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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | 时空交互视角下长三角城市群雾霾污染动态关联网络及协同治理研究显示文摘基于长三角26个城市2013~2018年空气质量指数日报数据,利用非格兰杰因果检验、复杂网络等方法,从时空交互视角分析了长三角城市群雾霾污染动态关联网络特征。结果发现:样本考察期长三角城市群总体雾霾污染指数及天数总体呈现下降趋势,冬季、春季及对应月份雾霾污染相对较重;长三角城市群雾霾污染空间网络相对稳定,各城市间都存在关联关系,整网关系紧密度逐年提升,但空间影响等级结构则渐趋松散;基于考察期污染指数均值及空间网络核心度的二维时空标准,可将长三角城市群细分为四种区别性治理类型。最后,提出长三角乃至全国城市群雾霾污染协同治理的相关对策与建议。 | 杨传明 Gabor Horvath | 2019 | 软科学2019，33，12： | 10 |
| 3 | 细胞学方法治疗缺血性心脏病的新进展显示文摘尽管缺血性心脏病在防治手段,介入治疗方面有了很大的进展,但是缺血性心脏病仍然是世界上导致患者死亡最多的疾病之一.为了使缺血性心脏病患者心肌梗死部位心肌再生,研究人员尝试了多种物理治疗方法[1-3],如移植乳内动脉到坏死部位的心肌组织[4],或是应用药物治疗,如肝素[2],血管内皮生长因子(VEGF),肝素结合生长因子1和碱性成纤维细胞生长因子[7-10]. | Yifu Zhou Suna Wang Bogdan Kindzelski Keith A Horvath 程斌 黄益民 | 2014 | 心肺血管病杂志2014，33，6： | 4 |
| 4 | 卒中一级预防指南美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘这份更新版指南旨在为既往无卒中或短暂性脑缺血发作史的人群提供适时的综合性卒中预防循证建议,包括危险因素控制、头颈部动脉粥样硬化性疾病的干预方法以及预防血栓形成和血栓栓塞性卒中的抗栓治疗。此外,本指南还提供了针对遗传和药理学检测以及在其他特殊情况下(包括镰状细胞疾病和卵圆孔未闭)进行卒中预防的建议。 | James F. Meschia Cheryl Bushnell Bernadette Boden-Albala Lynne T. Braun Dawn M. Bravata Seemant Chaturvedi Mark A. Creager Robert H. Eckel Mitchell S.V. Elkind Myriam Fornage Larry B Goldstein Steven M. Greenberg Susanna E. Horvath Costantino Iadecola Edward C. Jauch Wesley S. Moore John A. Wilson 李迪 高一鹭 陈政弘 霍晓川 孙海欣 孙冬玲 茹小娟 江滨 | 2015 | 国际脑血管病杂志2015，23，6： | 4 |
| 5 | RNA-guided genome editing a la carte显示文摘 | Philippe Horvath Rodolphe Barrangou | 2013 | Cell Research2013，23，6： | 3 |
| 6 | Adoption of Laparoscopy for Elective Colorectal Resection: A Report from the Surgical Care and Outcomes Assessment Program显示文摘 | Steve Kwon Richard Billingham Ellen Farrokhi Michael Florence Daniel Herzig Karen Horvath Terry Rogers Scott Steele Rebecca Symons Richard Thirlby Mark Whiteford David R. Flum | 2012 | Journal of the American College of Surgeons2012，，6： | 3 |
| 7 | Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury显示文摘 | Neel R. Sodha Richard T. Clements Jun Feng Yuhong Liu Cesario Bianchi Eszter M. Horvath Csaba Szabo Gregory L. Stahl Frank W. Sellke | 2009 | The Journal of Thoracic and Cardiovascular Surgery2009，，： | 3 |
| 8 | Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines显示文摘AIM: To study the effect of anti-copper treatment for survival of hepatic cells expressing different ATP7 B mutations in cell culture. METHODS: The most common Wilson disease(WD) mutations p.H1069 Q, p.R778 L and p.C271*, found in the ATP7 B gene encoding a liver copper transporter, were studied. The mutations represent major genotypes of the United States and Europe, China, and India, respectively. A human hepatoma cell line previously established to carry a knockout of ATP7 B was used to stably express WD mutants. m RNA and protein expression of mutant ATP7 B, survival of cells, apoptosis, and protein trafficking were determined.RESULTS: Low temperature increased ATP7 B protein expression in several mutants. Intracellular ATP7 B localization was significantly impaired in the mutants. Mutants were classified as high, moderate, and no survival based on their viability on exposure to toxic copper. Survival of mutant p.H1069 Q and to a lesser extent p.C271* improved by D-penicillamine(DPA) treatment, while mutant p.R778 L showed a pronounced response to zinc(Zn) treatment. Overall, DPA treatment resulted in higher cell survival as compared to Zn treatment; however, only combined Zn + DPA treatment fully restored cell viability. CONCLUSION: The data indicate that the basic impact of a genotype might be characterized by analysis of mutant hepatic cell lines. | Gursimran Chandhok Judit Horvath Annu Aggarwal Mohit Bhatt Andree Zibert Hartmut HJ Schmidt | 2016 | World Journal of Gastroenterology2016，22，16： | 3 |
| 9 | Glucomannan for abdominal pain-related functional gastrointestinal disorders in children:A randomized trial显示文摘AIM:To assess the efficacy of glucomannan(GNN) as the sole treatment for abdominal pain-related functional gastrointestinal disorders(FGIDs).METHODS:We conducted a double-blind,placebocontrolled,randomized trial.Patients were recruited among children referred to the Department of Paediatrics,Medical University of Warsaw.Included in the study were children aged 7-17 years with abdominal pain-related FGIDs classified according to the Rome Ⅲ diagnostic criteria.The children were randomly assigned to receive GNN,a polysaccharide of 1,4-D-glucose and D-mannose,a soluble fiber from the Japanese Konjac plant,at a dosage of 2.52 g/d(1 sachet of 1.26 g 2 times a day),or a comparable placebo(maltodextrin) at the same dosage.The content of each sachet was dissolved in approximately 125 mL of fluid and was consumed twice daily for 4 wk.RESULTS:Of the 89 eligible children,84(94%) completed the study.'No pain' and 'treatment success'(defined as no pain or a decrease ≥ 2/6 points on the FACES Pain Scale Revised) were similar in the GNN(n = 41) and placebo(n = 43) groups [no pain(12/41 vs 6/43,respectively;RR = 2.1,95%CI:0.87-5.07) as well as treatment success(23/41 vs 20/43;RR = 1.2,95%CI:0.79-1.83)].No significant differences between the groups were observed in the secondary outcomes,such as abdominal cramps,abdominal bloating/gassiness,episodes of nausea or vomiting,or a changed in stool consistency.GNN demonstrated no significant influence on the number of children requiring rescue therapy,school absenteeism,or daily activities.CONCLUSION:In our setting,GNN,as dosed in this study,was no more effective than the placebo in achieving therapeutic success in the management of FGIDs in children. | Andrea Horvath Piotr Dziechciarz Hania Szajewska | 2013 | World Journal of Gastroenterology2013，19，20： | 3 |
| 10 | 农业景观的形成与演化显示文摘农业景观的形成与演化[美]JESpencerRJHorvath农业景观的形成有其历史、自然、人文等原因,比较复杂。本文对美国玉米带、菲律宾椰子景观和马来西亚橡胶景观的形成、演化作简略介绍。一、美国玉米带的形成与演化从农业生产综合体的观点来看,... | JESpencer RJHorvath 张落成 | 1997 | 世界农业1997，，11： | 3 |
| 11 | Evolution of disease phenotype in adult and pediatric onset Crohn's disease in a population-based cohort显示文摘AIM:To investigate the evolution of disease phenotypein adult and pediatric onset Crohn's disease(CD) populations,diagnosed between 1977 and 2008.METHODS:Data of 506 incident CD patients were analyzed(age at diagnosis:28.5 years,interquartile range:22-38 years).Both in-and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which included incident patients diagnosed between January 1,1977 and December 31,2008 in adult and pediatric onset CD populations.Disease phenotype according to the Montreal classification and long-term disease course was analysed according to the age at onset in time-dependent univariate and multivariate analysis.RESULTS:Among this population-based cohort,seventy-four(12.8%) pediatric-onset CD patients were identified(diagnosed ≤ 17 years of age).There was no significant difference in the distribution of disease behavior between pediatric(B1:62%,B2:15%,B3:23%) and adult-onset CD patients(B1:56%,B2:21%,B3:23%) at diagnosis,or during follow-up.Overall,the probability of developing complicated disease behaviour was 49.7% and 61.3% in the pediatric and 55.1% and 62.4% in the adult onset patients after 5-and 10-years of follow-up.Similarly,time to change in disease behaviour from non stricturing,non penetrating(B1) to complicated,stricturing or penetrating(B2/B3) disease was not significantly different between pediatric and adult onset CD in a Kaplan-Meier analysis.Calendar year of diagnosis(P = 0.04),ileal location(P < 0.001),perianal disease(P < 0.001),smoking(P = 0.038) and need for steroids(P < 0.001) were associated with presence of,or progression to,complicated disease behavior at diagnosis and during follow-up.A change in disease location was observed in 8.9% of patients and it was associated with smoking status(P = 0.01),but not with age at diagnosis.CONCLUSION:Long-term evolution of disease behavior was not different in pediatric-and adult-onset CD patients in this population-based cohort but was associated to location,perianal disease and smoking status. | Barbara Dorottya Lovasz Laszlo Lakatos Agnes Horvath Istvan Szita Tunde Pandur Michael Mandel Zsuzsanna Vegh Petra Anna Golovics Gabor Mester Mihaly Balogh Csaba Molnar Erzsebet Komaromi Lajos Sandor Kiss Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，14： | 2 |
| 12 | Guidelines for the Primary Prevention of Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | James F. Meschia Cheryl Bushnell Bernadette Boden-Albala Lynne T. Braun Dawn M. Bravata Seemant Chaturvedi Mark A. Creager Robert H. Eckel Mitchell S.V. Elkind Myriam Fornage Larry B. Goldstein Steven M. Greenberg Susanna E. Horvath Costantino Iadecola Ed | 2014 | Stroke2014，，12： | 2 |
| 13 | A tumor-selective somatostatin analog(TT232) with strong in vitro and vivo antitumor activity显示文摘 | Keri GY Erchegyi J Horvath A | 1996 | Proc Natl Acad Sci USA1996，93，12： | 2 |
| 14 | 发霉和霉菌毒素的预防和消除显示文摘霉菌会使饲料中各种成份的质量和适口性降低。霉菌抑制剂有助于防止发生这些问题的发生。 | 星阁 C.A.Adams Eva Maria Horvath | 1999 | 国外畜牧学(饲料)1999，，2： | 2 |
| 15 | Intestinal tuberculosis: return of an old disease显示文摘 | Karen D. Horvath Richard L. Whelan | 1998 | The American Journal of Gastroenterology1998，，5： | 2 |
| 16 | 适合水稻悬浮培养细胞蛋白质组分析的双向电泳技术显示文摘水稻是研究植物蛋白质组学的一个重要试材,从蛋白质的提取,裂解缓冲液的成份和浓度,第一向聚焦的条件,蛋白上样量和二向胶的选择方面,对水稻悬浮培养细胞的双向电泳条件进行了比较和优化。结果表明,采用甲醇/氯仿沉淀蛋白,裂解缓冲液中加入0.5%的两性电解质、并加入盐桥,17cm的胶条、850μg的上样量可达到较好的等电聚焦效果;8%-16%梯度胶分离蛋白较为适宜。 | 刘悦萍 杨爱珍 郭蓓 余萍 Horvath Gabor V Gyula Orosz | 2010 | 生物技术通报2010，26，11： | 2 |
| 17 | Meta‐analysis: sequential therapy for H elicobacter pylori eradication in children显示文摘 | A. Horvath P. Dziechciarz H. Szajewska | 2012 | Aliment Pharmacol Ther2012，，6： | 2 |
| 18 | 钼催化剂结构对其催化气相丙烯环氧化反应选择性的影响(英文)显示文摘考察了Mo基催化剂上空气气相氧化丙烯反应.从无机的和有机金属Mo前驱体出发,采用浸渍法和物理气相沉积法(PVD)制备了不同类型的SiO2负载氧化钼和Mo-Bi复合氧化物催化剂.透射电镜结果证实,所制催化剂上环氧化反应活性与其纳米结构直接有关.催化剂中出现部分或完全结晶的氧化钼相,它们与载体SiO2的相互作用较弱,使得反应生成环氧丙烷的选择性低于10%,而锚合在SiO2上的非结晶的八配位Mo物种上的环氧丙烷选择性达55%以上,此时丙烯转化率约为11%.不同形貌氧化钼的电化学表征结果证实了结构缺陷的重要性.另外,还讨论了Bi对氧化钼催化环氧化活性的直接促进效应. | Martin Sustek Blazej Horvath Ivo Vavra Miroslav Gal Edmund Dobrocka Milan Hronec | 2015 | Chinese Journal of Catalysis2015，36，11： | 2 |
| 19 | 物流管理专业实训实践校企耦合与实践研究显示文摘围绕人才培养中实训实践校企耦合环节,以苏州科技大学物流管理专业研究对象,以强化学生实际工作能力、就业适应力和竞争力为目标导向,通过设计新型人才培养方案、加强双师型教师队伍培养、健全质量保障机制等举措,构建以学生中心,兼具目的性、系统性、全程性、规范性原则的互补互动校企耦合方案。实践证明该方案取得了较好的实际效果,为应用型高校经管类专业实训实践教学体系建设提供了创新思路。 | 杨传明 Gabor Horvath | 2019 | 现代商贸工业2019，40，26： | 2 |
| 20 | An Ultrasonogram Reporting System for Thyroid Nodules Stratifying Cancer Risk for Clinical Management显示文摘 | Eleonora Horvath Sergio Majlis Ricardo Rossi Carmen Franco Juan P. Niedmann Alex Castro Miguel Dominguez | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，5： | 2 |
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