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| 1 | The role and modulation of autophagy in experimental models of myocardial ischemia-reperfusion injury显示文摘称为 autophagy 品质上的一个生理的序列由移开蛋白质总数和损坏细胞质的成分决定细胞的生存能力,并且显著地作出贡献到心肌的 ischemia-reperfusion (I/R ) 的度损害。这紧安排的分解代谢的细胞的 ‘ housekeeping’过程向房间提供精力的新来源适应紧张的条件。当支持幸存的机制,而是增加的证据建议它能也导致房间的遗赠,这个过程首先被描述。Autophagy 包括心肌的 I/R 损害在多重心脏的条件的致病被含有。然而,争论至于 autophagy 是否充当保护的机制或在心贡献 I/R 损害的有害效果坚持。这争吵可以在试验性的模型和种包括可变性源自几个因素,并且方法论过去常估计 autophagy。这评论在向操作 autophagy 显著地在压力大多数的条件下面增加心脏的 myocytes 的幸存受到 I/R,和成长兴趣的孤立的心脏的房间在 autophagy 的调整和角色上提供更新的知识是 I/R 损害。这的不安 evolutionarily 保存了细胞内部的清洁的 autophagy 机制,由指向的调整通过在其它之中, rapamycin ( mTOR )的哺乳动物的目标禁止者,腺苷 激活monophosphate 的蛋白质 kinase ( AMPK )调节的人,钙降低代理人, resveratrol , longevinex , sirtuin 使活跃之物, proapoptotic 基因 Bnip3 , IP3 和 lysosome 禁止者,可以对 I/R 授与抵抗到心房间导致的房间死亡。因此,在质问心肌层的 autophagy 的治疗学的操作可以有益于梗塞以后的心脏的愈合并且改变。 | Carol Chen-Scarabelli Pratik R. Agrawal Louis Saravolatz Cadigia Abuniat Gabriele Scarabelli Anastasis Stephanou Leena Loomba Jagat Narula Tiziano M. Scarabelli Richard Knight | 2014 | Journal of Geriatric Cardiology2014，11，4： | 37 |
| 2 | Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies显示文摘 | Siddharth Singh Alina M. Allen Zhen Wang Larry J. Prokop Mohammad H. Murad Rohit Loomba | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 2 |
| 3 | Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial显示文摘 | NEUSCHWANDER-TETRI B A LOOMBA R SANYAL A J | 2015 | Lancet2015，385，9972： | 1 |
| 4 | Hepatitis B immunoglobulin and Lamivudine improve hepatitis B-related outcomes afler liver transplantation: meta-analysis 显示文摘 | Loomba R Rowley AK Wesley R | 2008 | Clin Gastroenterol Hepatol2008，6，6： | 1 |
| 5 | Advantageous cost structure a strategic costing case study显示文摘 | Buckingham M Loomba A P S | 2001 | Production and Inventory Management Journal2001，42，1： | 1 |
| 6 | Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease 显示文摘 | Chalassani N Guo X Loomba R | 2010 | Gastroenterology2010，139，5： | 1 |
| 7 | The global NAFLD epidemic 显示文摘 | Loomba R Sanyal AJ | 2013 | Nat Rev Gastroenterol Hepatol2013，10，11： | 1 |
| 8 | Fibrates: where are we now? 显示文摘 | Seth Loomba R Arora R | 2009 | Ther Adv Cardiovasc Dis2009，3，1： | 1 |
| 9 | Service-driven global supply chains显示文摘 | YOUNGDAHL W E LOOMBA A P | 2000 | International Journal of Service Industry Management2000，11，4： | 1 |
| 10 | Prevention of cardiovascular disease u-tilizing fibratesa pooled meta-analysis显示文摘 | Loomba RS Arora R | 2010 | Am J Ther2010，17，6： | 1 |
| 11 | Influenzavaccination and cardiovascular morbidity and mortality:analysis of 292,383 patients显示文摘 | Loomba RS Aggarwal S Shah PH | 2012 | J Cardiovasc Pharmacol Ther2012，17，3： | 1 |
| 12 | Apexification of anteri- or teeth:a comparative evaluation of mineral trioxide ag- gregate and calcium hydroxide paste显示文摘 | Damle SG Bhattal H Loomba A | 2012 | J Clin Pediatr Dent2012，36，3： | 1 |
| 13 | Famesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-al- coholic steatohepatitis (FLINT): a muhicentre, randomised, place- bo-controlled trial显示文摘 | Neuschwander-Tetri BA Loomba R Sanyal AJ | 2015 | Lancet2015，385，： | 1 |
| 14 | Association of atrial tachya- rrhythmias with atrial septal defect, Ebstein' s anomaly and Fontan patients 显示文摘 | Loomba RS Chandrasekar S Sanan P | 2011 | Expert Rev Cardiovasc Ther2011，9，7： | 1 |
| 15 | Delayed brain abscess after embolization of arteriovenous malformation: report of two cases and review of literature 显示文摘 | Sharma A Jagetia A Loomba P | 2011 | Neurol India2011，59，4： | 1 |
| 16 | Apexification of anteri-or teeth:a comparative evaluation of mineral trioxide ag-gregate and calcium hydroxide paste 显示文摘 | Damle SG Bhattal H Loomba A | 2012 | Clin PediatrDent2012，36，3： | 1 |
| 17 | Systematic review: the effect of preventive lamivudine on hepatitis B reactivation during chemotherapy显示文摘 | Loomba R Rowley A Wesley R | 2008 | Ann Intern Med2008，148，7： | 1 |
| 18 | Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis,organ dysfunction and mortality in severe sepsis and septic shock 显示文摘 | Nguyen HB Loomba M Yang JJ | 2010 | J Inflamm (Lond)2010，7，： | 1 |
| 19 | Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status显示文摘 | Stein LL Dong MH Loomba R | 2009 | Adv Ther2009，26，10： | 1 |
| 20 | Role of N-acetylcysteine to prevent contrast-induced nephropathy: a meta-analysis显示文摘 | Loomba RS Shah PH Aggarwal S | 2013 | Am J Ther2013，23，1： | 1 |
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