|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antitumor Activity and Immune Enhancement of Murine Interleukin-23 Expressed in Murine Colon Carcinoma Cells显示文摘cytokine p19 和 IL-12 的 p40 子单元填写了的 Interleukin (IL )-23, ,能从激活的 T 房间提高记忆 T 房间和 IFN- 的生产的增长。它能也在鼠科的模型导致 antitumor 效果。为了推进,在 vivo 评估 antitumor 活动和 IL-23 的有免疫力的改进,鼠科的结肠癌房间 retrovirally,有 mIL-23 基因的 transduced 皮下地被注射(s.c ) 进 BALB/c mice.Survival,时间和肿瘤体积被观察。LDH 版本试金,[3H ]-TdR 加入试金和 ELISA 被用来决定 CTL 活动, splenocytes 的增长和 cytokines 的水平分别地。树枝状的房间(DC ) 的数字被流动 cytometry (FCM ) 分析。Colon26/IL-23 房间分泌的 IL-23 压制了肿瘤的生长并且延长了老鼠, splenocytes 的提高的增长, CTL 活动,和 DC 的数字的幸存时间。IL-23 也支持了象 IFN- , IL-12 和 TNF-o 那样的 Th1 cytokines 的生产。然而, IL-4 的水平没显著地被提高。这些数据建议肿瘤房间分泌的 IL-23 能由提高有免疫力的反应导致 antitumor 活动。 | Baoen Shan Jingsheng Hao Qiaoxia Li Masatoshi Tagawa | 2006 | Cellular & Molecular Immunology2006，3，1： | 11 |
| 2 | 地震作用下钢结构的破坏及抗震性能的提高显示文摘首先探讨了地震对现代钢结构建筑的破坏情况,主要介绍了1995年兵库县南部地震的震害情况。研究了地震作用对梁柱节点、柱、梁、支撑以及柱脚的破坏。对非结构构件在地震作用下的破坏以及结构对长周期地震的响应进行了研究。其次,列出了钢结构抗震性能提高和抗震评估的方法。对改进的梁柱节点形式,例如改进扇形开孔形状和减小梁截面等进行了研究并建议在实际工程中采用。介绍并探讨了约束屈曲支撑和阻尼器的应用。最后,列出了对既有钢结构建筑抗震性能的评估方法。 | Hiroshi Tagawa 雷克 杨彬 | 2011 | 建筑结构2011，41，12： | 6 |
| 3 | Phosphorylation of alphaB-crystallin in epiretinal membrane of human proliferative diabetic retinopathy显示文摘AIM: To examine phosphorylation of alpha B-crystallin(p-αBC), a vascular endothelial growth factor(VEGF)chaperone, and immunohistochemically investigate relationship between p-αBC, VEGF and phosphorylated p38-mitogen-activated protein kinase(p-p38 MAPK) in the epiretinal membrane of human proliferative diabetic retinopathy(PDR).METHODS: Eleven epiretinal membranes of PDR surgically excised were included in this study. Two normal retinas were also collected from enucleation tissues due to choroidal melanoma. Paraformaldehyde-fixed, paraffin-embedded tissue sections were processed for immunohistochemistry with anti-p-αBC, VEGF, CD31,and p-p38 MAPK antibodies.RESULTS: Immunoreactivity for p-αBC was observed in all of the epiretinal membranes examined, where phosphorylation on serine(Ser) 59 showed strongest immunoreactivity in over 70% of the membranes. The immunolocalization of p-αBC was detected in the CD31-positive endothelial cells, and co-localized with VEGF and p-p38 MAPK in PDR membranes. Immunoreactivity for p-αBC, however, was undetectable in endothelial cells of the normal retinas, where p-p38 MAPK immunoreactivity was less marked than PDR membranes.CONCLUSION: Phosphorylation of αBC, in particular,phosphorylation on Ser59 by p-p38 MAPK may play a potential role as a molecular chaperon for VEGF in the pathogenesis of epiretinal membranes in PDR. | Yoko Dong Zhenyu Dong Satoru Kase Ryo Ando Junichi Fukuhara Satoshi Kinoshita Saori Inafuku Yoshiaki Tagawa Erdal Tan Ishizuka Wataru Saito Miyuki Murata Atsuhiro Kanda Kousuke Noda Susumu Ishida | 2016 | International Journal of Ophthalmology(English edition)2016，9，8： | 4 |
| 4 | Efficacy of tolvaptan in patients with refractory ascites in a clinical setting显示文摘AIM: To elucidate the efficacies of tolvaptan(TLV) as a treatment for refractory ascites compared with conventional treatment. METHODS: We retrospectively enrolled 120 refractory ascites patients between January 1, 2009 and September 31, 2014. Sixty patients were treated with oral TLV at a starting dose of 3.75 mg/d in addition to sodium restriction(> 7 g/d), albumin infusion(10-20 g/wk), and standard diuretic therapy(20-60 mg/d furosemide and 25-50 mg/d spironolactone) and 60 patients with large volume paracentesis in addition to sodium restriction(less than 7 g/d), albumin infusion(10-20 g/wk), and standard diuretic therapy(20-120 mg/d furosemide and 25-150 mg/d spironolactone). Patient demographics and laboratory data, including liver function, were not matched due to the small number of patients. Continuous variables were analyzed by unpaired t-test or paired t-test. Fisher's exact test was applied in cases comparing two nominal variables. We analyzed factors affecting clinical outcomes using receiver operating characteristic curves and multivariate regression analysis. We also used multivariate Cox's proportional hazard regression analysis to elucidate the risk factors that contributed to the increased incidence of ascites.RESULTS: TLV was effective in 38(63.3%) patients. The best cut-off values for urine output and reduced urine osmolality as measures of refractory ascites improvement were > 1800 mL within the first 24 h and > 30%, respectively. Multivariate regression analysis indicated that > 25% reduced urine osmolality [odds ratio(OR) = 20.7; P < 0.01] and positive hepatitis C viral antibodies(OR = 5.93; P = 0.05) were positively correlated with an improvement of refractory ascites, while the total bilirubin level per 1.0 mg/dL(OR = 0.57;P = 0.02) was negatively correlated with improvement. In comparing the TLV group and controls, only the serum sodium level was significantly lower in the TLV group(133 mE q/L vs 136 mE q/L; P = 0.02). However, there were no significant differences in the other parameters between the two groups. The cumulative incidence rate was significantly higher in the control group with a median incidence time of 30 d in the TLV group and 20 d in the control group(P = 0.01). Cox hazard proportional multivariate analysis indicated that the use of TLV(OR = 0.58; P < 0.01), uncontrolled liver neoplasms(OR = 1.92; P < 0.01), total bilirubin level per 1.0 mg/dL(OR = 1.10; P < 0.01), and higher sodium level per 1.0 m Eq/L(OR = 0.94; P < 0.01) were independent factors that contributed to incidence. CONCLUSION: Administration of TLV results in better control of refractory ascites and reduced the incidence of additional invasive procedures or hospitalization compared with conventional ascites treatments. | Takamasa Ohki Koki Sato Tomoharu Yamada Mari Yamagami Daisaku Ito Koki Kawanishi Kentaro Kojima Michiharu Seki Nobuo Toda Kazumi Tagawa | 2015 | World Journal of Hepatology2015，7，12： | 4 |
| 5 | Numerical simulation of icing effects on static flow field around blade airfoil for vertical axis wind turbine显示文摘Icing on blade surface of the straight-bladed vertical axis wind turbine(SB-VAWT)set in cold regions is a serious problem.To study the performance effects of icing on SB-VAWT,numerical simulations were carried out on the ice accretion on NACA 0015 airfoil which was always used for blade airfoil of SB-VAWT by CFD methods based on 2D steady incompressible N-S Equation.The morphology and procedure of icing on blade airfoil were obtained under different wind speeds,attack angles of blade and water flow flux in wind.The static flow fields,especially the static pressure fields around blade airfoil with or without icing on it were computed.The aerodynamic characteristics including the lift and drag force coefficients of blade airfoil were also calculated.The results indicated that icing caused the static pressure field changed greatly and led to the increasing of drag force and reducing the aerodynamic performance. | Li Yan Chi Yuan Han Yongjun Li Shengmao Tagawa Kotaro | 2011 | International Journal of Agricultural and Biological Engineering2011，4，3： | 2 |
| 6 | Ceria-based solid electrolyte显示文摘 | Tagawa H | 1996 | Solid State Ionics1996，83，： | 1 |
| 7 | Production of monozygotic twin calves using the blastomere separation technique and Well of the Well culture system显示文摘 | Tagawa M Matoba S Narita M | 2008 | Theriogenology2008，69，5： | 1 |
| 8 | percutaneous ethanol injectiontherpy of hepatocellular carcinoma:analsis of 77 patients显示文摘 | Shina S Tagawa K Unuma T | 1990 | AJRAm J Roentgenol1990，155，6： | 1 |
| 9 | Cytokine therapy for cancer显示文摘 | Tagawa M | 2000 | Curr Pharm Des2000，6，6： | 1 |
| 10 | Effect of Oxygen Plasma Treatment on Field Emission Characteristics of Boron-nitride Films 显示文摘 | Sogino T Tagawa S | 1999 | Appl Phys Lett1999，74，： | 1 |
| 11 | Association of p53 gene mutation with decreased chemosensitivity in human malignant gliomas显示文摘 | Iwadata Y Fujimoto S Tagawa M | 1996 | Int J Cancer1996，69，3： | 1 |
| 12 | Biophysical characterization of the DNA binding and condensing properties of adenoviral core peptide μ ( mu ) 显示文摘 | Keller M Tagawa T Preuss M | 2002 | Biochemistry2002，41，2： | 1 |
| 13 | Immunohistochemical localization of tubulin and actin in rat prostate显示文摘 | Murukoshi M Inada R Tagawa M | 1993 | Tokai J Exp Clin Med1993，18，： | 1 |
| 14 | Displacement Restraint Brac- ing for Seismic Retrofit of Steel Moment Frames显示文摘 | Xingguo Hou Hiroshi Tagawa | 2009 | Journal of Constructional Steel Research2009，65，： | 1 |
| 15 | Controller development for the E-Defense shaking table显示文摘 | Tagawa Y Kajiwara K | 2007 | Proceedings of the Institution of Mechanical Engineers Part I:Journal of Systems and Control Engineering2007，221，2： | 1 |
| 16 | Hepatoma-derived growth factor, a new trophic factor for motor neurons, is up-regulated in the spine cord of PQBP-I transgenic mice before onset of degenera- tion显示文摘 | Marubchi S Okuda T Tagawa K | 2006 | J Neurochem2006，99，1： | 1 |
| 17 | Role of microRNA in the pathogenesis of malignant lymphoma显示文摘 | Tagawa H Ikeda S Sawada K | 2013 | Cancer Sci2013，104，7： | 1 |
| 18 | Multiple periods of functional ocular dominance plasticity in mouse visual cortex 显示文摘 | Tagawa Y Kanold PO Majdan M Shatz CA | 2005 | Nat Neurosci2005，8，3： | 1 |
| 19 | Methods for visual understanding of hierarchical systems 显示文摘 | SUGIYAMA K TAGAWA S TODA M | 1981 | IEEE Transactions on Systems Man and Cybernetics1981，11，2： | 1 |
| 20 | Bone morphogenetic protein-2 stimulates differentiation of cultured spinal ligament cells from patients with ossification of the posterior longitudinal ligament显示文摘 | Yamazaki M Tagawa M | 1997 | Calcif Tissue Int1997，60，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员