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3篇 您的检索式：作者名="David Chapel"

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		题名	作者	年代	出处	被引量
	1	Role of the complement cascade in cerebral aneurysm formation,growth,and rupture显示文摘Rupture of intracranial aneurysms is the most common cause of nontraumatic subarachnoid hemorrhage,but the intricate neuroinflammatory processes which contribute to aneurysm pathophysiology are not well‑understood.Mounting evidence has implicated the complement cascade in the progression of aneurysms from their formation to rupture.In this article,we identify and review studies that have sought to determine the role of the complement system in the aneurysm pathogenesis.The studies were generally conducted by immunhistological analyses on aneurysm tissue collected intraoperatively,and multiple components of the complement cascade and its modulators were identified in specific regions of the aneurysm wall.The results of the studies suggest that the complement cascade is locally upregulated and disinhibited in the perianeurysmal environment,and that it contributes to chronic as well as acute immunological damage to the aneurysm wall.In the future,understanding the mechanisms at work in complement‑mediated damage is necessary to leading the development of novel therapies.	Blake E.S.Taylor Geoff Appelboom Robert Zilinyi Ariana Goodman David Chapel Melissa LoPresti Edward Sander Connolly Jr.	2015	Neuroimmunology and Neuroinflammation2015，2，1：	2
	2	Prevention of Pneumonia in Elderly Stroke Patients by Systematic Diagnosis and Treatment of Dysphagia: An Evidence-Based Comprehensive Analysis of the Literature显示文摘	David L. Doggett Karyn A. Tappe Matthew D. Mitchell R. Chapell V. Coates Charles M. Turkelson	2001	Dysphagia2001，，4：	1
	3	Hépatite aigu? cholestatique à la Glucosamine forte ?显示文摘	Roch Anicet Ossendza Philippe Grandval Farid Chinoune Fanny Rocher Fran?oise Chapel David Bernardini	2007	Gastroenterologie Clinique et Biologique2007，，4：	1

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