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| 1 | Chemopreventive and Growth Inhibitory Effects of Selenium显示文摘There is very convincing evidence that a high dietary level of selenium substantially reduces the incidence of a wide variety of animal cancers. The human epidemiological evidence is less clear cut, but overall suggests that selenium may be protective: the evidence is strongest in men in relation to gastro-intestinal cancers. There is evidence that dietary selenium compounds reduce the formation of DNA adducts by carcinogens. Selenium compounds also inhibit growth in vitro and induce apoptosis. In general, there is a good correlation between the effectiveness of selenium compounds in chemoprevention and growth inhibition, implying that the mechanisms of growth inhibition and chemoprevention may be similar and that a major factor in the chemopreventive effects of selenium compounds in vivo is their ability to retard outgrowth of pre-malignant cells. Various hypotheses have been advanced as to how selenium compounds might prevent tumour cellgrowth. One is that they cause apoptosis by inducing oxidative stress. However, we have shown that the most potent selenium compound, selenodiglutathione (SDG), a natural metabolite of selenite, does not induce oxidative stress, at least not in the sarne way as other oxidants such as H2O2 and diamide. Firstly, a partially selenium-resistant variant cell line does not show increased resistance to H2O2. Moreover, SDG does not induce widespread tyrosine phosphorylation, including MAP and SAN kinases, like other oxidants such as H2O2 and diamide and its effects are not reversed by pretreatment with the tyrosine kinase inhibitor, herbimycin. Our experiments with the selenium-resistant variant suggest that a novel selenium-binding protein may be involved in growth inhibition by | P. R. HARRISON J. LANFEAR L. WU J. FLEMING L. MCGARRY, AND L. BLOWER (The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road,Bearsden, Glasgow, G61 1BD, Scotland, UK) | 1997 | Biomedical and Environmental Sciences1997，10，2： | 5 |
| 2 | Kras G12D -Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma显示文摘 | Jianhua Ling Ya’an Kang Ruiying Zhao Qianghua Xia Dung-Fang Lee Zhe Chang Jin Li Bailu Peng Jason B. Fleming Huamin Wang Jinsong Liu Ihor R. Lemischka Mien-Chie Hung Paul J. Chiao | 2012 | Cancer Cell2012，，1： | 2 |
| 3 | Borderline Resectable Pancreatic Cancer: The Importance of This Emerging Stage of Disease显示文摘 | Matthew H.G. Katz Peter W.T. Pisters Douglas B. Evans Charlotte C. Sun Jeffrey E. Lee Jason B. Fleming J. Nicolas Vauthey Eddie K. Abdalla Christopher H. Crane Robert A. Wolff Gauri R. Varadhachary Rosa F. Hwang | 2008 | Journal of the American College of Surgeons2008，，5： | 1 |
| 4 | Outcomes of Endoscopic and Percutaneous Drainage of Pancreatic Fluid Collections Arising after Pancreatic Tail Resection显示文摘 | Nabeel Azeem Todd H. Baron Mark D. Topazian Ning Zhong Chad J. Fleming Michael L. Kendrick | 2012 | Journal of the American College of Surgeons2012，，2： | 1 |
| 5 | Brain Tumors in Children显示文摘 | Adam J. Fleming Susan N. Chi | 2012 | Current Problems in Pediatric and Adolescent Health Care2012，，4： | 1 |
| 6 | Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection显示文摘 | Scott M. Ward Bridget C. Fox Philip J. Brown Joy Worthington Stephen B. Fox Roger W. Chapman Kenneth A. Fleming Alison H. Banham Paul Klenerman | 2007 | Journal of Hepatology2007，，3： | 1 |
| 7 | Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection显示文摘 | Scott M. Ward Bridget C. Fox Philip J. Brown Joy Worthington Stephen B. Fox Roger W. Chapman Kenneth A. Fleming Alison H. Banham Paul Klenerman | 2007 | Journal of Hepatology2007，，3： | 1 |
| 8 | Orbital Metastasis: Clinical Features, Management and Outcome显示文摘 | Alejandra A. Valenzuela Curtis W. Archibald Ben Fleming Lorraine Ong Brett O’Donnell John Crompton J Dinesh Selva Alan A. McNab Timothy J. Sullivan | 2009 | Orbit (-)2009，，2： | 1 |
| 9 | Randomized controlled trial of recombinant alpha-2a-interferon for chronic hepatitis C显示文摘 | David D. Douglas MD Dr. Jorge Rakela MD Hsiang Ju Lin DSc F. Blaine Hollinger MD Howard F. Taswell MD Albert J. Czaja MD John B. Gross MD Monte L. Anderson MD Kevin Parent MD C. Richard Fleming MD John R. Cangemi MD Peter C. O’Brien PhD Pauline E. Powis R | 1993 | Digestive Diseases and Sciences1993，，4： | 1 |
| 10 | Intervention for Recoarctation in the Single Ventricle Reconstruction Trial: Incidence, Risk, and Outcomes显示文摘 | Kevin D. Hill John F. Rhodes Ranjit Aiyagari G. Hamilton Baker Lisa Bergersen Paul J. Chai Gregory A. Fleming J. Curt Fudge Matthew J. Gillespie Robert G. Gray Russel Hirsch Kyong-Jin Lee Jennifer S. Li Richard G. Ohye Matthew E. Oster Sara K. Pasquali An | 2013 | Circulation2013，，9： | 1 |
| 11 | Toll-like receptor 4 signaling is required for induction of gluconeogenic gene expression by palmitate in human hepatic carcinoma cells显示文摘 | Laman K. Mamedova Kai Yuan Amber N. Laudick Sherry D. Fleming Douglas G. Mashek Barry J. Bradford | 2013 | The Journal of Nutritional Biochemistry2013，，8： | 1 |
| 12 | Experimental Demonstration of Guiding and Bending of Electromagnetic Waves in a Photonic Crystal显示文摘 | S Y Lin J G Fleming D L Hetherington B. K.Simth T. Biswas K. M. Ho M. M. Sigalas W. Zubrzycki S. R. Kurtz and J. Bur | | 0，，： | 1 |
| 13 | Overexpression of CEACAM6 in borderline and invasive mucinous ovarian neoplasms显示文摘 | Behrang Litkouhi Babak Litkouhi Evelyn Fleming William R. Welch Ross S. Berkowitz Michael J. Birrer Samuel C. Mok | 2008 | Gynecologic Oncology2008，，2： | 1 |
| 14 | Grain refinement of an aluminum alloy by introducing gas bubbles during solidification显示文摘 | J. Wannasin R.A. Martinez M.C. Flemings | 2006 | Scripta Materialia2006，，2： | 1 |
| 15 | The role of lymphadenectomy in the management of preoperative grade 1 endometrial carcinoma显示文摘 | Nikki L. Neubauer Laura J. Havrilesky Brian Calingaert Anuradha Bulusu Marcus Q. Bernardini Nicole D. Fleming Amy E. Bland Angeles Alvarez Secord | 2008 | Gynecologic Oncology2008，，3： | 1 |
| 16 | UV absorption cross sections of nitrous oxide (N2O) and carbon tetrachloride (CCl4) between 210 and 350 K and the atmospheric implications显示文摘 | Rontu Carlon N. Papanastasiou D. K. Fleming E. L. Jackman C. H. Newman P. A. Burkholder J. B | 2010 | 2010 (201)2010，，201： | 1 |
| 17 | Infiltration of fibrous preforms by a pure metal: Part I. Theory显示文摘 | A. Mortensen L. J. Masur J. A. Cornie M. C. Flemings | 1989 | Metallurgical Transactions A1989，，11： | 1 |
| 18 | Effects of pneumoperitoneum on intraoperative pulmonary mechanics and gas exchange during laparoscopic gastric bypass显示文摘 | N. T. Nguyen J. T. Anderson M. Budd N. W. Fleming H. S. Ho J. Jahr C. M. Stevens B. M. Wolfe | 2004 | Surgical Endoscopy2004，，1： | 1 |
| 19 | Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection显示文摘 | Scott M. Ward Bridget C. Fox Philip J. Brown Joy Worthington Stephen B. Fox Roger W. Chapman Kenneth A. Fleming Alison H. Banham Paul Klenerman | 2007 | Journal of Hepatology2007，，3： | 1 |
| 20 | Bone structure and breaking strength in laying hens housed in different husbandry systems显示文摘 | R. H. Fleming C. C. Whitehead D. Alvey N. G. Gregory L. J. Wilkins | 1994 | British Poultry Science1994，，5： | 1 |
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