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| 1 | In Vivo Therapeutic Silencing of Hypoxia-Inducible Factor 1 Alpha(HIF-1)Using Single-Walled Carbon Nanotubes Noncovalently Coated with siRNA显示文摘A new approach is described for delivering small interfering RNA(siRNA)into cancer cells by noncovalently complexing unmodifi ed siRNA with pristine single-walled carbon nanotubes(SWCNTs).The complexes were prepared by simple sonication of pristine SWCNTs in a solution of siRNA,which then served both as the cargo and as the suspending agent for the SWCNTs.When complexes containing siRNA targeted to hypoxia-inducible factor 1 alpha(HIF-1)were added to cells growing in serum containing culture media,there was strong specific inhibition of cellular HIF-1 activity.The ability to obtain a biological response to SWCNT/siRNA complexes was seen in a wide variety of cancer cell types.Moreover,intratumoral administration of SWCNT-HIF-1 siRNA complexes in mice bearing MiaPaCa-2/HRE tumors signifi cantly inhibited the activity of tumor HIF-1.As elevated levels of HIF-1 are found in many human cancers and are associated with resistance to therapy and decreased patient survival,these results imply that SWCNT/siRNA complexes may have value as therapeutic agents. | Geoffrey Bartholomeusz Paul Cherukuri John Kingston Laurent Cognet Robert Lemos Jr Tonya KLeeuw Laura Gumbiner-Russo RBruce Weisman Garth Powis | 2009 | Nano Research2009，2，4： | 7 |
| 2 | 骑车者及乘客佩戴头盔现状及干预措施研究进展显示文摘颅脑损伤是导致骑车者伤亡的主要原因,佩戴头盔可以有效降低骑车者头部受伤的风险。通过普遍性的头盔立法,提供符合标准并且舒适的头盔,以及开展相关执法和宣传教育,可以促进道路交通骑车者佩戴头盔。 | 李融 胡国清 Brent Powis | 2015 | 伤害医学(电子版)2015，4，3： | 3 |
| 3 | Crystal structure of the Egol-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORCl signaling显示文摘 | Katie Powis Tianlong Zhang Nicolas Panchaud Rong Wang Claudio De Virgilio Jianping Ding | 2015 | Cell Research2015，25，9： | 3 |
| 4 | Selenium and the thioredoxin redox system:Effects on cell growth and death 显示文摘 | Powis G Gaskaska JR Gasdaska PY | 1997 | Oncol Res1997，9，67： | 2 |
| 5 | Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF -Mutated Colorectal Cancer显示文摘 | Kopetz Scott Desai Jayesh Chan Emily Hecht Joel Randolph O’Dwyer Peter J. Maru Dipen Morris Van Janku Filip Dasari Arvind Chung Woonbook Issa Jean-Pierre J. Gibbs Peter James Brian Powis Garth Nolop Keith B. Bhattacharya Suman Saltz Leonard | 2015 | Journal of Clinical Oncology2015，，34： | 2 |
| 6 | 煤矸石制砖企业职业安全健康风险与控制现状调查研究显示文摘调查与分析煤矸石制砖企业职业安全与健康风险与控制现状,为预防与控制职业安全健康风险提供依据。采用填表、现场监测与核查等方法,对13家煤矸石制砖企业的基本情况、危险和有害因素、防护措施等情况进行了调查、分析与评价。工作场所可能存在坍塌、机械伤害、挤压伤害、烧伤/灼烫、触电/电击、车辆伤害/撞击、中毒和窒息和砸伤、粉尘、噪声、高温和有害气体、不良工效学因素等危险、有害因素。防护罩、活动栏杆、地沟盖板、人行过梯、高压保护和隔离栏杆、通风除尘设施、喷淋设施、窑口引风机、烟尘脱硫除尘系统等为该类企业配置的主要防护设施;防尘口罩、防护手套和劳动护肤品为该类企业使用的个体防护装备,所有企业均未为噪声接触人员提供护听器。煤矸石制砖企业存在多种危险、有害因素,企业配有相应防护设施,但其效果欠佳,企业应加强对工作场所噪声危害的预防与控制。 | 王忠旭 Brent Powis 毛吉祥 邵华 李玉珍 凌瑞杰 秦汝莉 郭知喜 贾宁 刘吉祥 李刚 张雪艳 | 2013 | 中国安全生产科学技术2013，9，1： | 2 |
| 7 | Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis 显示文摘 | Nonn L Berggren M Powis G | 2003 | Mol Cancer Res2003，1，9： | 1 |
| 8 | Cloning and sequencing of human thioredoxin reductase 显示文摘 | Gasdaska PY Gasdaska JR Cochran S Powis G | 1995 | FEBS Lett1995，373，1： | 1 |
| 9 | Passing the baton: the HIF switch显示文摘 | Mei Yee Koh Garth Powis | 2012 | Trends in Biochemical Sciences2012，，： | 1 |
| 10 | Free radica1 formation by antitumor quinones显示文摘 | | 1989 | Free Rad Biol Med1989，6，： | 1 |
| 11 | Dysregulation of LDL receptor under the influence of inflammatory cytokines: a new pathway for foam cell formation显示文摘 | Ruan XZ Varghese Z Powis SH et ol | 2001 | Kidney Int2001，60，5： | 1 |
| 12 | Properties and biological activities of thioredoxins 显示文摘 | Powis G Monffort WR | 2001 | Annu Rev Pharmacol Toxicol2001，41，： | 1 |
| 13 | A prospective evaluation of re- current laryngeal nerve paralysis durlngthyroidectomy 显示文摘 | Chung YL Ka FK POWY | 2000 | Arch Surg2000，135，2： | 1 |
| 14 | Effect of body weight on the pharmacokinetics of cyclophosphamide in breast cancer patients显示文摘 | Powis G Reece P Ahmann DL Ingle JN | | 0，，： | 1 |
| 15 | Properties and biological activities of thioredoxins显示文摘 | Powis G Monffort WR | 2001 | Annu Rev Pharmacol Toxicol2001，41，1： | 1 |
| 16 | The promise of patient-derived xen- ografts: the best laid plans of mice and men显示文摘 | Kopetz S Lemos R Powis G | 2012 | Clin Cancer Res2012，18，19： | 1 |
| 17 | Inflammatory stress exacer- bates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice 显示文摘 | Ma KL Ruan XZ Powis SH | 2008 | Hepatology2008，48，3： | 1 |
| 18 | HIF-lalpha and cancer thera- py显示文摘 | Koh MY Spivak-Kroizman TR Powis G | 2010 | Recent Results Cancer Res2010，180，： | 1 |
| 19 | The influence of critical thinking skillson performance and progression in a pre - registration nursing pro-gram显示文摘 | Victoria Pitt David Powis | 2014 | Nurse Educ Today2014，，8： | 1 |
| 20 | Subsets of null and gamma delta T-cell receptor^+ T lymphocytes in the blood of young pigs identified by specific monoclonal antibodies 显示文摘 | Binns R M Duncan I A Powis S J | 1992 | Immunology1992，77，： | 1 |
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