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| 1 | Portal vein thrombosis in cirrhosis: Controversies and latest developments显示文摘Portal vein thrombosis(PVT) is encountered in livercirrhosis, particularly in advanced disease. It has been a feared complication of cirrhosis, attributed to significant worsening of liver disease, poorer clinical outcomes and potential inoperability at liver transplantation; also catastrophic events such as acute intestinal ischaemia. Optimal management of PVT has not yet been addressed in any consensus publication.We review current literature on PVT in cirrhosis; its prevalence, pathophysiology, diagnosis, impact on the natural history of cirrhosis and liver transplantation,and management. Studies were identified by a search strategy using MEDLINE and Google Scholar. The incidence of PVT increases with increasing severity of liver disease: less than 1% in well-compensated cirrhosis, 7.4%-16% in advanced cirrhosis. Prevalence in patients undergoing liver transplantation is 5%-16%.PVT frequently regresses instead of uniform thrombus progression. PVT is not associated with increased risk of mortality. Optimal management has not been addressed in any consensus publication. We propose areas for future research to address unresolved clinical questions. | Damian J Harding M Thamara PR Perera Frederick Chen Simon Olliff Dhiraj Tripathi | 2015 | World Journal of Gastroenterology2015，21，22： | 42 |
| 2 | 白内障药物治疗的研究现状显示文摘白内障的药物治疗仍然面临着严峻的挑战。尽管近 40多种抗白内障药物被广泛的临床使用 ,但证明其有效性的直接证据甚少。醛糖还原酶抑制剂 (ARIs)的副作用严重 ,药物机制“名不符实” ;阿司匹林类药物廉价方便 ,副作用少 ,有望达到预期的效果 ;维生素类抗氧化剂的预防和治疗白内障的作用有限 ,临床资料缺乏可比性 ;糖基化抑制剂 ,谷胱甘肽和药物前体 ,相分离抑制剂和Calpain抑制剂等的研究有较大的进展 ,需要临床研究的进一步验证。可能有效的药物治疗白内障的手段仍将是联合用药的方法。 | 严宏 李明勇 Harding JJ | 2002 | 国外医学(眼科学分册)2002，26，3： | 10 |
| 3 | Characterization of Gibberellin Receptor Mutants of Barley (Hordeum vulgare L.)显示文摘Gid1 的顺序(为赤霉素(GA ) 的基因从米饭的受体) 被用来从大麦识别通常认为的 orthologue。这在 E 被表示。coli,并且生产了能与结构的特性和 saturability 在 vitro 绑 GA 的蛋白质。它在 GA 回答的潜在的角色与减少的 GA 敏感(gse1 异种) 用大麦异种被调查。十六不同 gse1 异种各在这个序列带了唯一的核苷酸替换。在里面几乎一个案例,这些变化导致了单个氨基酸替换,并且,为留下的异种,在 mRNA 的 5 untranslated 区域的替换被建议防碍翻译开始。在分离有完美的连接在新变异的等位基因和 gse1 显型之间的人口,导致在大麦的通常认为的 GID1 GA 受体顺序对应于 Gse1 地点的结论。在异种之一的内长的 GA 内容的决心揭示了 C20 GA 先锋的 bioactive GA1,和赤字的提高的累积。所有在通常正在浸透的集中 gse1 异种把敏感归结为外长的 GA3,并且到 AC94377 (GA 类似物) ,,但是,在高得多的集中,经常有可观的回答。在大麦和米饭异种之间的比较揭示这之间的有趣的差别在 GA 的二谷物种神经质的生理学。 | Peter M. Chandler Carol A. Harding Anthony R. Ashton Mark D. Mulcair Nicholas E. Dixonb Lewis N. Manderb | 2008 | Molecular Plant2008，1，2： | 10 |
| 4 | Modeling Delay and Packet Drop in Networked Control Systems Using Network Simulator NS2显示文摘Wireless Networked Control Systems (WNCS) are used to implement a control mechanism over a wireless network that is capable of carrying real-time traffic. This field has drawn enormous attention from current researchers because of its flexibility and robustness. However, designing efficient WNCS over Mobile Ad Hoc Networks (MANET) is still a challenging topic because of its less-predictable aspects, such as inconsistent delay, packet drop probability, and dynamic topology. This paper presents design guidelines for WNCS over MANET using the Network Simulator version 2, NS2 software. It investigates the impact of packet delay and packet drop under the AODV and DSR routing protocols. The simulation results have been compared to MATLAB results for validation. | Mohammad Shahidul Hasan Christopher Harding Alison Griffiths | 2005 | International Journal of Automation and computing2005，2，2： | 9 |
| 5 | Significance of Shale Gas Development显示文摘Natural gas production from shale formations is growing exponentially in the United States. This paper introduces the five major shale formations in the United States and the technologies used to produce them. The Barnett, Haynesville, Fayetteville, Woodford, and Marcellus combined hold an estimated 978 trillion cubic feet of total gas reserves. These findings along with recent technological advances in horizontal drilling and completion methods have transformed the natural gas exploration and production industry in the U.S. and have fundamentally changed the U.S. energy picture. Specifically this paper states that the United States through the utilization of natural gas from shale can reduce its carbon emissions and can become more energy self-sufficient. Finally, the Harding & Shelton Group states in this paper that the opportunity to locate and produce shale gas in China is very similar to that which has taken place in the United States. | John Shelton Mike D. Burnaman Wenwu Xia Nathaniel Harding | 2009 | 中国石油勘探2009，14，3： | 9 |
| 6 | Late Cretaceous biota and the Cretaceous-Paleogene(K--Pg)Boundary in Jiayin of Heilongjiang,China显示文摘An international cooperative study of the Late Cretaceous biota and non-marine strata including the Cretaceous-Paleogene(K--Pg) boundary in Jiayin near the Heilongjiang River,China during 2002-2010,is summarized in this paper. The strata includes the Upper Cretaceous Yong'ancun-,Taipinglinchang-,Yuliang-zi-,and Furao formations,and the Paleocence Wuyun Formation consisting of Baoshantou Member and a Coalbearing Member. Seven palynological assemblages from Santonian to Paleocene are recognized,which is used for definition of the K--Pg boundary. Through the palynological analysis of three drilled boreholes (XHY-2005,2006,2008) in Xiaoheyan of western Jiayin,the K--Pg boundary is defined within 20. 00-20. 05 m in the borehole XHY-2006 (as a standard boundary) which is just between the top of Furao Formation (late Maasterichtian) and the base of Baishantou Member (early Danian) . These new research results are supported by paleo- magnetic,geochemical and other analyses,also. On the other hand,the presence of eight taxa of Maasterichtian dinosaurs (mostly hadrosaurids) have been recognized by the authors; and two mega-plant assemblages from the Yong'ancun Fm (Santonian) to Taipinglinchang Fm (Campanian) are confirmed. These research a-chievements indicate that the Upper Cretaceous-Paleocene in Jiayin can be well correlated to the strata in the neighboring Zeya-Bureja basin,Russia. The K--Pg boundary definited in Jiayin is the first well documented non-marine K--Pg boundary in China. Also the related paleoclimate,paleoenvironment and the mass extinctions in this area during the Cretaceous-Paleocene transition are also discussed. | Sun G. Akhmetiev M. Markevich V. Ashraf A. R. Bugdaeva E. Godefroit P. Bolotsky Yu. Dong Z. M. Golovneva L. Yang H. X. Sun C. L. Sun Y. W. Quan C. Kodrul T. Kezina T. Johnson K. Nishida H Dilcher D. L. Harding I. Chen Y. J. | 2011 | Global Geology2011，14，3： | 9 |
| 7 | Analysis of the carbon source for diamond crystal growth显示文摘The lattice constants of diamond and graphite at high pressure and high temperature (HPHT) were calculated on the basis of linear expansion coefficient and elastic constant. According to the empirical electron theory of solids and molecules (EET), the valence electron structures (VESs) of diamond, graphite crystal and their common planes were calculated. The relationship between diamond and graphite structure was analyzed based on the boundary condition of the improved Thomas-Fermi-Dirac theory by Cheng (TFDC). It was found that the electron densities of common planes in graphite were not continuous with those of planes in diamond at the first order of approximation. The results show that during the course of diamond single crystal growth at HPHT with metal catalyst, the carbon sources forming diamond structure do not come from the graphite structure directly. The diamond growth mechanism was discussed from the viewpoint of valence electron structure. | LI Li1,2, XU Bin2,3 & LI MuSen1,2 1 School of Materials Science & Engineering, Shandong University, Jinan 250061, China 2 Shandong Engineering Research Center for Super Hard Materials, Zoucheng 273500, China 3 School of Materials Science & Engineering, Shandong Jianzhu University, Jinan 250101, China | 2008 | Chinese Science Bulletin2008，53，6： | 6 |
| 8 | Evaluating the Ryman-Laikre effect for marine stock enhancement and aquaculture显示文摘 | Robin S. WAPLES Kjetil HINDAR Sten KARLSSON Jeffrey J. HARD | 2016 | Current Zoology2016，62，6： | 5 |
| 9 | β→α Transformation of γ-Phase in Sintered WC-Co Cemented Carbides显示文摘Varying the morphology and the structure of γ-phase (Co-base Co-W-C solid solution) by means of altering the cooling rate and the preparing method of liquid sintered WC-Co cemented carbides samples, the mechanism of fcc→hcp transformation of γ-phase in WC-Co alloy has been explored. The results show that, the cooling rate is an important affecting factor on fcc→hcp transformation of γ-phase and the fcc→hcp transformation is mainly a diffusive type when cooling WC-Co samples above room | Shourong LIU (Tianjin Institute of Hard Alloy Tianjin 300222, China)Yi LIU (Shandong University Jinan 250100, China) | 1996 | Journal of Materials Science & Technology1996，12，5： | 4 |
| 10 | Effects of luteinizing hormone and androgen on the development of rat progenitor Leydig cells in vitro and in vivo显示文摘祖先 Leydig 房间从干细胞被导出。祖先 Leydig 房间的增长和区别显著地在发身期间贡献 Leydig 房间数字。然而,这些过程的规定仍然保持不清楚。现在的学习的目的是决定 luteinizing 荷尔蒙(LH ) 或雄激素是否贡献祖先 Leydig 房间的增长和区别。Fourteen-day-old 男 Sprague-Dawley 老鼠与 NalGlu 被对待 7 天,它是一个释放 gonadotropin 荷尔蒙对手,到在垂体并且这样减少 LH 的分泌物,在睾丸的雄激素。老鼠与 LH 或 7 α 被共同管理; -methyl-nortestosterone (MENT ) 是对由 5 α 的新陈代谢抵抗的雄激素, -reductase 1 在祖先 Leydig 房间,和 LH 或雄激素的随后的效果被测量。3 H-Thymidine 静脉内地也被注入老鼠在祖先 Leydig 房间学习 thymidine 加入。祖先 Leydig 房间被检验。NalGlu 管理由 83 % 减少了祖先 Leydig 房间增长;。另外, LH 或 MENT 处理恢复了 Leydig 房间 proliferative 能力到 73 %或 50 %控制,分别地。增长相关的基因的送信人 RNA 层次用即时 PCR 被测量。Igf1, Lifr, Pdgfra, Bcl2, Ccnd3 和 Pcna 的表示层次是由 MENT 的 upregulated,并且 Pdgfra, Ccnd3 和 Pcna 的那些是由 LH 的 upregulated。LH 和 MENT 在 vitro 刺激了祖先 Leydig 房间的区别。我们断定 LH 和 MENT 涉及调整祖先 Leydig 房间的发展。 | Jing-Jing Guo Xue Ma Claire Q F Wang Yu-Fei Ge Qing-Quan Lian Dianne O Hard Yu-Fei Zhang Qiang Dong Yun-Fei Xu Ren-Shan Ge | 2013 | Asian Journal of Andrology2013，15，5： | 4 |
| 11 | 猪圆环病毒病的其它预防方法显示文摘1前言
断奶后多系统衰竭综合征(post-weaning multisystemic wasting syndrome,PMWS)自1995年在加拿大西部地区被发现并确定了特征性症状后.其重要性已逐渐被人们所认识,而传播范围也与日俱增,该病已经成为一个严重影响全球养猪业的疾病。最近,由于在加拿大东部地区.尤其是自2004年后期开始加拿大魁北克省爆炸性地发病以来,该病受到的关注高度显著提高。 | John harding 李胜兴(译) 丁博文(校) | 2007 | 国外畜牧学(猪与禽)2007，，2： | 4 |
| 12 | Identification of the preferentially targeted proteins by carbamylation during whole lens incubation by using radio-labelled potassium cyanate and mass spectrometry显示文摘AIM:To attempt to identify the primary targets of carbamylation in bovine lenses incubated under physiological condition. METHODS:Fresh intact bovine lenses were incubated with [14C]-labelled potassium cyanate for seven days.The water-soluble proteins(WSP)of both cortex and nucleus lens were isolated by size-exclusion chromatography on a Sephacryl S-300HR column.The higher radioactive fractions were pooled and freeze-dried,and separated further by loading on an Affi Blue column to separate some enzymes.In addition,WSP from cortex was separated directly by affinity chromatography.The most reactive fractions with higher radioactivity from[14C]-cyanate were further analysed by SDS-gels and mass spectrometry. RESULTS:The majority of protein incorporating[14C]-labelled potassium cyanate was in the water-soluble fractions,and much more in cortex than in nucleus.Chromatography results demonstrated that the major incorporated[14C]-carbamylated crystallins were fractions corresponding toα-crystallin,β-crystallin andξ-crystallin in cortex,butβ-crystallin andγ-crystallin in nucleus.The SDS gels showed that bound fractions of cortex crystallins after Affi-Gel Blue separation were abundant 20 and 35kDa proteins.However,the bound fractions of nucleus crystallins mainly showed 20kDa proteins. Mass spectrometry analysis of these higher radioactivity fractions and a database search revealed that the proteins originated from bovineα-crystallin A and B chains andξ-crystallin in cortex;βA1 andαB-crystallins with a littleγB-crystallin in nucleus respectively.Further analysis suggested the location of this carbamylation ofαB-crystallin in nucleus to be at Lys 92 and 103. CONCLUSION:α-andξ-crystallin from cortex can be preferentially targeted by carbamylation during whole lens incubations.Carbamylation of these crystallins at the earlier stage may lead to further unfolding and misfolding of lens proteins,leading to aggregation of crystallins and eventually to cataract formation. | John J Harding | 2010 | International Journal of Ophthalmology(English edition)2010，3，2： | 3 |
| 13 | Dephosphorylation of Translation Initiation Factor 2α Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice显示文摘 | Seiichi Oyadomari Heather P. Harding Yuhong Zhang Miho Oyadomari David Ron | 2008 | Cell Metabolism2008，，6： | 2 |
| 14 | The hypoglycaemic effect of pumpkins as anti-diabetic and functional medicines显示文摘 | Gary G. Adams Shahwar Imran Sheng Wang Abubaker Mohammad Samil Kok David A. Gray Guy A. Channell Gordon A. Morris Stephen E. Harding | 2011 | Food Research International2011，，4： | 2 |
| 15 | Oxygen desaturation during sleep in hepatopulmonary syndrome显示文摘 | David T. Palma George M. Philips Miguel R. Arguedas Susan M. Harding Michael B. Fallon | 2008 | Hepatology2008，，4： | 2 |
| 16 | A comparison of two business cycle dating methods显示文摘 | Don Harding Adrian Pagan | 2002 | Journal of Economic Dynamics and Control2002，，9： | 2 |
| 17 | Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial显示文摘 | Usha Chakravarthy Simon P Harding Chris A Rogers Susan M Downes Andrew J Lotery Lucy A Culliford Barnaby C Reeves | 2013 | The Lancet2013，，： | 2 |
| 18 | Ranibizumab versus Bevacizumab to Treat Neovascular Age-related Macular Degeneration显示文摘 | Usha Chakravarthy Simon P. Harding Chris A. Rogers Susan M. Downes Andrew J. Lotery Sarah Wordsworth Barnaby C. Reeves | 2012 | Ophthalmology2012，，7： | 2 |
| 19 | 有重叠的自相似集的Hausdorff维数显示文摘对于一类满足一定条件的相似压缩迭代函数系生成的不变集,本文证明了一个计算其Hausdorff维数的简单公式.该公式是通过把满足所给条件的迭代函数系联系到一个非重叠的无穷迭代函数系,然后利用Moran的计算无穷迭代函数系生成的不变集的Hausdorff维数的方法得到的.该方法可以应用于一些不满足Ngai和Wang引进的有限型条件的迭代函数系. | 邓起荣 John HARDING 胡天佑 | 2008 | 中国科学(A辑)2008，38，6： | 2 |
| 20 | Spectroelctrochemical study of the role played by carbon functionality in fuel cell electrodes显示文摘 | ROY S C HARDING A W RUSSELL A E | 1997 | J Electrochem Soc1997，144，7： | 2 |
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