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| 1 | Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies显示文摘Immune checkpoint blockade therapies(ICBs)are a prominent breakthrough in cancer immunotherapy in recent years(named the 2013“Breakthrough of the Year”by the Science magazine).Thus far,FDA-approved ICBs primarily target immune checkpoints CTLA-4,PD-1,and PD-L1.Notwithstanding their impressive long-term therapeutic benefits,their efficacy is limited to a small subset of cancer patients.In addition,ICBs induce inadvertent immune-related adverse events(irAEs)and can be costly for long-term use.To overcome these limitations,two strategies are actively being pursued:identification of predictive biomarkers for clinical response to ICBs and multi-pronged combination therapies.Biomarkers will allow clinicians to practice a precision medicine approach in ICBs(biomarker-based patient selection)such as treating triple-negative breast cancer patients that exhibit PD-L1 staining of tumor-infiltrating immune cells in1%of the tumor area with nanoparticle albumin-bound(nab)epaclitaxel plus anti-PD-L1 and treating patients of MSI-H or MMR deficient unresectable or metastatic solid tumors with pembrolizumab(anti-PD-1).Importantly,the insights gained from these biomarker studies can guide rational combinatorial strategies such as CDK4/6 inhibitor/fractionated radiotherapy/HDACi in conjunction with ICBs to maximize therapeutic benefits.Further,with the rapid technological advents(e.g.,ATCT-Seq),we predict more reliable biomarkers will be identified,which in turn will inspire more promising combination therapies. | Hongxing Shen Eddy Shih-Hsin Yang Marty Conry John Fiveash Carlo Contreras James A.Bonner Lewis Zhichang Shi | 2019 | Genes & Diseases2019，6，3： | 5 |
| 2 | Initial treatment of efficacy and toxicity显示文摘 | RADBILL A E FIVEASH J F FALKENBERG E T | 2004 | Cancer2004，，4： | 1 |
| 3 | Imaging glioma extent with ^131I-TM-601显示文摘 | Hockaday DC Shen S Fiveash J | 2005 | Nucl Med2005，46，4： | 1 |
| 4 | Preoperative ra- diation therapy with selective dose escalation to the mar-gin at risk for retroperitoneal sarcoma显示文摘 | Tzeng CW Fiveash JB Popple RA | 2006 | Cancer2006，107，2： | 1 |
| 5 | Role of radiation therapy and radiosurgery in gliobastoma multiforme显示文摘 | Fiveash JB Spencer SA | 2003 | Med Dosim2003，28，4： | 1 |
| 6 | Imaging glioma extent with ^131I-TM-601 显示文摘 | Hockaday D C Shen S Fiveash J | 2005 | J Nucl Med2005，46，4： | 1 |
| 7 | Multimodality treatment of Merkel cell carcinoma: Case series and literature re- view of 1024 cases 显示文摘 | Medina-Franco H Urist MM Fiveash J | 2001 | Ann Surg Oncol2001，8，3： | 1 |
| 8 | Dosimetric and radiobiological impact of dose fractionation on respiratory motion induced IMRT delivery errors:a volumetric dose measurement study显示文摘 | Shen S Fiveash JB | 2006 | Med Phys2006，33，5： | 1 |
| 9 | role of radiation therapy and radiosurgery in glioblastoma mulfiforme显示文摘 | Fiveash JB Spencer SA | 2003 | Cancer J2003，9，3： | 1 |
| 10 | Treatment of adults with recurrent malignant gliomas显示文摘 | Nabors LB Fiveash J | 2005 | Expert Rev Neurother2005，5，4： | 1 |
| 11 | Effect of Tumor Subtype on Survival and the Graded Prognostic Assessment for Patients With Breast Cancer and Brain Metastases显示文摘 | Paul W. Sperduto Norbert Kased David Roberge Zhiyuan Xu Ryan Shanley Xianghua Luo Penny K. Sneed Samuel T. Chao Robert J. Weil John Suh Amit Bhatt Ashley W. Jensen Paul D. Brown Helen A. Shih John Kirkpatrick Laurie E. Gaspar John B. Fiveash Veronica Chia | 2012 | International Journal of Radiation Oncology Biology Physics2012，，5： | 1 |
| 12 | Stereotactic body radiationtherapy for liver metastases and primary hepatocellular carcinoma :normal tissue tolerances and toxicity 显示文摘 | Sawrie SM Fiveash JB Caudell JJ | 2010 | Journal of the MoffittCancer2010，2，： | 1 |
| 13 | Preoperative radiation therapy with selective dose escalation to the margin at risk for retroperitoneal sarcoma显示文摘 | Tzeng CW Fiveash JB Popple RA | 2006 | Cancer2006，107，2： | 1 |
| 14 | Spencer,Role of radiation therapy and radiosurgery in glioblastoma multiforme显示文摘 | Fiveash JB Spencer SA | | 0，，3： | 1 |
| 15 | Gene expression analysis in radiotherapy patients and C57BL/6 mice as a measure of exposure to ionizing radiation显示文摘 | Filiano AN Fathallah-Shaykh HM Fiveash J | 2011 | Kadiat Res2011，176，1： | 1 |
| 16 | Preoperative radiation therapy with selective dose escalation to margin at risk for retroperitoneal sarcoma显示文摘 | Tzeng CW Fiveash JB Popple RA | | 0，，02： | 1 |
| 17 | Preoperative ra- diation therapy with selective dose escalation to the mar- gin at risk for retroperitoneal sarcoma显示文摘 | Tzeng CW Fiveash JB Popple RA | 2006 | Cancer2006，107，2： | 1 |
| 18 | Dosimetric effect of respiration gated beam on IMRT delivcry显示文摘 | Duan J Shen S Fiveash J B | 2003 | Med Phys2003，30，8： | 1 |
| 19 | Radionecrosis of the inferior occipital lobes with altitudinal visual field loss after gamma knife radiosurgery显示文摘 | Monheit BE Fiveash JB Girkin CA | 2004 | J Neuro - Ophthalmol2004，24，3： | 1 |
| 20 | Enhancement of glioma radiotherapy and chemotherapy response with targeted antibody therapy against death receptor5显示文摘 | Fiveash IB Gillespie GY Oliver PG et a1 | 2008 | Int 1 Radiat Oncol Bioi Phys2008，71，2： | 1 |
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