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| 1 | Constipation-predominant irritable bowel syndrome: A review of current and emerging drug therapies显示文摘Irritable bowel syndrome(IBS) is a highly prevalent medical condition that adversely affects patient quality of life and constitutes a significant economic burden on healthcare resources. A large proportion of patients suffer from the constipation subtype of IBS(IBS-C), most commonly afflicting older individuals and those with a lower socioeconomic status. Conventional pharmacologic and nonpharmacologic treatment options have limited efficacies and/or significant adverse events, which lead to increased long-term health care expenditures. Failure to effectively treat IBS-C patients over the past decades has largely been due to a poor understanding of disease pathophysiology, lack of a global view of the patient, and an inappropriate selection of patients and treatment endpoints in clinical trials. In recent years, however, more effective and safer drugs have been developed for the treatment of IBS-C. The advancement in the area of pharmacologic treatment is based on new knowledge of the pathophysiologic basis of IBS-C and the development of drugs with increased selectivity within pharmacologic classes with recognized efficacies. This narrative review covers the spectrum of available drugs and their mechanisms of action, as well as the efficacy and safety profiles of each as determined in relevant clinical trials that have investigated treatment options for IBS-C and chronic constipation. A brief summary of laxative-based treatment options is presented, followed by up-to-date assessments for three classes of drugs: prokinetics, prosecretory agents, and bile acid modulators. | Khaled A Jadallah Susan M Kullab David S Sanders | 2014 | World Journal of Gastroenterology2014，20，27： | 9 |
| 2 | 动脉瘤性蛛网膜下腔出血患者的重症监护处理:神经危重症监护学会多学科共识会议的推荐意见显示文摘蛛网膜下腔出血(subarachnoidhemorrhage,SAH)是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏,使得治疗方法各异,可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防,很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域,此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验,选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价(GradesofRecommendationsAssessment,DevelopmentandEvaluation,GRADE)系统进行文献回顾,结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见,其制定原则不仅强调研究资料的质量,而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见,即使缺乏高质量的证据。 | Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿 英英(译) | 2013 | 国际脑血管病杂志2013，21，5： | 5 |
| 3 | Endoscopic retrograde cholangiopancreatography:Current practice and future research显示文摘Endoscopic retrograde cholangiopancreatography(ERCP)has evolved from a primarily diagnostic to therapeutic procedure in hepatobiliary and pancreatic disease.Most commonly,ERCPs are performed for choledocholithiasis with or without cholangitis,but improvements in technology and technique have allowed for management of pancreatic duct stones,benign and malignant strictures,and bile and pancreatic leaks.As an example of necessity driving innovation,the new disposable duodenoscopes have been introduced into practice.With the advantage of eliminating transmissible infections,they represent a paradigm shift in quality improvement within ERCP.With procedures becoming more complicated,the necessity for anesthesia involvement and safety of propofol use and general anesthesia has become better defined.The improvements in endoscopic ultrasound(EUS)have allowed for direct bile duct access and EUS facilitated bile duct access for ERCP.In patients with surgically altered anatomy,selective cannulation can be performed with overtube-assisted enteroscopy,laparoscopic surgery assistance,or the EUS-directed transgastric ERCP.Cholangioscopy and pancreatoscopy use has become ubiquitous with defined indications for large bile duct stones,indeterminate strictures,and hepatobiliary and pancreatic neoplasia.This review summarizes the recent advances in infection prevention,quality improvement,pancreaticobiliary access,and management of hepatobiliary and pancreatic diseases.Where appropriate,future research directions are included in each section. | David J Sanders Shivanand Bomman Rajesh Krishnamoorthi Richard A Kozarek | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，8： | 5 |
| 4 | Gastric sarcoidosis mimicking irritable bowel syndrome-Cause not association?显示文摘肉状瘤是可以在身体影响任何机关的未知原因论的系统病。胃肠道仅仅很少然而在肝外面被影响。症状可能是非特定的。急躁的肠症候群(IBS ) 是普通诊断。IBS 的识别被罗马 II 标准的使用帮助 - 当器质性病不在时。我们与胃的肉状瘤描述一个病人的第一个盒子与 IBS 介绍了症状,但是随后对抑制免疫力的治疗作出回应。 | John Samuel Leeds Mark Edward McAlindon Eleanor Lorenz Asha Kumari Dube David Surendran Sanders | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 5 | Consensus Statements for Management of Barrett’s Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process显示文摘 | Cathy Bennett Nimish Vakil Jacques Bergman Rebecca Harrison Robert Odze Michael Vieth Scott Sanders Laura Gay Oliver Pech Gaius Longcroft–Wheaton Yvonne Romero John Inadomi Jan Tack Douglas A. Corley Hendrik Manner Susi Green David Al Dulaimi Haythem Ali | 2012 | Gastroenterology2012，，2： | 2 |
| 6 | Role of the complement cascade in cerebral aneurysm formation,growth,and rupture显示文摘Rupture of intracranial aneurysms is the most common cause of nontraumatic subarachnoid hemorrhage,but the intricate neuroinflammatory processes which contribute to aneurysm pathophysiology are not well‑understood.Mounting evidence has implicated the complement cascade in the progression of aneurysms from their formation to rupture.In this article,we identify and review studies that have sought to determine the role of the complement system in the aneurysm pathogenesis.The studies were generally conducted by immunhistological analyses on aneurysm tissue collected intraoperatively,and multiple components of the complement cascade and its modulators were identified in specific regions of the aneurysm wall.The results of the studies suggest that the complement cascade is locally upregulated and disinhibited in the perianeurysmal environment,and that it contributes to chronic as well as acute immunological damage to the aneurysm wall.In the future,understanding the mechanisms at work in complement‑mediated damage is necessary to leading the development of novel therapies. | Blake E.S.Taylor Geoff Appelboom Robert Zilinyi Ariana Goodman David Chapel Melissa LoPresti Edward Sander Connolly Jr. | 2015 | Neuroimmunology and Neuroinflammation2015，2，1： | 2 |
| 7 | Inflammatory response to coronary artery bypass surgery: Does the heme-oxygenase-1 gene microsatellite polymorphism play a role?显示文摘Background Heme-oxygenase 1 (HO-1) is a rate-limiting enzyme in the degradation of heme to bilirubin, ferritin and carbon monoxide (CO) and may have significant anti-inflammatory function. The HO-1 gene promoter region shows microsatellite polymorphism with different (GT)n repeats, reported to differently induce gene expression, with the short allele associated with higher gene expression. We measured the acute inflammatory response using coronary artery bypass surgery (CABG) as a well-characterized and uniform stimulus and examined the correlation between levels of IL-6, C-reactive protein (CRP) and fibrinogen and their relationship to HO-1 genotype.Methods Two hundred and seventy-five consecutive patients undergoing CABG were genotyped for the HO-1 promoter polymorphism using PCR and automated DNA capillary sequencer. IL-6, CRP and fibrinogen were measured at baseline and 6, 24, 48, 72, 96 and 120 hours after CABG.Results Complete IL-6,CRP and fibrinogen measures were available in 220 patients. Before surgery IL-6 levels showed a strong correlation with CRP and fibrinogen ( r =0.48, P <0.0001; r =0.41, P <0.0001 respectively), with a significant correlation between CRP and fibrinogen ( r =0.61, P <0.0001). All three acute phase reactants showed a significant increase after CABG. After surgery, peak IL-6 was strongly correlated with peak CRP ( r =0.34, P =0.0009) but not with peak fibrinogen ( r =0.15, P =0.13), while peak CRP and peak fibrinogen were significantly correlated ( r =0.415, P <0.0001). HO-1 allelic repeats ranged from 22-42, with (GT) 25 and (GT) 32 being the two most common alleles, and subsequently divided into three groups according to previous published work: <30(GT)n were designated as S (short), 30-37(GT)n as M (middle) and long repeats with >37(GT)n as L (long); allele frequency 0.35, 0.58 and 0.07 respectively. Baseline CRP differed by genotype: those carrying at least one long allele having higher CRP than those with no long allele (3.76±0.79 vs. 2.07±0.17, P =0.013). Conversely, those carrying at least one short allele had higher fibrinogen levels than those with no short allele (3.83±0.79 vs. 3.51±0.88, P =0.006). Conclusions There is a strong correlation between the measured acute phase reactants both at baseline and after the inflammatory response to CABG in patients with coronary disease. There was an association between the HO-1 microsatellite polymorphism and CRP and fibrinogen levels at baseline but there was no similar association following CABG. This may indicate that HO-1 is associated with chronic atherosclerotic inflammatory processes rather than acute. | LI Ping Jules Sanders Emma Hawe David Brull Hugh Montgomery Steve Humphries | 2005 | Chinese Medical Journal2005，，15： | 2 |
| 8 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 9 | An information-centric energy infrastructure: The Berkeley view显示文摘 | Randy H. Katz David E. Culler Seth Sanders Sara Alspaugh Yanpei Chen Stephen Dawson-Haggerty Prabal Dutta Mike He Xiaofan Jiang Laura Keys Andrew Krioukov Ken Lutz Jorge Ortiz Prashanth Mohan Evan Reutzel Jay Taneja Jeff Hsu Sushant Shankar | 2010 | Sustainable Computing: Informatics and Systems2010，，1： | 1 |
| 10 | Multi-functional smart aggregate-based structural health monitoring of circular reinforcedconcrete columns subjected to seismic excitations显示文摘 | Haichang Gu Yashar Moslehy David Sanders Gangbing Song Y L Mo | 2010 | Smart Materials and Structures2010，，6： | 1 |
| 11 | Helicobacter pylori-associated diseases显示文摘 | Michael K. Sanders MD David A. Peura MD | 2002 | Current Gastroenterology Reports2002，，6： | 1 |
| 12 | Reflux and irritable bowel syndrome are negative predictors of quality of life in coeliac disease and inflammatory bowel disease显示文摘 | Stephen M. Barratt John S. Leeds Kerry Robinson Premal J. Shah Alan J. Lobo Mark E. McAlindon David S. Sanders | 2011 | European Journal of Gastroenterology & Hepatology2011，，： | 1 |
| 13 | Evaluating the role of small-bowel endoscopy in clinical practice: the largest single-centre experience显示文摘 | Reena Sidhu Mark E. McAlindon Kaye Drew Suzanne Hardcastle Iain C. Cameron David S. Sanders | 2012 | European Journal of Gastroenterology & Hepatology2012，，5： | 1 |
| 14 | Review of cathodic arc depositiontechnology at the start of the new millennium 显示文摘 | David M Sanders Andre Anders | 2000 | Surface andCoatings Technology2000，13，3134： | 1 |
| 15 | Prevention of Child Behavior Problems Through Universal Implementation of a Group Behavioral Family Intervention显示文摘 | Stephen R. Zubrick Kristine A. Ward Sven R. Silburn David Lawrence Anwen A. Williams Eve Blair Deborah Robertson Matthew R. Sanders | 2005 | Prevention Science2005，，4： | 1 |
| 16 | A humic acid improves growth of tomato seedling in solution culture显示文摘 | David P P Nelson P V Sanders D C | 1994 | J Plant Nutr1994，17，1： | 1 |
| 17 | No false start for novel pseudotyped vectors显示文摘 | David Avram Sanders | 2002 | Current Opinion in Biotechnology2002，，5： | 1 |
| 18 | Land clearance not dieback continues to drive tree loss in a Tasmanian rural landscape显示文摘 | Lynda D. Prior Gregor J. Sanders Kerry L. Bridle Scott C. Nichols Rowan Harris David M. J. S. Bowman | 2013 | Regional Environmental Change2013，，5： | 1 |
| 19 | Prevalence of Irritable Bowel Syndrome-Type Symptoms in Patients with Celiac, Disease: A Meta-analysis显示文摘 | Anita Sainsbury David S. Sanders Alexander C. Ford | 2012 | Clinical Gastroenterology and Hepatology2012，，： | 1 |
| 20 | Consensus Statements for Management of Barrett’s Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process显示文摘 | Cathy Bennett Nimish Vakil Jacques Bergman Rebecca Harrison Robert Odze Michael Vieth Scott Sanders Laura Gay Oliver Pech Gaius Longcroft–Wheaton Yvonne Romero John Inadomi Jan Tack Douglas A. Corley Hendrik Manner Susi Green David Al Dulaimi Haythem Ali | 2012 | Gastroenterology2012，，2： | 1 |
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