的鲍曼不动杆菌。CNS中84.7%(83/98)为耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)。金黄色葡萄球菌中43.5%(10/23)为耐甲氧西林金黄色葡萄球菌(MRSA)。未发现对万古霉素、利奈唑胺、替加环素耐药的G’菌。结论福建医科大学附属协和医院血液恶性肿瘤患者化疗后合并血流感染病原菌种类分布较广,以G-菌为主,耐药情况较严峻。临床上对怀疑有G’菌血液感染的患者可经验性选择万古霉素、利奈唑胺或替加环素抗感染治疗。 | 陈少桢 林康昵 肖敏 骆晓峰 李芊 任金华 黄若瑶 陈敏敏 Issa Hajji Ally 陈志哲 杨婷 胡建达 | 2017 | 中华血液学杂志2017，38，11： | 24 |
| 5 | Probiotics for antibiotic-associated diarrhea:Do we have a verdict?显示文摘Probiotics use has increased tremendously over the past ten years.This was coupled with a surge of data relating their importance in clinical practice.Antibioticassociated diarrhea,whose frequency has risen recently,was one of the earliest targets with data published more than ten years ago.Unfortunately,available trials suffer from severe discrepancies associated with variability and heterogeneity of several factors.Most published randomized controlled trials and subsequent meta-analyses suggest benefit for probiotics in the prevention of antibiotic-associated diarrhea.The same seems to also apply when the data is examined for Clostridium difficile-associated colitis.However,the largest randomized double-blind placebo-controlled trial to date examining the use of a certain preparation of probiotics in antibiotic-associated diarrhea showed disappointing results,but it was flawed with several drawbacks.The commonest species of probiotics studied across most trials is Lactobacillus;however,other types have also shown similar benefit.Probiotics have enjoyed an impeccable safety reputation.Despite a few reports of severe infections sometimes leading to septicemia,most of the available trials confirm their harmless behavior and show similaradverse events compared to placebo.Since a consensus dictating its use is still lacking,it would be advisable at this point to suggest prophylactic use of probiotics to certain patients at risk for antibiotic-associated diarrhea or to those who suffered previous episodes. | Iyad Issa Rami Moucari | 2014 | World Journal of Gastroenterology2014，20，47： | 17 |
| 6 | Mesenteric panniculitis: Various presentations and treatment regimens显示文摘Mesenteric panniculitis is a rare, benign and chronic f ibrosing inflammatory disease that affects the adipose tissue of the mesentery of the small intestine and colon. The specific etiology of the disease is unknown. The diagnosis is suggested by computed tomography and is usually confirmed by surgical biopsies. Treatment is empirical and based on a few selected drugs. Surgical resection is sometimes attempted for def initive therapy, although the surgical approach is often limited. We report two cases of mesenteric panniculitis with two different presentations and subsequently varying treatment regimens. Adequate response was obtained in both patients. We present details of these cases as well as a literature review to compare various presentations, etiologies and potential treatment modalities. | Iyad Issa Hassan Baydoun | 2009 | World Journal of Gastroenterology2009，15，30： | 12 |
| 7 | The effects of the rotor-stator interaction on unsteady pressure pulsation and radial force in a centrifugal pump显示文摘An unsteady numerical analysis has been conducted to study the strong interaction between impeller blade and volute tongue of a centrifugal pump. The 3-D-URANS equations were solved with the shear stress transport turbulence model for a wide range of flow rates. These unsteady interactions are mostly related to the unsteady radial force due to an imbalance in the pressure field at the impeller periphery. This force represents dynamic load that are one of the most important sources of vibration and hydraulic noise. Based on this phenomenon, this work analyzes and gives a more realistic prediction of the pressure fluctuation and the radial force during steady and unsteady calculation by considering the effect of the change in the pump operating point. Actually, the pressure fluctuations in the impeller and the volute were recorded by mounting nine monitoring points on the impeller and volute casing. The results of the existing analysis has proven that the pressure fluctuation is periodic due to the relative position of impeller blade to volute tongue. The characteristics of the time domain and frequency domain of the pressure pulsation were analyzed under different coupling conditions. Fast Fourier transform was performed to obtain the spectra of pressure pulsation. Besides, the steady and unsteady forces were calculated around the impeller periphery to fully characterize the pump behavior. The obtained pump performance curves were numerically compared with the experimental ones, and the outcome have shown an acceptable agreement between both curves. | Issa Chalghoum Sami Elaoud Hatem Kanfoudi Mohsen Akrout | 2018 | Journal of Hydrodynamics2018，30，4： | 12 |
| 8 | 丘陵山区小型马铃薯收获机设计与试验显示文摘针对中国西南丘陵山区马铃薯收获作业中存在的引进机型适用性低、明薯率低、伤薯率高、破皮较严重、机械化收获程度低的问题,设计一种适用于丘陵山区的小型马铃薯收获机,整机主要由三点悬挂装置、挖掘装置、激振式分离筛、多级振动调整装置、挖掘调整装置、变速箱、传动装置等组成。结合具体作业要求,对挖掘装置和升运分离装置进行参数确定和选型设计。挖掘铲为设有圆弧过渡曲面的二阶铲,增强了碎土剪切性能,提高了顺土能力。建立挖掘过程的挖掘装置阻力模型和运动学模型,并对挖掘装置进行有限元分析,得出挖掘装置的最大应变为5.05×10-8 m·m-1,最大应力为9327.7 Pa,最大变形为2.98×10-4 mm。建立马铃薯升运过程的运动学模型,对薯土混合物的运动形态进行分析,根据所计算的相关参数设计了二次正交旋转组合试验,分别对各试验指标进行响应曲面分析。发现影响明薯率的主要因素为作业速度和分离筛倾角,影响伤薯率的主要因素为作业速度和分离筛倾角,影响破皮率的最主要因素为入土角和分离筛倾角。田间试验结果表明:当作业速度为1.05 m·s-1,入土角为17°,分离筛倾角为15°时,试验条件下的明薯率为96.7%,伤薯率为1.3%,破皮率为1.5%,上述指标优于国家标准,符合马铃薯收获作业要求。 | 王海翼 张兆国 IBRAHIM Issa 解开婷 Wael EL-KOLALY 曹钦洲 | 2021 | 浙江农业学报2021，33，4： | 10 |
| 9 | 从马钱子中选择分离马钱子碱新方法的研究显示文摘本文采用分子模板聚合物技术对中草药马钱子 (Strychnosnux vomicaL .)粗提物中有效成分马钱子碱 (brucine)、士的宁 (strychnine)进行了选择性分离。用丙烯酸为单体 ,TMPTA为交联剂 ,合成对马钱子碱有特异选择性的模板聚合物 (MIP)。选择性分离出粗提物中的马钱子碱 ,纯度可达 99 7% ,同时得到士的宁为主的生物碱 ,纯度为 94 6 %。 | 郭文生 丁超 宛彤昕 Issa Madongo mathurin 李莹 陈颖 | 2004 | 天然产物研究与开发2004，16，2： | 6 |
| 10 | Comparison of HbAlc in Chinese patients with type 1 or type 2 diabetes randomized to twice daily insulin lispro low mix 25 or twice daily human insulin mix 30/70显示文摘背景 Glycemic 控制阻止发作,这研究客观的糖尿病相关的长期的 complications.The 的前进是表明那两次每日的胰岛素 lispro 低的混合 25 是到在完成由血红素 A1c ( HbA1c )测量了的 glycemic 控制的两次每日的人的胰岛素混合 30/70 的 noninferior ,从基线到端点,在有在这个阶段的类型 1 或 2 diabetes.Methods 的病人,转线路,开标签, multicenter 学习,有糖尿病的 117 | LI Yan LI Qiang LI Cheng-jiang WANG Chang-jiang ZHENG Yi-man Maher Issa ZHANG Jia | 2009 | Chinese Medical Journal2009，，21： | 6 |
| 11 | Effect of granulated rubber on shear strength of fine-grained sand显示文摘Review of the literature related to the mixture of shredded tire and sand shows that,despite of the increase in shear strength due to addition of tire chips,granulated rubber causes reduction in shear strength of sand.In this study,the shear behavior of mixtures of fine-grained sand and 1-5 mm granulated rubber is investigated.Sixty direct shear tests were conducted on sandegranulated rubber mixtures with various rubber contents(0%,5%,10%,20% and 30%) at different relative densities(50%,70% and 90%) and different normal stresses(34.5 kPa,54.5 kPa,74.5 kPa and 104.5 kPa).The obtained results show that the granulated rubber improves the shear strength of fine-grained sand at medium relative density and low normal stress.The degree of improvement in shear strength is a function of rubber content,relative density and normal stress.The results show that at relative density of 50%,by adding 5% granulated rubber,the internal friction angle of sand increases from 35.1° to 39.2°.However,at relative densities of 70% and 90%,addition of granulated rubber to sand decreases its internal friction angle.The results also indicate that the behavior of sand becomes more ductile with increasing granulated rubber content.Adding granulated rubber leads to greater yielding strain and less tangent stiffness of sand.The maximum dilation angle decreases with the decrease in granulated rubber content.The stress ratio of sample at critical state(ψ= 0°) decreases with increasing granulated rubber content. | Seyed Mahmoud Anvari Issa Shooshpasha Saman Soleimani Kutanaei | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，5： | 6 |
| 12 | Tandem synthesis of functionalized hexaalkyl benzoisoquinolinopyrrolonaphthyridine-hexacarboxylate, via isoquinoline based multi-component reaction显示文摘An expedient,synthetic method to fused polycyclic derivatives of isoquinoline is described via tandem reaction of isoquinoline,dialkyl acetylenedicarboxylates and dialkyl chloromalonate. | Mohammad Piltan Issa Yavari Loghman Moradi | 2013 | Chinese Chemical Letters2013，24，11： | 5 |
| 13 | Migration of a biliary stent causing duodenal perforation and biliary peritonitis显示文摘Migration of endoscopically placed biliary stents is a well-recognized complication of endoscopic retrograde cholangiopancreatography. Less than 1% of migrated stents however cause intestinal perforation. We present a case of a migrated biliary stent that resulted in duodenal perforation and biliary peritonitis. | Hussain Issa Mamdouh Nahawi Bahaa Bseiso Ahmed Al-Salem | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，10： | 3 |
| 14 | Altered central pain processing after pancreatic surgery for chronic pancreatitis显示文摘 | S. A. Bouwense U. Ahmed Ali R. P. ten Broek Y. Issa C. H. van Eijck O. H. Wilder‐Smith H. van Goor | 2013 | Br J Surg2013，，13： | 3 |
| 15 | 地中海贫血高血清铁蛋白与造血干细胞移植后血细胞恢复的关系显示文摘目的研究重型β地中海贫血(地贫)造血干细胞移植(HSCT)植入后血细胞减少(CPE)的影响因素。方法对2009年1月1日-2015年6月30日在本中心行7/8 HLA相合HSCT治疗的61例地贫患者进行了回顾性分析。61例患者分为CPE组(n=38)和无CPE组(n=23),运用单因素和多因素回归分析对两组中移植前铁蛋白(PTSF)、供者年龄、受者年龄与CPE的相关性。结果在单因素分析中证明PTSF为CPE的危险因素。CPE组PTSF水平明显高于无CPE组(3927.9±1314.9 ng/mL vs 2291.0±994.4 ng/mL,P=0.000)。同样的结果在多因素回归分析中也被证实(P=0.001)。运用R语言(R 2.15.2)校正两组中PTSF界限值为2500 ng/mL。结论高PTSF是7/8 HLA相合地贫HSCT发生CPE的高危因素,在地贫患者接受7/8 HLA相合HSCT时,PTSF应降至2500 ng/mL以下。 | 廖建云 温建芸 Issa mardo 周小辉 彭智勇 许文峰 陈丽白 何岳林 裴夫瑜 吴学东 冯晓勤 白静 苏清霞 李春富 | 2018 | 中国小儿血液与肿瘤杂志2018，23，1： | 3 |
| 16 | 实时剪切波弹性成像技术对A型肉毒毒素治疗扭转型痉挛性斜颈的应用评价显示文摘目的探讨实时剪切波弹性成像评价A型肉毒毒素治疗扭转型痉挛性斜颈疗效的临床应用价值。方法选取扭转型痉挛性斜颈患者46例(观察组)及健康志愿者50例(对照组),观察组进行A型肉毒毒素治疗,于治疗前及治疗后2周进行Tsui评分,同时应用实时剪切波超声弹性成像技术测量观察组及对照组的胸锁乳突肌、头夹肌杨氏模量值,对2组结果进行统计分析。结果观察组治疗后Tsui评分较治疗前下降(P <0. 01),治疗后胸锁乳突肌、头夹肌杨氏模量值较治疗前下降,差异有统计学意义(P <0. 01),与对照组同名肌比较,差异有统计学意义(P <0. 01)。结论实时剪切波超声弹性成像技术有助于评价A型肉毒毒素治疗扭转型痉挛性斜颈肌痉挛的疗效。 | 宋烨 张天杰 李园 Malam Djibo Issa 高源 | 2019 | 河北医药2019，41，2： | 3 |
| 17 | MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes显示文摘BACKGROUND Nonalcoholic steatohepatitis-related cirrhosis is one of the liver complications in type 2 diabetes mellitus(T2DM)and reported to be a risk factor for developing hepatocellular carcinoma(HCC).A reliable screening biomarker of liver cirrhosis(LC)and HCC among T2DM patients is important to reduce the morbidity and mortality of this disease.MicroRNA(miRNA)is considered a key player in HCC and T2DM,and it might be a hidden culprit in diabetes-associated HCC,making it a promising reliable prognostic tool.AIM To investigate the signature of serum miRNAs as early biomarkers for the screening of HCC among diabetic patients.METHODS Expression profiles of miRNAs in serum samples of diabetic LC and diabetic HCC patients were assessed using Illumina sequencing;then,RT-qPCR was used to validate significantly altered miRNAs between the two groups.Candidate miRNAs were tested in serum samples of 200 T2DM patients,270 LC patients,200 HCC patients,and 225 healthy control subjects.Additionally,receiver operating characteristic(ROC)analysis,with area under the curve(AUC),was performed to assess the diagnostic performance of the screened miRNAs for discriminating HCC from LC and nonmalignant patients(LC+T2DM).RESULTS Expression of the sequenced miRNAs in serum was different in HCC vs LCpositive T2DM patients.Two miRNAs(miR-34a,miR-221)were significantly upregulated and five miRNAs(miR-16,miR-23-3p,miR-122-5p,miR-198,miR-199a-3p)were significantly down-regulated in HCC compared to LC patients.Analysis of ROC curve demonstrated that the combination of these seven miRNAs can be used as a reliable biomarker for detection of HCC in diabetic patients,as it could identify HCC with high diagnostic accuracy in diabetic LC patients(AUC=0.993)and in diabetic nonmalignant patients(AUC=0.961).CONCLUSION This study validates a panel of serum miRNAs that can be used as a reliable noninvasive screening biomarker of HCC among T2DM cirrhotic and noncirrhotic patients.The study recommends further research to shed light on a possible role of c-Met in T2DM-associated HCC via the miRNA regulatory pathway. | Moustafa Nouh Elemeery Marwa Anwar Mohamed Marwa Ahmed Madkour Mohammed Mohammed Shamseya Noha Mahmoud Issa Ahmed Noah Badr Doaa Ahmed Ghareeb Cheol-Ho Pan | 2019 | World Journal of Gastroenterology2019，25，42： | 3 |
| 18 | Synthesis of functionalized azadienes from aminobenzothiazole,acetylenic esters and isocyanides显示文摘在有 dialkyl acetylenedicarboxylates 的 2-aminobenzothiazole 之间的反应面对 isocyanides,在好收益导致 functionalized azadienes。 | Issa Yavari Samira Arab-Salmanabadi Ali Aminkhani | 2012 | Chinese Chemical Letters2012，23，1： | 3 |
| 19 | BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc显示文摘 | Jake E. Delmore Ghayas C. Issa Madeleine E. Lemieux Peter B. Rahl Junwei Shi Hannah M. Jacobs Efstathios Kastritis Timothy Gilpatrick Ronald M. Paranal Jun Qi Marta Chesi Anna C. Schinzel Michael R. McKeown Timothy P. Heffernan Christopher R. Vakoc P. Lei | 2011 | Cell2011，，6： | 3 |
| 20 | 西非209例中国人恶性疟临床分析显示文摘目的探讨近年到西非的中国人感染恶性疟的临床特点及治疗方法。方法收集西非国家209例实验室确诊的中国人恶性疟病例,对其临床表现、实验室检查结果、治疗方案及效果进行回顾性分析。结果209例恶性疟临床表现不典型、复杂多样,可伴有头痛、咽痛、肌肉痛、怠倦等症候群、咳嗽、咳痰等呼吸道症状以及腹痛、腹泻、呕吐等消化道症状,采用青蒿素衍生物和奎宁类药物早期、联合、分级、系统抗疟治疗后症状均消失,无恶性疟重症病例发生,仅3例实验室复查仍有少量疟原虫,成为无症状带虫者。结论恶性疟临床表现复杂多样,疟疾高发区应予给高度重视和警惕,早期、联合、分级、系统抗疟治疗效果满意,可以有效减少和避免重症恶性疟的发生。 | 杨景毅 谢福生 Issa Malam Djibo | 2013 | 中国热带医学2013，13，1： | 2 |
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