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| 1 | Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies显示文摘巨噬细胞代表天生的免疫的一种主要房间类型并且在许多长期的煽动性的疾病作为一个批评播放器和治疗学的目标出现了。肝的巨噬细胞由 Kupffer 房间组成,它从胎儿的蛋黄麻袋被发源,并且渗入了骨头导出髓的单核白血球 / 巨噬细胞。肝的巨噬细胞在维持肝并且在肝损害的致病的动态平衡起一个中央作用,使他们成为为肝疾病的一个吸引人的治疗学的目标。然而,肝的巨噬细胞的各种各样的人口显示不同显型并且施加不同函数。因此,更多的研究被要求更好理解这些房间指导基于巨噬细胞的治疗学的干预的发展。这篇评论文章将在支持并且解决肝发炎,损害,和纤维变性在肝的巨噬细胞,他们在维持肝的动态平衡的功能,和他们的参与的起源和作文上总结当前的知识。最后,当前的策略正在被开发指向肝的巨噬细胞因为肝疾病的处理将被考察。 | Cynthia Ju Frank Tacke | 2016 | Cellular & Molecular Immunology2016，13，3： | 54 |
| 2 | Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis显示文摘Stress-related mucosal disease is a typical complication of critically ill patients in the intensive care unit(ICU). It poses a risk of clinically relevant upper gastrointestinal(GI) bleeding. Therefore, stress ulcer prophylaxis(SUP)is recommended in high-risk patients, especially those mechanically ventilated > 48 h and those with a manifest coagulopathy. Proton pump inhibitors(PPI) and, less effectively, histamine 2 receptor antagonists(H2RA) prevent GI bleeding in critically ill patients in the ICU. However, the routine use of pharmacological SUP does not reduce overall mortality in ICU patients. Moreover, recent studies revealed that SUP in the ICU might be associated with potential harm such as an increased risk of infectious complications, especially nosocomial pneumonia and Clostridium difficile-associated diarrhea. Additionally, special populations such as patients with liver cirrhosis may even have an increased mortality rate if treated with PPI. Likewise, PPI can be toxic for both the liver and the bone marrow, and some PPI show clinically relevant interactions with important other drugs like clopidogrel. Therefore, the agent of choice, the specific balance of risks and benefits for individual patients as well as the possible dose of PPI has to be chosen carefully. Alternatives to PPI prophylaxis include H2 RA and/or sucralfate. Instead of routine SUP, further trials should investigate risk-adjusted algorithms, balancing benefits and threats of SUP medication in the ICU. | Lukas Buendgens Alexander Koch Frank Tacke | 2016 | World Journal of Critical Care Medicine2016，5，1： | 24 |
| 3 | Hepatic macrophages in liver homeostasis and diseasesdiversity,plasticity and therapeutic opportunities显示文摘Macrophages,which are key cellular components of the liver,have emerged as essential players in the maintenance of hepatic homeostasis and in injury and repair processes in acute and chronic liver diseases.Upon liver injury,resident Kupffer cells(KCs)sense disturbances in homeostasis,interact with hepatic cell populations and release chemokines to recruit circulating leukocytes,including monocytes,which subsequently differentiate into monocyte-derived macrophages(MoMφs)in the liver.Both KCs and MoMφs contribute to both the progression and resolution of tissue inflammation and injury in various liver diseases.The diversity of hepatic macrophage subsets and their plasticity explain their different functional responses in distinct liver diseases.In this review,we highlight novel findings regarding the origins and functions of hepatic macrophages and discuss the potential of targeting macrophages as a therapeutic strategy for liver disease. | Yankai Wen Joeri Lambrecht Cynthia Ju Frank Tacke | 2021 | Cellular & Molecular Immunology2021，18，1： | 21 |
| 4 | Molecular identification of hepatitis B virus genotypes/subgenotypes:Revised classification hurdles and updated resolutions显示文摘The clinical course of infections with the hepatitis B virus(HBV)substantially varies between individuals,as a consequence of a complex interplay between viral,host,environmental and other factors.Due to the high genetic variability of HBV,the virus can be categorized into different HBV genotypes and subgenotypes,which considerably differ with respect to geographical distribution,transmission routes,disease progression,responses to antiviral therapy or vaccination,and clinical outcome measures such as cirrhosis or hepatocellular carcinoma.However,HBV(sub)genotyping has caused some controversies in the past due to misclassifications and incorrect interpretations of different genotyping methods.Thus,an accurate,holistic and dynamic classification system is essential.In this review article,we aimed at highlighting potential pitfalls in genetic and phylogenetic analyses of HBV and suggest novel terms for HBV classification.Analyzing fulllength genome sequences when classifying genotypes and subgenotypes is the foremost prerequisite of this classification system.Careful attention must be paid to all aspects of phylogenetic analysis,such as bootstrapping values and meeting the necessary thresholds for(sub)genotyping.Quasi-subgenotype refers to subgenotypes that were incorrectly suggested to be novel.As many of these strains were misclassified due to genetic differences resulting from recombination,we propose the term'recombino-subgenotype'.Moreover,immigration is an important confounding facet of global HBV distribution and substantially changes the geographic pattern of HBV(sub)genotypes.We therefore suggest the term'immigro-subgenotype'to distinguish exotic(sub)genotypes from native ones.We are strongly convinced that applying these two proposed terms in HBV classification will help harmonize this rapidly progressing field and allow for improved prophylaxis,diagnosis and treatment. | Mahmoud Reza Pourkarim Samad Amini-Bavil-Olyaee Fuat Kurbanov Marc Van Ranst Frank Tacke | 2014 | World Journal of Gastroenterology2014，20，23： | 20 |
| 5 | 功能性消化不良、胃排空延迟和生活质量下降显示文摘功能性消化不良(FD)是一种临床上最常见的综合征,表现为慢性反复性中上腹疼痛或不适,传统的诊断检测方法不能检测出病因。许多FD患者诉说症状与饮食有关,但病理生理情况不明。25%~50%的FD患者发生胃排空延迟症状,这与胃窦部动力降低有关。其他FD的异常表现包括胃底容受性限制、胃扩张过度敏感和幽门螺杆菌(H.pylori)感染。 | Talley NJ Locke Ⅲ GR Lahr B Zinsmeister AR Tougas G Ligozio G Rojavin MA Tack J.Mayo Clinic Rochester MN 陆红 | 2006 | 胃肠病学2006，11，2： | 12 |
| 6 | IBS and the role of otilonium bromide显示文摘 | Guy Boeckxstaens Enrico S. Corazziari Fermín Mearin Jan Tack | 2013 | International Journal of Colorectal Disease2013，，3： | 4 |
| 7 | Role of gamma-delta T cells in liver inflammation and fibrosis显示文摘Conventional adaptive T cell responses contribute to liver inflammation and fibrogenesis,especially in chronic viral infections and autoimmune hepatitis.However,the role of unconventional gamma-delta(γδ)T cells in liver diseases is less clear.In the past two decades,accumulating evidence revealed thatγδT cell numbers remarkably increase in the liver upon various inflammatory conditions in mice and humans.More recent studies demonstrated that the functional effect ofγδT cells on liver disease progression depends on the subsets involved,which can be identified by the expression of distinct T cell receptor chains and of specific cytokines.Fascinatingly,γδT cells may have protective as well as pathogenic functions in liver diseases.Interferonγ-producingγδT cells,for example,induce apoptosis in hepatocytes but also in hepatic tumor cells;while interleukin-17-expressingγδT cells can downregulate pathogenic effector functions of other immune cells and can promote apoptosis of fibrogenic stellate cells.However,the results obtained in human liver disease as well as murine models are not fully conclusive at present,and the effects ofγδT cells on the outcome of liver disease might vary dependent on etiology and stage of disease.Further definitions of theγδT cell subsets in-volved in acute and chronic liver inflammation,as well as their effector cytokines might uncover whether interference withγδT cells could be a useful target for the treatment of liver disease. | Linda Hammerich Frank Tacke | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，2： | 4 |
| 8 | Microbiota in health and irritable bowel syndrome: current knowledge, perspectives and therapeutic options显示文摘 | Leonilde Bonfrate Jan Tack Ignazio Grattagliano Rosario Cuomo Piero Portincasa | 2013 | Scandinavian Journal of Gastroenterology2013，，9： | 3 |
| 9 | 新型吸入麻醉剂-七氟醚的研究进展II.兽医药效学显示文摘新型吸入麻醉剂七氟醚在犬、猫、马、鼠的 MAC分别为 2 .1 0~ 2 .36 ,2 .5 8,2 .31 ,2 .40~ 2 .5 0 Vol%。像异氟醚那样 ,七氟醚可降低脑血管阻力、脑代谢率、脑耗氧量、心肌收缩功能和血压。七氟醚可引起猫惊厥。虽然猪的心跳在七氟醚麻醉下维持稳定 ,但研究表明犬的心率则升高。七氟醚麻醉下引起心律失常的肾上腺素剂量与异氟醚相似 ,但大大高于氟烷或安氟醚。七氟醚对呼吸道的刺激性明显低于其他吸入麻醉剂。尚未见其肝肾毒性。 | 熊惠军 Sabine Tacke Ernst Schimke | 2001 | 动物医学进展2001，22，2： | 3 |
| 10 | Inflammatory Pathways in Liver Homeostasis and Liver Injury显示文摘 | Frank Tacke Tom Luedde Christian Trautwein | 2009 | Clinical Reviews in Allergy & Immunology2009，，1： | 3 |
| 11 | Functional Gastroduodenal Disorders显示文摘 | Jan Tack Nicholas J. Talley Michael Camilleri Gerald Holtmann Pinjin Hu Juan-R. Malagelada Vincenzo Stanghellini | 2006 | Gastroenterology2006，，5： | 3 |
| 12 | Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis显示文摘 | Christoph Roderburg Gerd‐Willem Urban Kira Bettermann Mihael Vucur Henning Zimmermann Sabine Schmidt J?rn Janssen Christiane Koppe Percy Knolle Mirco Castoldi Frank Tacke Christian Trautwein Tom Luedde | 2011 | Hepatology2011，，1： | 3 |
| 13 | 七氟醚 氟烷 异氟醚对犬心脏功能影响的临床比较显示文摘为评价七氟醚对心脏功能的影响 ,并与氟烷和异氟醚作比较 ,对动物医院就诊、心肺功能正常、拟作手术治疗的 86例患犬进行麻醉试验。所有犬均以 l-美散痛和安定作为麻醉前给药。分别以 1.5 %七氟醚、1.0 %七氟醚与 6 6 .7%笑气、1.0 %氟烷、1.5 %异氟醚维持手术麻醉 ,并作人工呼吸。各组均未观察到心律异常。手术麻醉期间 ,七氟醚组犬心率降幅 (4 .73% )低于异氟醚组 (9.74% )或氟烷组 (10 .2 3% )。七氟醚组、氟烷组和异氟醚组的收缩压 /舒张压轻度升高 (七氟醚 3.38% / 11.93% ,氟烷 6 .0 9% / 9.0 9% ,异氟醚 4.82 % / 6 .2 5 % )。而七氟醚与笑气组的收缩压 /舒张压则降低 (6 .84% / 5 .73% )。 | 熊惠军 Sabine Tacke Ernst Schimke | 2001 | 中国兽医杂志2001，37，5： | 3 |
| 14 | A MEMS ultrasound stimulation system for modulation of neural circuits with high spatial resolution in vitro显示文摘Neuromodulation by ultrasound has recently received attention due to its noninvasive stimulation capability for treating brain diseases.Although there have been several studies related to ultrasonic neuromodulation,these studies have suffered from poor spatial resolution of the ultrasound and low repeatability with a fixed condition caused by conventional and commercialized ultrasound transducers.In addition,the underlying physics and mechanisms of ultrasonic neuromodulation are still unknown.To determine these mechanisms and accurately modulate neural circuits,researchers must have a precisely controllable ultrasound transducer to conduct experiments at the cellular level.Herein,we introduce a new MEMS ultrasound stimulation system for modulating neurons or brain slices with high spatial resolution.The piezoelectric micromachined ultrasonic transducers(pMUTs)with small membranes(submm membranes)generate enough power to stimulate neurons and enable precise modulation of neural circuits.We designed the ultrasound transducer as an array structure to enable localized modulation in the target region.In addition,we integrated a cell culture chamber with the system to make it compatible with conventional cell-based experiments,such as in vitro cell cultures and brain slices.In this work,we successfully demonstrated the functionality of the system by showing that the number of responding cells is proportional to the acoustic intensity of the applied ultrasound.We also demonstrated localized stimulation capability with high spatial resolution by conducting experiments in which cocultured cells responded only around a working transducer. | Jungpyo Lee Kyungmin Ko Hyogeun Shin Soo-Jin Oh CJustin Lee Namsun Chou Nakwon Choi Min Tack Oh Byung Chul Lee Seong Chan Jun Il-Joo Cho | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
| 15 | Randomised clinical trials: linaclotide phase 3 studies in IBS ‐C – a prespecified further analysis based on European Medicines Agency‐specified endpoints显示文摘 | E. M. M. Quigley J. Tack W. D. Chey S. S. Rao J. Fortea M. Falques C. Diaz S. J. Shiff M. G. Currie J. M. Johnston | 2012 | Aliment Pharmacol Ther2012，，1： | 3 |
| 16 | Interleukin-33 in the pathogenesis of liver fibrosis: alarming ILC2 and hepatic stellate cells显示文摘 | Ralf Weiskirchen Frank Tacke | 2017 | Cellular & Molecular Immunology2017，14，2： | 3 |
| 17 | The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders显示文摘 | Michael D. Gershon Jan Tack | 2007 | Gastroenterology2007，，1： | 3 |
| 18 | Symptom Patterns and Pathophysiological Mechanisms in Dyspeptic Patients with and Without Helicobacter pylori显示文摘 | Giovanni Sarnelli Rosario Cuomo Jozef Janssens Jan Tack | 2003 | Digestive Diseases and Sciences2003，，12： | 2 |
| 19 | Consensus Statements for Management of Barrett’s Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process显示文摘 | Cathy Bennett Nimish Vakil Jacques Bergman Rebecca Harrison Robert Odze Michael Vieth Scott Sanders Laura Gay Oliver Pech Gaius Longcroft–Wheaton Yvonne Romero John Inadomi Jan Tack Douglas A. Corley Hendrik Manner Susi Green David Al Dulaimi Haythem Ali | 2012 | Gastroenterology2012，，2： | 2 |
| 20 | CREMa overexpression decreases IL-2 production,induces a TH17 phenotype and accelerates autoimmunity显示文摘Dear Editor,External cytokines produced by cells of the innate immune system induce the dif-ferentiation of CD4+T cells into helper T cell subsets with distinct functions and cytokine profiles.Apart from TH1 and TH2 cells a third subset of helper T cells has been described,which is characterized by increased expression of IL-17A,IL-17F,IL-21 and IL-22(TH17 cells). | Ralph Lippe Kim Ohl Georg Varga Thomas Rauen Jose C.Crispin Yuang-Taung Juang Stefanie Kuerten Frank Tacke Marc Wolf Kirsten Roebrock Thomas Vogl Eva Verjans Nora Honke Jan Ehrchen Dirk Foell Boris Skryabin Norbert Wagner George C.Tsokos Johannes Roth Klaus Tenbrock | 2012 | Journal of Molecular Cell Biology2012，4，2： | 2 |
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