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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Malignant hepatic vascular tumors in adults: Characteristics,diagnostic difficulties and current management显示文摘Malignant vascular tumors of the liver include rare primary hepatic mesenchymal tumors developed in the background of a normal liver parenchyma. Most of them are detected incidentally by the increased use of performing imaging techniques. Their diagnosis is challenging, involving clinical and imaging criteria, with final confirmation by histology and immunohistochemistry. Surgery represents the mainstay of treatment. Liver transplantation(LT) has improved substantially the prognosis of hepatic epithelioid hemangioendothelioma(HEHE), with 5-year patient survival rates of up to 81%, based on the European Liver Intestine Transplantation AssociationEuropean Liver Transplant Registry study. Unfortunately, the results of surgery and LT are dismal in cases of hepatic angiosarcoma(HAS). Due to the disappointing results of very short survival periods of approximately 6-7 mo after LT, because of tumor recurrence and rapid progression of the disease, HAS is considered an absolute contraindication to LT. Recurrences after surgical resection are high in cases of HEHE and invariably present in cases of HAS. The discovery of reliable prognostic markers and the elaboration of prognostic scores following LT are needed to provide the best therapeutic choice for each patient.Studies on a few patients have demonstrated the stabilization of the disease in a proportion of patients with hepatic vascular tumors using novel targeted antiangiogenic agents, cytokines or immunotherapy. These new approaches,alone or in combination with other therapeutic modalities, such as surgery and classical chemotherapy, need further investigation to assess their role in prolonging patient survival. Personalized therapeutic algorithms according to the histopathological features, behavior, molecular biology and genetics of the tumors should be elaborated in the near future for the management of patients diagnosed with primary malignant vascular tumors of the liver. | Daniela Cornelia Lazar Mihaela Flavia Avram Ioan Romosan Violetta Vacariu Adrian Goldis Marioara Cornianu | 2019 | World Journal of Clinical Oncology2019，10，3： | 7 |
| 3 | 同步构绘学龄儿童脑模版和生长曲线显示文摘大脑的生长发育曲线和各年龄的标准脑模版是研究个体发育异常的必要工具.本研究构建了以一岁为间隔的儿科脑模版及相应的脑发育轨线,探究了年龄和民族在儿科脑影像研究中的影响.本研究使用了来自中美共四个站点且实验设计相同的两组纵向加速儿童脑影像队列数据,对正常发育的学龄儿童间隔五个季节进行了三次磁共振扫描.我们分别构建并比较了不同民族和年龄阶段的脑模版及发育轨线.对457名和133名正常发育的中美儿童青少年进行了总计674次和190次磁共振扫描.我们评估了使用不同民族和年龄阶段的脑模版进行配准产生的形变量,并建模大脑皮层400个不同区域体积的生长曲线.分析结果表明:构建各年龄阶段和民族特异性的脑模版对于脑生长发育曲线的绘制是必要的.脑体积在不同民族间的发育差异主要体现在结构和功能上个体差异较为明显的外侧额叶和顶叶区域,使用年龄和民族相对应的脑模版可以避免在构绘脑生长曲线时由此产生的系统偏差.本研究的所有结果及分析代码均已公开. | 董昊铭 F.Xavier Castellanos 杨宁 张喆 周荃 何叶 张蕾 徐婷 Avram J.Holmes B.T.Thomas Yeo 陈飞燕 王滨 Christian Beckmann Tonya White Olaf Sporns 邱江 冯廷勇 陈安涛 刘勋 陈旭 翁旭初 Michael P.Milham 左西年 | 2020 | Science Bulletin2020，65，22： | 4 |
| 4 | 甘蔗糖厂联产燃料酒精及全面降低能耗——可获取最大的经济效益显示文摘近年来,由于生物量电能的价格较高,更为有利可图,糖厂进行联产发电(糖厂利用蔗渣发电,并将多余的电量出售给糖厂以外的用户)的需求越来越大。本文论述为获得最大联产效果而重新设计糖厂的主要措施,例如,工艺用汽的用量降低,采用高压锅炉,以及冷凝式和部分背压式透平机,全部工序用电动机操作。措施也包括把甘蔗中糖量的50%用于产糖,其余用于酒精生产。为了提高糖厂的联产潜力,在酒精生产的蒸馏过程中尽量减少蒸汽消耗显得很有必要。在蒸馏车间采用中压蒸汽和多抽用汁汽,这比传统普遍使用的方法降低约43%的汽耗,可使联产的糖厂减少乏汽的用量,并可增加高压蒸汽入冷凝式透平机。糖厂和酒精厂重新设计组合能获得最大的联产效果,生产能力从目前的12.8kW·h/t提高到82.6kW·h/t,这种联产的经济效益十分显著。特别是像巴西、危地马拉、毛里求斯,甚至印度等这些地区可在甘蔗生产季节中以相当可观的电价出售大量的电能。 | Pedro Avram Thomas Stark 蓝艳华 | 2006 | 甘蔗糖业2006，35，1： | 3 |
| 5 | Polymers with pendent functional groupsV: thermooxidative and thermal behavior of chloro-methylated polysulfones显示文摘 | Avram E Brebu M A Warshawsky A | 2000 | Polym Deg& Sta2000，69，： | 1 |
| 6 | Gabapentin does not improve multimodal analgesia outcomes for total knee arthroplasty: a randomized controlled trial显示文摘 | James E. Paul Manyat Nantha-Aree Norman Buckley Ji Cheng Lehana Thabane Antonella Tidy Justin DeBeer Mitchell Winemaker David Wismer Dinshaw Punthakee Victoria Avram | 2013 | Canadian Journal of Anesthesia/Journal canadien d’anesthésie2013，，5： | 1 |
| 7 | The ubiquitin system显示文摘 | Avram H Aaron C Alexander V | 2000 | Nat Med2000，6，： | 1 |
| 8 | Statistical methods in anesthesia articles: an evaluation of two American journals during two six-month periods显示文摘 | Avram MJ Shanks CA Dykes MHM | 2005 | Anesth Analg2005，64，6： | 1 |
| 9 | Predictors of survzval in continuous ambulatory preritoneal dialysis patients:the importance of preALbumin and other nutritional and metabolic markers显示文摘 | Avram MM Goldwasserp P Erroa M | 1994 | Am J Kidney Dialysis1994，23，2： | 1 |
| 10 | A systematic review of early versus delayed wound closure in patients with open fractures requi- ting flap coverage 显示文摘 | Wood T Sameem M Avram R | 2012 | J Trauma Acute Care Surg2012，72，4： | 1 |
| 11 | Radioiodine scintigraphy with SPECT/CT: an important diagnostic tool for thyroid cancer staging and risk stratification 显示文摘 | Avram AM | 2012 | J NuclMed2012，53，5： | 1 |
| 12 | Monte Carlo-based filtering for fatigue crack growth estimation显示文摘 | Cadini F Zio E Avram D | 2009 | Probabilistic Engineering Mechanics2009，24，3： | 1 |
| 13 | SSU1 encodes a plasma membrane protein with a central role in a network of proteins conferring sulfite tolerance in Saccharomyces cerevisiae显示文摘 | Avram D Bakalinsky A T | 1997 | Bacteriol1997，179，18： | 1 |
| 14 | Surgical Experience with Pancreatic and Periampullary Cancer显示文摘 | FREDERIC P. HERTER AVRAM M. COOPERMAN THOMAS N. AHLBORN CHARLES ANTINORI | 1982 | Annals of Surgery1982，，3： | 1 |
| 15 | Oxidation of phenylyclohexane to hydroper-oxide in the presence of cobalt acetylacetonate 显示文摘 | Loan C Avram R Lovu H | 1995 | Revista de Chimie1995，46，9： | 1 |
| 16 | The Pharmacokinetics of dexmedetomidine in volunteers with severe renal impairment 显示文摘 | De Wolf AM Rangen R J Avram M J | 2001 | Anesth Analg2001，93，5： | 1 |
| 17 | Statistical methods in anesthesia articles:an evaluation of two American journals during two six-month periods显示文摘 | Avram MJ Shanks CA Dykes MH | 1985 | Anesth Anglg1985，64，6： | 1 |
| 18 | Hemodynamic contsequences of continuous arteriovenous hemofiltration显示文摘 | Lauer A Alvis R Avram M | 1998 | Am J Kidney Dis1998，12，： | 1 |
| 19 | Signal dependence on magnetic nanoparticles position over a planar Hall effect biosensor显示文摘 | Volmer M Avram M | 2013 | Microelectronic Engineering2013，108，： | 1 |
| 20 | The effectiveness of electromyographicbiofeedback as part of a meniscal repair rehabilitationprogramme 显示文摘 | ORAVITAN M AVRAM C | 2013 | J Sports Sci Med2013，12，3： | 1 |
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