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| 1 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 2 | 异硫氰酸苯己酯对Molt-4细胞组蛋白甲基化、乙酰化调控的实验研究显示文摘目的研究异硫氰酸苯己酯(PHI)在体外对淋巴细胞白血病 Molt-4细胞系的作用,观察 PHI 对 Molt-4细胞组蛋白甲基化、乙酰化调控的影响。方法采用 MTF 法、克隆抑制实验观察 PHI对 Molt-4细胞增殖的影响;采用流式细胞术检测 PHI 诱导细胞凋亡和对细胞周期的影响;用 Westernblot 法观察 PHI 作用后细胞的组蛋白乙酰化酶、组蛋白甲基化及乙酰化状态的变化。结果 PHI 可上调 Molt-4细胞组蛋白乙酰化酶 P300/CBP 水平,显著提高组蛋白 H3、H4乙酰化及 H3K4甲基化水平,抑制组蛋白甲基化 H3K9表达,阻滞细胞于 G_0/G_1期,并诱导细胞凋亡。结论 PHI 可能是一种组蛋白去乙酰化酶抑制剂,同时能调控组蛋白甲基化,影响其表观遗传学,可能作为新的抗白血病治疗药物。 | 黄轶群 马旭东 郑瑞玑 CHIAO Jen-wei LIU De-long | 2007 | 中华血液学杂志2007，28，9： | 16 |
| 3 | Role of surgical intervention in managing gastrointestinal metastases from lung cancer显示文摘AIM:To investigate the clinicopathological characteristics of late-stage lung cancer patients with gastrointestinal(GI)-tract metastases,focusing on therapeutic options and outcomes.METHODS:Our institution(the National Taiwan University Hospital) diagnosed 8159 patients with lung cancer between 1987 and 2008,of which 21 developed symptomatic GI metastases.This study reviewed all of the patients' information,including survival data,pathological reports,and surgical notes.RESULTS:The most common histological type of lung cancer was adenocarcinoma,and 0.26% of patients with lung cancer developed GI metastases.The median duration from lung cancer diagnosis to GI metastases was three months(range,0-108 mo),and the average time from diagnosis of GI metastasis to death was 2.8 mo.Most patients with symptomatic gastric and/or duodenal metastases exhibited GI bleeding and were diagnosed by panendoscopy.In contrast,small bowel metastases typically presented as an acute abdomen and were not diagnosed until laparotomy.All patients with small bowel or colonic metastases underwent surgical intervention,and their perioperative mortality was 22%.Our data revealed a therapeutic effect in patients with solitary GI metastasis and a favorable palliative effect on survival when metastases were diagnosed preoperatively.In patients with multiple GI metastases,the presentation varied according to the locations of the metastases.CONCLUSION:Surgical treatment is worthwhile in a select group of patients with bowel perforation or obstruction.Physicians should be more alert to symptoms or signs indicating GI metastases. | Po-Chu Lee Chiao Lo Ming-Tsan Lin Jin-Tung Liang Been-Ren Lin | 2011 | World Journal of Gastroenterology2011，17，38： | 7 |
| 4 | K-ras^G12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis显示文摘增加的氧气的 glycolysis 和氧化应力是癌症房间新陈代谢的重要特征,但是内在的生物化学、分子的机制留下逃犯。用四圜素可诱导的模型,我们显示出 K 地岬 G12V 原因 mitochondrial 机能障碍,导致反应的氧的减少的呼吸,提高的 glycolysis,和增加的产生种类。K 地岬蛋白质与线粒体被联系,并且导致呼吸的链建筑群的快速的抑制 -- 我和在由影响 cyclosporin 敏感的渗透的 mitochondrial transmembrane 潜力的减少转移毛孔。而且, K 地岬 在 vitro 的 G12V 表示提高转变房间的能力允许新陈代谢的改编到高 glycolytic 新陈代谢在 vivo 形成肿瘤。我们的学习建议 mitochondrial 机能障碍的那正式就职是由 K 地岬 G12V 在癌症房间引起新陈代谢的变化和 ROS 应力,并且支持肿瘤开发。 | Yumin Hu Weiqin Lu Gang Chen Peng Wang Zhao Chen Yan Zhou Marcia Ogasawara Dunyaporn Trachootham Li Feng Helene Pelicano Paul J Chiao Michael J Keating Guillermo Garcia-Manero Peng Huang | 2012 | Cell Research2012，22，2： | 6 |
| 5 | Bacterial Type Ⅰ Glutamine Synthetase of the Rifamycin SV Producing Actinomycete,Amycolatopsis mediterranei U32,is the Only Enzyme Responsible for Glutamine Synthesis under Physiological Conditions显示文摘为夫酸安合成酶的结构基因, glnA,从 Amycolatopsismediterranei, U32 经由从 Streptomycescoelicolor.The 用模拟基因屏蔽一个 genomic 图书馆被克隆克隆被在一个紫胶倡导者的控制下面为 anEscherichia 关口 i glnA 0 异种的夫酸安要求补充机能上地验证。顺序分析显示出编码 466 氨基酸残余的蛋白质的一个开的读物框架。推出的氨基酸顺序忍受重要相同到另外的细菌的类型我夫酸安合成酶,明确地与 5 .coelicolor 和 Mycobacterium 肺结核的酶相同的71%and72%,在 A.mediterranei U32 的这 glnA 基因导致了的 respectively.Disruptionof 没有在 vivo.In 的可检测的夫酸安合成酶活动的夫酸安营养缺陷型对比,为两显型 intrans.It 的克隆的glnA^+基因罐头补充因此建议在 A.mediterranei U32 ,编码夫酸安合成酶的 glnA 基因是特别地负责的因为在 vivo 夫酸安在我们的实验室下面的合成定义生理的条件。 | Wen-Tao PENG Jin WANG Ting WU Jian-Qiang HUANG Jui-Shen CHIAO Guo-Ping ZHAO | 2006 | Acta Biochimica et Biophysica Sinica2006，38，12： | 4 |
| 6 | Molecular hosts for triplet emitters in organic light-emitting diodes and the corresponding working principle显示文摘This paper summarizes the mechanism and routes for excitation of triplet emitters in dopant emission based phosphorescent organic light-emitting diodes (PhOLEDs),providing a comprehensive overview of recent progress in molecular hosts for triplet emitters in PhOLEDs.Particularly,based on the nature of different hosts,e.g.,hole transporting,electron transporting or bipolar materials,in which the dopant emitters can be hosted to generate phosphorescence,the respective device performances are summarized and compared.Highlights are given to the relationships among the molecular structure,thermal stability,triplet energy,carrier mobility,molecular orbital energy level and their corresponding device performances. | MI BaoXiu1,2,GAO ZhiQiang1,LIAO ZhangJin2,HUANG Wei2 & CHEN Chin Hsin3 1Jiangsu Engineering Center for Flat-Panel Displays & Solid-State Lighting School of Materials Science & Engineering,Nanjing University of Posts & Telecommunications,Nanjing 210046,China 2Key Laboratory for Organic Electronics & Information Displays (KLOEID),Institute of Advanced Materials (IAM),Nanjing University of Posts & Telecommunications,Nanjing 210046,China 3Display Institute,Microelectronics and Information Systems Research Center,National Chiao Tung University Hsinchu,Hsinchu,300 China | 2010 | Science China Chemistry2010，53，8： | 4 |
| 7 | 视觉研究:人脸识别的意义显示文摘在他的1865年的书中,在人和动物的情绪表达中,查尔斯·达尔文首次提出人类因脸而迷人的进化说明。他说道,在极其害怕或者高兴期间,提示是通过面部表情表达的,强烈提议说脸是我们祖先交流的一个重要的工具。现在我们快速识别熟悉面孔和微妙面部表情的能力,仍然是人类学家、心理学家、神经科学家和医生们的一个重大兴趣来源,查明是否人脸识别是一个专门的人类能力可能会导致新的关于我们的大脑怎么运作的见识。 | Joan Chiao | 2007 | 医疗保健器具2007，，10： | 2 |
| 8 | PHSICAL MODELLING AND PROCESSING OF Ti-6Al-4V ELI显示文摘Titanium has been widely used as the implant materials of joint prostheses. This paper simulates the microstructures of the hot forged titanium knee joint component by physical modeling. Ti-6Al-4V ELI were deformed by GLEEBLE 2000 hot deforma- tion simulator in compression mode to determine the hot workability, in the range of 900 to 1100℃, with the strain rates between 0.05 to 5 s-1. Test results derived from specimens processed by on-cooling test and on-heating test were compared, thereby estimating the effect due to thermal history. The forging process of Ti-6Al-4V ELI tibial base plate of knee joint prostheses was design based on the workability data obtained. | C.P. Chou, S.C. Wang, C.C. Chang and W.R. Wang 1) Department of Mechanical Engineering, National Chiao Tung University Hsinchu, Taiwan 300, China 2) Materials Research Laboratories, Industrial Technology Research Institute Chutung, Taiwan 310, China | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 2 |
| 9 | 异硫氰酸苯己酯调控肝癌细胞株SMMC-7721组蛋白乙酰化及诱导细胞凋亡显示文摘目的 研究异硫氰酸苯己酯(PHI)对肝癌SMMC-7721细胞组蛋白乙酰化调控及凋亡的影响.方法 采用台盼蓝拒染直接计数法观察PHI对SMMC-7721细胞增殖的影响,采用原位末端标记(TUNEL)法检测PHI对SMMC-7721细胞凋亡的影响,采用Western blot法检测PHI对SMMC-7721细胞组蛋白乙酰化及凋亡相关蛋白表达的影响.结果 PHI可抑制SMMC-7721细胞的增殖,与0 μmol/L作用组比较,5、10、20、40和80 μmol/L的PHI对SMMC-7721细胞均有不同程度的增殖抑制作用.PHI可诱导SMMC-7721细胞产生凋亡,PHI作用于SMMC-7721细胞7 h后,10、20和40 μmol/LPHI组的细胞凋亡率分别为6.9%±2.4%、17.5%±4.2%和54.5%±5.4%,明显高于0 μmol/L PHI组(4.5%±2.3%,P<0.05).PHI作用于SMMC-7721细胞3 h时,与0 μmol/L PHI组比较,10、20和40 μmol/L PHI组中Bcl-2、Procaspse-9和Procaspse-3的表达下降,caspase-9和caspase-3的表达上升,而Procaspase-8的表达未见明显变化;作用7 h时,这种变化趋势更加明显.PHI作用于SMMC-7721细胞3 h时,与0 μmol/L PHI组比较,10、20和40 μmol/L PHI组中组蛋白H3的乙酰化分别增加了1.87倍、2.43倍和3.67倍,组蛋白H4的乙酰化分别增加了1.29倍、1.45倍和2.25倍;作用7 h时,这种变化趋势更加明显.结论 PHI是一种组蛋白去乙酰化酶抑制剂,可调控组蛋白的乙酰化水平,影响其表观遗传学,并通过线粒体凋亡途径诱导细胞凋亡. | 赖亚栋 马旭东 黄轶群 许向农 王小众 Dicky JW Chiao Delong liu | 2010 | 中华肿瘤杂志2010，32，11： | 2 |
| 10 | Relationship between debt, R&D and physical investment, evidence from US firm-level data显示文摘 | Chaoshin Chiao | 2002 | Applied Financial Economics2002，，2： | 2 |
| 11 | 异硫氰酸苯己酯对SMMC-7721细胞甲基化和乙酰化组蛋白表达及细胞生长和凋亡的影响显示文摘目的研究异硫氰酸苯己酯(PHI)在体外对原发性肝癌细胞株SMMC-7721细胞的作用,观察PHI对SMMC-7721细胞甲基化和乙酰化组蛋白表达及细胞生长和凋亡的影响。方法采用锥虫蓝拒染直接计数法观察PHI对SMMC-7721细胞增殖的影响;原位末端标记法观察PHI对SMMC7721细胞凋亡的作用;用Westernblot方法观察PHI作用后SMMC-7721细胞组蛋白H3K4、H3K9甲基化及组蛋白H3、H4乙酰化状态的改变。计量资料实验数据以均数±标准差(x-±s)表示,进行单因素方差分析。结果PHI处理后的细胞增殖受抑制;0、10、20、40μmol/LPHI处理7h后,细胞凋亡率分别为4.50%±2.33%、6.85%±2.43%、17.50%±4.15%、54.50%±3.41%,差异有统计学意义(F=34.22,D〈0.05);PHI显著提高组蛋白乙酰化H3、H4及甲基化H3K4水平,抑制组蛋白甲基化H3K9表达。结论PHI可能是一种组蛋白去乙酰化酶抑制剂,同时能调控组蛋白甲基化,影响其表观遗传学特性,可能作为新的抗癌药物。 | 黄轶群 马旭东 赖亚栋 王小众 CHIAO Jen-wei LIU De-long | 2010 | 中华肝脏病杂志2010，18，3： | 2 |
| 12 | Nanotrap-enabled quantification of KRAS-induced peptide hydroxylation in blood for cancer early detection显示文摘Circulating peptide is a potential source of biomarkers for cancer detection.However,the existence of large molecular weight proteins in plasma have a disastrous effect on circulating peptides isolating and detecting.Herein,nanotrap fractionation following by mass spectrometry have been applied to quantify the levels of bradykinin (BK) and hydroxylated bradykinin (Hyp-BK) as a relative measure of KRAS-regulated prolyl-4-hydroxylase alpha-1 (P4HA1) which may serve as early diagnosis marker for pancreatic ductal adenocarcinoma (PDAC).We found that P4HA1 can be upregulated by KRASG12v,which is a PDAC driver mutation,using HPNE/KRAS and HPNE cells.And we revealed that P4HA1 is overexpressed in PDAC tumors,compared to normal and inflamed pancreatic tissues.RNA interference revealed that P4HA1 activity was primarily responsible for Hyp-BK production.Mass spectrometry analysis revealed that plasma Hyp-BK/BK ratio was higher in PDAC than pancreatitis patients and healthy controls,while the area under the receiver operating characteristic (ROC) curve (AUC) is 0.8209 (95%Cl,0.7269-0.9149).The Hyp-BK/BK association with PDAC was reproduced in another cohort,where this ratio was found to increase with advancing tumor stage.These novel findings paved the way for wider applications of Nanotrap coupled mass spectrometry as a powerful tool for revealing biosignatures from plasma. | Zaian Deng Zhen Zhao Bo Ning Jeffery Basilio Karen Mann Jie Fu Yajun Gu Yuanqing Ye Xifeng Wu Jia Fan Paul Chiao Tony Hu | 2019 | Nano Research2019，12，6： | 2 |
| 13 | Kras G12D -Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma显示文摘 | Jianhua Ling Ya’an Kang Ruiying Zhao Qianghua Xia Dung-Fang Lee Zhe Chang Jin Li Bailu Peng Jason B. Fleming Huamin Wang Jinsong Liu Ihor R. Lemischka Mien-Chie Hung Paul J. Chiao | 2012 | Cancer Cell2012，，1： | 2 |
| 14 | Analyzing experiments with correlated multiple responses显示文摘 | Hamada M | 2001 | Journal of Quality Technology2001，33，4： | 1 |
| 15 | Statistics of cone responses to natural images: Implications for visual coding 显示文摘 | RUDERMAN D L CRONIN T W CHIAO C C | 1998 | Journal of the Optical Society of America1998，15，8： | 1 |
| 16 | An evaluation of the in- vestment environment in international logistics zones: A Taiwanese manufacturer' s perspective 显示文摘 | CHIN - SHAN LU CHING - CHIAO YANG | 2007 | Production Economics2007，，107： | 1 |
| 17 | Sulforaphane and its metabolite mediate growth arrest and apoptosis in hu- man prostate cancer cells 显示文摘 | Chiao JW Chung FL Kancherla R | 2004 | Int J Oncol2004，20，3： | 1 |
| 18 | Culture-gene coevolution of individualism-collectivism and the serotonin transporter gene显示文摘 | Chiao J.Y Blizinsky K.D | | 0，，： | 1 |
| 19 | CD133+glioblastoma stem-like cells induce vascular mimicry in vivo显示文摘 | Chiao MT Yang YC Cheng WY | 2011 | Curr Neurovasc Res2011，8，3： | 1 |
| 20 | Statistics of Cone Responses to Natural Images: Implications for Visual Coding显示文摘 | Ruderman D L Cronin T W Chiao C C | 1998 | Journal of the Optical Society of America1998，15，8： | 1 |
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