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| 1 | Liver stiffness in the hepatitis B virus carrier:A non-invasive marker of liver disease influenced by the pattern of transaminases显示文摘AIM: To investigate the usefulness of transient elastography by Fibroscan (FS),a rapid non-invasive technique to evaluate liver fibrosis,in the management of chronic hepatitis B virus (HBV) carriers.METHODS: In 297 consecutive HBV carriers,we studied the correlation between liver stiffness (LS),stage of liver disease and other factors potentially influencing FS measurements.In 87 chronic hepatitis B (CHB) patients,we monitored the FS variations according to the spontaneous or treatment-induced variations of biochemical activity during follow-up.RESULTS: FS values were 12.3 ± 3.3 kPa in acute hepatitis,10.3 ± 8.8 kPa in chronic hepatitis,4.3 ± 1.0 kPa in inactive carriers and 4.6 ± 1.2 kPa in blood donors.We identified the cut-offs of 7.5 and 11.8 kPa for the diagnosis of fibrosis ≥ S3 and cirrhosis respectively,showing 93.9% and 86.5% sensitivity,88.5% and 96.3% specificity,76.7% and 86.7% positive predictive value (PPV),97.3% and 96.3% negative predictive value (NPV) and 90.1% and 94.2% diagnostic accuracy.At multivariate analysis in 171 untreated carriers,fibrosis stage (t = 13.187,P < 0.001),active vs inactive HBV infection (t = 6.437,P < 0.001),alanine aminotransferase (ALT) (t = 4.740,P < 0.001) and HBV-DNA levels (t = -2.046,P = 0.042) were independently associated with FS.Necroinflammation score (t = 2.158,> 10/18 vs ≤ 10/18,P = 0.035) and ALT levels (t = 3.566,P = 0.001) were independently associated with LS in 83 untreated patients without cirrhosis and long-term biochemical remission (t = 4.662,P < 0.001) in 80 treated patients.During FS monitoring (mean follow-up 19.9 ± 7.1 mo) FS values paralleled those of ALT in patients with hepatitis exacerbation (with 1.2 to 4.4-fold increases in CHB patients) and showed a progressive decrease during antiviral therapy.CONCLUSION: FS is a non-invasive tool to monitor liver disease in chronic HBV carriers,provided that the pattern of biochemical activity is taken into account.In the inactive carrier,it identifies non-HBV-related causes of liver damage and transient reactivations.In CHB patients,it may warrant a more appropriate timing of control liver biopsies. | Filippo Oliveri Barbara Coco Pietro Ciccorossi Piero Colombatto Veronica Romagnoli Beatrice Cherubini Ferruccio Bonino Maurizia Rossana Brunetto | 2008 | World Journal of Gastroenterology2008，14，40： | 43 |
| 2 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 3 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 4 | Accuracy of the ultrasonic cardiac output monitor in healthy term neonates during postnatal circulatory adaptation显示文摘背景 Echocardiography 为测量血液动力学的价值被认为是一个标准答案。超声的心脏的输出监视器(USCOM ) 是为测量 hemodynamics 的一个新方法并且能提供照顾指导的非侵略的点。到目前为止,为出生不满一月的婴儿没有出版 USCOM 参考价值, USCOM 的精确性也没在这张人口被建立。我们试图相对出版 echocardiographic 数据在健康出生不满一月的婴儿决定精确性和 USCOM 的临床的用途,并且作为一个趋势监视器作为 echocardiography 的一种选择估计 USCOM 的可能的角色,到建立它测量的正常血液动力学的参数。90 个正常出生不满一月的婴儿的方法正确、左的心 hemodynamics 用 USCOM 在生活的开始的三天在循环改编期间被测量并且自动化了 oscillotonometry。结果心率从天显示出重要衰落一~三,从 126 ~ 120 (P < 0.001 ) 。收缩、心脏舒张、吝啬的动脉的压力都从 66 ~ 71 mmHg, 33 ~ 38 mmHg 和 44 ~ 49 mmHg 显著地增加了,分别地(P < 0.001 在每种情况中) 。恰好室的心脏的索引(RV-CI ) 没与 5.07 L | HE Shao-ru ZHANG Cheng LIU Yu-mei SUN Yun-xia ZHUANG Jian CHEN Ji-mei Veronica M. Madigan Brendan E. Smith SUN Xin | 2011 | Chinese Medical Journal2011，，15： | 14 |
| 5 | Molecular targeting agents associated with transarterial chemoembolization or radiofrequency ablation in hepatocarcinoma treatment显示文摘Hepatocellular carcinoma(HCC)is the fifth most common cause of cancer in the world.According to Barcelona Clinic Liver Cancer modified criteria,patients with early stage disease are candidate to radiofrequency ablation(RFA),while patients with intermediate stage HCC are usually treated by transarterial chemoembolization(TACE).TACE and RFA induce a transient devascularisation effect followed by strong neoangiogenic stimulus.In fact,after these procedures,it has been demonstrated an up-regulation of pro-angiogenic and growth factors such as vascular endothelial growth factor-A,which might contribute to accelerated progression in patients with incomplete response.Several studies have demonstrated that MAP-kinase and AKT pathways,in addition to neo-angiogenesis,have an important role in the development of HCC.In advanced HCC,anti-angiogenic therapy and tyrosine kinases inhibitors showed potential clinical benefit.Actually,a number of clinical studies are ongoing testing these agents in combination with TACE or RFA.In this paper,we have reviewed the most recent preclinical and clinical results of such trials. | Girolamo Ranieri Ilaria Marech Vito Lorusso Veronica Goffredo Angelo Paradiso Domenico Ribatti Cosmo Damiano Gadaleta | 2014 | World Journal of Gastroenterology2014，20，2： | 14 |
| 6 | Frequency dependent polarization analysis of ambient seismic noise recorded at a broadband seismometer in the central United States显示文摘We present a new approach to polarization analysis of seismic noise recorded by three-component seismometers.It is based on statistical analysis of frequency-dependent particle motion properties determined from a large number of time windows via eigenanalysis of the 3-by-3,Hermitian,spectral covariance matrix.We applied the algorithm to continuous data recorded in 2009 by the seismic station SLM,located in central North America.A rich variety of noise sources was observed.At low frequencies (<0.05 Hz) we observed a tilt-related signal that showed some elliptical motion in the horizontal plane.In the microseism band of 0.05-0.25 Hz,we observed Rayleigh energy arriving from the northeast,but with three distinct peaks instead of the classic single and double frequency peaks.At intermediate frequencies of 0.5-2.0 Hz,the noise was dominated by non-fundamental-mode Rayleigh energy,most likely P and Lg waves.At the highest frequencies (>3 Hz),Rayleigh-type energy was again dominant in the form of Rg waves created by nearby cultural activities.Analysis of the time dependence of noise power shows that a frequency range of at least 0.02-1.0 Hz (much larger than the microseism band) is sensitive to annual,meteorologically induced sources of noise. | Keith D. Koper Veronica L. Hawley | 2010 | Earthquake Science2010，23，5： | 13 |
| 7 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Progress of mesenchymal stem cell therapy for neural and retinal diseases显示文摘Complex circuitry and limited regenerative power make central nervous system(CNS)disorders the most challenging and difficult for functional repair.With elusive disease mechanisms,traditional surgical and medical interventions merely slow down the progression of the neurodegenerative diseases.However,the number of neurons still diminishes in many patients.Recently,stem cell therapy has been proposed as a viable option.Mesenchymal stem cells(MSCs),a widely-studied human adult stem cell population,have been discovered for more than 20 years.MSCs have been found all over the body and can be conveniently obtained from different accessible tissues:bone marrow,blood,and adipose and dental tissue.MSCs have high proliferative and differentiation abilities,providing an inexhaustible source of neurons and glia for cell replacement therapy.Moreover,MSCs also show neuroprotective effects without any genetic modification or reprogramming.In addition,the extraordinary immunomodulatory properties of MSCs enable autologous and heterologous transplantation.These qualities heighten the clinical applicability of MSCs when dealing with the pathologies of CNS disorders.Here,we summarize the latest progress of MSC experimental research as well as human clinical trials for neural and retinal diseases.This review article will focus on multiple sclerosis,spinal cord injury,autism,glaucoma,retinitis pigmentosa and age-related macular degeneration. | Tsz Kin Ng Veronica R Fortino Daniel Pelaez Herman S Cheung | 2014 | World Journal of Stem Cells2014，6，2： | 13 |
| 8 | Challenges and perspectives on high and intermediate-temperature sodium batteries显示文摘 | Karina B. Hueso Veronica Palomares Michel Armand Teofilo Rojo | 2017 | Nano Research2017，10，12： | 12 |
| 9 | Genetic Analysis of Cold Tolerance at Seedling Stage and Heat Tolerance at Anthesis in Rice (Oryza sativa L.)显示文摘A set of 240 introgression lines derived from the advanced backcross population of a cross between a japonica cultivar,Xiushui 09,and an indica breeding line,IR2061,was developed to dissect QTLs affecting cold tolerance (CT) at seedling stage and heat tolerance (HT) at anthesis.Survival rate of seedlings (SRS) and spikelet fertility (SF),the index traits of CT and HT,showed significant differences between the two parents under stresses.A total of four QTLs (qSRS1,qSRS7,qSRS11a and qSRS11b) for CT were identified on chromosomes 1,7,11,and the Xiushui 09 alleles increased SRS at all loci except qSRS7.Four QTLs for SF were identified on chromosomes 4,5,6,and 11.These QTLs could be classified into two major types based on their behaviors under normal and stress conditions.The first was QTL expressed only under normal condition;and the second QTL was apparently stress induced and only expressed under stress.Among them,two QTLs (qSF4 and qSF6) which reduced the trait difference between heat stress and normal conditions must have contributed to HT because of their obvious contribution to trait stability,and the IR2061 allele at the qSF6 and the Xiushui 09 allele at the qSF4 improved HT,respectively.No similar QTL was found between CT at seedling stage and HT at anthesis.Therefore,it is possible to breed a new variety with CT and HT by pyramiding the favorable CT-and HT-improved alleles at above loci from Xiushui 09 and IR2061,respectively,through marker-assisted selection (MAS). | CHENG Li-rui WANG Jun-min Veronica Uzokwe MENG Li-jun WANG Yun SUN Yong ZHU Linghua XU Jian-long LI Zhi-kang | 2012 | Journal of Integrative Agriculture2012，11，3： | 11 |
| 10 | The Dynamic Pollen Tube Cytoskeleton: Live Cell Studies Using Actin-Binding and Microtubule- Binding Reporter Proteins显示文摘花粉试管在雌蕊以内伸长为授精把精子房间搬运到胚胎囊。生长专门在试管顶发生,显示花粉试管延伸一个很戏剧的极的房间生长过程。一个特点花粉试管特征它的细胞骨架,它精心地包括被组织并且动态肌动朊微细丝和微导管。花粉试管生长依赖于肌动朊细胞骨架;它的组织和规定被各种各样的途径广泛地检验了,包括荧光灯在实时房间标记肌动朊绑定蛋白质的蛋白质学习。用以前描述的 GFP-NtADF1 和 GFP-LlADF1,并且新肌动朊记者蛋白质 NtPLIM2b-GFP,我们重申占优势的肌动朊在伸长组织烟草和百合花粉试管,这长,沿着花粉试管胫的流的肌动朊电报,和包括更短的肌动朊电报的接近顶点的结构。肌动朊微细丝的接近顶点的收集经历动态变化,产生从 basket-shaped,的结构的外观或塑造漏斗,对一枚微妙的戒指像网孔。NtPLIM2b-GFP 为 Rho GTPases 与一个 guanine 核苷酸交换因素在联合被使用, AtROP-GEF1,说明这些肌动朊记者蛋白质的使用探索在极的细胞生长过程和它的肌动朊细胞骨架之间的连接。与肌动朊细胞骨架相反,微导管看起来不在在被子植物花粉试管支持极的房间生长过程起一个直接作用。从 Arabidopsis AtEB1 基于微导管结束绑定蛋白质使用微导管记者蛋白质, GFP-AtEB1,我们证明广泛的微导管在伸长联网改变动力学的度的花粉试管显示器。这些记者蛋白质提供万用的工具探索在极的花粉试管生长过程的主要结构、发信号的部件之间的功能的连接。 | Alice Y. Cheung Qiao-hong Duan Silvia Santos Costa Barend H.J. de Graaf Veronica S. DiStilio Jose Feijo Hen-Ming Wu | 2008 | Molecular Plant2008，1，4： | 10 |
| 11 | Cardiovascular dysfunction following spinal cord injury显示文摘Both sensorimotor and autonomic dysfunctions often occur after spinal cord injury(SCI). Particularly, a high thoracic or cervical SCI interrupts supraspinal vasomotor pathways and results in disordered hemodynamics due to deregulated sympathetic outflow. As a result of the reduced sympathetic activity, patients with SCI may experience hypotension, cardiac dysrhythmias, and hypothermia post-injury. In the chronic phase, changes within the CNS and blood vessels lead to orthostatic hypotension and life-threatening autonomic dysreflexia(AD). AD is characterized by an episodic, massive sympathetic discharge that causes severe hypertension associated with bradycardia. The syndrome is often triggered by unpleasant visceral or sensory stimuli below the injury level. Currently the only treatments are palliative – once a stimulus elicits AD, pharmacological vasodilators are administered to help reduce the spike in arterial blood pressure. However, a more effective means would be to mitigate AD development by attenuating contributing mechanisms, such as the reorganization of intraspinal circuits below the level of injury. A better understanding of the neuropathophysiology underlying cardiovascular dysfunction after SCI is essential to better develop novel therapeutic approaches to restore hemodynamic performance. | Elizabeth Partida Eugene Mironets Shaoping Hou Veronica J.Tom | 2016 | Neural Regeneration Research2016，11，2： | 10 |
| 12 | Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients显示文摘AIM:To investigate prevalence,type and time of onset of extraintestinal manifestations(EIMs)in a series of Italian inflammatory bowel disease(IBD)patients.METHODS:Data of 811 IBD consecutive patients,first referred to our Centre from 2000 to 2011,were retrospectively evaluated.RESULTS:Eight hundred and eleven IBD patients(437M,374 F)were studied:595 ulcerative colitis(UC)(73.4%)and 216 Crohn’s disease(CD)(26.6%).Among these,329(40.6%)showed EIMs:210 UC(35.3%)and119 CD(55.1%)(P<0.0001).Considering the time of the diagnosis of IBD,37 EIMs(11.2%)were developed before,229(69.6%)after and 63(19.2%)were simultaneous.The type of EIM were as follows:240 musculoskeletal(29.6%),in 72 CD patients and in 168 UC(P<0.0001);47 mucocutaneous(5.8%),in 26 CD and in21 UC(P=0.0049);26 ocular(3.2%),in 16 CD and in10 UC(CD 7.4%vs UC 1.7%,P=0.0093);6 hepatobiliary(0.8%);10 endocrinological(1.2%).In particular,with regards to the involvement of the musculoskeletal system,arthritis Type 1 was found in 41 CD(19%)and in 61 UC(10.2%)(P=0.0012)and Type 2 in 25 CD(11.6%)and in 100 UC(16.8%)(P=0.0012).CONCLUSION:Mucocutaneous manifestations,arthritis Type 1 and uveitis were significantly more frequent in CD than UC.The complications of the musculoskeletal system were the mostly observed ones,often with symptoms more severe than intestinal ones,confirming the need for close cooperation with rheumatologists. | Maddalena Zippi Claudia Corrado Roberta Pica Eleonora Veronica Avallone Claudio Cassieri Daniela De Nitto Paolo Paoluzi Piero Vernia | 2014 | World Journal of Gastroenterology2014，20，46： | 10 |
| 13 | Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease显示文摘Hepatitis B virus(HBV) infection is a dynamic state ofinteractions among HBV, hepatocytes, and the host immune system. Natural history studies of chronic hepatitis B(CHB) infection have shown an association between active viral replication and adverse clinical outcomes such as cirrhosis and hepatocellular carcinoma. The goal of therapy for CHB is to improve quality of life and survival by preventing progression of the disease to cirrhosis, decompensation, end-stage liver disease, hepatocellular carcinoma(HCC) and death. This goal can be achieved if HBV replication is suppressed in a sustained manner. The accompanying reduction in histological activity of CHB lessens the risk of cirrhosis and of HCC, particularly in non-cirrhotic patients. However, CHB infection cannot be completely eradicated, due to the persistence of covalently closed circular DNA in the nucleus of infected hepatocytes, which may explain HBV reactivation. Moreover, the integration of the HBV genome into the host genome may favour oncogenesis, development of HCC and may also contribute to HBV reactivation. | Francesco Paolo Russo Kryssia Rodríguez-Castro Laura Scribano Giorgia Gottardo Veronica Vanin Fabio Farinati | 2015 | World Journal of Hepatology2015，7，8： | 10 |
| 14 | Schwann cell development,maturation and regeneration:a focus on classic and emerging intracellular signaling pathways显示文摘The development,maturation and regeneration of Schwann cells(SCs),the main glial cells of the peripheral nervous system,require the coordinate and complementary interaction among several factors,signals and intracellular pathways.These regulatory molecules consist of integrins,neuregulins,growth factors,hormones,neurotransmitters,as well as entire intracellular pathways including protein-kinase A,C,Akt,Erk/MAPK,Hippo,mTOR,etc.For instance,Hippo pathway is overall involved in proliferation,apoptosis,regeneration and organ size control,being crucial in cancer proliferation process.In SCs,Hippo is linked to merlin and YAP/TAZ signaling and it seems to respond to mechanic/physical challenges.Recently,among factors regulating SCs,also the signaling intermediates Src tyrosine kinase and focal adhesion kinase(FAK)proved relevant for SC fate,participating in the regulation of adhesion,motility,migration and in vitro myelination.In SCs,the factors Src and FAK are regulated by the neuroactive steroid allopregnanolone,thus corroborating the importance of this steroid in the control of SC maturation.In this review,we illustrate some old and novel signaling pathways modulating SC biology and functions during the different developmental,mature and regenerative | Luca Franco Castelnovo Veronica Bonalume Simona Melfi Marinella Ballabio Deborah Colleoni Valerio Magnaghi | 2017 | Neural Regeneration Research2017，12，7： | 9 |
| 15 | 急诊医学专业住院医师培训课程的标准化探讨显示文摘目前,国内绝大多数医院设有急诊科(室),但其运行和管理模式千差万别,急诊医师也缺乏专业训练,这一现状加剧了急诊工作环境的恶化,制约了急诊医疗质量的提高。急诊住院医师培训课程的标准化则是住院医师培训质量和急诊医疗质量的有力保证。本研究的目的是在急诊住院医师培训年限、核心课程、相关制度等方面对急诊住院医师培训课程标准化进行初步探讨。 | 徐腾达 Veronica Pei 于学忠 Jeffery Smith 马遂 王仲 | 2006 | 中华急诊医学杂志2006，15，12： | 6 |
| 16 | Interactions between Axillary Branches of Arabidopsis显示文摘顶端的优势的研究在豌豆和豆子,射击系统在被整修回到叶子极大地得益于二分支的试金仅仅二活跃 cotyledonary 腋的分支。在这些二分支的射击,证据的大身体证明一个活跃地成长的分支能禁止其它的生长,推动禁止的信号的性质上的研究,它仍然糟糕被理解。这里,我们在 Arabidopsis 描述二分支的试金的建立,用跑的茎上的连续分支。就象在豌豆和豆子的古典研究,这些连续分支能禁止对方的生长。上面的分支能不仅禁止更低的分支,而且更低的分支能禁止上面的分支,说明禁止的信号的双向行动。用异种,当抑制清楚地越过stem from 被播送时,我们证明抑制部分依赖于 MAX 小径和那对禁止的分支活跃,二个分支的脉管的连接是弱的,并且 MAX 小径能够在茎单方地行动。 | Veronica Ongaro Katherine Bainbridge Lisa Williamson Ottoline Leyser | 2008 | Molecular Plant2008，1，2： | 6 |
| 17 | Acute arterial mesenteric ischemia and reperfusion:Macroscopic and MRI findings, preliminary report显示文摘AIM:To explore the physiopathology and magnetic resonance imaging(MRI)findings in an animal model of acute arterial mesenteric ischemia(AAMI)with and without reperfusion.METHODS:In this study,8 adult Sprague-Dawley rats underwent superior mesenteric artery(SMA)ligation and were then randomly divided in two groups of 4.In groupⅠ,the ischemia was maintained for 8 h.In groupⅡ,1-h after SMA occlusion,the ligation was removed by cutting the thread fixed on the back of the animal,and reperfusion was monitored for 8 h.MRI was performed using a 7-T system.RESULTS:We found that,in the case of AAMI without reperfusion,spastic reflex ileus,hypotonic reflex ileus,free abdominal fluid and bowel wall thinning are present from the second hour,and bowel wall hyperintensity in T2-W sequences are present from the fourth hour.The reperfusion model shows the presence of early bowel wall hyperintensity in T2-W sequences after 1 h and bowel wall thickening from the second hour.CONCLUSION:Our study has shown that MRI can assess pathological changes that occur in the small bowel and distinguish between the presence and absence of reperfusion after induced acute arterial ischemia. | Luca Saba Daniela Berritto Francesca Iacobellis Mariano Scaglione Sigismondo Castaldo Santolo Cozzolino Maria Antonietta Mazzei Veronica Di Mizio Roberto Grassi | 2013 | World Journal of Gastroenterology2013，19，40： | 5 |
| 18 | Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis显示文摘 | Erica Villa Calogero Cammà Marco Marietta Monica Luongo Rosina Critelli Stefano Colopi Cristina Tata Ramona Zecchini Stefano Gitto Salvatore Petta Barbara Lei Veronica Bernabucci Ranka Vukotic Nicola De Maria Filippo Schepis Aimilia Karampatou Cristian Ca | 2012 | Gastroenterology2012，，5： | 5 |
| 19 | Does Helicobacter pylori infection eradication modify peptic ulcer prevalence? A 10 years' endoscopical survey显示文摘瞄准:为了在病人比较消化性溃疡流行,在根除治疗的进步散开以后在 pre-Helicobacter 时代和十年在二所意大利的医院里为上面的胃肠的内视镜检查法参考了。方法:我们检查了连续地在 1992 和 2002 期间在 1986-1987 和 1995-1996 期间在 Padova 的肠胃病学单位,并且在 Parma 的肠胃病学单位执行的所有内视镜的考试。迟平方测试被用于统计分析。结果:从两个的数据内视镜的中心在溃疡的流行显示出统计上重要的减少:从 12.7% ~ 6.3%(P<0.001 ) 在 Padova 并且从 15.6% ~ 12%(P<0.001 ) 在 Parma。减少两个都是重要的为十二指肠(从 8.8% ~ 4.8% , P<0.001 ) 并且胃溃疡(3.9% ~ 1.5% , P<0.001 ) 在 Padova,并且仅仅为在 Parma 的十二指肠溃疡(9.2% ~ 6.1% , P<0.001;胃溃疡:6.3% ~ 5.8% , NS ) 。结论:在征兆的病人的根除在消化性溃疡流行导致了重要减小的广泛的 Helicobacter pylori (H pylori ) 的十年。这减小在 Padova 是特别地明显的,在为在一般 practioners 之中的 H pylori 根除的致敏的一个工程在 1990 和 1992 之间被执行的地方。假如我们的假设应该是真的, H pylori 根除可能在未来导致是的消化性溃疡一稀罕内视镜的发现。 | Giorgio Nervi Stefania Liatopoulou Lucas Giovanni Cavallaro Alessandro Gnocchi Nadia Dal Bò Massimo Rugge Veronica Iori Giulia Martina Cavestro Marta Maino Giancarlo Colla Angelo Franzè Francesco Di Mario | 2006 | World Journal of Gastroenterology2006，12，15： | 5 |
| 20 | Debris flow hazard assessment by means of numerical simulations:implications for the Rotolon creek valley(Northern Italy)显示文摘On 4^(th) November 2010, a debris flow detached from a large debris cover accumulated above the lowermost portion of the Rotolon landslide(Vicentine Pre-Alps, NE Italy) and channelized in the valley below within the Rotolon Creek riverbed. Such event evolved into a highly mobile and sudden debris flow, damaging some hydraulic works and putting at high risk four villages located along the creek banks. A monitoring campaign was carried out by means of a ground based radar interferometer(GB-In SAR) to evaluate any residual displacement risk in the affected area and in the undisturbed neighbouring materials.Moreover, starting from the current slope condition, a landslide runout numerical modelling was performed by means of DAN-3D code to assess the impacted areas, flow velocity, and deposit distribution of the simulated events. The rheological parameters necessary for an accurate modelling were obtained through the back analysis of the 2010 debris flow event. Back analysis was calibrated with all of the available terrain data coming from field surveys and ancillary documents, such as topographic,geomorphological and geological maps, with pre-and post-event Li DAR derived DTMs, and with orthophotos. Finally, to identify new possible future debris flow source areas as input data for the new modelling, all the obtained terrain data were reanalysed and integrated with the GB-In SAR displacement maps; consequently, new simulations were made to forecast future events. The results show that the integration of the selected modelling technique with ancillary data and radar displacement maps can be a very useful tool for managing problems related to debris flow events in the examined area. | SALVATICI Teresa MORELLI Stefano PAZZI Veronica FRODELLA William FANTI Riccardo | 2017 | Journal of Mountain Science2017，14，4： | 5 |
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