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| 1 | Colorectal cancer surveillance in inflammatory bowel disease: The search continues显示文摘Patients with infl ammatory bowel disease (IBD) are at increased risk for colorectal cancer (CRC). Risk factors for the development of CRC in the setting of IBD include disease duration, anatomic extent of disease, age at time of diagnosis, severity of inflammation, family history of colon cancer, and concomitant primary sclerosing cholangitis. The current surveillance strategy of surveillance colonoscopy with multiple random biopsies most likely reduces morbidity and mortality associated with IBD-related CRC. Unfortunately, surveillance colonoscopy also has severe limitations including high cost, sampling error at time of biopsy, and interobserver disagreement in histologically grading dysplasia. Furthermore, once dysplasia is detected there is disagreement about its management. Advances in endoscopic imaging techniques are already underway, and may potentially aid in dysplasia detection and improve overall surveillance outcomes. Management of dysplasia depends predominantly on the degree and focality of dysplasia, with the mainstay of management involving either proctocolectomy or continued colonoscopic surveillance. Lastly, continued research into additional chemopreventive agents may increase our arsenal in attempting to reduce the incidence of IBD-associated CRC. | Anis Ahmadi Steven Polyak Peter V Draganov | 2009 | World Journal of Gastroenterology2009，15，1： | 7 |
| 2 | The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells显示文摘 | Sendurai A. Mani Wenjun Guo Mai-Jing Liao Elinor Ng. Eaton Ayyakkannu Ayyanan Alicia Y. Zhou Mary Brooks Ferenc Reinhard Cheng Cheng Zhang Michail Shipitsin Lauren L. Campbell Kornelia Polyak Cathrin Brisken Jing Yang Robert A. Weinberg | 2008 | Cell2008，，4： | 7 |
| 3 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 4 | Inhibition of T-Cell Inflammatory Cytokines, Hepatocyte NF-κB Signaling, and HCV Infection by Standardized Silymarin显示文摘 | Stephen J. Polyak Chihiro Morishima Margaret C. Shuhart Chia C. Wang Yanze Liu David Y.–W. Lee | 2007 | Gastroenterology2007，，5： | 2 |
| 5 | Randomized, controlled trial of standard, large-capacity versus jumbo biopsy forceps for polypectomy of small, sessile, colorectal polyps显示文摘 | Peter V. Draganov Myron N. Chang Ahmad Alkhasawneh Lisa R. Dixon John Lieb Baharak Moshiree Steven Polyak Shahnaz Sultan Dennis Collins Amitabh Suman John F. Valentine Mihir S. Wagh Samir L. Habashi Chris E. Forsmark | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 6 | Inhibition of T-Cell Inflammatory Cytokines, Hepatocyte NF-κB Signaling, and HCV Infection by Standardized Silymarin显示文摘 | Stephen J. Polyak Chihiro Morishima Margaret C. Shuhart Chia C. Wang Yanze Liu David Y.–W. Lee | 2007 | Gastroenterology2007，，5： | 2 |
| 7 | Cloning of p27Kip1,a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals显示文摘 | Polyak K Lee MH Erdjument-Bromage H | 1994 | Cell1994，78，1： | 1 |
| 8 | Gene Discovery Using the Serial Analysis of Gene Expression Technique: Implications for Cancer Research 显示文摘 | POLYAK K RIGGINS G L | 2001 | J Clin Oncol2001，19，11： | 1 |
| 9 | p27Kip1,a cyclin-Cdk inhibitor,links transforming growth factor -beta and contact inhibition to cell cycle arrest显示文摘 | Polyak K Kato JY Solomon MJ | 1994 | Genes Dev1994，8，1： | 1 |
| 10 | Cellular heterogeneity and molecular evolution in cancer显示文摘 | Almendro V Marusyk A Polyak K | 2013 | Annu Rev Pathol2013，8，： | 1 |
| 11 | Microenvironmental regulation of cancer develop-ment 显示文摘 | Hu M Polyak K | 2008 | Curr Opin Genet Dev2008，18，1： | 1 |
| 12 | The method of projections for finding tile common point of convex sets 显示文摘 | GUBIN L G POLYAK B T RAIK E V | 1967 | Computational Mathematics and Mathematical Physics1967，7，6： | 1 |
| 13 | p27^kipl, a cyclin-cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest显示文摘 | Polyak K Kato J Y Solomon M J | 1994 | Genes Dev1994，8，： | 1 |
| 14 | Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins显示文摘 | Shi S T Polyak S J Tu H | 2002 | Virology2002，292，： | 1 |
| 15 | Abdominoperineal resection via total mesorectal excision and nerve preservation for low rectal cancer显示文摘 | Enker WE Havenga K Polyak T | 1997 | World J Surg1997，21，7： | 1 |
| 16 | CD20-mediated apoptosis: Signaling through lipid rafts显示文摘 | Deans JP Li H Polyak MJ | 2002 | Immunology2002，107，2： | 1 |
| 17 | Abdominoperineal resection via total mesorectal excision and autonomic nerve preservation for low rectal cancer显示文摘 | Enker WE Harenge K Polyak J | 1998 | W J Surg1998，21，7： | 1 |
| 18 | Contribution of myosin rod protein to the structural organization of adult and embryonic muscles in Drosophila显示文摘 | POLYAK E STANDIFORD D M YAKOPSON V | 2003 | J Mol Biol2003，331，5： | 1 |
| 19 | P27kipl, a cyclin-CDK into cell arrest显示文摘 | Polyak K Kato J Y Solomon M J | 1994 | Cenes Dev1994，8，： | 1 |
| 20 | Contribution of bone marrow-derived endothelial cells to human tumor vasculature显示文摘 | Peters BA Diaz LA Polyak K | 2005 | Nat Med2005，11，3： | 1 |
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