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| 1 | Constipation-predominant irritable bowel syndrome: A review of current and emerging drug therapies显示文摘Irritable bowel syndrome(IBS) is a highly prevalent medical condition that adversely affects patient quality of life and constitutes a significant economic burden on healthcare resources. A large proportion of patients suffer from the constipation subtype of IBS(IBS-C), most commonly afflicting older individuals and those with a lower socioeconomic status. Conventional pharmacologic and nonpharmacologic treatment options have limited efficacies and/or significant adverse events, which lead to increased long-term health care expenditures. Failure to effectively treat IBS-C patients over the past decades has largely been due to a poor understanding of disease pathophysiology, lack of a global view of the patient, and an inappropriate selection of patients and treatment endpoints in clinical trials. In recent years, however, more effective and safer drugs have been developed for the treatment of IBS-C. The advancement in the area of pharmacologic treatment is based on new knowledge of the pathophysiologic basis of IBS-C and the development of drugs with increased selectivity within pharmacologic classes with recognized efficacies. This narrative review covers the spectrum of available drugs and their mechanisms of action, as well as the efficacy and safety profiles of each as determined in relevant clinical trials that have investigated treatment options for IBS-C and chronic constipation. A brief summary of laxative-based treatment options is presented, followed by up-to-date assessments for three classes of drugs: prokinetics, prosecretory agents, and bile acid modulators. | Khaled A Jadallah Susan M Kullab David S Sanders | 2014 | World Journal of Gastroenterology2014，20，27： | 9 |
| 2 | Review of cathodic arc depositiontechnology at the start of the new millennium 显示文摘 | David M Sanders Andre Anders | 2000 | Surface andCoatings Technology2000，13，3134： | 1 |
| 3 | Nonlinear Earthquake Response Modeling of a Large- Scale Two-Span Concrete Bridge显示文摘 | Nathan Johnson M Saiid Saiidi David Sanders | 2009 | Journal of Bridge Engineering2009，14，6： | 1 |
| 4 | Complement Component C3 Mediates Inflammatory Injury Following Focal Cerebral Ischemia显示文摘 | J Mocco William J. Mack Andrew F. Ducruet Sergei A. Sosunov Michael E. Sughrue Benjamin G. Hassid M Nathan Nair Ilya Laufer Ricardo J. Komotar M Claire H. Holland David J. Pinsky E Sander Connolly | 2006 | Circulation Research2006，，： | 1 |
| 5 | Acrylamide formation mechanism in heated foods 显示文摘 | David V Zyzak Robert A Sanders Marko Stokanovic M | 2003 | Journal of Agricultural and Food Chemistry2003，51，： | 1 |
| 6 | Review of cathodic arc deposition technology at the start of the new millennium 显示文摘 | David M Sanders Andre Anders | 2000 | Surface and Coatings Technology2000，13，： | 1 |
| 7 | Review of cathodic arc deposition technology at the start of the new millennium 显示文摘 | David M Sanders Andre Anders | 2000 | Surface & Coatings Technology2000，13，： | 1 |
| 8 | Seismic Performance of Reinforced Concrete Bridge Bents显示文摘 | Moustafa Khaled F Sanders David Saiidi M Saiid El-Azazy Saad | 2011 | ACI Structural Journal2011，，1： | 1 |
| 9 | Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification显示文摘 | Morgan L. Maeder Stacey Thibodeau-Beganny Anna Osiak David A. Wright Reshma M. Anthony Magdalena Eichtinger Tao Jiang Jonathan E. Foley Ronnie J. Winfrey Jeffrey A. Townsend Erica Unger-Wallace Jeffry D. Sander Felix Müller-Lerch Fengli Fu Joseph Pearlber | 2008 | Molecular Cell2008，，2： | 1 |
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