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| 1 | 亚太地区慢性乙型肝炎治疗共识(2012最新版)显示文摘自2008年至今,有大量关于慢性HBV感染的自然史和治疗的最新数据不断涌现。其中包括慢性HBV感染的无症状感染者,以社区为基础的队列研究,HBV基因型的作用,非药物诱导的自然HBV变异型毒株,无创性肝纤维化评估方法的应用,HBsAg定量在临床中的应用,更有效的新治疗药物和新治疗方案等等。来自亚太地区的专家审查和评估了相关数据,并共同商讨了近年来报道的最有意义的发现,基于此,对2008年版的亚太地区慢性乙型肝炎治疗共识进行修订,同时对2008年版治疗指南定义的关键词组进行了修订。修订后的指南包括以下几方面内容:一般治疗,肝纤维化评价适应证,何时开始治疗或停药,初始抗病毒治疗药物的选择,如何监测治疗中和治疗后的患者。关于特殊人群的治疗建议中包括了对妊娠妇女,已发生耐药,合并其他病毒感染,肝功能失代偿,接受免疫抑制治疗、化疗,肝移植或肝细胞癌患者的具体治疗建议。 | 廖运范 Jia-HorngKao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Wan-Long Chuang Laurentius A.Lesmana Jose D.Sollano Dong-Jin Suh Masao Omata 刘颖 徐莹 李芸 黄祖雄 樊蓉 李小溪 吕国涛 周彬 孙剑 侯金林 | 2012 | 临床肝胆病杂志2012，28，8： | 182 |
| 2 | 根据重力数据研究黄海周边断裂带在海区的延伸显示文摘根据黄海及周边地区的布格重力资料 ,通过解析延拓、目标场提取、任意水平方向导数计算、离散小波变换等处理 ,得到各种有关断裂的信息 .经过与地质资料综合分析 ,选择1 2 3°E经线为典型剖面 ,以地震资料建立初始模型 ,对该剖面进行重力正反演迭代拟合 ,最终得到各模块的密度参数及分布 ,并在此基础上分析了研究区主要断裂的地质地球物理特征 ,给出了研究区的断裂带、块体结合带分布图 .重点对朝鲜半岛西缘断裂带和五莲—青岛—荣城断裂带进行了讨论 ,提出五莲—青岛—荣城断裂带并未进入朝鲜半岛与临津江断裂带相连 .认为朝鲜半岛西缘断裂带西侧属于扬子块体的部分曾受北向应力作用向北发生了平移 .由五莲—青岛—荣城断裂带和南黄海北部断裂带。 | 郝天珧 SUH Mancheol 王谦身 CHOI Suckwon 江为为 宋海斌 阎晓蔚 刘建华 姚长利 | 2002 | 地球物理学报2002，45，3： | 77 |
| 3 | 黄海深部结构与中朝—扬子块体结合带在海区位置的地球物理研究显示文摘以黄海及其邻区为研究对象 ( 32~ 4 2°N ,1 2 0~ 1 30°E) ,以研究区的空间重力异常、布格重力异常和地震层析成像数据为基础 ,在研究区中分辨出方向各异的主要断裂带并给出它们的分布。对在朝鲜半岛存在的一条近SN向分布的断裂带进行了重点讨论。根据重力数据、莫霍深度分布特点和层析成像的结果 ,认为该断裂带的两侧应属于不同的构造地质单元 ;提出该断裂带与五莲—青岛断裂带和济州岛南缘断裂带一起组成了中朝与扬子块体在黄海海区的边界结合带的认识 ;并推测在三叠纪的晚期 ,沿郯庐断裂带和该断裂带曾分别发生过左旋和右旋走滑。受SN向挤压应力的作用 ,(下 )扬子块体被平移嵌入到中朝块体之中。因此 ,两个块体在海区的结合带为一个巨大的“Z” | 郝天珧 SUH Mancheol 刘建华 阎晓蔚 CHOI Suckwon 姚长利 刘少华 戴明刚 徐亚 | 2004 | 地学前缘2004，11，3： | 50 |
| 4 | 对黄海—东海研究区深部结构的一些新认识显示文摘综合地震层析成像与重磁数据的处理结果,选择26°N~36°N,120°E~130°E的范围作为研究区,讨论了黄、东海研究区的深部结构特点及其与周边各地质单元的相互关系,完成了研究区两条剖面的密度结构反演,认为东海陆架地区地壳厚度变化与大陆地区相比并不明显,显著减薄开始于冲绳海槽地区,中地壳消失;琉球岛弧处地壳厚度明显再度增加,特别是上地壳的厚度增加最大,推断其原因应与俯冲作用及俯冲带附近板块与地幔的运动速率之差有关.地球物理场“东西分带”是黄海—东海地区壳内结构从西向东变化的反映,但随着深度的增加,研究区的岩石层结构出现以近EW向为优势的构造格局.因此推断深部近EW向的异常是三叠纪时期南北板块碰撞、挤压所致,浅部的NE向条带异常是后期构造运动在岩石层较浅部位构造效应的反映.黄海—东海地区岩石层结构存在浅部与深部优势构造方向不协调的现象.层析成像结果证实了南黄海东缘断层的存在,还勾绘出绍兴—十万大山碰撞带为以40°左右的倾角向NW方向倾斜的高速带,另一条倾向基本相同的高速带则是南、北扬子块体结合带在深部的反映. | 郝天珧 徐亚 胥颐 Suh Mancheol 刘建华 戴明刚 李志伟 | 2006 | 地球物理学报2006，49，2： | 49 |
| 5 | 黄海及其邻区深部结构特点与地质演化显示文摘根据黄海及其周边地区的布格重力资料 ,通过多种方法处理 ,得到有关断裂的信息并求取了研究区的地壳厚度分布 .经过与地震层析成像结果、地质资料的对比和综合分析 ,认为朝鲜半岛西缘断裂带和济州岛南缘断裂带均为深大断裂 ,断裂带的两侧速度结构存在较大差异 .推断朝鲜半岛和南黄海分别属于不同的地质单元 .根据对岩石层结构的综合分析 ,认为中朝与扬子块体在黄海海域的接触关系是扬子块体推覆于中朝块体之上 .从目前的地震层析成像、重力异常、地壳厚度分布等结果来看 ,还不足以判断扬子与华南块体结合带在黄海海域中的准确位置 . | 郝天珧 刘建华 Suh Mancheol Choi Suckwon 阎晓蔚 刘振峰 | 2003 | 地球物理学报2003，46，6： | 43 |
| 6 | 关于黄海深部构造的地球物理认识显示文摘利用黄海海区重磁观测数据,以最新的地震层析成像和浅层反射地震探测结果作为约束,并利用小波分解、纹理特征图像处理等手段,对研究区进行了地球物理场特征分析、岩石物性总结、断裂信息提取和磁性基底埋深反演计算,同时对南黄海海域三条剖面进行了广义逆重磁数据拟合反演和地震P波速度成像.根据地球物理数据的各种处理结果,提出在南黄海西部存在一条串珠状地球物理线性构造带,并将这条NNW向断续延伸的构造带称之为南黄海西缘断裂带.该断裂带延伸长,断裂两侧前新生代地层差异较大,有可能是造成陆区和南黄海南部盆地区前新生代油气远景差异的原因之一.文中得到南黄海磁性基底埋藏分布具有'中间浅四周深'的分布特征,与地震层析成像结果相吻合.磁性基底的局部起伏和局部构造的边界断层共同控制了前新生代残留盆地的格架和残余厚度分布,反映出'区域控制局部,深层约束浅层'的规律. | 郝天珧 黄松 徐亚 李志伟 张丽莉 王家林 Suh Mancheol Kim Kwangkee | 2010 | 地球物理学报2010，53，6： | 26 |
| 7 | Current management of hepatocellular carcinoma:An Eastern perspective显示文摘Hepatocellular carcinoma(HCC) is one of the leading causes of cancer death, especially in Eastern areas. With advancements in diagnosis and treatment modalities for HCC, the survival and prognosis of HCC patients are improving. However, treatment patterns are not uniform between areas despite efforts to promote a common protocol. Although many hepatologists in Asian countries may adopt the principles of the Barcelona Clinic Liver Cancer staging system, they are also independently making an effort to expand the indications of each treatment and to combine therapies for better outcomes. Several expanded criteria for liver transplantation in HCC have been developed in Asian countries. Living donor liver transplantation is much more commonly performed in these countries than deceased donor liver transplantation, and it may be preceded by other treatments such as the down-staging of tumors. Local ablation therapies are often combined with transarterial chemoembolization( TACE) and the outcome is comparable to that of surgical resection. The indications of TACE are expanding, and there are new types of transarterial therapies. Although data on drug-eluting beads, TACE, and radioembolization in Asian countries are still relatively sparse compared with Western countries, these methods are gradually gaining popularity because of better tolerability and the possibility of improved response rates. Hepatic arterial infusion chemotherapy and radiotherapy are not included in Western guidelines, but are currently being used actively in several Asian countries. For more advanced HCCs, appropriate combinations of TACE, radiotherapy, and sorafenib can be considered, and emerging data indicate improved outcomes of combination therapies compared with single therapies. To include these paradigm shifts into newer treatment guidelines, more studies may be needed, but they are certainly in progress. | Hyung Joon Yim Sang Jun Suh Soon Ho Um | 2015 | World Journal of Gastroenterology2015，21，13： | 26 |
| 8 | Recent Advances in Cuticular Wax Biosynthesis and Its Regulation in Arabidopsis显示文摘The aerial parts of land plants are covered with cuticular waxes that limit non-stomatal water loss and gaseous exchanges,and protect plants from ultraviolet radiation and pathogen attacks.They are composed of very-long-chain fatty acids (VLCFAs;C20 to C34) in addition to their derivatives,aldehydes,alkanes,primary and secondary alcohols,and wax esters.Due to their physical properties,such as solidity at room temperature and a translucency ranging from transparent to opaque,plant waxes have been used as raw materials in the production of cosmetics,detergents,plastics,soaps,paints,drugs,lubricants,and high-value renewable fuels.Many genes involved in cuticular wax biosynthesis and export have been characterized by forward and reverse genetic approaches as well as by stem epidermis transcriptome analysis.The regulatory mechanisms of cuticular wax biosynthesis have been reported at the transcriptional,posttranscriptional,and translational levels.Recent advances in cuticular wax biosynthesis and its regulation are reviewed in this paper. | Saet Buyl Lee Mi Chung Suh | 2013 | Molecular Plant2013，6，2： | 24 |
| 9 | Diverse Functions of VDUP1 in Cell Proliferation,Differentiation,and Diseases显示文摘Vitamin D3 up-regulated protein 1 (VDUP1) is a multifunctional protein involved in maintaining cellular homeostasis. VDUP1 is induced by a variety of stresses. Inversely,VDUP1 is often reduced in various tumor tissues and cell lines. Over-expression of VDUP1 inhibits cell proliferation through cell cycle arrest. VDUP1 interacts with thioredoxin (Trx) and negatively regulates the expression and antioxidant function of Trx which is involved in redox regulation. VDUP1-/-mice are more susceptible to carcinogenesis than wild-type mice and are defective in establishing immune system including the development and function of natural killer cells. Furthermore,VDUP1-/-mice show impaired Kreb cycle-mediated fatty acid utilization. In this review,we have discussed the multifunctional roles of VDUP1 in diverse cellular responses,in particular its relation to proliferation,apoptosis,differentiation,and diseases such as cancer and stress-related diseases. | Sang Yong Kim Hyun-Woo Suh Jin Woong Chung Suk-Ran Yoon Inpyo Choi | 2007 | Cellular & Molecular Immunology2007，4，5： | 22 |
| 10 | 黄海中央断裂带的地球物理证据及其与边缘海演化的关系显示文摘根据黄海及周边地区的布格重力资料 ,通过解析延拓、目标场提取、任意水平方向导数计算、离散小波变换等处理 ,得到各种有关断裂的信息 .经过与地震层析成像结果和地质资料的综合分析 ,认为黄海中央断裂带是一组“X”型交叉断裂而不仅仅是一条NW向延伸的断裂 ,并提出了有关的地球物理证据 .经分析认为 :黄海中央断裂带的存在是造成黄海东西两侧在地球物理场面貌、断裂分布特点与规模上有较大差异的原因之一 .由于该断裂带的存在 ,致使郯庐断裂带的右旋活动所产生的应力对黄海东西两侧的影响不一致 ,因而产生了黄海西部重力异常等值线凌乱、密集、断裂密布但规模相对东部较小的现象 .认为黄海中央断裂带受扬子块体向中朝块体嵌入过程的影响 ,形成一组近SN向为锐角的“X”断裂带 ,但该断裂带具有明显多期活动的迹象 ,不仅与特提斯体制下块体碰撞、俯冲作用有关 ,也与后期太平洋板块向欧亚板块的聚敛、俯冲作用有关 . | 郝天珧 Suh Mancheol 阎晓蔚 江为为 宋海斌 胥颐 刘振峰 | 2003 | 地球物理学报2003，46，2： | 23 |
| 11 | Histopathology and TB-PCR kit analysis in differentiating the diagnosis of intestinal tuberculosis and Crohn’s disease显示文摘AIM: To compare the histopathologic features of intestinal tuberculosis (ITB) and Crohn’s disease (CD) and to identify whether polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) would be helpful for differential diagnosis between ITB and CD.METHODS: We selected 97 patients with established diagnoses (55 cases of ITB and 42 cases of CD) who underwent colonoscopic biopsies.Microscopic features of ITB and CD were reviewed,and eight pathologic parameters were evaluated.Nine cases of acid fast bacilli culture-positive specimens and 10 normal colonic tissue specimens were evaluated as the positive and negative control of the TB-PCR test,respectively.PCR assays were done using two commercial kits: kit detected IS6110 and MPB64,and kit detected IS6110 only;a manual in-house PCR method was also performed on formalin-fi xed,paraffi n-embedded colonoscopic biopsy specimens.RESULTS: Statistically significant differences were noted between ITB and CD with regard histopathologic criteria: size of granulomas (P = 0.000),giant cells (P = 0.015),caseation necrosis (P = 0.003),confluent granulomas (P = 0.001),discrete granulomas (P = 0.000),and granulomas with lymphoid cuffs (P = 0.037).However,29 cases (52.7%) of ITB showed less than fi ve kinds of pathologic parameters,resulting in confusion with CD.The sensitivities and specificities of the TB-PCR test by kit ,kit ,and the in-house PCR method were 88.9% and 100%,88.9% and 100%,and 66.7% and 100% in positive and negative controls,respectively.The PCR test done on endoscopic biopsy specimens of ITB and CD were signifi cantly different with kit (P = 0.000) and kit (P = 0.000).The sensitivities and specifi cities of TB-PCR were 45.5% and 88.1%,36.4% and 100%,and 5.8% and 100%,for kit and kit and inhouse PCR method on endoscopic biopsy specimens.Among the 29 cases of histopathologically confusing CD,10 cases assayed using kit and 6 cases assayed using kit were TB-PCR positive.A combination of histologic fi ndings and TB-PCR testing led to an increase of diagnostic sensitivity and the increase (from 47.3% to 58.2) was statistically signifi cant with kit (P = 0.000).CONCLUSION: The TB-PCR test combined with histopathologic factors appears to be a helpful technique in formulating the differential diagnosis of ITB and CD in endoscopic biopsy samples. | Joon Mee Kim Hyung Kil Kim Lucia Kim Suk Jin Choi In Suh Park Jee Young Han Young Chae Chu Kye Sook Kwon Eun Joo Kim | 2010 | World Journal of Gastroenterology2010，16，20： | 20 |
| 12 | Eosinophilic gastroenteritis presenting as small bowel obstruction: A case report and review of the literature显示文摘Eosinophilic gastroenteritis is a rare disease of unknown etiology. It is characterized by eosinophilic infiltration of the bowel wall to a variable depth and symptoms associated with gastrointestinal tract. Recently, the authors experienced a case of eosinophilic gastroenteritis presenting as small bowel obstruction. A 51-year old woman was admitted to our hospital complaining of abdominal pain and vomiting. Physical examination revealed a distended abdomen with diffuse tenderness. Complete blood count showed mild leukocytosis without eosinophilia. Computed tomography confirmed a dilatation of the small intestine with ascites. An emergency laparotomy was performed for a diagnosis of peritonitis due to intestinal obstruction. Segmental resection of the ileum and end to end anastomosis were performed. Histologically, there was a dense infiltration of eosinophils throughout the entire thickness of ileal wall and eosinophilic enteritis was diagnosed. The patient recovered well, and was free from gastrointestinal symptoms at the time when we reported her disease. | Min Young Yun Young Up Cho In Suh Park Sun Keun Choi Sei Joong Kim Seok Hwan Shin Kyung Rae Kim | 2007 | World Journal of Gastroenterology2007，13，11： | 19 |
| 13 | Hepatic stellate cells and innate immunity in alcoholic liver disease显示文摘Constant alcohol consumption is a major cause of chronic liver disease, and there has been a growing concern regarding the increased mortality rates worldwide. Alcoholic liver diseases (ALDs) range from mild to more severe conditions, such as steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The liver is enriched with innate immune cells (e.g. natural killer cells and Kupffer cells) and hepatic stellate cells (HSCs), and interestingly, emerging evidence suggests that innate immunity contributes to the development of ALDs (e.g. steatohepatitis and liver fibrosis). Indeed, HSCs play a crucial role in alcoholic steatosis via production of endocannabinoid and retinol metabolites. This review describes the roles of the innate immunity and HSCs in the pathogenesis of ALDs, and suggests therapeutic targets and strategies to assist in the reduction of ALD. | Yang-Gun Suh Won-Il Jeong | 2011 | World Journal of Gastroenterology2011，17，20： | 18 |
| 14 | Role of oxygen free radicals in patients with acute pancreatitis显示文摘The generation of oxygen free radicals has been implicated in the pathogenesis of experimental pancreatitis.The aim of this study was to determine the role of oxygen free radicals in patients with acute pancreatitis.METHODS: The plasma levels of C-reactive protein (CRP),lipid peroxide (LPO), myeloperoxidase (MPO) and superoxide dismutase (SOD) were measured in 13 patients with acute pancreatitis and 14 healthy volunteers.RESULTS: Among the patients with acute pancreatitis, there were higher plasma levels of LPO and MPO and lower SOD activity in patients with severe pancreatitis than in those with mild pancreatitis. However, there was no significant difference in the serum marker of oxidative stress no matter what the etiology was. The LPO level was especially correlated with the concentration of serum CRP and CT severity index.CONCLUSION: The oxygen free radicals may be closely associated with inflammatory process and the severity of acute pancreatitis. Especially, the concentration of plasma LPO is a meaningful index for determining the severity of the disease. | Byung Kyu Park Jae Bock Chung Jin Heon Lee Jeong Hun Suh Seung Woo Park Si Young Song Hyeyoung Kim Kyung Hwan Kim Jin Kyung Kang | 2003 | World Journal of Gastroenterology2003，9，10： | 18 |
| 15 | Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial–mesenchymal transition in mice显示文摘Growing evidence suggests close associations between periodontitis and atherosclerosis.To further understand the pathological relationships of these associations,we developed periodontitis with ligature placement around maxillary molars or ligature placement in conjunction with Porphyromonas gingivalis lipopolysaccharide injection at the ligature sites (ligature/P.g.LPS) in Apolipoprotein E knock out mice and studied the atherogenesis process in these animals.The mice were fed with high fat diet for 11 weeks and sacrificed for analyzing periodontitis,systemic inflammation,and atherosclerosis.Controls did not develop periodontitis or systemic inflammation and had minimal lipid deposition in the aortas,but mice receiving ligature or ligature/P.g.LPS showed severe periodontitis,systemic inflammation,and aortic plaque formation.The aortic plaque contained abundant macrophages and cells expressing both endothelial and mesenchymal cell markers.The severity of periodontitis was slightly higher in mice receiving ligature/P.g.LPS than ligature alone,and the magnitude of systemic inflammation and aortic plaque formation were also notably greater in the mice with ligature/P.g.LPS.These observations indicate that the development of atherosclerosis is due to systemic inflammation caused by severe periodontitis.In vitro,P.g.LPS enhanced the secretion of pro-inflammatory cytokines from macrophages and increased the adhesion of monocytes to endothelial cells by upregulating the expression of adhesion molecules from endothelial cells.Moreover,secretory proteins,such as TNF-α,from macrophages induced endothelial–mesenchymal transitions of the endothelial cells.Taken together,systemic inflammation induced by severe periodontitis might exacerbate atherosclerosis via,in part,causing aberrant functions of vascular endothelial cells and the activation of macrophages in mice. | Jin Sook Suh Sol Kim Kristina I.Bostrom Cun-Yu Wang Reuben H.Kim No-Hee Park | 2019 | International Journal of Oral Science2019，11，3： | 15 |
| 16 | Treatment outcome of localized Helicobacter pylori-negative low-grade gastric MALT lymphoma显示文摘AIM: To investigate treatment outcome of Helicobacter pylori (H.pylori )-negative low-grade gastric mucosaassociated lymphoid tissue (MALT) lymphoma.METHODS: In this study,we retrospectively reviewed the clinical outcome and clinicopathologic factors of stage Ⅰ E H.pylori -negative low-grade gastric MALT lymphoma cases from August 1998 to June 2009.RESULTS: A total of eleven patients with H.pylori -negative low-grade gastric MALT lymphoma were enrolled in the study and received anti-H.pylori eradication treatment and/or radiotherapy or excisional therapy.Complete remission (CR) of gastric MALT lymphoma was achieved in all patients.The time to CR was 1-66 mo (median,1 mo).CONCLUSION: Eradication therapy may be offered as an initial treatment option even in cases of localized H.pylori -negative gastric MALT lymphoma. | Hyung Soon Park Yu Jin Kim Woo Ick Yang Chang Ok Suh Yong Chan Lee | 2010 | World Journal of Gastroenterology2010，16，17： | 13 |
| 17 | Management of entecavir-resistant chronic hepatitis B with adefovir-based combination therapies显示文摘AIM: To evaluate the long-term efficacy adefovir(ADV)-based combination therapies in entecavir(ETV)-resistant chronic hepatitis B(CHB) patients. METHODS: F i fty CHB pat ient s wi t h genotypic resistance to ETV at 13 medical centers in South Korea were included for the analysis. All the patients received rescue therapy with the combination of ADV plus ETV(ADV/ETV,n = 23) or ADV plus lamivudine(LMV)(ADV/LMV,n = 27) for more than 12 mo. Patients were monitored at least every 3-4 mo during ADV-based combination therapy by clinical examination as well as biochemical and virological assessments. Hepatitis B virus(HBV) DNA levels were measured by realtime PCR and logarithmically transformed for analysis. Cumulative rates of virologic response(VR; HBV DNA < 20 IU/m L) were calculated using the Kaplan-Meier method,and the difference was determined by a logrank test. Multivariate logistic regression and Cox proportional hazards models were used to identify independent risk factors significantly associated with short-term and long-term VR,respectively.RESULTS: Baseline median HBV DNA levels were 5.53(2.81-7.63) log10 IU/m L. The most commonly observed ETV genotypic mutation sites were rt184 and rt202. Patients were treated for a median of 27(12-45) mo. Overall,cumulative VR rates at 6,12,24,and 36 mo were 26%,36%,45%,and 68%,respectively. Patients treated with the ADV/ETV combination showed higher cumulative VR rates(35%,43%,65%,and 76%,respectively) than those with the ADV/LAM combination(18%,30%,30%,and 62%,respectively; P = 0.048). In the multivariate analysis,low baseline HBV DNA levels(< 5.2 log10 IU/m L) and initial virologic response at 3 mo(IVR-3; HBV DNA < 3.3 log10 IU/m L after 3 mo) were independent predictive factors for VR. Patients with favorable predictors achieved cumulative VR rates up to 90% at 36 mo. During the same period,the cumulative incidence of virologic breakthrough was as low as 6% in patients with the both favorable predictors.CONCLUSION: If tenofovir is not available,ADV/ETV combination could be considered in ETV-resistant patients with low HBV DNA titers,and may becontinued if IVR-3 is achieved. | Hyoung Su Kim Hyung Joon Yim Myoung Kuk Jang Ji Won Park Sang Jun Suh Yeon Seok Seo Ji Hoon Kim Bo Hyun Kim Sang Jong Park Sae Hwan Lee Sang Gyune Kim Young Seok Kim Jung Il Lee Jin-Woo Lee In Hee Kim Tae Yeob Kim Jin-Wook Kim Sook-Hyang Jeong Young Kul Jung Hana Park Seong Gyu Hwang | 2015 | World Journal of Gastroenterology2015，21，38： | 13 |
| 18 | Low grade gastric mucosa associated lymphoid tissue lymphoma:Treatment strategies based on 10 year follow-up显示文摘AIM:To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities.METHODS:A total of 55 patients with MALTOMA from May 1992 to August 2002 were retrospectively reviewed.RESULTS: Complete remission was obtained in 24 (82.8%) of 29 patients treated with anti Helicobacter pylori(H pylori) regimen only. The duration to reach complete remission was 12 months (85 percentile, 2-33 months).Five patients showed complete remission with radiation therapy (26-86 months).Two of them were Hpyloritreatment failure cases.CONCLUSION: Hpylorieradication is an effective primary treatment option for low grade MALTOMA and radiation therapy could be considered in patients with no evidence of Hpyloninfection or who do not respond to Hpylorieradication therapy 12 months after successful eradication. | Sang Kil Lee Yong Chan Lee Jae Bock Chung Chae Yoon Chon Young Myoung Moon Jin Kyung Kang In-Suh Park Chang Ok Suh Woo Ik Yang | 2004 | World Journal of Gastroenterology2004，10，2： | 12 |
| 19 | Factors influencing syphilis treatment failure and/or re-infection in HIV co-infected patients: immunosuppression or behaviors显示文摘背景最近的研究报导了有高度的梅毒的总的来说增加的率人的免疫不全评估病毒(HIV ) 合作感染。然而,几乎在 HIV 影响梅毒治疗失败或再感染的因素没有很少信息共同感染的病人。我们进行了研究评估在 HIV 与梅毒治疗 failure/re-infection 联系的因素到 2007 年 12 月的从 2005 年 1 月的感染 HIV 的病人的 3542 个医药记录列在后面在上面的我们考察了的共同感染的 patients.Methods 在在纽约的 HIV 诊所城市。病人们被快速的血浆分类重获 titer ( RPR )进 success/serofast (在到在治疗以后的 12 个月的 RPR 的4褶层减少, RPR 变换到没有4褶层增加的非电抗的、固执地稳定的反应 RPR ),并且 failure/re-infection (失败到在到在治疗以后的 12 个月的 RPR 的减少 4 褶层,从基线的 RPR 的4褶层增加)在满足了资格标准的 156 个病人的一个总数之中的 .Results ,( 78.2 ) 122 在 success/serofast 范畴下面,并且( 21.8 ) 34 在 failure/r 下面高度活跃的 antiretroviral 治疗(HAART ) 的 HIV 病毒的负担, CD4 房间计数,和使用没与梅毒治疗 failure/re-infection 被联系。然而,早梅毒舞台(OR:11.036, 95 CI:2.499-48.740, P=0.002 ) 并且高度(164 ) RPR titers (或:715.921, 95 CI:422.175-23 113.396, P 0.001 ) 显著地 associated.Conclusions 没有关联与梅毒治疗失败或再感染与沮丧的有免疫力的州被看见。然而,有早阶段梅毒的协会建议危险心理性行为可以是最重要的带因素,强调对安全的性教育的需要。 | Jong Hun Kim George Psevdos Jr Jin Suh Victoria Sharp | 2011 | Chinese Medical Journal2011，，14： | 10 |
| 20 | 中国海-西太平洋莫霍面深度分布特征及其地质意义显示文摘中国海—西太平洋位于欧亚板块、印澳板块和太平洋板块的交汇处,构造运动剧烈,地质情况复杂,是认识板块运动、洋陆相互作用、物质交换和能量传递不可多得的窗口,而莫霍面深度对于研究壳幔结构以及深部动力过程有着重要的意义.本文使用最新的覆盖全球的重力和地形数据,收集了深地震测深、多道地震测深等剖面183条,数字化得到2982个控制点,使用带控制点的三维界面反演方法来约束反演过程,得到中国海—西太平洋莫霍面深度,由莫霍面形态分析可知大洋板块的俯冲和印澳板块与欧亚板块的碰撞对西太平洋边缘海的形成演化有着重要作用.结合地热、岩石圈厚度、地震活动等地质地球物理资料,分析得知研究区内各个海域莫霍深度和地壳性质的变化是处于不同构造演化阶段的表现.并在马里亚纳沟弧盆拟合一条重力2.5维剖面,结果表明热物质上涌导致了马里亚纳海槽处地幔密度减小,马里亚纳海槽以及帕里西维拉海盆到西马里亚纳海岭的下地壳高密度异常是由残留的岩浆岩引起的. | 胡立天 郝天珧 邢健 胡卫剑 SUH Man-Cheol KIM Kwang-Hee | 2016 | 地球物理学报2016，59，3： | 10 |
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