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| 1 | New insights of T cells in the pathogenesis of psoriasis显示文摘干癣是 hyperproliferative keratinocytes 和 T 房间,树枝状的房间,巨噬细胞和 neutrophils 的渗入描绘的最普通的调停免疫者的长期的、煽动性的皮肤病之一。尽管干癣的致病充分没被理解,有宽大的证据,建议在皮肤的有免疫力的房间的 dysregulation,特别地 T 房间,在干癣开发起一个关键作用。在这评论,我们主要集中于病原的 T 房间并且讨论这些 T 房间怎么被激活并且在疾病致病包含了。最新识别的 ‘ professional’IL-17-producing 真皮的 γ δ在干癣的 T 房间和他们的潜在的角色将也被包括。最后,我们将简短为干癣处理在 T 房间和它的相关指向 cytokine 的治疗上总结最近的进步。 | Yihua Cai Chris Fleming Jun Yan | 2012 | Cellular & Molecular Immunology2012，9，4： | 49 |
| 2 | Coarctation of the aorta:Management from infancy to adulthood显示文摘Coarctation of the aorta is a relatively common form of congenital heart disease, with an estimated incidence of approximately 3 cases per 10000 births. Coarctation is a heterogeneous lesion which may present across all age ranges, with varying clinical symptoms, in isolation, or in association with other cardiac defects. The first surgical repair of aortic coarctation was described in 1944, and since that time, several other surgical techniques have been developed and modified. Additionally, transcatheter balloon angioplasty and endovascular stent placement offer less invasive approaches for the treatment of coarctation of the aorta for some patients. While overall morbidity and mortality rates are low for patients undergoing intervention for coarctation, both surgical and transcatheter interventions are not free from adverse outcomes. Therefore, patients must be followed closely over their lifetime for complications such as recoarctation, aortic aneurysm, persistent hypertension, and changes in any associated cardiac defects. Considerable effort has been expended investigating the utility and outcomes of various treatment approaches for aortic coarctation, which are heavily influenced by a patient's anatomy, size, age, and clinical course. Here we review indications for intervention, describe and compare surgical and transcatheter techniques for management of coarctation, and explore the associated outcomes in both children and adults. | Rachel D Torok Michael J Campbell Gregory A Fleming Kevin D Hill | 2015 | World Journal of Cardiology2015，7，11： | 27 |
| 3 | Critical Thinking Ⅰ: Seeking Conceptual Clarity显示文摘this first paper focuses on seeking conceptual clarity;the second paper will focus on how nurses use critical thinking in clinical cases;and the third paper will focus on how advanced nurse practitioners use critical thinking to provide safe and high quality care to patients and families.We welcome nursing colleagues in China respond our paper. | ZHAN Lin LEE Shirleatha FLEMING Belinda | 2014 | 护理学报2014，21，1： | 23 |
| 4 | 利用RNA干扰技术抑制水稻淀粉极限糊精酶基因表达显示文摘构建了含极限糊精酶基因片段反向重复结构的RNAi载体,抑制水稻籽粒中极限糊精酶基因表达获得了极限糊精酶基因功能缺失突变体。经酶切及序列测定证实,成功地构建了胚乳特异表达启动子启动的水稻极限糊精酶基因反向重复结构RNAi载体;通过根癌农杆菌(Agrobacterium tumefaciens)介导水稻(Oryza sativa sp.japonica)转化,经PCR及Southern杂交检测,获得28个水稻转基因再生株系;以极限糊精酶抗体对转基因株系胚乳发育期籽粒蛋白质进行Western杂交,并经SDS-PAGE极限糊精酶活性检测,结果显示,该反向重复结构在胚乳发育期表达,减少了极限糊精酶的积累,获得了不同沉默效果的转基因株系。转化株系012的极限糊精酶活性只有野生型的10%,表明该载体可有效地抑制水稻胚乳中极限糊精酶的活性。 | 黄冰艳 李忠谊 吉万全 海燕 Fleming J Morell M Rahman S | 2007 | 农业生物技术学报2007，15，1： | 13 |
| 5 | 自动化显微镜检测和数字化胸片诊断系统在肺结核筛查中的应用显示文摘中国有世界上第二大的结核病疫情(仅次于印度),具有较高的结核病感染、发病、耐药以及病死率。因此,快速、准确的诊断,以及时采取治疗,是控制这种疾病的关键问题。涂片荧光显微镜与金胺-O染色是在病理实验室检测肺结核抗酸杆菌(acid fast bacilli,AFB)最常用的诊断方法。但是以眼睛观察显微镜来筛查检测抗酸杆菌是一项烦琐、劳动密集型任务。低质量、不一致的痰涂片染色技术,标本碎屑,人眼视觉的变异和疲劳等因素会导致灵敏度低至40%。使用基于人工智能(artificial intelligence,AI)计算机辅助诊断(computer aided diagnostic,CAD)技术的自动显微镜系统对结核病进行自动诊断,提供了一个有效解决当前痰涂片诊断结核病所存在的缺陷。胸部X射线片也是世界卫生组织认定的非常有效的快速分流和转诊检测方法。但是,在不发达地区,因放射医生缺乏,它无法为大量的感染人群提供服务。为解决这一需要,将先进的数字化医学影像精准诊断应用于肺结核(pulmonary tuberculosis,PTB)检测,基于人工智能的CAD自动化智能系统,为肺结核的数字化医学影像精准诊断开辟了一条新路。 | Fleming Y.M.Lure Stefan Jaeger Sameer Antani Shenwen Quan | 2017 | 新发传染病电子杂志2017，2，1： | 11 |
| 6 | Proposed case of mesalazine-induced cardiomyopathy in severe ulcerative colitis显示文摘Five-amino salicylic acids are recommended for use in the management of inflammatory bowel disease,cardiac complications are a rare although recognised phenomenon.This report aims to highlight this serious but rare adverse reaction.We report here a case of a young man presenting with cardiogenic shock in the context of recent mesalazine treatment in severe ulcerative colitis. | Kathryn Fleming Andrew Ashcroft Christopher Alexakis Demitrios Tzias Christopher Groves Andrew Poullis | 2015 | World Journal of Gastroenterology2015，21，11： | 9 |
| 7 | Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms显示文摘刺激干扰素的基因 56 (ISG56 ) 家庭成员在堵住病毒的复制并且然而,调整细胞的功能起重要作用他们的内在的分子的机制大部分是不清楚的。这里,我们在场 ISG54 的水晶结构,有新奇 RNA 有约束力的结构的 ISG56 家庭蛋白质。结构证明 ISG54 单体有 9 tetratricopeptide 像重复的主题和伙伴到形成交换域的 dimers。C 终端部分合拢进超级螺旋状的结构并且在它的内部表面上有一条广泛地断然控告的核苷酸绑定隧道。EMSA 结果证明 ISG54 明确地绑在一些 RNA,例如 adenylate uridylate (AU ) 富有的 RNA,与或没有 5 ′triphosphorylation。Mutagenesis 和功能的研究证明这个 RNA 有约束力的能力对它的抗病毒的活动重要。我们的结果建议位于这干扰素可诱导的基因的抗病毒的活动下面的新机制 56 家庭成员。 | Zhenlin Yang Huanhuan Liang Qian Zhou Ying Li Haiwei Chen Wen Ye Danying Chen Joy Fleming Hongbing Shu Yingfang Liu | 2012 | Cell Research2012，22，9： | 8 |
| 8 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013显示文摘 | Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso | 2014 | The Lancet2014，，： | 7 |
| 9 | Metabolism pathways of arachidonic acids:mechanisms and potential therapeutic targets显示文摘The arachidonic acid(AA)pathway plays a key role in cardiovascular biology,carcinogenesis,and many inflammatory diseases,such as asthma,arthritis,etc.Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2),which is in turn further metabolized by cyclooxygenases(COXs)and lipoxygenases(LOXs)and cytochrome P450(CYP)enzymes to a spectrum of bioactive mediators that includes prostanoids,leukotrienes(LTs),epoxyeicosatrienoic acids(EETs),dihydroxyeicosatetraenoic acid(diHETEs),eicosatetraenoic acids(ETEs),and lipoxins(LXs).Many of the latter mediators are considered to be novel preventive and therapeutic targets for cardiovascular diseases(CVD),cancers,and inflammatory diseases.This review sets out to summarize the physiological and pathophysiological importance of the AA metabolizing pathways and outline the molecular mechanisms underlying the actions of AA related to its three main metabolic pathways in CVD and cancer.progression will provide valuable insight for developing new therapeutic drugs for CVD and anti-cancer agents such as inhibitors of EETs or 2J2.Thus,we herein present a synopsis of AA metabolism in human health,cardiovascular and cancer biology,and the signaling pathways involved in these processes.To explore the role of the AA metabolism and potential therapies,we also introduce the current newly clinical studies targeting AA metabolisms in the different disease conditions. | Bei Wang Lujin Wu Jing Chen Lingli Dong Chen Chen Zheng Wen Jiong Hu Ingrid Fleming Dao Wen Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 7 |
| 10 | 胚乳特异sbeⅡa启动子在小麦中的评价及特性分析显示文摘淀粉的合成是一个复杂的生化过程。sbeⅡa基因是淀粉合成过程中的关键酶基因之一,在小麦籽粒成熟过程中对淀粉,尤其对支链淀粉的生物合成调控起重要作用。为了解sbeⅡa基因的调控机理及其胚乳特异表达特性,利用APCR方法克隆了sbeⅡa启动子3094 bp片段,并对该片段进行测序,同时利用GUS瞬间表达体系对sbeⅡa启动子序列进行不同片段的功能缺失研究。研究结果表明,3094 bp序列(存在于sbe.g融合体中)具有稳定的启动子活性,而5'或3'缺失体的启动子活性明显降低。在sbeⅡa启动子中间缺失体中,一些缺失体仅有微弱活性,但sbe.e在缺失-1579—1210 bp片段情况下,却具有比sbe.g(含启动子全长序列)还要高的启动子活性,研究初步证明,一些固定序列(motifs),如-300 bp因子、G盒以及醇溶蛋白盒(Prolamin box)等作为正调控因子在决定启动子胚乳特异表达模式中是必需的,而且在-1579—1210 bp片段中也存在一些负调控因子或固定序列。在瞬间表达检测体系中,小麦胚乳组织年龄对检测结果有着重要影响。 | 苗红梅 Fleming Joy E 吕德彬 韩锦峰 | 2004 | 科学通报2004，49，5： | 7 |
| 11 | 水稻组织培养中Tos17诱发体细胞无性系变异纯合体筛选技术初探显示文摘利用PCR技术对从日本引进的Tos17插入水稻极限糊精酶基因变异体后代进行了插入位点鉴定和纯合体筛选分析。结果表明,利用Tos17末端2 6bpDNA序列和插入位点上下游各2 0 0bp和30 0bp处的目标基因序列片段设计引物,可以有效地进行Tos17插入突变纯合体筛选,为突变体的进一步利用提供了分子依据。 | 黄冰艳 吉万全 海燕 康明辉 侯大虎 Fleming Joy 李忠谊 Rahman Sadequr | 2005 | 河南农业科学2005，34，6： | 6 |
| 12 | Chemopreventive and Growth Inhibitory Effects of Selenium显示文摘There is very convincing evidence that a high dietary level of selenium substantially reduces the incidence of a wide variety of animal cancers. The human epidemiological evidence is less clear cut, but overall suggests that selenium may be protective: the evidence is strongest in men in relation to gastro-intestinal cancers. There is evidence that dietary selenium compounds reduce the formation of DNA adducts by carcinogens. Selenium compounds also inhibit growth in vitro and induce apoptosis. In general, there is a good correlation between the effectiveness of selenium compounds in chemoprevention and growth inhibition, implying that the mechanisms of growth inhibition and chemoprevention may be similar and that a major factor in the chemopreventive effects of selenium compounds in vivo is their ability to retard outgrowth of pre-malignant cells. Various hypotheses have been advanced as to how selenium compounds might prevent tumour cellgrowth. One is that they cause apoptosis by inducing oxidative stress. However, we have shown that the most potent selenium compound, selenodiglutathione (SDG), a natural metabolite of selenite, does not induce oxidative stress, at least not in the sarne way as other oxidants such as H2O2 and diamide. Firstly, a partially selenium-resistant variant cell line does not show increased resistance to H2O2. Moreover, SDG does not induce widespread tyrosine phosphorylation, including MAP and SAN kinases, like other oxidants such as H2O2 and diamide and its effects are not reversed by pretreatment with the tyrosine kinase inhibitor, herbimycin. Our experiments with the selenium-resistant variant suggest that a novel selenium-binding protein may be involved in growth inhibition by | P. R. HARRISON J. LANFEAR L. WU J. FLEMING L. MCGARRY, AND L. BLOWER (The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road,Bearsden, Glasgow, G61 1BD, Scotland, UK) | 1997 | Biomedical and Environmental Sciences1997，10，2： | 5 |
| 13 | Impact of biochar amendments on the quality of a typical Midwestern agricultural soil显示文摘 | David A. Laird Pierce Fleming Dedrick D. Davis Robert Horton Baiqun Wang Douglas L. Karlen | 2010 | Geoderma2010，，3： | 5 |
| 14 | Behavior of metal alloys in the semisolid state显示文摘 | Merton C. Flemings | 1991 | Metallurgical Transactions A1991，，5： | 4 |
| 15 | 木质包装中黄斑星天牛微波处理初探显示文摘为了探索微波处理作为木质包装替代处理方法的可能性 ,对不同规格和含水量的杨树木块进行微波处理试验 ,结果表明 :频率为 2 4 50MHz的微波能够穿透厚度为 1 0cm的杨树木材 ;当微波功率为 90 0W时 ,规格为 1 0cm× 1 0cm× 1 0cm和 1 0cm× 1 0cm× 2 5cm的新木块中黄斑星天牛 (Anoplophoranobolis)幼虫完全死亡所需时间分别为 5min和 2min ;而干木块中则仅需 3min和 30s。对微波处理引起木材温度变化和水分损失以及天牛幼虫的水分损失进行了初步研究。 | 王跃进 王新 徐亮 詹国平 刘波 李顺平 Mary Fleming Fang Yi 黄晓旭 刘文敏 朱蕴智 吴颖 | 2004 | 植物检疫2004，18，4： | 4 |
| 16 | Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin显示文摘 | Anthony H. Barnett Bernard Charbonnel Mark Donovan Douglas Fleming Roland Chen | 2012 | Current Medical Research & Opinion2012，，4： | 3 |
| 17 | Biochar impact on nutrient leaching from a Midwestern agricultural soil显示文摘 | David Laird Pierce Fleming Baiqun Wang Robert Horton Douglas Karlen | 2010 | Geoderma2010，，3： | 3 |
| 18 | WONCA研究论文摘要汇编——初级医疗团队社会网络对心血管疾病患者医疗质量和费用的效果研究显示文摘目的心血管疾病是美国人口死亡与发病的首要原因。初级医疗团队可以最大化地提高心血管疾病患者的医疗质量,降低医疗成本。本研究探讨初级医疗团队交流、互动、协作(即社会网络)与心血管疾病医疗质量、费用之间的关系。方法从6家初级医疗诊所的31个团队中,选取155名专业医护人员进行社会经济调查,确保调查对象日常进行医疗互动。通过社会网络分析,计算团队互动密度与集中度变量。采用三级模式分析法,评估团队社会网络密度、集中度与过去12个月内控制血压和胆固醇的心血管疾病患者数量、上门急救次数、急诊室来访次数、住院天数、医疗费用之间的关系。结果医疗团队成员的互动密度越大,心血管疾病患者的住院天数就越少〔RR=0.62,95%CI(0.50,0.77)〕,医疗费用就越低〔-$556,95%CI(-$781,-$331)〕。相反,如团队围绕少数个体进行更集中的互动,患者的住院天数就越多〔RR=1.45,95%CI(1.09,1.94)〕,医疗费用就越高〔$506,95%CI($202,$810)〕。团队内部就目标进行分享与沟通,能够调整社会网络结构与医疗质量之间的关系。结论增强初级医疗团队互动,降低互动集中度,共享团队目标,可以凭借更少的医疗成本获得高质量的心血管医疗服务。 | Mundt MP Gilchrist VJ Fleming MF 本刊编辑部 | 2015 | 中国全科医学2015，18，11： | 3 |
| 19 | Fractal analysis of retinal vasculature in normal subjects on ultra-wide field fluorescein angiography显示文摘AIM: To evaluate the fractal feature of the retinal vasculature of normal eyes on a stereographic projected and montaged ultra-wide field(UWF) fluorescein angiography(FA).METHODS: Prospective, observational, cross-sectional study. Totally 59 eyes of 31 normal subjects were imaged using the Optos 200 Tx. Images obtained at different gaze angles stereographically projected and montaged. The early-phase UWF FA frames were processed to segment the retinal vasculature and the results were exported as binary masks. The fractal dimension(FD) was calculated using the box-counting method.RESULTS: The global FD for the entire retina was 1.6±0.04, with no difference between males and females(1.59±0.04 vs 1.61±0.04, P=0.084) or between right and left eyes(1.6±0.04 vs 1.6±0.05, P=0.61). FD was nonuniformly distributed among four quadrants(P<0.001) and decreased as the distance from the fovea increased(P<0.001). A negative association was observed between FD and age(R=-0.37, P=0.006), and this relationship was observed in the posterior and mid-peripheral retina(P<0.05) but absent in far-periphery(P>0.05).CONCLUSION: Fractal geometry is non-uniformly distributed across the retina in normal eyes and decreases from the fovea to the far-periphery. Subjects with an older age tend to have a smaller FD, however, the FD in the farperiphery does not appear to be influenced by age. | Wen-Ying Fan Alan Fleming Gavin Robertson Akihito Uji Jano van Hemert Michael Singer Min Sagong Michael Ip SriniVas R.Sadda | 2020 | International Journal of Ophthalmology(English edition)2020，13，7： | 3 |
| 20 | Critical Thinking II: Teaching Strategies to Foster Critical Thinking in Undergraduate Nursing Students: A Case Analysis Approach显示文摘Due to increasingly complex issues,challenging and acutely ill patients,advancing technology and ethical dilemmas it is important that nurses are able to think critically to improve patient outcomes.Therefore,nurse educators continually seek to identify effective learning strategies that foster critical thinking in their undergraduate students to make theoretical and clinical teaching seamless.Therefore,the purpose of this article is to describe the role of the nurse educator in helping nursing students to think critically.We will examine a case analysis and describe various teaching strategies that support critical thinking,can increase student learning,and aid in the provision of nursing care. | LEE Shirleatha ZHAN Lin FLEMING Belinda | 2014 | 护理学报2014，21，23： | 3 |
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