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| 1 | 阿尔金断裂带年代学和阿尔金山隆升显示文摘对阿尔金山断裂带内变形的中生代剪切带中眼球状片麻岩、糜棱岩化花岗片麻岩和新生代剪切带中强变形绿片岩系列样品中同构造新生云母矿物的^40Ar-^39Ar法定年,获得了164.3—178.4Ma和26.3—36.4Ma两组年龄。结合阿尔金走滑断裂水平错距的研究,认为164.3—178.4Ma的年龄代表阿尔金走滑断裂带的起始活动时间(早侏罗世末—中侏罗世),尔后分别在距今100—85Ma,40—25Ma和10—8Ma发生多次脉冲式走滑活动。新生代沉积物研究表明上干柴沟组和下干柴沟组砂岩骨架矿物成份含量明显不同,随时间变化,石英含量减少,岩屑组份和不稳定矿物含量增加,分选性逐渐变差。这表明阿尔金山在渐新世(下干柴沟组时期)开始发生明显的隆升。地震和柴达木—塔里木盆地沉积速率资料显示在晚中新世山体也发生了一次强烈的隆升。七个泉组(上新世末—早更新世初)和下伏沉积物(上新世中期)之间的角度不整合反映了最后一次强烈隆升事件发生在晚上新世。多数隆升事件和阿尔金断裂带新生代脉冲式活动的同位素年龄完全一致,表明阿尔金山的隆升和断裂带的活动具有密切的成因联系。 | 刘永江 Franz Neubauer 葛肖虹 Johann Genser 袁四化 李伟民 巩庆林 陈元忠 | 2007 | 地质科学2007，42，1： | 83 |
| 2 | 柴达木盆地北缘晚中生代—新生代构造应力场——来自构造节理分析的证据显示文摘柴达木盆地的构造演化,尤其是中、新生代的构造演化历史及其影响程度一直存在争议。在冷湖0号、冷湖4号、鄂博梁、结绿素等剖面开展了野外构造节理测量,应用地层恢复技术,分析了柴北缘晚中生代—新生代构造应力场的演化过程。结果表明:晚侏罗世之后,柴北缘主要受东西方向的挤压,这与区域上的研究结果一致;早白垩世北西—南东向的挤压应力可能再次影响了侏罗系;晚白垩世受南北挤压应力的影响,地层隆升遭受剥蚀;始新世下干柴沟期至上新世狮子沟期,柴北缘处于弱活动时期,接受稳定沉积;上新统狮子沟组沉积之后,由于阿尔金山的隆升,盆地北缘主体受北西—南东向应力的影响,涉及地层包括上干柴沟组、下油砂山组和上油砂山组;早、中更新世七个泉期之后,受南北向构造应力场的强烈影响,在狮子沟组、上油砂山组和下油砂山组中都有其分量,较老地层的地表露头中也有记录,这期构造运动对柴北缘油气运聚具有破坏和二次成藏的作用。因此,围绕柴北缘其他地质剖面开展更进一步的构造节理测量和分析工作,对油气资源勘探具有指导意义。 | 任收麦 葛肖虹 刘永江 乔德武 尹成明 Franz NEUBAUER Johann GENSER | 2009 | 地质通报2009，28，7： | 31 |
| 3 | Development of early gastric cancer 4 and 5 years after complete remission of Helicobacter pyloriassociated gastric low-grade marginal zone B-cell lymphoma of MALT type显示文摘AIM To report 3 of 120 patients on the German MALT lymphoma trial with H. pYlori-associated gastric MALT Iymphoma who developed early gastric cancer 4 and 5 years, after complete Iymphoma remission following cure of H. pylori infection.PATIENTS AND RESULTS Three patients (two men, 74 and 70 years; one women, 77 years)with H. pylori -associated low-grade MALTlymphoma achieved complete lymphoma remission after being cured. Surveillance endoscopies were performed twice a year in accordance to the protocol. Four years aftercomplete lymphoma remission in two patients,and after 5 years in the other, early gastric adenocarcinoma of the mucosa-type, type Ⅱ a and type Ⅱ c, respectively, was detetcted,which were completely removed by endoscopic mucosa resection. in one patient, the gastric cancer was diagnosed at the same location as the previous. MALT lymphoma, in the other patients it was detected at different sites of the stomach distant from location of the previous MALT lymphoma. The patients were H. pylori negative during the whole follow-up time.CONCLUSION These findings strengthen the importance of regular long-term follow-up endoscopies in patients with complete remission of gastric MALT lymphoma after cure of H.pylori infection. Furthermore, gastric adenocarcinoma may develop despite eradication of H. pylori. | Andrea Morgner Stephan Miehlke Manfred Stolte Andreas Neubauer Birgit Alpen Christian Thiede Hermann Klann Franz-Xaver Hierlmeier Christian Ell Gerhard Ehninger Ekkehard Bayerdorffer | 2001 | World Journal of Gastroenterology2001，7，2： | 28 |
| 4 | 造山带挤出构造显示文摘挤出构造模式已经从二维变形进入三维变形研究。在喜马拉雅造山带 ,高喜马拉雅结晶地体沿北倾的主中央逆冲断层和北倾的绒布寺正断层 ,表现为相对刚性体之间的韧性体的楔状挤出。非连续介质大变形有限元数值模拟结果为这一模式提供了力学依据。在前人工作的基础上 ,提出了东阿尔卑斯三维管状挤出模式。将上部脆性层划分出北部左行平移带 ,南部右行平移带和中部挤出楔。中部韧性层在南阿尔卑斯和欧洲前陆碰撞过程中 ,既有垂向挤出 ,也有侧向挤出。在平行缩短方向的剖面上 ,由箱状背形隆起演化成逆—逆断层组合的楔状挤出 ,形成三角断面的管状。在垂直缩短方向的剖面上 ,中部韧性层呈不均匀流动 ,形成管状层流——韧性层中心为纯剪切 ,上部和侧部为简单剪切。在陕甘川邻接区 ,由于祁连山—北秦岭加里东造山带向南的推挤和川西前陆的刚性阻挡 ,造成西秦岭和东松潘—甘孜复合造山体的三维滑脱挤出。以北西西向玛曲—略阳滑脱逆冲断裂和北东向青川—茂县滑脱逆冲断裂为界 ,将陕甘川邻接区的三维滑脱挤出复合造山体划分为西秦岭滑脱挤出带、摩天岭—若尔盖滑脱挤出楔和龙门山滑脱挤出逆冲推覆带。以近南北向岷江滑脱逆冲断裂为界将滑脱挤出楔进一步划分成摩天岭滑脱挤出体和若尔盖滑脱挤出体。除了不同构造单? | 曾佐勋 杨巍然 Franz Neubauer 刘立林 郭铁鹰 | 2001 | 地质科技情报2001，20，1： | 28 |
| 5 | 柴北缘-南祁连地区构造热事件显示文摘对柴北缘路乐河剖面新生代沉积物和山前现代河沙中碎屑的锆石U-Pb同位素热年代学研究表明:研究区物源区发育~260、~450、500~600、800~900Ma 4个主要年龄峰值和~1.8、2.5~2.6Ga 2个较小的年龄峰值。结合研究区已有的同位素年龄数据提出:柴北缘—南祁连地区在二叠纪中—晚期遭受了一次较强烈的低温区域构造热事件的改造;柴北缘高压榴辉岩及其相关的地质体隆升到地表的时间晚于上新世;柴北缘—南祁连地区先后主要经历了800~900 Ma的Rodinia超大陆裂解事件,500~600 Ma的泛非区域变质事件和~450Ma的俯冲碰撞变质事件;柴北缘—南祁连地区的主要构造热事件发生在元古代,主要集中在500~600Ma和800~900Ma,表明柴北缘—南祁连地区的前寒武纪基底性质与扬子板块相似,与华北板块完全不同。 | 刘永江 Franz Neubauer 李伟民 Johann Genser 李伟 | 2012 | 吉林大学学报(地球科学版)2012，42，5： | 26 |
| 6 | 松辽盆地西缘边界断裂带中南段走滑性质、时间及其位移量显示文摘松辽盆地的西缘边界断裂带,又称嫩江-八里罕断裂带,位于东北地区中部,大兴安岭的东缘,传统认识上认为其为一条NNE向的大型正断层或拆离断层.通过对断裂带中南段楼子店,岭下地区韧性变形岩石构造要素系统测量和统计,显微构造观察,有限应变测量,石英组构EBSD(电子背散射衍射)分析和变形带白云母40Ar/39Ar年代学等方面的对比研究,证实断裂带南段楼子店地区与中段岭下地区变形岩石具有相同的变形组构特征,应为同一断裂带同期变形的产物,初步确定了松辽盆地西缘边界断裂带中南段在早白垩世早期(~130 Ma)曾经历左行走滑变形阶段;通过对断裂带两侧西拉木伦河缝合带和倭勒根岩群展布的研究,确定嫩江-八里罕断裂带的现今累计走滑位移量在40~50 km之间. | 韩国卿 刘永江 Franz NEUBAUER Johann GENSER 邹运鑫 李伟 梁琛岳 | 2012 | 中国科学:地球科学2012，42，4： | 12 |
| 7 | 黑龙江省嫩江地区科洛杂岩隆升时代显示文摘科洛杂岩出露于黑龙江省嫩江县大兴安岭北段,构造解析指示其为一大型伸展滑脱构造,整体反映杂岩体向南东伸展滑脱的特征。依据杂岩体显微构造特征,推测科洛地区伸展滑脱变形带变形温度约为300~450℃。滑脱带中变形花岗片麻岩样品中黑云母单矿物的^(40)Ar/^(39)Ar年龄为118.39~117.37 Ma,指示伸展滑脱带形成时代为早白垩世晚期。结合大兴安岭地区中生代岩浆活动特征和南北变质核杂岩对比研究,认为大兴安岭整体经历了早白垩世中晚期的快速隆升,形成一系列变质核杂岩,发育大规模伸展变形作用,与松辽盆地坳陷期具有良好的耦合关系。 | 梁琛岳 刘永江 李伟 韩国卿 温泉波 Neubauer F | 2012 | 地质科学2012，47，2： | 10 |
| 8 | 滇西哀牢山深变质杂岩新生代多期变质、剪切变形及地质意义显示文摘造山带内大型走滑断层带的运动、变形及变质事件的精细厘定,对研究造山带演化具有重要意义。沿着红河-哀牢山走滑断裂带出露大量深变质杂岩体,这些深变质杂岩保存了极其丰富的变形-变质以及热-构造演化信息。本文重点以红河-哀牢山走滑断层带中的变基性岩和变泥质岩为研究对象,开展了详细的宏观和显微构造、岩相矿物组合、变形温压条件及年代学的综合分析。所有的结果表明哀牢山深变质杂岩经历了至少三个阶段的变质以及依次的变形,即早期进变质阶段(M1)、峰期麻粒岩相变质阶段(M2)(T=780~840℃,P=~0. 95GPa)以及峰后近等温减压阶段(M3),具有明显的顺时针PT演化轨迹。获得片麻岩中的锆石边的变质或熔融年龄为35. 2±0. 9Ma^33. 9±0. 8Ma。同时结合EBSD变形矿物晶格优选定向分析,可以确定峰后近等温减压阶段(M3)与区域左行剪切变形阶段相一致。 | 王浩博 曹淑云 李俊瑜 程雪梅 吕美霞 Bernroider MANFRED Franz NEUBAUER | 2019 | 岩石学报2019，35，8： | 9 |
| 9 | 松辽盆地西缘边界断裂带中北段尼尔基L型构造岩构造年代学及其构造意义显示文摘松辽盆地西缘与大兴安岭东缘的边界断裂带,又称嫩江-八里罕断裂带,位于东北地区中部,中亚造山带东段。断裂带呈NNE走向,沿内蒙古自治区、黑龙江省与吉林省的交界,一直向南延伸至河北省境内与平场-桑园大断裂相接,全长1200km。该断裂带传统认识上被认为是一条NNE向的大型正断层或拆离断层。目前对于断裂带性质的研究主要集中在其北段的嫩江断裂,但侧重区域地球物理方面,通过布格重力异常、航磁异常、深反射剖面研究确定了断裂带的走向、展布位置,及伸展拆离断层或大型低角度正断层的性质;其南段断裂带(红山-八里罕断裂)的研究,主要与喀喇沁隆起的形成时间、性质、演化阶段等方面相联系;然而对断裂带中段的嫩江-八里罕断裂的研究少有报道。近期,我们报导了嫩江-白令海断裂带岭下及白城地区发现的具有左旋走滑性质的韧性剪切带,并同断裂带南段的红山-八里罕断裂带楼子店地区进行系统的对比。通过对岭下地区韧性剪切带详细的野外调查、构造要素测量、显微构造研究、同构造变形岩石的有限应变分析、石英EBSD组构分析以及白云母40Ar/39Ar年代学研究,我们认为岭下韧性剪切带与楼子店韧性剪切带的变形特征一致,证实了红山-八里罕断裂带至少可以向北延伸至中段岭下地区,其性质同为左行走滑韧性剪切带,并具有相同的早期走滑时限(~130Ma)。本次,我们进一步对嫩江-白令海断裂带中北段尼尔基地区韧性剪切带进行研究,通过对带内韧性变形岩石构造要素系统测量和统计、显微构造观察、有限应变测量等方面的研究,表明其岩石类型属L型构造岩,具左行剪切特征。综合分析发现除构造岩的类型(岭下与楼子店地区发育S-L型构造岩),其余与岭下与楼子店地区韧性剪切带性质相同。另外,年代学表明L型花岗质岩石中发育的锆石,1)呈自形具有致密的韵律环带,且Th/U比值介于0.06至1.25之间,显示了岩浆成因特点;2)年龄大体分为两个区间258~403Ma(n=5)和207~174Ma(n=15,加权平均年龄为190.0±6.1Ma);3)较老年龄258~403Ma的锆石普遍具有"核-边"结构,证实了该区域存在多期古生代岩浆事件。207~174Ma的锆石中,两粒锆石呈现~190Ma核部年龄,反映了区域内曾经历了早侏罗世的一次强烈的岩浆侵入事件,此后尼尔基地区韧性剪切带形成于中侏罗世(~170Ma),而并非是前人认为的二叠纪。白云母激光40Ar/39Ar年代学显示了一个稳定的年龄坪为158.99±0.61Ma。通过显微构造的观测发现长石残斑与S-C组构指示了左行韧性剪切特征,其动态重结晶主要为膨凸式特点(BLG)。而石英颗粒边界相嵌现象明显,为亚晶粒旋转(SR)向颗粒边界迁移(GBM)重结晶过渡阶段。综合长石和石英的重结晶特征指示,其变质条件为高绿片岩相,变形温度在500℃左右,显然高于白云母的封闭温度(300~400℃),故此我们认为尼尔基左行韧性剪切带的快速隆升时间应为中晚侏罗世(158.99±0.61Ma)。结合最新发表的东北地区黑龙江蓝片岩(前人称之"黑龙江群")与郯庐断裂带北段两个分支(佳依断裂与敦密断裂)的年代学数据,以及西太平洋板块的俯冲速度和方向的相关证据,我们认为1)嫩江-八里罕断裂可能经历了三期变形演化阶段,包括中-晚侏罗世左行伸展走滑阶段(~160Ma),早白垩世中期左行走滑/斜滑剪切阶段(~130Ma)及早白垩世晚期的伸展阶段;2)两期走滑剪切阶段与郯庐断裂带及其北段两个分支具有相似性,其中早期~160Ma的走滑剪切事件相对于佳木斯地块与松嫩地块的拼合时间(~170Ma)晚近10Myr;3)松辽盆地形成早期受到中-晚侏罗世的左行走滑断裂的控制,该左行走滑断裂的成因应归功于侏罗纪时西太平洋板块向欧亚大陆下快速的斜向俯冲有关。 | 韩国卿 刘永江 Franz NEUBAUER Johann GENSER 梁琛岳 温泉波 赵英利 | 2014 | 岩石学报2014，30，7： | 9 |
| 10 | Systemic interleukin-9 in inflammatory bowel disease: Association with mucosal healing in ulcerative colitis显示文摘AIM To evaluate circulating IL9 in inflammatory bowel disease and disease-associated anemia/cachexia and assess its potential as a mucosal healing marker.METHODS Serum IL9 as well as other cytokines(IL1β, IL6, IL13, IFNγ, TNFα, and VEGF-A) were determined in 293 individuals: 97 patients with Crohn's disease(CD) and 74 with ulcerative colitis(UC) and in 122 apparently healthy controls. The clinical activity of CD and UC was expressed in terms of the Crohn's Disease Activity Index(CDAI) and the Mayo Scoring System(MDAI), respectively, and the severity of bowel inflammation in UC patients was assessed using Mayo endoscopic score. Cytokine concentrations were measured by a flow cytometry-based method using Luminex x MAP? technology. Highsensitive C-reactive protein concentrations(hs CRP) were determined in CD and UC patients using the enhanced immunoturbidimetric method.RESULTS Systemic IL9 was significantly lower in healthy individuals [9 pg/m L(95%CI: 8.2-10)] than in patients with inflammatory bowel disease(IBD): both inactive [14.3 pg/m L(11.9-19.9)] and active [27.6 pg/m L(24.5-32), P < 0.0001]. Cytokine concentrations were significantly higher in active CD [27.4 pg/m L(23.4-32.2)] and in active UC [32.7 pg/m L(27-38.9)] compared to inactive diseases [15.9 pg/m L(10.8-23.4) in CD and 19.4 pg/m L(13.9-27.1) in UC, P = 0.001]. IL9 correlated weakly with CDAI(ρ = 0.32, P = 0.003) and MDAI(ρ = 0.35, P = 0.002) and strongly with endoscopic inflammation in UC(ρ = 0.74, P < 0.0001). As a negative marker of mucosal healing(MH), IL9 had an accuracy superior to hs CRP and IL6 [97%(P < 0.0001), 67%(P = 0.071), and 55%(P = 0.525), respectively]. IL9 was significantly higher in cachectic IBD patients [30.25 pg/m L(24.4-37.5) vs 21.88 pg/m L(18-26.5), P = 0.026] and negatively correlated with hemoglobin concentrations(ρ =-0.27, P < 0.001). Multiple regression showed IL1β and IL13 to be the independent predictors of circulating IL9 in healthy individuals, IFNγ or IL6 in active and inactive UC, respectively, and IL13 and VEGF-A in both active and inactive CD.CONCLUSION The systemic IL9 level is higher in IBD and corresponds with endoscopic inflammation, suggesting its possible application as a negative marker of mucosal healing in UC. | Malgorzata Matusiewicz Katarzyna Neubauer Iwona Bednarz-Misa Sabina Gorska Malgorzata Krzystek-Korpacka | 2017 | World Journal of Gastroenterology2017，23，22： | 9 |
| 11 | 利用GC-ICP-MS分析生物组织中的汞形态显示文摘汞的形态对于其对生物的毒性具有非常重要的影响.本文利用气相色谱仪与ICP-MS进行联用,对海产品中的汞形态进行精确分离和定量,并给出了优化后的接口条件、色谱条件等仪器参数. | Joaudimir Castro Kenneth Neubauer 张桢 | 2017 | 环境化学2017，36，10： | 7 |
| 12 | Characteristics,timing,and offsets of the middle-southern segment of the western boundary strike-slip fault of the Songliao Basin in Northeast China显示文摘作为 Songliao 盆和 Da Hinggan 山的东方边缘的西方边界差错, Nenjiang-Balihan 差错位于东北中国的中央部分。是一个巨大的深层的 NNE 惹人注目的差错传统地被认为,由一个正常差错或分开差错排水量描绘了。域调查导致了发现可锻砍在 Lingxia 和 Louzidian 区域,中间和差错系统的南部的扇区的地区。作者在这个领域里进行了结构的元素的大小,微结构研究,有限紧张大小,石英的比较喜欢的水晶取向上的研究用电子背决定了散布使变形的岩石的衍射和白云母 40Ar/39Ar 年表在可锻砍地区。变丑 Lingxia 和 Louzidian 展示的结果表演可锻砍地区是类似的,并且他们代表一个连续差错,即, Nenjiang-Balihan 的中间南部的片断指责在早白垩纪(130 妈) 的可锻的砍,它经历了左首的罢工滑倒。由在 Nenjiang-Balihan 差错的双方上测量 Xar 蠢人河缝术和 Wolegen 组的排水量,差错的累积罢工滑倒偏移量是大约 4050 km,这被发现。 | HAN GuoQing LIU YongJiang Franz NEUBAUER Johann GENSER ZOU YunXin LI Wei LIANG ChenYue | 2012 | Science China Earth Sciences2012，55，3： | 7 |
| 13 | 东阿尔卑斯原-古特提斯构造演化显示文摘新生代阿尔卑斯是非洲和欧洲之间的陆陆碰撞造山带。强烈的造山作用使大量前中生代基底出露地表,尽管这些基底被强烈逆冲推覆和走滑叠置,但是仍保留较丰富的前中生代基底演化信息。结合近几年对东阿尔卑斯原-古特提斯的研究,本文梳理和重建了阿尔卑斯前中生代基底的构造格局,认为前阿尔卑斯基底受原特提斯、南华力西洋、古特提斯洋构造体系影响而经历了多期造山过程。新元古代-早古生代的原阿尔卑斯作为环冈瓦纳地块群的组成部分,受原特提斯洋俯冲的制约,是新元古-早古生代环冈瓦纳活动陆缘的组成部分,其中,海尔微-彭尼内基底组成外缘增生系统,包括卡多米期地壳碎片在内的陆缘弧/岛弧以及大量增生楔组成内缘增生系统。早奥陶世瑞亚克洋打开,随后原阿尔卑斯从冈瓦纳陆缘裂离,在泥盆纪-石炭纪受南华力西洋控制,海尔微-彭尼内-中、下奥地利阿尔卑斯从冈瓦纳分离。在早石炭世(维宪期)南阿尔卑斯(或与之相当的冈瓦纳源地块)与北部阿莫里卡地块群拼贴增生于古欧洲大陆南缘,共同组成华力西造山带(广义),华力西期缝合带保留在绍山-科尔山南侧。晚石炭世-早二叠世,阿尔卑斯受古特提斯洋的俯冲影响,在华力西造山带南侧形成安第斯山型活动大陆边缘,古特提斯洋在阿尔卑斯的演化至少持续到早三叠世,消亡遗迹保留在中奥地利阿尔卑斯基底的Plankogel杂岩中。 | 袁四化 刘永江 NEUBAUER Franz 常瑞虹 GENSER Johann 关庆彬 黄倩雯 | 2020 | 岩石学报2020，36，8： | 5 |
| 14 | 从多岛弧盆系构造看西特提斯造山系构造演化显示文摘本文通过综述近年西特提斯带主要缝合带的研究进展及所代表洋盆的发育特征,提出了古特提斯缝合带可能的位置和俯冲消亡方式。结合区域资料探讨了西特提斯带古生代末-中生代洋陆构造格局,认为东、西古特提斯洋完全可以类比,自晚古生代末西特提斯带主要受古特提斯大洋双向俯冲制约,在俯冲带后缘以二叠纪裂谷带为基础逐渐发展成中生代多岛弧盆系的新特提斯构造格局,西特提斯造山系主要表现为弧后洋盆消减造山作用。 | 袁四化 刘永江 常瑞虹 Franz Neubauer Johann Genser 关庆彬 黄倩雯 | 2021 | 沉积与特提斯地质2021，41，2： | 3 |
| 15 | Optical inline analysis and monitoring of particle size and shape distributions for multiple applications: Scientific and industrial relevance显示文摘Particles occur in almost all processes in chemical and life sciences. The particle size and shape influence the process performance and product quality, and in turn they are influenced by the flow behavior of the particles during production. Monitoring and controlling such characteristics in multiphase systems to obtain sufficient qualities will greatly facilitate the achievement of reproducible and defined distributions. So far, obtaining this information inline has been challenging, because existing instruments lack measurement precision, being unable to process overlapping signals from different particle phases in highly concentrated multiphase systems. However, recent advances in photo-optics made it possible to monitor such features(particle size distribution(PSD), aspect ratio and particle concentration) with advanced image analysis(IA) in real-time. New analysis workflows as well as single feature extractions from the images using multiple image analysis algorithms allowed the precise real-time measurements of size, shape and concentration of particle collectives even separated from each other in three phase systems. The performances, advantages and drawbacks with other non-photo-optical methods for assessing the particle size distribution are compared and discussed. | J?rn Emmerich Qiao Tang Yundong Wang Peter Neubauer Stefan Junne Sebastian Maa? | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 3 |
| 16 | Role of wide-field autofluorescence imaging and scanning laser ophthalmoscopy in differentiation of choroidal pigmented lesions显示文摘·AIM:Toevaluatethe diagnostic properties of wide-field fundus autofluorescence(FAF) scanning laser ophthalmoscope(SLO) imaging for differentiating choroidal pigmented lesions.·METHODS: A consecutive series of 139 patients were included, 101 had established choroidal melanoma with13 untreated lesions and 98 treated with radiotherapy.Thirty-eight had choroidal nevi. All patients underwent a full ophthalmological examination, undilated wide-field imaging, FAF and standardized US examination. FAF images and imaging characteristics from SLO were correlated with the structural findings in the two patient groups.·RESULTS: Mean FAF intensity of melanomas was significantly lower than the FAF of choroidal nevi. Only 1out of 38 included eyes with nevi touched the optic disc compared to 31 out of 101 eyes with melanomas. In 18 out of 101 melanomas subretinal fluid was seen at the pigmented lesion compared to none seen in eyes with confirmed choroidal nevi. In 'green laser separation', a trend towards more mixed FAF appearance of melanomas compared to nevi was observed. The mean maximal and minimal transverse and longitudinal diameters of melanomas were significantly higher than those of nevi.·CONCLUSION: Wide-field SLO and FAF imaging may be an appropriate non-invasive diagnostic screening tool to differentiate benign from malign pigmented choroidal lesions. | Lukas Reznicek Carmen Stumpf Florian Seidensticker Anselm Kampik Aljoscha S Neubauer Marcus Kernt | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 3 |
| 17 | Navigated laser in diabetic macular edema: the impact of reduced injection burden on patients and physicians-who wins and who loses?显示文摘We inquired the impact of reduced therapy discontinuation in diabetic macular edema(DME) on physician's revenue considering anti-vascular endothelial growth factor(VEGF) monotherapy and its combination with Navilas treatment. Data were collected on injection frequency, treatment discontinuation and reimbursement fees for DME treatment with anti-VEGF compared to anti-VEGF in combination with navigated laser. Based on these data an economic model was built to compare physicians revenue over a 5y period using either therapy for 4 European countries and the USA. Due to patients' higher therapy adherence, physicians using navigated laser therapy with anti-VEGF generate similar or higher revenues compared to VEGF monotherapy in all analyzed countries. The use of Navilas decreases the patient's injection burden at the same clinical outcome, while the physician's revenue remained stable or increased. Therewith, therapy discontinuation in DME can be reduced using the combination therapy with Navilas. | Jacob Menzler Aljoscha Neubauer Focke Ziemssen | 2019 | International Journal of Ophthalmology(English edition)2019，12，2： | 3 |
| 18 | Head-to-head comparison of N-terminal pro-brain natriuretic peptide, brain natriuretic peptide and N-terminal pro-atrial natriuretic peptide in diagnosing left ventricular dysfunction显示文摘 | Angelika Hammerer-Lercher Elke Neubauer Silvana Müller Otmar Pachinger Bernd Puschendorf Johannes Mair | 2001 | Clinica Chimica Acta2001，，2： | 2 |
| 19 | Correlation of leaking microaneurysms with retinal thickening in diabetic retinopathy显示文摘AIM: To investigate the contribution of fluorescein angiographic leaking microaneurysms (leak-MA) versus non-leaking microaneurysms (non-leak-MA) to retinal thickening in diabetic retinopathy.METHODS: A consecutive series of 38 eyes from 24 patients with diabetic retinopathy was included.Leak-MA and non-leak-MA in each eye were selected in pairs at corresponding topographic location.Leaking was defined by late phase fluorescein angiograms compared to early phase.Retinal thickness was measured with Heidelberg Spectralis OCT topographically aligned on early phase angiograms at the MA site and within a 1 mm circle.RESULTS: In all eyes,significant retinal thickening at the site of leaking compared to non-leaking microaneurysms was observed (356±69μm vs 318±56μm,P <0.001),showing a mean increase in thickness in the areas of leak-MA vs non-leak-MA of 38±39μm (95% confidence interval 2551μm,P<0.001).All 1mm area measurements also showed significant (P<0.001) thickening of the leak-MA with average thickness of leak-MA vs non-leak-MA as 351±67μmvs 319±59μm;minimum thickness 311±62μm vs 284±60μm;maximum thickness 389±78μm vs 352±66μm;and retina volume 26.4±6.0mmvs 23.6±3.7mm3,respectively.CONCLUSION: Leaking of microaneurysms on fluorescein angiography appears to cause focal thickening of retina,which can be measured with high-resolution OCT.Therefore,targeting leaking microaneursyms in diabetic retinopathy has the potential to reduce retinal thickening. | Lukas Reznicek Marcus Kernt Christos Haritoglou Michael Ulbig Anselm Kampik Aljoscha S Neubauer | 2011 | International Journal of Ophthalmology(English edition)2011，4，3： | 2 |
| 20 | Small-bowel MRI in children and young adults with Crohn disease: retrospective head-to-head comparison of contrast-enhanced and diffusion-weighted MRI显示文摘 | Henning Neubauer Thomas Pabst Anke Dick Wolfram Machann Laura Evangelista Clemens Wirth Herbert K?stler Dietbert Hahn Meinrad Beer | 2013 | Pediatric Radiology2013，，1： | 2 |
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