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| 1 | Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma显示文摘AIM To conduct a cohort study of 101 patients with hepatocellular carcinoma (HCC) presenting to a tertiary care medical referral center in Germany between 1997 and 1999.METHODS AND RESULTS Data were retrospectively analyzed by chart review. In 95cases (72 males and 23 females) sufficient data were available for analysis. Twenty-five (29%)of 8.5 patients were HBsAg or anti-HBc positive,21/85 (25%) were anti-HCV positive, and 6/85(7%) were positive for both HBV and HCV-markers. Age was significantly lower in HBV-positive patients than in the other two groups.Thirty-one (34%) of 90 patients had histories of alcohol abuse, In 79/ 94 (84%) patients,cirrhosis was diagnosed. Of these cirrhotic patients, 29/79 (37%) belonged to Child-Pugh's group (CHILD) A, 32/79 (40%) to CHILD B, and 18/79 (23%) to CHILD C. AFP was elevated in 61/91 (67%) patients. A single tumor nodule was found in 38/94 (40%), more than one nodule in 31/94 (34%), and 25/94 (26%) had a diffusely infiltrating tumor, i.e. the tumor margins could not be seen on imaging procedures. Portal vein thrombosis was present in 19/ 94 (20%).Imaging data consistent with lymph node metastases were found in 10/92 (11%), while distant metastases were found in 8/93 (9%).According to Okuda 28/94 (30%) were grouped to stage Ⅰ, 53/94 (56%) were grouped to stage Ⅱ, and 13/94 (14%) were grouped to stage Ⅲ.Survival data were available for 83 patients. The Kaplan-Meier estimate for median survival was 8.4 months. Factors influencing survival were the Okuda score, the presence of portal vein thrombosis, and the presence of ascites. The presence of non-complicated liver cirrhosis by itself, distant metastases, or infection with hepatitis viruses did not influence survival. AFP positivity by itself did not influence survival,though patients with an AFP value greater than 100μg/L did experience shortened survival.Treatment besides tamoxifen or supportive care was associated with prolonged survival. The influence of therapy on survival was most pronounced in Okuda stage Ⅱ patients. There was longer survival in those Okuda stage Ⅱpatients who were treated with percutaneous ethanol injection.CONCLUSION Even in a Iow incidence area such as Germany, the majority of HCC is caused by viral hepatitis and therefore potentially preventable. Reflecting the high proportion of advanced stage tumors in our patients, the median survival was poor. Patients who received active therapy had a longer survival. | Christian Rabe Tillmann Pilz Christoph Klostermann Marc Berna Hans H.Schild Tilman Sauerbruch Wolfgang H.Caselmann | 2001 | World Journal of Gastroenterology2001，7，2： | 60 |
| 2 | 维生素D对心力衰竭患者全因死亡率的影响:4000U/d维生素D口服3年随机临床试验结果显示文摘循环25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]〈75nmol/L与死亡率风险的非线性增加相关。这种低25(OH)D水平在心力衰竭患者中很常见。因此,Zittermann等进行研究检查口服维生素D补充剂能否降低晚期心力衰竭患者的死亡率。 | 刘莉 叶鹏 Zittermann A Ernst JB Prokop S Fuchs U Dreier J Kuhn J Knabbe C Birschmann I Schulz U Berthold HK Pilz S Gouni-Berthold I Gummert JF Dittrich M Brgermann J | 2017 | 中华高血压杂志2017，25，10： | 7 |
| 3 | Vitamin D Status and Mortality Risk in CKD: A Meta-analysis of Prospective Studies显示文摘 | Stefan Pilz Simona Iodice Armin Zittermann William B. Grant Sara Gandini | 2011 | American Journal of Kidney Diseases2011，，3： | 2 |
| 4 | Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression显示文摘 | Strieth S Hartschuh W Pilz L | 2002 | Br J Cancer2002，87，11： | 2 |
| 5 | A new spectrophotometic method for determination of 5-nucleotidase显示文摘 | Heinz F Pilz R Reckes | 1980 | J Clin Chem Biochem1980，18，： | 2 |
| 6 | Beyond cholesterol-inflam-matory cytokines,the key mediators in atherosclerosis显示文摘 | Mangge H Hubmann H Pilz S | 2004 | Clin Chem Lab Med2004，42，5： | 1 |
| 7 | Adiponectin serum concentrations in men with coronary artery disease:the LUdwigshafen Risk and Cardiovascular Health(LURIC) study显示文摘 | Pilz S Maerz W Weihrauch G | 2006 | Clin Chim Acta2006，364，12： | 1 |
| 8 | Two Countries--One System of Vocational Education? A Comparison of the Apprenticeship Reform in the Commercial Sector in Switzerland and Germany显示文摘 | Matthias Pilz | 2007 | A Journal of Comparative Education2007，37，1： | 1 |
| 9 | Association of vitamin D deficiency with heart failure and sudden cardiac death in a large crosg - sectional study of patients refered for coronary angiograply 显示文摘 | Pilz SL Larz W Wellnitz B | 2008 | J Clin Endocrinol Metab2008，93，： | 1 |
| 10 | Independent association of low serum 25-hydroxyvitamin d and 1, 25dihydroxyvitamin d levels with all-cause and cardiovascular mortality 显示文摘 | Dobnig H Pilz S Scharnagl H | 2008 | Arch Intern Med2008，168，12： | 1 |
| 11 | 查看详情显示文摘 | Pilz C Enkerli J Wegensteiner R | | 0，，06： | 1 |
| 12 | Adult cirrhosis due to untreated congenital hypopituitarism显示文摘 | Nyunt A Kochar N Pilz DT | 2005 | J R Soc Med2005，98，7： | 1 |
| 13 | Plasma aldosterone and left ventricular diastolic function in treatment-nave patients with hypertension:tissue-Doppler imaging study显示文摘 | Catena C Verheyen N Pilz S | 2015 | Hypertension2015，65，6： | 1 |
| 14 | Distal external lymph fistula of the tibia as a complication of vena saphena magna harvesting显示文摘 | PIZA-KATZER H PILZ E | 1992 | Vasa1992，21，： | 1 |
| 15 | Policy-Maker--A toolkit for policy-based security management 显示文摘 | Pilz A | 2004 | Network Operations and Management2004，，1： | 1 |
| 16 | Muhi-parametric MRI of rectal cancer-Do quantitative functional MR meas- urements correlate with radiologic and pathologic tumor sta- ges显示文摘 | Attenberger UI Pilz LR Morelli JN | 2014 | Eur J RadiolEuropean Journal of Radiology2014，83，7： | 1 |
| 17 | Undifferentiated sarcoma of the liver in childhood : a curable disease显示文摘 | Bisogno G Pilz T Perilongo G | 2002 | Cancer2002，94，1： | 1 |
| 18 | Taurine chloramine induces apoptosis in human osteosarcoma cell lines 显示文摘 | Pilz M Holinka J Vavken P | 2012 | J Orthop Res2012，30，12： | 1 |
| 19 | Folded reflectarray antenna 显示文摘 | PILZ D MENZEL W | 1998 | Electronics letters1998，34，9： | 1 |
| 20 | Vitamin D status and mortality risk in CKD: a meta-analysis of prospective studies 显示文摘 | PILZ S IODICE S ZITI'ERMANN A | 2011 | Am J Kidney Dis2011，58，3： | 1 |
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