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| 1 | Differences in neuroplasticity after spinal cord injury in varying animal models and humans显示文摘Rats have been the primary model to study the process and underlying mechanisms of recovery after spinal cord injury. Two weeks after a severe spinal cord contusion, rats can regain weight-bearing abilities without therapeutic interventions, as assessed by the Basso, Beattie and Bresnahan locomotor scale. However, many human patients suffer from permanent loss of motor function following spinal cord injury. While rats are the most understood animal model, major differences in sensorimotor pathways between quadrupeds and bipeds need to be considered. Understanding the major differences between the sensorimotor pathways of rats, non-human primates, and humans is a start to improving targets for treatments of human spinal cord injury. This review will discuss the neuroplasticity of the brain and spinal cord after spinal cord injury in rats, non-human primates, and humans. A brief overview of emerging interventions to induce plasticity in humans with spinal cord injury will also be discussed. | Mallory E.Filipp Benjamin J.Travis Stefanie S.Henry Emma C.Idzikowski Sarah A.Magnuson Megan YF Loh Daniel J.Hellenbrand Amgad S.Hanna | 2019 | Neural Regeneration Research2019，14，1： | 8 |
| 2 | Advances in the treatment of cervical rheumatoid: Less surgery and less morbidity显示文摘Rheumatoid arthritis is a chronic systemic inflammatory disease that often affects the cervical spine.While it was initially thought that cervical involvement was innocuous,natural history studies have substantiated the progressive nature of untreated disease.Over the past 50 years,there has been further elucidation in the pathophysiology of the disease,as well as significant advancements in medical and surgical therapy.The introduction of disease modifying drugs and biologic agents has reduced the amount of patients with advanced stages of the disease needing surgery.Advancement in instrumentation techniques has improved patient outcomes and fusion rates.The introduction of endoscopic approaches for ventral decompression may further lower surgical morbidity.In this review,we give a brief overview of the pertinent positives of the disease.A discussion of historical techniques and the evolution of surgical therapy into the modern era is provided.With improved medical therapies and lessinvasive approaches,we will likely continue to see less advanced cases of disease and less surgical morbidity.Nonetheless,a thorough understanding of the disease is crucial,as its systemic involvement and need for continued medical therapy have tremendous impact on overall complications and outcomes even in patients being seen for standard degenerative disease with comorbid rheumatoid. | Grant W Mallory Sasha R Halasz Michelle J Clarke | 2014 | World Journal of Orthopedics2014，5，3： | 5 |
| 3 | On the Nature of the P-Wave Velocity Gradient in the Inner Core beneath Central America显示文摘We conduct an experiment to investigate whether linearity in the observed velocity gradient in the volume of the inner core sampled by the PKP ray paths beneath Central America is a robust approximation. Instead of solving an optimization problem, we approach it within the Bayesian inference. This is an ensemble approach, where model specification is relaxed so that instead of only one solution, groups of reasonable models are acceptable. Furthermore, in transdimensional Bayesian inference used here, the number of basis functions needed to model observations is by itself an unknown. Our modeling reveals that in the ensemble of models, the most likely are those containing only 2 nodes(linear trend). Thus our result justifies the assumption used for the determination of inner core rotation with respect to the rest of the mantle that the observed gradient is constant in its nature(linear). Recent observations in seismology suggest that it is likely that the spatial variability in elastic parameters is a widespread phenomenon in the inner core. Future array observations will further constrain spatial extent and magnitude of velocity changes and show whether there is a significant difference between these observations in the two quasi-hemispheres of the inner core. | Hrvoje Tkali Thomas Bodin Mallory Young Malcolm Sambridge | 2013 | Journal of Earth Science2013，24，5： | 2 |
| 4 | Immunoreactivity of CD45,a protein phosphotyrosine phosphatase,in Alzheimer' s disease 显示文摘 | Masliah E Mallory M Hansen L Alford M Albright T Terry R | 1991 | Acta Neuropathol( Berl )1991，83，1： | 2 |
| 5 | Development of species-specific PCR and PCR-restriction fragment length polymorphism assays for L. infantum / L. donovani discrimination显示文摘 | Mohammad A. Oshaghi Naseh Maleki Ravasan Mallorie Hide Ezat-Aldin Javadian Yavar Rassi Mohammad M. Sedaghat Mehdi Mohebali Homa Hajjaran | 2009 | Experimental Parasitology2009，，1： | 2 |
| 6 | Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice显示文摘Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor(PXR) and constitutive androstane receptor(CAR) is well-known to increase drug metabolism and reduce inflammation. Little is known regarding their physiological functions on the gut microbiome. In this study, we discovered bivalent hormetic functions of PXR/CAR modulating the richness of the gut microbiome using genetically engineered mice. The absence of PXR or CAR increased microbial richness, and absence of both receptors synergistically increased microbial richness. PXR and CAR deficiency increased the pro-inflammatory bacteria Helicobacteraceae and Helicobacter. Deficiency in both PXR and CAR increased the relative abundance of Lactobacillus, which has bile salt hydrolase activity, corresponding to decreased primary taurine-conjugated bile acids(BAs) in feces, which may lead to higher internal burden of taurine and unconjugated BAs, both of which are linked to inflammation, oxidative stress, and cytotoxicity. The basal effect of PXR/CAR on the gut microbiome was distinct from pharmacological and toxicological activation of these receptors. Common PXR/CAR-targeted bacteria were identified, the majority of which were suppressed by these receptors. h PXR-TG mice had a distinct microbial profile as compared to wild-type mice. This study is the first to unveil the basal functions of PXR and CAR on the gut microbiome. | Mallory Little Moumita Dutta Hao Li Adam Matson Xiaojian Shi Gabby Mascarinas Bruk Molla Kris Weigel Haiwei Gu Sridhar Mani Julia Yue Cui | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 7 | Functions of microRNAs and related small RNAs in plants显示文摘 | Mallory A C Vaucheret H | 2006 | Nat Genet2006，，： | 1 |
| 8 | Neurodegenerationin the central nervous system of apoE-deficient mice显示文摘 | Masliah E Mallory M Ge N | 1995 | Exp Neurol1995，136，： | 1 |
| 9 | AFP - L3 : a new generation of tumor marker for hepatocellular carcinoma显示文摘 | Li D Mallory T | 2001 | Clin Chim Acta2001，313，： | 1 |
| 10 | Altered expression of glutamate transporters under hypoxic conditions in vitro显示文摘 | Hsu L Rockenstein E Mallory M | 2001 | J Neurosci Res2001，64，： | 1 |
| 11 | MicroRNA control of PHABULOSA in leaf development:importance of pairing to the mieroRNA 5' region 显示文摘 | Mallory A C Reinhart B J Jones-Rhoades M W Tang G L Zamore P D Barton M K Barrel D P | 2004 | The EMBO Journal2004，23，： | 1 |
| 12 | Sleep-associated breathing disorders in morbidly obese children and adolescents显示文摘 | Mallory GB Fiser DH Jackson R | | 0，，06： | 1 |
| 13 | Electroless Deposition of Ternary Allory 显示文摘 | Mallory G O Horhn T R | 1979 | Metal Finishing1979，66，4： | 1 |
| 14 | Defining spinal mobility in ankylosing spondylitis (AS) : The Bath AS metrology Index 显示文摘 | Jenkinson TR Mallorie PA Whiteloek HC | 1994 | J Rheumatol1994，21，9： | 1 |
| 15 | Ichthyosis, deafness, and Hirschsprung's disease 显示文摘 | Mallory SB Haynie LS Williams ML | 1989 | Pediatr Dermatol1989，6，1： | 1 |
| 16 | Functions of microRNAs andrelated small RNAs in plants显示文摘 | Mallory A C Vaucheret H | 2006 | Nature Genetics2006，386，： | 1 |
| 17 | Geological symbol set for manifold geographic information system显示文摘 | MIHALYNUK M G MALLORY M S GRANT B | 2006 | Computers&Geosciences2006，32，： | 1 |
| 18 | Dermatologic Disorders Associated With Chronic Hepatitis C: Effect of Interferon Therapy显示文摘 | David R. Berk Susan Bayliss Mallory Emmet B. Keeffe Aijaz Ahmed | 2007 | Clinical Gastroenterology and Hepatology2007，，2： | 1 |
| 19 | Preparation of the proximal femur in cementless total hip revision显示文摘 | Mallory TH | 1988 | Clin Orthop Relat Res1988，，235： | 1 |
| 20 | Brain Volume and Neurobehavior in Newborns with Complex Congenital Heart Defects显示文摘 | Mallory Owen Michael Shevell Mary Donofrio Annette Majnemer Robert McCarter Gilbert Vezina Marine Bouyssi-Kobar Iordanis Evangelou Dena Freeman Neil Weisenfeld Catherine Limperopoulos | 2013 | The Journal of Pediatrics2013，，： | 1 |
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