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| 1 | Deep vein thrombosis and pulmonary embolism in cirrhotic patients:Systematic review显示文摘Patients with liver cirrhosis were traditionally believed to be protected against development of blood clots.Lately,studies have shown that these patients may probably be at an increased risk of venous thrombotic complications.Although the hemostatic changes in the chronic liver disease patients and the factors that may predict bleeding vs thrombotic complications remains an area of active research,it is believed that the coagulation cascade is delicately balanced in these patients because of parallel reduced hepatic synthesis of pro and anticoagulant factors.Thrombotic state in cirrhotic patients is responsible for not only portal or non-portal thrombosis[deep vein thrombosis(DVT)and pulmonary embolism(PE)];it has also been associated with progression of liver fibrosis.The use of anticoagulants in cirrhosis patients is a challenging,and often a scary situation.This review summarizes the current literature on the prevalence of venous thrombosis(DVT and PE),risk factors and safety of prophylactic and therapeutic anticoagulation in patients with chronic liver disease. | Ashish Aggarwal Kanika Puri Suthat Liangpunsakul | 2014 | World Journal of Gastroenterology2014，20，19： | 14 |
| 2 | Targeting the insulin-like growth factor pathway in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the third leading cause of cancer-related deaths worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments, which include surgical resection as the first option, liver transplantation and percutaneous ablation. Unfortunately, there is a high frequency of tumor recurrence after surgical resection and most HCC seem resistant to conventional chemotherapy and radiotherapy. Sorafenib, a multi-tyrosine kinase inhibitor, is the only chemotherapeutic option for patients with advanced hepatocellular carcinoma. Patients treated with Sorafenib have a significant increase in overall survival of about three months. Therefore, there is an urgent need to develop alternative treatments. Due to its role in cell growth and development, the insulin-like growth factor system is commonly deregulated in many cancers. Indeed, the insulin-like growth factor(IGF) axis has recently emerged as a potential target for hepatocellular carcinoma treatment. To this aim, several inhibitors of the pathway have been developed suchas monoclonal antibodies, small molecules, antisense oligonucleotides or small interfering RNAs. However recent studies suggest that, unlike most tumors, HCC development requires increased signaling through insulin growth factor Ⅱ rather than insulin growth factor Ⅰ. This may have great implications in the future treatment of HCC. This review summarizes the role of the IGF axis in liver carcinogenesis and the current status of the strategies designed to target the IGF-Ⅰ signaling pathway for hepatocellular carcinoma treatment. | Mónica Enguita-Germán Puri Fortes | 2014 | World Journal of Hepatology2014，6，10： | 10 |
| 3 | 宏观长期风险与资产价格:国际比较与中国经验显示文摘基于宏观长期风险的资本资产定价模型成功解释了美国股票市场上的股权溢价之谜、市场波动之谜等典型事实。本文通过模型校准模拟、关键假设与推论检验等方法,对长期风险模型在主要发达国家和中国股票市场的应用进行研究。经验检验发现,长期风险模型可以拟合这些国家股市的典型事实,股票价格-股利比对于未来经济增长和时变宏观经济波动具有一定的预测能力,这与长期风险模型的理论推导和模型模拟相符合;作为宏观长期风险的测度,消费和股利的协整关系对于股利增长率和股市收益有较好的预测作用,这符合协整长期风险模型的基本假设。 | 陈国进 黄伟斌 Tribhuvan Puri | 2014 | 世界经济2014，37，6： | 9 |
| 4 | A phase Ⅱ study of gemcitabine and carboplatin combination chemotherapy in gallbladder carcinoma显示文摘BACKGROUND: Patients with carcinoma of the gallbladder have advanced, unresectable tumor at the time of presentation and face a dismal prognosis in the absence of a standard palliative chemotherapy regimen. This study was undertaken to evaluate the efficacy and safety of combined chemotherapy of gemcitabine and carboplatin in 20 patients with advanced gallbladder carcinoma. METHODS: The criteria of eligibility included chemonaive patients with unresectable gallbladder cancer, bidimensionaIly measurable disease, Zubrod’s performance status≤2, and adequate major organ function. The patients received gemcitabine (1000 mg/m^2) on days 1 and 8, and carboplatin (target AUC of 5.0 mg/ml) on day 1, in a 21-day cycle. CT was used for response assessment. RESULTS: In this group of 20 patients with advanced gallbladder carcinoma 6 were men and 14 women, with a median age of 55 years. The stage of the tumor at presentation was IVB in 14 patients (70%), IVA in 3 (15%) and Ⅲ in 3 (15%). Four patients (21%) achieved a complete response, and 3 (15.7%), a partial response; an overall response rate was 36.7%. The median time to progression of the tumor was 33.8 weeks, and 1-year survival rate of the patients was 43.3%. Anemia of WHO grade Ⅲ or Ⅳ was seen in 2 patients (10%) and 1 patient (5%), respectively. Grade Ⅲ neutropenia and thrombocytopenia were observed in 2 patients (10%) and 1 patient (5%), respectively. CONCLUSION: With mild toxicity, combined chemotherapy of gemcitabine and carhoplatin is effective in the treatment of advanced gallbladder carcinoma. | Pramod Kumar Julka Tarun Puri Goura Kishore Rath | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，1： | 7 |
| 5 | Ribosome Inactivating Proteins from Plants Inhibiting Viruses显示文摘Many plants contain ribosome inactivating proteins (RIPs) with N-glycosidase activity, which depurinate large ribosomal RNA and arrest protein synthesis. RIPs so far tested inhibit replication of mRNA as well as DNA viruses and these proteins, isolated from plants, are found to be effective against a broad range of viruses such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) and herpes simplex virus (HSV). Most of the research work related to RIPs has been focused on antiviral activity against HIV; however, the exact mechanism of antiviral activity is still not clear. The mechanism of antiviral activity was thought to follow inactivation of the host cell ribosome, leading to inhibition of viral protein translation and host cell death. Enzymatic activity of RIPs is not limited to depurination of the large rRNA, in addition they can depurinate viral DNA as well as RNA. Recently, Phase I/II clinical trials have demonstrated the potential use of RIPs for treating patients with HIV disease. The aim of this review is to focus on various RIPs from plants associated with anti-HIV activity. | Inderdeep Kaur R C Gupta Munish Puri | 2011 | Virologica Sinica2011，26，6： | 7 |
| 6 | Forest fire risk assessment in parts of Northeast India using geospatial tools显示文摘Forest fire is a major cause of changes in forest structure and function. Among various floristic regions, the northeast region of India suffers maximum from the fires due to age-old practice of shifting culti- vation and spread of fires from jhum fields. For proper mitigation and management, an early warning of forest fires through risk modeling is required. The study results demonstrate the potential use of remote sens- ing and Geographic Information System (GIS) in identifying forest fire prone areas in Manipur, southeastern part of Northeast India. Land use land cover (LULC), vegetation type, Digital elevation model (DEM), slope, aspect and proximity to roads and settlements, factors that influ- ence the behavior of fire, were used to model the forest fire risk zones. Each class of the layers was given weight according to their fire inducing capability and their sensitivity to fire. Weighted sum modeling and ISODATA clustering was used to classify the fire zones. To validate the results, Along Track Scanning Radiometer (ATSR), the historical fire hotspots data was used to check the occurrence points and modeled forest fire locations. The forest risk zone map has 55 63% of agreement with ATSR dataset. | Kanchan Puri G. Areendran Krishna Raj Sraboni Mazumdar P.K. Joshi | 2011 | Journal of Forestry Research2011，22，4： | 7 |
| 7 | Salt Tolerance Mechanisms and Approaches:Future Scope of Halotolerant Genes and Rice Landraces显示文摘All rice plant developmental stages are severely affected by soil salinity. Salinity-induced ionic and osmotic stresses affect stomata closure and gaseous exchange, and reduce transpiration and the rate of carbon assimilation, and hence decrease plant yield. Understanding the response of rice plants toward salinity stress at the genetic level and developing salt-tolerant varieties are the vital mandates for its effective management. This review described the present status of salt-tolerance achieved in rice by various mechanisms including the ion homeostasis(Na^+/H^+, OsNHX antiporters), compatible organic solutes(glycine betaine and proline), antioxidative genes(OsECS, OsVTE1, OsAPX and OsMSRA4.1), salt responsive regulatory elements(transcription factors, cis-acting elements and miRNAs) and genes ecoding protein kinases(MAPKs, SAPKs and STRKs). Further, the future perspective of developing salt-tolerant varieties lies in exploring halotolerant gene homologs from rice varieties, especially the landraces. Genetic diversity among rice landraces can serve as a valuable resource for future studies toward variety improvement through breeding and genome editing. Further, identification, multiplication, preservation and utilization of biodiversity among landraces are the urgent buffers to be saved as a heritage for future generations to come. | Tarun Bhatt Aditi Sharma Sanjeev Puri Anu Priya Minhas | 2020 | Rice science2020，27，5： | 6 |
| 8 | Endoscopic ultrasound guided drainage of pancreatic fluid collections: Assessment of the procedure, technical details and review of the literature显示文摘Endoscopic ultrasound(EUS) guided drainage of pancreatic fluid collections(PFC) has become increasingly popular and become first line management option in many centers. Use of therapeutic echoendoscopes has greatly increased the applicability of EUS guided transmural drainage. Drainage is indicated in symptomatic PFCs, PFC related infection, bleed, luminal obstruction, fistulization and biliary obstruction. EUS guided transmural drainage of PFCs is preferred in patients with non bulging lesions, portal hypertension, bleeding tendency and in those whom conventional drainage has failed. In the present decade significant progress has been made in minimally invasive endoscopic techniques. There are newer stent designs, access devices and techniques for more efficient drainage of PFCs. In this review, we discuss the EUS guided drainage of PFCs in acute pancreatitis. | Rajesh Puri Ragesh Babu Thandassery Abdulrahman A Alfadda Saad Al Kaabi | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，4： | 5 |
| 9 | Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease显示文摘AIM: To determine if hyperpolarisation-activated nucleotide-gated(HCN) channels exist in human colon, and to investigate the expression of HCN channels in Hirschsprung's disease.METHODS:We investigated HCN1,HCN2,HCN3 and HCN4 protein expression in pull-through specimens from patients with Hirschsprung’s disease(HSCR,n=10)using the proximal-most ganglionic segment and distalmost aganglionic segment,as well as in healthy control specimens obtained at the time of sigmoid colostomy closure in children who had undergone anorectoplasty for imperforate anus(n=10).Fluorescent immunohistochemistry was performed to assess protein distribution,which was then visualized using confocal microscopy.RESULTS:No HCN1 channel expression was observed in any of the tissues studied.Both HCN2 and HCN4proteins were found to be equally expressed in the aganglionic and ganglionic bowel in HSCR and controls.HCN3 channel expression was found to be markedly decreased in the aganglionic colon vs ganglionic colon and controls.HCN2-4 channels were seen to be expressed within neurons of the myenteric and submucosal plexus of the ganglionic bowel and normal controls,and also co-localised to interstitial cells of Cajal in all tissues studied.CONCLUSION:We demonstrate HCN channel expression in human colon for the first time.Reduced HCN3expression in aganglionic bowel suggests its potential role in HSCR pathophysiology. | Anne Marie O’Donnell David Coyle Prem Puri | 2015 | World Journal of Gastroenterology2015，21，18： | 4 |
| 10 | 心腔内超声在卵圆孔未闭封堵术中的应用显示文摘目的 探讨心腔内超声 (ICE)在经导管卵圆孔未闭 (PFO)封堵术中的应用价值。方法 应用ICE观察 86例PFO的解剖形态及周围结构 ,测量PFO通道的直径和长度 ,监测与引导封堵过程、伞释放后位置 ,并通过彩色血流显像和超声造影判断有无残余分流。结果 ICE清晰地观察到各种形态的PFO ,86例中有 85例封堵成功 ,1例失败。结论 ICE指导经导管封堵PFO是一种安全、有效。 | 刘政 张萍 Daniel McCormick Timothy Puri Amy Loyd Mani Vannan | 2004 | 中华超声影像学杂志2004，13，10： | 4 |
| 11 | 心腔内超声引导下经导管卵圆孔未闭封堵术显示文摘目的探讨心腔内超声(ICE)在经导管卵圆孔未闭(PFO)封堵术中的初步应用经验及其与X线的比较.方法应用ICE监测与引导86例PFO的封堵过程,在ICE上测量基础状态PFO通道的直径和长度,分别用ICE和X线透视测量PFO球囊伸展径(BSD).ICE观察封堵器释放后的位置,并通过彩色血流显像和声学造影判断有无残余分流.结果 ICE清晰地显示PFO解剖形态及周围结构,在ICE上测量基础状态PFO通道长度和直径分别为3.6~22 mm(11±4 mm),0~9 mm(4±2 mm).ICE上测量的PFO球囊伸展径为5~16 mm(9.2±2.6 mm),经X线透视测量的PFO球囊伸展径为5~17 mm(9.7±2.8 mm),二者相关非常显著(r=0.90,P<0.0001),86例中有85例封堵成功,1例失败.结论 ICE不仅能提供PFO的解剖和血流动力学信息,而且能准确提供PFO各种测量值. | 刘政 张萍 Daniel McCormick Timothy Puri Amy Loyd Mani Vannan | 2005 | 中国介入心脏病学杂志2005，13，3： | 4 |
| 12 | Pathological,molecular,and clinical characteristics of cholangiocarcinoma:A comprehensive review显示文摘Cholangiocarcinomas are a heterogeneous group of highly aggressive cancers that may arise anywhere within the biliary tree.There is a wide geographical variation with regards to its incidence,and risk-factor associations which may include liver fluke infection,primary sclerosing cholangitis,and hepatolithiasis amongst others.These tumours are classified into intrahepatic,perihilar and distal based on their anatomical location.Morphologically,intrahepatic cholangiocarcinomas are further sub-classified into small and large duct variants.Perihilar and distal cholangiocarcinomas are usually mucin-producing tubular adenocarcinomas.Cholangiocarcinomas develop through a multistep carcinogenesis and are preceded by dysplastic and in situ lesions.While clinical characteristics and management of these tumours have been extensively elucidated in literature,their ultra-structure and tumour biology remain relatively unknown.This review focuses on the current knowledge of pathological characteristics,molecular alterations of cholangiocarcinoma,and its precursor lesions(including biliary intraepithelial neoplasia,intraductal papillary neoplasms of the bile duct,intraductal tubulopapillary neoplasms and mucinous cystic neoplasm). | Mukul Vij Yogesh Puri Ashwin Rammohan Gowripriya G Rajesh Rajalingam Ilankumaran Kaliamoorthy Mohamed Rela | 2022 | World Journal of Gastrointestinal Oncology2022，14，3： | 4 |
| 13 | The insulinotropic activity of a Nepalese medicinal plant Biophytum sensitivum : preliminary experimental study显示文摘 | Dinesh Puri | 2001 | Journal of Ethnopharmacology2001，，1： | 3 |
| 14 | Substitution of tenofovir/emtricitabine for Hepatitis B immune globulin prevents recurrence of Hepatitis B after liver transplantation显示文摘 | R. Todd Stravitz Mitchell L. Shiffman Melissa Kimmel Puneet Puri Velimir A. Luketic Richard K. Sterling Arun J. Sanyal Adrian H. Cotterell Marc P. Posner Robert A. Fisher | 2012 | Liver Int2012，，7： | 3 |
| 15 | Economical effect of lumen apposing metal stents for treating benign foregut strictures显示文摘AIM To evaluate the clinical and economical efficacy of lumen apposing metal stent(LAMS) in the treatment of benign foregut strictures.METHODS A single center retrospective database of patients who underwent endoscopic treatment of benign foregut strictures between January 2014 and May 2017 was analyzed. A control group of non-stented patients who underwent three endoscopic dilations was compared to patients who underwent LAMS placement. Statistical tests performed included independent t-tests and fiveparameter regression analysis RESULTS Nine hundred and ninety-eight foregut endoscopic dilations were performed between January 2014 and May 2017. 15 patients underwent endoscopic LAMS placement for treatment of benign foregut stricture. Thirty-six patients with recurrent benign foregut strictures underwent three or more endoscopic dilations without stent placement. The cost ratio of endoscopic dilation to LAMS(stent, placement and retrieval) is 5.77. Cost effective analysis demonstrated LAMS to be economical after three endoscopic dilation overall.LAMS was cost effective after two dilations in the Postsurgical stricture subgroup. CONCLUSION Endoscopists should consider LAMS for the treatment of benign foregut strictures if symptoms persist past three endoscopic dilations. Post-surgical strictures may benefit from LAMS if symptoms persist after two dilations in a post-surgical. Early intervention with LAMS appears to be a clinically and economically viable option for durable symptomatic relief in patients with these strictures. | Alexander Hallac Wichit Srikureja Eashen Liu Parag Dhumal Ashish Thatte Nishant Puri | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，10： | 3 |
| 16 | Recognizing Local People's Priorities for Tropical Forest Biodiversity显示文摘热带雨林地区的人们常常受到与威胁生物多样性同样的过程的影响。加深了解什么对当地人是重要的能够改善决策。明确询问什么对当地人是重要的,本文调查了这种询问的作用。我们所用的例子来源于东加里曼丹(印度尼西亚婆罗洲)的生物多样性调查。我们与当地社区合作重点描述了当地看重的生境、物种和地点的特征以及它们的重要性。这个过程明确了不同的优先权和威胁,对管理的完善和权限提出了建议,指出了必要的特别行动、进一步调查或两者都需要做的问题。研究还表明了在当地人的引导下生物评价更为有效,并且揭示了当地社区与那些保护参与者合作的潜力。这样的评价是推动当地利益进入更高水平决策的第一步。结合当地观点的环保人士能够得到更广泛的支持以及有效保护的新机会。 | Douglas Sheil Rafindra Puri Meilinda Wan Miriam Van Heist Nining Liswanti Rukmiyati Ike Rachmatika Ismayadi Samsoedin 丁莉(译) | 2006 | AMBIO-人类环境杂志2006，35，1： | 3 |
| 17 | myocardial 以后梗塞巨人让室的 pseudoaneurysm 与严重的心失败介绍显示文摘 Left ventricle(LV) pseudoaneurysm is a late mechanical complication of myocardial infarction.A giant LV pseudoaneurysm is a rare presentation.We report a case of giant LV pseudoaneurysm in a post-MI patient who presented with gross congestive heart failure.The patient had a successful surgical repair of the aneurysm and had a favorable 3-mo outcome.The imaging modality and surgical treatment of the pseudoaneurysm are discussed. | Rajesh Vijayvergiya Alok Kumar Sandeep S Rana Harkant Singh Goverdhan D Puri Manphool Singhal | 2012 | World Journal of Cardiology2012，4，11： | 3 |
| 18 | Choledochal cyst with large stone cast and portal hypertension显示文摘BACKGROUND:Choledochal cysts in adults are more commonly associated with complications such as cystolithiasis,recurrent cholangitis,portal hypertension and malignancy,than in the pediatric age group.METHOD:We report a case of adult choledochal cyst with long-term complication of large stone cast and portal hypertension due to secondary biliary cirrhosis.RESULTS:A 50-year-old patient presented with obstructive jaundice and hepatosplenomegaly.On investigation,she was diagnosed as having a choledochal cyst with large stone cast and portal hypertension.Single stage resection of the choledochal cyst with Roux-en-Y hepaticojejunostomy was done by meticulous dissection and ligation of collaterals.CONCLUSION:Single stage resection of a choledochal cyst is possible in spite of associated portal hypertension,if the portal vein is patent. | Shivendra Singh Laxman Singh Kheria Sunil Puri Amrinder S Puri Anil K Agarwal | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 2 |
| 19 | CT–guided percutaneous core needle biopsy in deep seated musculoskeletal lesions: a prospective study of 128 cases显示文摘 | A. Puri V. U. Shingade M. G. Agarwal C. Anchan S. Juvekar S. Desai N. A. Jambhekar | 2006 | Skeletal Radiology2006，，3： | 2 |
| 20 | Design of reaction conditions for the enhancement of microbial degradation of dyes in sequential cycles显示文摘The present study evaluated the potential of white-rot fungal strain Coriolus versicolor to decolorize five structurally different dyes in sequential batch reactors under optimized conditions. The experiments were run continuously for seven cycles of 8 d each. High decolorizing activity was observed even during the repeated reuse of the fungus, especially when the old medium was replaced with fresh medium after every cycle. Biodegradation was the dominating factor as the fungus was able to produce the enzyme laccase mainly, to mineralize synthetic dyes. The nutrients and composition of the medium played important roles in sustaining the decolorisation potential of the fungus. Corncob was found be an easy and cheap substitute for carbon source for the fungus. Glucose consumption by the fungus was in accordance to its decolorisation activity and chemical oxygen demand (COD) reduction. | Rashmi Sanghi Awantika Dixit Preeti Verma Sadhna Puri | 2009 | Journal of Environmental Sciences2009，21，12： | 2 |
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