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| 1 | Loco-regional therapies for patients with hepatocellular carcinoma awaiting liver transplantation: Selecting an optimal therapy显示文摘Hepatocellular carcinoma(HCC) is a common, increasingly prevalent malignancy. For all but the smallest lesions, surgical removal of cancer via resection or liver transplantation(LT) is considered the most feasible pathway to cure. Resection- even with favorable survival- is associated with a fairly high rate of recurrence, perhaps since most HCCs occur in the setting of cirrhosis. LT offers the advantage of removing not only the cancer but the diseased liver from which the cancer has arisen, and LT outperforms resection for survival with selected patients. Since time waiting for LT is time during which HCC can progress, locoregional therapy(LRT) is widely employed by transplant centers. The purpose of LRT is either to bridge patients to LT by preventing progression and waitlist dropout, or to downstage patients who slightly exceed standard eligibility criteria initially but can fall within it after treatment. Transarterial chemoembolization and radiofrequency ablation have been the most widely utilized LRTs to date, with favorable efficacy and safety as a bridge to LT(and for the former, as a downstaging modality). The list of potentially effective LRTs has expanded in recent years, and includes transarterial chemoembolization with drug-eluting beads, radioembolization and novel forms of extracorporal therapy. Herein we appraise the various LRT modalities for HCC, and their potential roles in specific clinical scenarios in patients awaiting LT. | Thomas J Byrne Jorge Rakela | 2016 | World Journal of Transplantation2016，6，2： | 5 |
| 2 | A multicenter United States—Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B显示文摘 | Robert P. Perrillo Teresa Wright Jorge Rakela Gary Levy Eugene Schiff Robert Gish Paul Martin Jules Dienstag Paul Adams Rolland Dickson Gaya Anschuetz Steve Bell Lynn Condreay Nathaniel Brown | 2001 | Hepatology2001，，2： | 2 |
| 3 | The role of ultrasonography and automatic-needle biopsy in outpatient percutaneous liver biopsy显示文摘 | KD Lindor C Bru RA Jorgensen J Rakela JM Bordas JB Gross J Rodes DB McGill CC Reading EM James JW Charboneau J Ludwig KP Batts AR Zinsmeister | 1996 | Hepatology1996，，5： | 2 |
| 4 | A multicenter United stales-Canadian trial to assess lamivudine monotherapy hefor and after liver transplantation for ehronie hepatitis B 显示文摘 | Perrillo RP wright T Rakela J | 2001 | Hepatology2001，33，2： | 1 |
| 5 | Hepatitis C virus genotypes in the United State : epidemiology, pathogeneicity, and response to interferon therapy显示文摘 | Zein NN Rakela J Krawitt EL | 1996 | Ann Intern Med1996，125，： | 1 |
| 6 | Hepatitis C:Magnitude of the problem显示文摘 | Rakela J Vargas HE | 2002 | Liver Transpl2002，8，101： | 1 |
| 7 | A muhicenter Unit- ed States-Canadian trial to assess lamivudine monotherapy before and after liver traasplantation for chronic hepatitis B 显示文摘 | Perrillo RP Wright T Rakela J | 2001 | Hepatology2001，33，2： | 1 |
| 8 | A multicenter United States-Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B显示文摘 | Perrillo RP Wright T Rakela J | | 0，，02： | 1 |
| 9 | Multicenter study of lamivudine therapy for hepatitis B after liver transplantation显示文摘 | Perrillo R Rakela J Dienstag J | 1999 | Hepatology1999，29，5： | 1 |
| 10 | Lamivudine for decompensated cirrhosis resulting form chronic hepatitis B 显示文摘 | VILLENEUVE J P WIGNT T RAKELA J | 2000 | Hepatology2000，31，2： | 1 |
| 11 | Morbidity and Mortality in Cirrhotic Patients Undergoing Anesthesia and Surgery显示文摘 | Avishai Ziser David J. Plevak Russell H. Wiesner Jorge Rakela Kenneth P. Offord David L. Brown | 1999 | Anesthesiology1999，，1： | 1 |
| 12 | Recent advances in liver transplantation 显示文摘 | Russell H Wiesner Jorge Rakela Michael B Ishitani | 2003 | Mayo Clinic Proceedings2003，78，2： | 1 |
| 13 | A multicenter United States-Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B显示文摘 | Perrillo RP Wright T Rakela J | 2001 | Hepatology2001，33，： | 1 |
| 14 | A 21-year experience with major haemorrhage after percutaneous liver biopsy显示文摘 | McGill DB Rakela J Zinsmeister AR | 1990 | Gastroenterology1990，99，5： | 1 |
| 15 | Virologically compromised donor grafts in liver transplantation 显示文摘 | Gallegos-Orozeo JF Vargas HE Rakela J | 2004 | J Hepatol2004，41，4： | 1 |
| 16 | Lamivudine for decompensated cirrhosis resulting form chronic hepatitis B显示文摘 | Wight T Rakela J | 2000 | Hepatology2000，31，： | 1 |
| 17 | Search for hepatitis C virus extrahepatic replication sites in patients with acquired immunodeficiency syndrome:specific detection of negative-strand viral RNA in various tissues显示文摘 | Laskus T Radkowski M Wang LF Vargas H Rakela J | | 0，，： | 1 |
| 18 | Cancer Antigen 125 in Patients With Chronic Liver Disease显示文摘 | Harshad Devarbhavi Dorothy Kaese Amy W. Williams Jorge Rakela George G. Klee Patrick S. Kamath | 2002 | Mayo Clinic Proceedings2002，，6： | 1 |
| 19 | Treatment of Hepatitis C in Renal Transplantation Candidates: A Single-Center Experience显示文摘 | T. Werner Bashar Aqel Vijayan Balan Thomas Byrne Elizabeth Carey David Douglas Raymond L. Heilman Jorge Rakela Kristin Mekeel Kunam Reddy Hugo E. Vargas | 2010 | Transplantation2010，，4： | 1 |
| 20 | Hepatitis B virus core promoter sequence analysis in fulminant and chronic hepatitis B显示文摘 | Laskus T Rakela J Nowicki MJ | 1995 | Gastroenterology1995，109，5： | 1 |
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