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| 1 | Gastric peritoneal carcinomatosis-a retrospective review显示文摘AIM To characterize patients with gastric peritoneal carcinomatosis(PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care.METHODS We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral centre.RESULTS We studied a total of 271 patients with a median age of 63.8 years and median follow-up duration of 5.1 mo. The majority(n = 217, 80.1%) had the peritoneum as the only site of metastasis at initial presentation. Palliative systemic chemotherapy was eventually planned for 175(64.6%) of our patients at initial presentation, of which 171 were initiated on it. Choice of first-line regime was in accordance with the National Comprehensive Cancer Network Guidelines for Gastric Cancer Treatment. Thesepatients underwent a median of one line of chemotherapy, completing a median of six cycles in total. Chemotherapy disruption due to unplanned hospitalizations occurred in 114(66.7%), while cessation of chemotherapy occurred in 157(91.8%), with 42 cessations primarily attributable to PC-related complications. Patients who had initiation of systemic chemotherapy had a significantly better median overall survival than those who did not(10.9 mo vs 1.6 mo, P < 0.001). Of patients who had initiation of systemic chemotherapy, those who experienced any disruptions to chemotherapy due to unplanned hospitalizations had a significantly worse median overall survival compared to those who did not(8.7 mo vs 14.6 mo, P < 0.001).CONCLUSION Gastric PC carries a grim prognosis with a clinical course fraught with disease-related complications which may attenuate any survival benefit which palliative systemic chemotherapy may have to offer. As such, investigational use of regional therapies is warranted and required validation in patients with isolated PC to maximize their survival outcomes in the long run. | Hwee Leong Tan Claramae Shulyn Chia Grace Hwei Ching Tan Su Pin Choo David Wai-Meng Tai Clarinda Wei Ling Chua Matthew Chau Hsien Ng Khee Chee Soo Melissa Ching Ching Teo | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 6 |
| 2 | Diagnosis and fine localization of deletion region in Wolf- Hirschhorn syndrome patients显示文摘 | JI Tao-yun David CHIA WANG Jing-min WU Ye LI Jie XIAO Jing JIANG Yu-wu | 2010 | Chinese Medical Journal2010，，13： | 4 |
| 3 | α-Fetoprotein, Des-γ Carboxyprothrombin, and Lectin-Bound α-Fetoprotein in Early Hepatocellular Carcinoma显示文摘 | Jorge A. Marrero Ziding Feng Yinghui Wang Mindie H. Nguyen Alex S. Befeler Lewis R. Roberts K. Rajender Reddy Denise Harnois Josep M. Llovet Daniel Normolle Jackie Dalhgren David Chia Anna S. Lok Paul D. Wagner Sudhir Srivastava Myron Schwartz | 2009 | Gastroenterology2009，，1： | 3 |
| 4 | Inhibition of T-Cell Inflammatory Cytokines, Hepatocyte NF-κB Signaling, and HCV Infection by Standardized Silymarin显示文摘 | Stephen J. Polyak Chihiro Morishima Margaret C. Shuhart Chia C. Wang Yanze Liu David Y.–W. Lee | 2007 | Gastroenterology2007，，5： | 2 |
| 5 | Inhibition of T-Cell Inflammatory Cytokines, Hepatocyte NF-κB Signaling, and HCV Infection by Standardized Silymarin显示文摘 | Stephen J. Polyak Chihiro Morishima Margaret C. Shuhart Chia C. Wang Yanze Liu David Y.–W. Lee | 2007 | Gastroenterology2007，，5： | 2 |
| 6 | Ki-67 index,HER-2 status,and prognosis of patients with luminal B breast cancer显示文摘 | Cheang MCU Chia SK David V | 2009 | J Natl Cancer Inst2009，101，10： | 1 |
| 7 | Silymarin Inhibits In Vitro T-Cell Proliferation and Cytokine Production in Hepatitis C Virus Infection显示文摘 | Chihiro Morishima Margaret C. Shuhart Chia C. Wang Denise M. Paschal Minjun C. Apodaca Yanze Liu Derek D. Sloan Tyler N. Graf Nicholas H. Oberlies David Y.–W. Lee Keith R. Jerome Stephen J. Polyak | 2010 | Gastroenterology2010，，2： | 1 |
| 8 | Radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation显示文摘 | Derek A.DuBay CharbelSandroussi John R.Kachura Chia SingHo J. RobertBeecroft Charles M.Vollmer AnandGhanekar MarkusGuba Mark S.Cattral Ian D.McGilvray David R.Grant Paul D.Greig | 2010 | HPB2010，，1： | 1 |
| 9 | Salivary Transcriptomic Biomarkers for Detection of Resectable Pancreatic Cancer显示文摘 | Lei Zhang James J. Farrell Hui Zhou David Elashoff David Akin No–Hee Park David Chia David T. Wong | 2010 | Gastroenterology2010，，3： | 1 |
| 10 | Ethanol extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cells显示文摘 | GuoLi Xiao‐aiZhang Jin‐fangZhang Chu‐yanChan David Tai WaiYew Ming‐liangHe Marie Chia‐miLin Ping‐chungLeung Hsiang‐fuKung | 2010 | Phytother Res2010，，4： | 1 |
| 11 | Effect of Tumor Subtype on Survival and the Graded Prognostic Assessment for Patients With Breast Cancer and Brain Metastases显示文摘 | Paul W. Sperduto Norbert Kased David Roberge Zhiyuan Xu Ryan Shanley Xianghua Luo Penny K. Sneed Samuel T. Chao Robert J. Weil John Suh Amit Bhatt Ashley W. Jensen Paul D. Brown Helen A. Shih John Kirkpatrick Laurie E. Gaspar John B. Fiveash Veronica Chia | 2012 | International Journal of Radiation Oncology Biology Physics2012，，5： | 1 |
| 12 | Expression levels of estrogen receptor beta in conjunction with aromatase predict survival in non-small cell lung cancer显示文摘 | Vei Mah Diana Marquez Mohammad Alavi Erin L. Maresh Li Zhang Nam Yoon Steve Horvath Lora Bagryanova Michael C. Fishbein David Chia Richard Pietras Lee Goodglick | 2011 | Lung Cancer2011，，2： | 1 |
| 13 | Radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation显示文摘 | Derek A.DuBay CharbelSandroussi John R.Kachura Chia SingHo J. RobertBeecroft Charles M.Vollmer AnandGhanekar MarkusGuba Mark S.Cattral Ian D.McGilvray David R.Grant Paul D.Greig | 2010 | HPB2010，，1： | 1 |
| 14 | Cardiovascular effects of tumour necrosis factor α antagonism in patients with acute myocardial infarction: a first in human study显示文摘 | Gareth J Padfield Jehangir N Din Elena Koushiappi Nicholas L Mills Simon D Robinson Nicholas Le May Cruden Andrew John Lucking Stanley Chia Scott A Harding David E Newby | 2013 | Heart2013，，18： | 1 |
| 15 | Needle Tract Seeding after Radiofrequency Ablation of Hepatic Tumors显示文摘 | Jeffrey D. Jaskolka Murray R. Asch John R. Kachura Chia S. Ho Marc Ossip Florence Wong Morris Sherman David R. Grant Paul D. Greig Steven Gallinger | 2005 | Journal of Vascular and Interventional Radiology2005，，4： | 1 |
| 16 | Evaluating the 'Rich-Get-Richer' Mechanism in Tropical Precipitation Change under Global Warming显示文摘 | Chou Chia Neelin J David Chen Chao-An Tu Jien-Yi | 2009 | Journal of Climate2009，，8： | 1 |
| 17 | 关于具有测边导坑和有限岩石覆盖层的隧道开口的离散分析(英文)显示文摘目的:针对新加坡的花岗岩地质结构,研究将典型马蹄形隧道挖掘成双拱隧道时岩石支撑的设计问题。利用离散元法分析侧边导坑对隧道主体开口的影响。创新点:1.基于平面应变假设,提出一个针对性的离散元模型以分析侧边导坑的设置对主体隧道支撑的影响;2.此模型适用于解决底下长跨度开口的支撑设计问题,如大众捷运系统隧道和紧贴式双孔隧道的建造,补充了传统经验主义的设计方法。方法:1.采用离散元法对马蹄形隧道开口支撑问题进行非连续分析;2.采用二维平面应变模型简化问题。结论:1.离散元法可用于分析有限岩石覆盖层的失效机制,单隧道支撑要求以及增加侧边导坑后的支撑要求;2.模型计算结果显示,侧边导坑的挖掘使得支柱总的螺栓连接作用力增加了一倍。 | Chia Weng BOON Chee Wei NEO David Chew Chiat NG Victor Chee Wee ONG | 2018 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2018，19，4： | 1 |
| 18 | In vitro approaches for studying blast-induced traumatic brain injury显示文摘 | Yung Chia Chen Douglas H.Smith David F Meaney | | 0，，03： | 1 |
| 19 | An open‐label, single‐arm, phase 2 trial of the polo‐like kinase inhibitor volasertib (BI 6727) in patients with locally advanced or metastatic urothelial cancer显示文摘 | Walter M. Stadler David J. Vaughn Guru Sonpavde Nicholas J. Vogelzang Scott T. Tagawa Daniel P. Petrylak Peter Rosen Chia‐Chi Lin John Mahoney Sanjiv Modi Peter Lee Marc S. Ernstoff Wu‐Chou Su Alexander Spira Korinna Pilz Richard Vinisko Charles Schloss H | 2014 | Cancer2014，，7： | 1 |
| 20 | Impact ionization in AlxGa1-x As/GaAs single heterostructures 显示文摘 | CHIA C K DAVID J P R REES G J | 1998 | JAP1998，84，8： | 1 |
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