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| 1 | Clinical implication of VEGF serum levels in cirrhotic patients with or without portal hypertension显示文摘INTRODUCTIONAngiogenesisorformationofnewbloodvesels,isatightlyregulatedprocesinwhichbloodveselssupplygrowingtisuewithnutrient... | Nimer Assy 1,4 , M Paizi 3,4 , D Gaitini 2, Y Baruch 1,4 and G Spira 3,4,5 | 1999 | World Journal of Gastroenterology1999，5，4： | 35 |
| 2 | Results of docetaxel plus oxaliplatin (DOCOX) ± cetuximab in patients with metastatic gastric and/or gastroesophageal junction adenocarcinoma: results of a randomized phase 2 study显示文摘 | Donald Richards Darren M. Kocs Alexander I. Spira A. David McCollum Sami Diab Lanny I. Hecker Allen Cohn Feng Zhan Lina Asmar | 2013 | European Journal of Cancer2013，，： | 3 |
| 3 | Diagnostic approach to patients with cholestatic jaundice显示文摘 | Assy N Jacob G Spira G Edoute Y | 1999 | World Journal of Gastroenterology1999，5，3： | 3 |
| 4 | Cognition in Obstructive Sleep Apnea-Hypopnea Syndrome (OSAS): Current Clinical Knowledge and the Impact of Treatment显示文摘 | Stephanie Kielb Sonia Ancoli-Israel George Rebok Adam Spira | 2012 | NeuroMolecular Medicine2012，，3： | 2 |
| 5 | Multidisciplinary management of lung cancer显示文摘 | SPIRA A ETTINGER D S | 2004 | N Engl J Med2004，350，4： | 1 |
| 6 | A distributed algorithm for minimum weight spanning trees显示文摘 | GALLAGER R HUMBLET P A SPIRA P M | 1983 | ACM Transactions on Programming Languages and Systems1983，5，1： | 1 |
| 7 | Validation of the Pittsburgh sleep quality index and the epworth sleepiness scale in older black and white women 显示文摘 | Beaudreau SA Spira AP Stewart A | 2012 | Sleep Medicine2012，13，1： | 1 |
| 8 | Hydrodynamics based transfection in normal and fibrotic rats显示文摘AIM: Hydrodynamics based transfection (HBT), the injection of a large volume of naked plasmid DNA in a short time is a relatively simple, efficient and safe method for in vivo transfection of liver cells. Though used for quite some time, the mechanism of gene transfection has not yet been elucidated. METHODS: A luciferase encoding plasmid was injected using the hydrodynamics based procedure into normal and thioacetamide-induced fibrotic Sprague Dawley rats. Scanning and transmission electron microscopy images were taken. The consequence of a dual injection of Ringer solution and luciferase pDNA was followed. Halofuginone, an anti collagen type I inhibitor was used to reduce ECM load in fibrotic rats prior to the hydrodynamic injection. RESULTS: Large endothelial gaps formed as soon as 10’ following hydrodynamic injection; these gradually returned to normal 10 d post injection. Hydrodynamic administration of Ringer 10 or 30 m prior to moderate injection of plasmid did not result in efficient transfection suggesting that endothelial gaps by themselves are not sufficient for gene expression. Gene transfection following hydrodynamic injection in thioacetamide induced fibrotic rats was diminished coinciding with the level of fibrosis. Halofuginone, a specific collagen typeⅠ inhibitor, alleviated this effect. CONCLUSION: The hydrodynamic pressure formedfollowing HBT results in the formation of large endothelial gaps. These gaps, though important in the transfer of DNA molecules from the blood to the space of Disse are not enough to provide the appropriate conditions for hepatocyte transfection. Hydrodynamics based injection is applicable in fibrotic rats provided that ECM load is reduced. | Rita Yeikilis Shunit Gal Natalia Kopeiko Melia Paizi Mark Pines Filip Braet Gadi Spira | 2006 | World Journal of Gastroenterology2006，12，38： | 1 |
| 9 | Progesterone implants enhance SIV vaginal transmission and early virus load 显示文摘 | Marx PA Spira AI Gettie A | 1996 | Nat Med1996，2，10： | 1 |
| 10 | Evaluation of hazard from self- heating of sulfide rock显示文摘 | ROSENBLUM F SPIRA P | 1995 | CIM Bull1995，88，989： | 1 |
| 11 | Clinical and Pathological Features of a Parkinsonian Syndrome in a Family with an Ala53Thr Alpha-Synuclein Mutation显示文摘 | SHARPE DM HALLIDAY G | 2001 | Ann Neurol(S0364-5134)2001，49，3： | 1 |
| 12 | Multidisciplinary management of lung cancer显示文摘 | Spira A Ettinger DS | 2004 | N Engl J Med2004，350，： | 1 |
| 13 | Ectopic pregnancy and occu pational exposure to antineoplastic drugs显示文摘 | Saurel-Cubizolles MJ Job Spira N Estrvn Behar | 1993 | Lancet1993，341，8854： | 1 |
| 14 | Cutaneous horn present for two months 显示文摘 | Spira J Rabinovit H | 2000 | Dermatol Online J2000，6，1： | 1 |
| 15 | Prefabricated flaps:experimental and clinical review显示文摘 | SHENAQ S M SPIRA M | 1995 | Plast Reconstr Surg1995，96，5： | 1 |
| 16 | Multidisciplinary management of lung cancer显示文摘 | Spira A Ettinger DS | 2004 | N Engl J Med2004，350，4： | 1 |
| 17 | Sleep - disordered breath- ing and cognition in older women 显示文摘 | Spira AP Blackwell T Stone KL | 2008 | J Am Geriatr Soc2008，56，1： | 1 |
| 18 | Apomorphine blocks form-deprivation myopia in chickens by a dopamine D2-receptor mechanism acting in retina or pigmented epithelium显示文摘 | Rohrer B Spira AW Stell WK | 1993 | Vis Neurosci1993，10，3： | 1 |
| 19 | Optimizing sleep in older adults: treating insomnia显示文摘 | Wennberg AM Canham SL Smith MT Spira AP | 2013 | Maturitas2013，76，3： | 1 |
| 20 | High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes:a novel in vitro model for the study of conduction显示文摘 | Kehat I Gepstein A Spira A | 2002 | Circ Res2002，91，8： | 1 |
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